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CEFAZOLINE SALA 1 g POWDER AND SOLVENT FOR INJECTABLE SOLUTION

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About the medicine

How to use CEFAZOLINE SALA 1 g POWDER AND SOLVENT FOR INJECTABLE SOLUTION

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Leaflet: Information for the user

Cefazoline Sala 1 g powder and solvent for injectable solution EFG

Cefazoline

Read the entire leaflet carefully before starting to use this medicine, as it contains important information for you

  • Keep this leaflet. You may need to read it again.
  • If you have any doubts, consult your doctor or pharmacist.
  • This medicine has been prescribed to you personally and should not be given to others, even if they have the same symptoms, as it may harm them.
  • If you experience side effects, consult your doctor or pharmacist, even if they are not listed in this leaflet. See section 4.

Contents of the leaflet:

  1. What Cefazoline Sala is and what it is used for.
  2. What you need to know before starting to use Cefazoline Sala.
  3. How to use Cefazoline Sala.
  4. Possible side effects.
  5. Storage of Cefazoline Sala.
  6. Package contents and additional information.

1. What Cefazoline Sala is and what it is used for

Cefazoline is an antibiotic belonging to the group of cephalosporins.

Antibiotics are used to treat bacterial infections and are not effective against viral infections such as the flu or the common cold.

It is essential to follow the instructions regarding dosage, administration interval, and treatment duration as indicated by your doctor.

Do not store or reuse this medicine. If you have any leftover antibiotic after completing the treatment, return it to the pharmacy for proper disposal. Do not throw away medicines down the drain or in the trash.

This medicine is used to treat the following bacterial infections caused by sensitive pathogens located in:

  • respiratory system
  • urinary system
  • skin and soft tissues
  • joints
  • heart
  • blood (septicemia)
  • in the prevention of infections in surgery.
Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before starting to use Cefazoline Sala

Do not use Cefazoline Sala:

  • If you are allergic (hypersensitive) to cefazoline, other cephalosporins, or any of its components.

Warnings and precautions

Be particularly careful with Cefazoline Sala

  • If you experience intense and prolonged diarrhea, it may be due to a special type of colitis called pseudomembranous colitis, which can be severe. In these cases, your doctor will decide whether to suspend cefazoline administration and initiate appropriate treatment.
  • If you undergo prolonged treatment with cefazoline, superinfections may occur.
  • If you have kidney failure, your doctor may need to adjust the dose of cefazoline you receive.
  • If you are to undergo any blood tests, inform the healthcare staff that you are being treated with this medicine, as cefazoline may interfere with the results.

Risk factors that may cause vitamin K deficiency or risk factors that influence other blood coagulation mechanisms.

On rare occasions, blood coagulation disorders may occur during treatment with cefazoline. Additionally, changes in blood coagulation may occur in patients with diseases that can cause or worsen bleeding, such as hemophilia or stomach or intestinal ulcers. In these cases, your blood coagulation will be monitored.

Other medicines and Cefazoline Sala

Inform your doctor or pharmacist if you are using or have recently used any other medicine, including those purchased without a prescription.

Cefazoline should not be administered with:

  • Other antibiotics with a similar mechanism of action, such as tetracyclines, sulfonamides, erythromycin, and chloramphenicol
  • Anticoagulants
  • Probenecid (used to treat gout)
  • Nephrotoxic agents

Pregnancy and breastfeeding

In case of pregnancy or breastfeeding, your doctor will decide whether to use this medicine. Consult your doctor or pharmacist before taking any medicine.

Driving and using machines

Cefazoline generally does not alter the ability to drive vehicles or operate machinery.

Cefazoline Sala contains sodium

Patients on low-sodium diets should note that this medicine contains 51 mg (2.2 mmol) of sodium per gram of cefazoline.

Cefazoline Sala contains lidocaine hydrochloride

This specialty contains lidocaine hydrochloride to increase local tolerance in intramuscular administration. Consequently, it should not be used intravenously or in patients with a history of hypersensitivity to lidocaine.

Lidocaine hydrochloride may produce a positive result in doping tests.

Medicine questions

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3. How to use Cefazoline Sala

Follow your doctor's instructions for administering this medicine exactly. If in doubt, consult your doctor or pharmacist again.

Your doctor will indicate the appropriate dose and determine the duration of your treatment; do not stop it before completing it or prolong it.

Recommended dose

Adults and children over 12 years old: in the case of mild infections, 500 mg every 8 hours; in moderate to severe infections, 500 mg to 1 g every 6 or 8 hours; in more severe infections, 1 g to 1.5 g every 6 hours.

Children (under 12 years old and over 1 year old): a total daily dose of 25 to 50 mg per kg of body weight, divided into three or four equal doses, is effective in most mild to moderate infections. The total daily dose should not exceed 100 mg/kg, even in severe infections.

Prophylactic treatment

  • 1-2 g intramuscularly administered 30 minutes to 1 hour before starting surgery.
  • for prolonged surgical procedures (e.g., 2 hours or more) 500 mg to 1 g intramuscularly during surgery (administration will be modified depending on the duration of the intervention).
  • 500 mg to 1 g intramuscularly every 6 to 8 hours for 24 hours post-operatively.

Patients with renal and/or hepatic insufficiency

A dose reduction may be necessary if you have any renal or hepatic impairment. In such cases, inform your doctor so that they can adjust the dose accordingly.

If you use more Cefazoline Sala than you should

In case of accidental overdose, consult your doctor or pharmacist immediately or call the Toxicology Information Service, phone: 91 562 04 20, indicating the medicine and the amount taken. Bring the leaflet with you.

If you forget to use Cefazoline Sala

Do not take a double dose to make up for forgotten doses.

If you interrupt treatment with Cefazoline Sala

Do not stop treatment before completing it, as the desired effect will not be achieved. It is very important to treat infections for the recommended time; otherwise, they may worsen.

If you have any other doubts about using this product, ask your doctor or pharmacist.

4. Possible side effects

Like other medicines, this medicine can cause the following side effects, although not all people will experience them.

The incidence of adverse reactions associated with Cefazoline Sala treatment is classified as follows:

Severe allergic reactions(very rare, may affect up to 1 in 10,000 people).

If you have a severe allergic reaction, inform your doctor immediately.

Possible symptoms include:

  • Sudden swelling of the face, throat, mouth, or lips, which can cause difficulty breathing or swallowing.

  • Sudden swelling of hands, feet, and ankles.
  • Other possible side effects

    Frequent(may affect up to 1 in 10 people):

    • Rash.
    • Nausea and vomiting.
    • Diarrhea.
    • Pain or induration (hardened skin) at the injection site.

    Uncommon(may affect up to 1 in 100 people):

    • Oral thrush.
    • Fever.
    • Seizures.
    • Phlebitis.
    • Itching and redness of the skin, joint pain, skin lesions, generalized rash, and urticaria.

    Rare(may affect up to 1 in 1,000 people):

    • Genital infection, vaginal candidiasis — vaginal pain or itching or vaginal discharge.
    • Prolonged use may cause the proliferation of non-susceptible bacteria.
    • Increased or decreased blood cell count.
    • Hyperglycemia (high blood sugar), hypoglycemia (low blood sugar)
    • Dizziness.
    • Respiratory disorders (breathing).
    • Kidney and urinary tract disorders.
    • Cough.
    • Rhinorrhea.
    • Lack of appetite.
    • Liver failure (detectable in blood tests), jaundice.
    • Severe rash with rapid progression (with blisters on the skin and skin peeling, and possible blisters in the mouth).
    • Severe fatigue and weakness.
    • Chest pain.

    Very rare(may affect up to 1 in 10,000 people):

    • Blood coagulation disorders.
    • Colon inflammation. Symptoms include diarrhea, usually with blood and mucus, abdominal pain, and fever.
    • Genital itching.

    Reporting side effects

    If you experience any side effects, consult your doctor or pharmacist, even if they are not listed in this leaflet. You can also report them directly through the Spanish Pharmacovigilance System for Human Use Medicines (https://www.notificaram.es). By reporting side effects, you can contribute to providing more information on the safety of this medicine.

    5. Storage of Cefazoline Sala

    Keep this medicine out of the sight and reach of children.

    Do not use this medicine after the expiration date stated on the packaging. The expiration date is the last day of the month indicated.

    Store in the outer packaging to protect it from light.

    The reconstituted solution with the solvent is stable for 8 hours at a temperature not exceeding 25°C and for 24 hours if stored in the refrigerator (2-8°C).

    Do not use this medicine if you notice visible signs of deterioration.

    Medicines should not be thrown away down the drain or in the trash. Deposit the packaging and unused medicines in a SIGRE collection point at the pharmacy. If in doubt, ask your pharmacist how to dispose of the packaging and unused medicines. This will help protect the environment.

    6. Package contents and additional information

    Composition of Cefazoline Sala 1 g powder and solvent for injectable solution EFG

    The active ingredient is cefazoline. Each vial contains 1 g of cefazoline (DOE) (as cefazoline sodium).

    Each ampoule of solvent includes 4 ml of lidocaine hydrochloride solution at 0.5% (20 mg)

    Appearance of the product and package contents

    Cefazoline Sala 1 g powder and solvent for injectable solution EFG is presented in a glass vial accompanied by a glass ampoule with the solvent.

    Each package contains 1 vial with 1 ampoule, and the clinical package contains 100 vials and 100 ampoules.

    Marketing Authorization Holder and Manufacturer

    Marketing Authorization Holder

    Laboratorio Reig Jofre S.A.

    Gran Capitán, 10 - 08970

    Sant Joan Despí (Barcelona)

    Spain

    Manufacturer:

    Laboratorio Reig Jofre, S.A.

    C/Jarama 11, Polígono industrial-45007

    Toledo-Spain

    This leaflet was approved in:December 2024

    Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/

    ---------------------------------------------------------------------------------------------------------------------------

    This information is intended only for healthcare professionals

    Warning text about specialty containing lidocaine hydrochloride and its intramuscular administration

    Intramuscular administration:reconstitute with the solvent from the ampoule. Shake well until dissolved. Cefazoline should be injected into a area of large muscle mass. It is infrequent to experience pain at the injection site, as the solvent ampoule contains lidocaine.

    Online doctors for CEFAZOLINE SALA 1 g POWDER AND SOLVENT FOR INJECTABLE SOLUTION

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    Hocine Lokchiri

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    Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

    Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

    • fever, chills, fatigue and viral symptoms
    • cough, sore throat, nasal congestion, breathing discomfort
    • bronchitis and mild asthma flare-ups
    • nausea, diarrhoea, abdominal pain, digestive infections
    • rashes, allergic reactions, redness, insect bites
    • muscle or joint pain, mild injuries, sprains
    • headache, dizziness, migraine symptoms
    • stress-related symptoms, sleep disturbances
    • questions about test results and treatment plans
    • management of chronic conditions in stable phases
    Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

    Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

    Dr. Lokchiri’s professional training includes:

    • Advanced Trauma Life Support (ATLS)
    • Basic and Advanced Cardiac Life Support (BLS/ACLS)
    • Pediatric Advanced Life Support (PALS)
    • Prehospital Trauma Life Support (PHTLS)
    • eFAST and critical care transthoracic echocardiography
    • aviation medicine
    He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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    Dr Okeke focuses on general internal medicine and adult primary care, combining clinical accuracy with careful attention to lifestyle, personal context, and everyday health concerns. His consultations are particularly well suited for people who seek medical advice online, live abroad, or need clear guidance without unnecessary complexity.

    He provides online consultations covering symptom assessment, prevention, and long-term management of chronic conditions, helping patients understand what is happening and decide on appropriate next steps.

    Common reasons for consultation:

    • General internal medicine concerns and initial health assessment.
    • Acute symptoms such as fever, cough, infections, pain, or weakness.
    • Chronic conditions and treatment adjustment.
    • Blood pressure issues, fatigue, metabolic concerns.
    • Preventive consultations and routine check-ups.
    • Interpretation of laboratory results and medical reports.
    • Medical advice for patients receiving care online.

    Dr Okeke is known for his clear communication, calm approach, and cultural awareness. He listens carefully, explains medical decisions in a structured way, and supports patients in making informed choices about their health.

    Online consultations with Dr Chikeluo Okeke offer reliable internal medicine care without geographic limitations, focused on medical relevance, clarity, and patient comfort.

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    Lina Travkina

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    Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

    Areas of medical care include:

    • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
    • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
    • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
    • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
    • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
    • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
    • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

    Additional care areas:

    • Preventive consultations and check-up planning.
    • Medical advice and follow-up consultations.
    • Test interpretation and diagnostic guidance.
    • Structured support for undiagnosed complaints.
    • Second opinion on diagnoses and treatment plans.
    • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
    • Post-operative recovery support and pain management.
    • Preconception counselling and postpartum support.
    • Immunity support and strategies to reduce frequency of infections.

    Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

    If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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    Dr. Tsurkan supports patients with a wide range of health issues, including:

    • Respiratory infections: cold, flu, bronchitis, pneumonia, and lingering coughs.
    • ENT conditions: sinusitis, tonsillitis, otitis (ear infections), sore throat, allergic rhinitis.
    • Eye conditions: allergic or infectious conjunctivitis, red eyes, irritation.
    • Digestive issues: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), constipation, bloating, nausea.
    • Urinary and reproductive health: urinary tract infections (UTIs), cystitis, prevention of recurrent infections.
    • Chronic diseases: hypertension, elevated cholesterol, weight management.
    • Neurological complaints: headaches, migraines, sleep disturbances, fatigue, general weakness.
    • Children’s health: fever, infections, digestive issues, follow-ups, vaccination guidance.

    She also provides:

    • IMT medical certificates for driving licence exchange in Portugal.
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    • Interpretation of test results and medical reports.
    • Follow-up care and medication review.
    • Support in managing multiple coexisting conditions.
    • Remote prescription management and medical documentation.

    Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

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    His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

    Pain: how he can help

    • Chronic pain (more than 3 months
    • Migraine and recurrent or high-intensity headaches
    •  Neck, lower back, back and joint pain
    •  Post-traumatic pain after injuries or surgeries
    •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

    General medicine

    • Frequent respiratory infections (cold, flu, persistent cough)
    • Hypertension, diabetes and metabolic disorders
    • Review of laboratory tests and MRI/CT reports (explained in clear language)
    • Preventive medicine and health monitoring
    • Second opinions and treatment adjustments (when clinically appropriate)

    What the consultation is like
     Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

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    Yevgen Yakovenko

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    Areas of medical expertise:

    • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
    • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
    • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
    • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
    • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
    • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
    • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
    • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
    • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

    Experience and qualifications:

    • 12+ years of clinical experience in university hospitals in Germany and Spain.
    • International education: Ukraine – Germany – Spain.
    • Member of the German Society of Surgeons (BDC).
    • Certified in radiological diagnostics and robotic surgery.
    • Active participant in international medical conferences and research.

    Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

    If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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    Joao Silva

    General medicine 6 years exp.

    Dr. João Silva is a physician with training and experience in the field of General and Family Medicine, dedicated to providing healthcare focused on the well-being and quality of life of his patients. Throughout his professional career, he has developed broad clinical competencies, striving to maintain a medical practice based on scientific evidence and continuous knowledge updates.

    Between 2013 and 2019, he completed the Integrated Master's Degree in Medicine at the Abel Salazar Institute of Biomedical Sciences in Porto, where he acquired a solid academic and clinical education.

    Subsequently, between January 2021 and December 2021, he completed the General Internship at the Entre Douro e Vouga Hospital Center in Santa Maria da Feira, where he had the opportunity to work in different hospital settings and deepen his competencies in several areas of medicine.

    From January 2022 until March 2026, he works as a Resident Physician in General and Family Medicine at USF Salvador Machado in Oliveira de Azeméis, developing clinical activities in primary healthcare, follow-up of chronic patients, and health promotion in the community.

    Complementing his medical training, Dr. João Silva also completed a Postgraduate Degree in Continuing and Palliative Care at CESPU, strengthening his preparation in the comprehensive approach to patient care, especially in situations requiring prolonged care and multidisciplinary support.

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    Frequently Asked Questions

    Is a prescription required for CEFAZOLINE SALA 1 g POWDER AND SOLVENT FOR INJECTABLE SOLUTION?
    CEFAZOLINE SALA 1 g POWDER AND SOLVENT FOR INJECTABLE SOLUTION requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
    What is the active substance in CEFAZOLINE SALA 1 g POWDER AND SOLVENT FOR INJECTABLE SOLUTION?
    The active ingredient in CEFAZOLINE SALA 1 g POWDER AND SOLVENT FOR INJECTABLE SOLUTION is cefazolin. This information helps identify medicines with the same composition but different brand names.
    Who manufactures CEFAZOLINE SALA 1 g POWDER AND SOLVENT FOR INJECTABLE SOLUTION?
    CEFAZOLINE SALA 1 g POWDER AND SOLVENT FOR INJECTABLE SOLUTION is manufactured by Laboratorio Reig Jofre, S.A.. Pharmacy brands and packaging may differ depending on the distributor.
    Which doctors can assess the use of CEFAZOLINE SALA 1 g POWDER AND SOLVENT FOR INJECTABLE SOLUTION online?
    Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether CEFAZOLINE SALA 1 g POWDER AND SOLVENT FOR INJECTABLE SOLUTION is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
    What are the alternatives to CEFAZOLINE SALA 1 g POWDER AND SOLVENT FOR INJECTABLE SOLUTION?
    Other medicines with the same active substance (cefazolin) include CEFAZOLIN LDP LABORATORIOS TORLAN 1g POWDER FOR INJECTABLE SOLUTION AND FOR INFUSION, CEFAZOLIN LDP LABORATORIOS TORLAN 2g POWDER FOR INJECTABLE SOLUTION AND FOR INFUSION, CEFAZOLIN NORMON 1 g POWDER AND SOLVENT FOR INTRAMUSCULAR INJECTION. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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