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ZEFFIX 100 mg FILM-COATED TABLETS

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About the medicine

How to use ZEFFIX 100 mg FILM-COATED TABLETS

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the Patient

Zeffix 100mg film-coated tablets

lamivudine

Read all of this leaflet carefully before you start taking this medicine.

  • Keep this leaflet, as you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What Zeffix is and what it is used for
  2. What you need to know before you take Zeffix
  3. How to take Zeffix
  4. Possible side effects
  5. Storage of Zeffix
  6. Contents of the pack and other information

1. What Zeffix is and what it is used for

The active substance of Zeffix is lamivudine.

Zeffix is used to treat long-term (chronic) hepatitis B infection in adults.

Zeffix is an antiviral medicine that stops the hepatitis B virus from multiplying and belongs to a group of medicines called nucleoside analogue reverse transcriptase inhibitors (NRTIs).

The hepatitis B virus infects the liver and can cause long-term (chronic) infection, which can lead to liver damage. Zeffix can be used in patients whose liver is damaged but still works normally (compensated liver disease) and in combination with other medicines in patients whose liver is damaged and does not work normally (decompensated liver disease).

Treatment with Zeffix can reduce the amount of hepatitis B virus in your body. This can lead to a reduction in liver damage and an improvement in the function of your liver. Not everyone responds to treatment with Zeffix in the same way. Your doctor will monitor the effectiveness of your treatment with regular blood tests.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you take Zeffix

Your doctor should offer you advice and testing to detect HIV infection before you start treatment with lamivudine for hepatitis B infection and during treatment. If you have or get HIV infection, see section 3.

Do not take Zeffix

  • if you are allergicto lamivudine or any of the other ingredients of this medicine (listed in section 6).
  • Consult your doctorif you think this applies to you.

Warnings and precautions

Some people who take Zeffix or similar medicines have a higher risk of getting serious side effects. You need to know that there is a higher risk:

  • if you have ever had other types of liver disease, such as hepatitis C
  • if you are overweight(especially if you are a woman)
  • Tell your doctorif you have any of these conditions. You may need extra checks, such as blood tests, while you are taking this medicine. For more information about the risks, see Section 4.

Do not stop taking Zeffixwithout your doctor's advice, as there is a risk that your hepatitis may get worse. When you stop taking Zeffix, your doctor will monitor you for at least four months to check for any problems. This will involve taking blood samples to check for increases in liver enzyme levels that may indicate liver damage. See section 3 for more information on how to take Zeffix.

Protect others

Hepatitis B is spread by having sexual contact with someone who has the disease or by transferring infected blood (for example, by sharing needles). Zeffix does not prevent the risk of passing on hepatitis B infection to others. To prevent others from getting hepatitis B:

  • Use a condomwhen you have oral or penetrative sex.
  • Avoid the risk of blood transfer— for example, do not share needles.

Other medicines and Zeffix

Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including those bought without a prescription and herbal medicines.

Remember to tell your doctor or pharmacist if you start taking any other medicines while you are taking Zeffix.

These medicines must not be taken with Zeffix:

  • medicines that contain sorbitol or other polyalcohols (such as xylitol, mannitol, lactitol, or maltitol) if taken regularly (usually liquids)
  • other medicines that contain lamivudine, used to treat HIV infection(sometimes also called AIDS virus)
  • emtricitabine, used to treat HIV infectionor hepatitis B
  • cladribine, used to treat hairy cell leukemia
  • Tell your doctorif you are being treated with any of these medicines.

Pregnancy

If you are pregnant, think you may be pregnant, or are planning to have a baby:

  • Ask your doctorabout the risks and benefits of taking Zeffix during pregnancy.

Do not stop taking Zeffix without your doctor's advice.

Breast-feeding

Zeffix can pass into breast milk. If you are breast-feeding or thinking of breast-feeding:

  • Ask your doctorbefore taking Zeffix.

Driving and using machines

Zeffix may make you feel tired, which could affect your ability to drive or use machines.

  • Do not drive or use machines unless you are sure it won't affect you.

Zeffix contains sodium

This medicine contains less than 1 mmol sodium (23 mg) per tablet, which is essentially 'sodium-free'.

3. How to take Zeffix

Always take this medicine exactly as your doctor has told you.If you are not sure, check with your doctor or pharmacist.

Keep in regular contact with your doctor

Zeffix helps to control your hepatitis B infection. You need to keep taking it every day to control the infection and prevent it from getting worse.

  • Stay in touch with your doctor and do not stop taking Zeffixwithout your doctor's advice.

How much to take

The usual dose of Zeffix is one tablet(100 mg of lamivudine) once a day.

Your doctor may prescribe a lower dose if you have kidney problems. Zeffix oral solution is available for people who need a lower dose than usual or who cannot take tablets.

  • Ask your doctorif you are in this situation.

Patients who also have or may get HIV infection

If you have or get HIV infection that is not being treated with medicines, while you are taking lamivudine for hepatitis B infection, the HIV virus can develop resistance to certain HIV medicines and become difficult to treat. Lamivudine is also used to treat HIV infection. Talk to your doctor if you have HIV infection. Your doctor may treat you with another medicine that contains a higher dose of lamivudine, usually 150 mg twice a day, as the lower dose of 100 mg is not enough to treat HIV infection. If you are planning to change your HIV treatment, discuss this change with your doctor before.

  • Ask your doctorif you are in this situation.

Swallow the tablet whole with water. Zeffix can be taken with or without food.

If you take more Zeffix than you should

If you accidentally take too much Zeffix, talk to your doctor or pharmacist, or go to the nearest hospital casualty department. If possible, show them the Zeffix pack.

If you forget to take Zeffix

If you miss a dose, take it as soon as you remember. Then continue taking it as before. Do not take a double dose to make up for a forgotten dose.

Do not stop taking Zeffix

Do not stop taking Zeffix without talking to your doctor. There is a risk that your hepatitis may get worse (see section 2). When you stop taking Zeffix, your doctor will monitor you for at least four months to check for any problems. This will involve taking blood samples to check for increases in liver enzyme levels that may indicate liver damage.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

The most common side effects reported with Zeffix in clinical trials were tiredness, infections of the respiratory tract, sore throat, headache, discomfort and stomach pain, nausea, vomiting, and diarrhea, increased liver enzymes, and increased muscle enzymes (see below).

Allergic reaction

This is rare (may affect up to 1 in 1,000 people). The signs include:

  • swelling of the eyelids, face, or lips
  • difficulty swallowing or breathing.
  • See a doctor immediatelyif you get these symptoms. Stop taking Zeffix.

Side effects that are thought to be caused by Zeffix:

A very common side effect(may affect more than 1 in 10people) that may appear in blood tests is:

  • an increase in the levels of some liver enzymes (transaminases), which may be a sign of liver inflammation or damage.

A common side effect(may affect up to 1 in 10people) is:

  • muscle cramps and muscle pain
  • rash or "hives" anywhere on the body.

A common side effect that may appear in blood tests is:

  • an increase in the level of a muscle enzyme (creatine phosphokinase) that may be a sign of muscle damage.

A very rare side effect(may affect up to 1 in 10,000 people) is:

  • lactic acidosis (excess of lactic acid in the blood).

Other side effects

Other side effects have been reported in a small number of people, but their exact frequency is unknown:

  • muscle breakdown
  • worsening of liver disease if the hepatitis B virus becomes resistant to Zeffix or if treatment is stopped. This can be fatal in some people.

A side effect that may appear in blood tests is:

  • a decrease in the number of blood cells involved in blood clotting (thrombocytopenia).

If you get side effects

  • Tell your doctor or pharmacisteven if you think the side effects are not caused by the medicine or are trivial. This includes any possible side effects not listed in this leaflet.

Reporting of side effects

If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Zeffix

Keep this medicine out of the sight and reach of children.

Do not take this medicine after the expiry date which is stated on the carton and blister.

Do not store above 30°C.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help protect the environment.

6. Contents of the pack and other information

What Zeffix contains

The active substance is lamivudine. Each film-coated tablet contains 100 mg of lamivudine.

The other ingredients are: microcrystalline cellulose, sodium carboxymethylcellulose, magnesium stearate, hypromellose, titanium dioxide, macrogol 400, polysorbate 80, synthetic red and yellow iron oxide.

Appearance and packaging

Zeffix film-coated tablets are presented in child-resistant blisters containing 28 or 84 tablets. The tablets are caramel-colored, capsule-shaped, biconvex, and marked "GX CG5" on one face.

Not all pack sizes may be marketed.

Manufacturer

Marketing Authorisation Holder

GlaxoSmithKline Pharmaceuticals S.A.

ul. Grunwaldzka 189

60-322 Poznan

Poland

GlaxoSmithKline Services Limited

12 Riverwalk

Citywest Business Campus

Dublin 24

Ireland

D24 YK11

You can ask for more information about this medicine from the local representative of the Marketing Authorisation Holder:

België/Belgique/Belgien

GlaxoSmithKline Pharmaceuticals s.a./n.v.

Tél/Tel: + 32 (0)10 85 52 00

Lietuva

GlaxoSmithKline Trading Services Limited

Tel: + 370 80000334

Text with contact information of GlaxoSmithKline Trading Services Limited and phone number

Luxembourg/Luxemburg

GlaxoSmithKline Pharmaceuticals s.a./n.v.

Belgique/Belgien

Tél/Tel: + 32 (0) 10 85 52 00

Ceská republika

GlaxoSmithKline s.r.o.

Tel: + 420 222 001 111

[email protected]

Magyarország

GlaxoSmithKline Trading Services Limited

Tel.: + 36 80088309

Danmark

GlaxoSmithKline Pharma A/S

Tlf: + 45 36 35 91 00

[email protected]

Malta

GlaxoSmithKline Trading Services Limited

Tel: + 356 80065004

Deutschland

GlaxoSmithKline GmbH & Co. KG

Tel.: + 49 (0)89 36044 8701

[email protected]

Nederland

GlaxoSmithKline BV

Tel: + 31 (0) 33 2081100

Eesti

GlaxoSmithKline Trading Services Limited

Tel: + 372 8002640

Norge

GlaxoSmithKline AS

Tlf: + 47 22 70 20 00

Ελλάδα

GlaxoSmithKline Μονοπρόσωπη A.E.B.E.

Τηλ: + 30 210 68 82 100

Österreich

GlaxoSmithKline Pharma GmbH

Tel: + 43 (0)1 97075 0

[email protected]

España

GlaxoSmithKline, S.A.

Tel: + 34 900 202 700

[email protected]

Polska

GSK Services Sp.zo.o.

Tel.: + 48 (0)22 576 9000

France

Laboratoire GlaxoSmithKline

Tél.: + 33 (0)1 39 17 84 44

[email protected]

Portugal

Glaxo Wellcome Farmacêutica, Lda.

Tel: + 351 21 412 95 00

[email protected]

Hrvatska

GlaxoSmithKline Trading Services Limited

Tel: + 385 800787089

România

GlaxoSmithKline Trading Services Limited

Tel: + 40 800672524

Ireland

GlaxoSmithKline Trading Services Limited

Tel: + 353 (0)1 4955000

Slovenija

GlaxoSmithKline Trading Services Limited

Tel: + 386 80688869

Ísland

Vistor hf.

Sími: + 354 535 7000

Slovenskárepublika

GlaxoSmithKline Trading Services Limited

Tel: + 421 800500589

Italia

GlaxoSmithKline S.p.A.

Tel: + 39 (0)45 7741 111

Suomi/Finland

GlaxoSmithKline Oy

Puh/Tel: + 358 (0)10 30 30 30

Κύπρος

GlaxoSmithKline Trading Services Limited

Τηλ: + 357 80070017

Sverige

GlaxoSmithKline AB

Tel: + 46 (0)8 638 93 00

[email protected]

Latvija

GlaxoSmithKline Trading Services Limited

Tel: + 371 80205045

Date of last revision of this leaflet: 05/2025

Detailed information on this medicine is available on the European Medicines Agency web site: http://www.ema.europa.eu

Online doctors for ZEFFIX 100 mg FILM-COATED TABLETS

Discuss questions about ZEFFIX 100 mg FILM-COATED TABLETS, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Doctor

Bulat Garipov

General medicine 15 years exp.

Dr. Bulat Garipov is a radiologist with more than 15 years of experience, specializing in magnetic resonance imaging (MRI). Throughout his professional career, he has worked in leading diagnostic imaging centers, both in on-site practice and teleradiology, which has allowed him to develop a broad and versatile approach to radiology.

Over the years, he has gained solid experience in interpreting MRI studies in various areas, including:

  •  Neuroimaging
  •  Musculoskeletal system (MSK)
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Additionally, Dr. Garipov is open to new collaboration opportunities in radiology and teleradiology projects. He offers his expertise in MRI, providing both first and second readings of studies, as well as advanced image interpretation, ensuring accurate and high-quality diagnostics.

You could consult Dr. Bulat Garipov in cases where accurate interpretation of MRI studies or a second expert opinion is required. His expertise is especially valuable in cases of suspected neurological conditions, back and joint pain, vascular disorders, as well as in the diagnosis of abdominal and pelvic diseases. The doctor also provides support in complex or unclear clinical situations, including the review of previously performed studies, which helps improve diagnostic accuracy and determine the optimal treatment strategy. A teleradiology format is available, allowing you to receive a professional opinion remotely.

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Lina Travkina

Family medicine 13 years exp.

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

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  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
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  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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Anna Biriukova

General medicine 6 years exp.

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

  • High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
  • Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
  • Leg swelling, chronic fatigue, reduced exercise tolerance.
  • EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
  • Post-COVID-19 cardiac monitoring and care.
Endocrinology – Diabetes, thyroid, metabolism:
  • Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
  • Individual treatment plans including oral medications and insulin therapy.
  • GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
  • Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
  • Metabolic syndrome – obesity, lipid disorders, insulin resistance.
Gastroenterology – Digestive health:
  • Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
  • Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
  • Respiratory infections – cough, colds, bronchitis.
  • Lab test analysis, therapy adjustments, medication management.
  • Adult vaccinations – planning, contraindications assessment.
  • Cancer prevention – screening strategies and risk assessment.
  • Holistic approach – symptom relief, complication prevention, and quality of life improvement.
Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
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Doctor

Alina Tsurkan

Family medicine 13 years exp.

Dr. Alina Tsurkan is a licensed family medicine physician based in Portugal, offering online consultations for adults and children. She provides professional primary care, with a focus on prevention, accurate diagnosis, and long-term management of acute and chronic conditions.

Dr. Tsurkan supports patients with a wide range of health issues, including:

  • Respiratory infections: cold, flu, bronchitis, pneumonia, and lingering coughs.
  • ENT conditions: sinusitis, tonsillitis, otitis (ear infections), sore throat, allergic rhinitis.
  • Eye conditions: allergic or infectious conjunctivitis, red eyes, irritation.
  • Digestive issues: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), constipation, bloating, nausea.
  • Urinary and reproductive health: urinary tract infections (UTIs), cystitis, prevention of recurrent infections.
  • Chronic diseases: hypertension, elevated cholesterol, weight management.
  • Neurological complaints: headaches, migraines, sleep disturbances, fatigue, general weakness.
  • Children’s health: fever, infections, digestive issues, follow-ups, vaccination guidance.

She also provides:

  • IMT medical certificates for driving licence exchange in Portugal.
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Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

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Andrei Popov

General medicine 7 years exp.

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

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Alexander Nazarchuk

Allergology 7 years exp.

Dr. Alexander Nazarchuk is a physician specialising in allergology and internal medicine. He provides online consultations for adults, following the principles of evidence-based medicine — no outdated treatments or unnecessary tests, with clear explanations and a personalised approach. He helps patients with a wide range of allergic and therapeutic conditions, from common day-to-day complaints to complex cases involving allergies, gastrointestinal issues, cardiovascular concerns, respiratory symptoms, and more.

You can consult Dr. Nazarchuk for:

  • Test interpretation and guidance on diagnostic plans.
  • Allergic rhinitis, hay fever, bronchial asthma (including severe cases).
  • Food and drug allergies, skin rashes, angioedema.
  • Atopic dermatitis, urticaria, contact allergies.
  • Allergen-specific immunotherapy (AIT) – initiation and ongoing management.
  • Abdominal pain, bloating, changes in bowel habits, nausea, heartburn.
  • High blood pressure and adjustment of baseline antihypertensive therapy.
  • Hyperlipidaemia and elevated cholesterol.
  • Cough, nasal congestion, fever, sore throat.
  • Anaemia, including iron deficiency and related conditions.
  • Other issues related to allergology and internal medicine.

During consultations, Dr. Nazarchuk takes a thorough, structured approach — analysing symptoms, identifying potential causes, and helping patients make informed decisions. Whether treatment, further investigation, or monitoring is needed, he explains each step clearly so you understand your health and how best to manage it.

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Frequently Asked Questions

Is a prescription required for ZEFFIX 100 mg FILM-COATED TABLETS?
ZEFFIX 100 mg FILM-COATED TABLETS requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in ZEFFIX 100 mg FILM-COATED TABLETS?
The active ingredient in ZEFFIX 100 mg FILM-COATED TABLETS is lamivudine. This information helps identify medicines with the same composition but different brand names.
Who manufactures ZEFFIX 100 mg FILM-COATED TABLETS?
ZEFFIX 100 mg FILM-COATED TABLETS is manufactured by Glaxosmithkline Trading Services Limited. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of ZEFFIX 100 mg FILM-COATED TABLETS online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether ZEFFIX 100 mg FILM-COATED TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to ZEFFIX 100 mg FILM-COATED TABLETS?
Other medicines with the same active substance (lamivudine) include EPIVIR 10 mg/mL ORAL SOLUTION, EPIVIR 150 MG FILM-COATED TABLETS, EPIVIR 150 MG FILM-COATED TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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