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Voraxaze 1000 IU/ml injectable

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Doctor
5.0(12)

Yevgen Yakovenko

General medicine12 years of experience
Licence no. 35/35/09707

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

Book a video appointment
€72
This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use VORAXAZE 1000 UNITS POWDER FOR INJECTABLE SOLUTION

Contents of the leaflet

  1. Introduction
  2. What is Voraxaze and what is it used for
  3. What you need to know before you are given Voraxaze
  4. How to take Voraxaze
  5. Possible side effects
  6. Storage of Voraxaze
  7. Contents of the pack and other information

Introduction

Package Leaflet: Information for the Patient

Voraxaze 1,000 units powder for solution for injection

Glucarpidase

This medicinal product is subject to additional monitoring, which will allow for quick identification of new safety information. You can help by reporting any side effects you may get. The last section of the leaflet includes information on how to report side effects.

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor.
  • If you get any side effects, talk to your doctor, even if they are not listed in this leaflet. See section 4.

Contents of the pack

  1. What is Voraxaze and what is it used for
  2. What you need to know before you are given Voraxaze
  3. How to take Voraxaze
  4. Possible side effects
  5. Storage of Voraxaze
  6. Contents of the pack and other information

1. What is Voraxaze and what is it used for

The active substance in this medicine is glucarpidase, an enzyme that breaks down the medicine methotrexate to treat cancer.

Voraxaze is indicated in adults and children over 28 days, if they are receiving methotrexate for cancer treatment, but their body is not able to eliminate methotrexate quickly enough and they are at risk of severe side effects. The medicine breaks down methotrexate in the blood, reducing methotrexate levels and thus helping to control side effects, preventing them from worsening. The medicine acts very quickly and can reduce the amount of methotrexate in the blood by more than 90% in 15 minutes. The medicine does not penetrate cells, so it does not prevent methotrexate that has already entered cancer cells from acting to treat cancer.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you are given Voraxaze

Do not take Voraxaze

  • if you are allergic to glucarpidase or any of the other ingredients of this medicine (listed in section 6).

Warnings and precautions

Talk to your doctor before you are given Voraxaze.

You will receive this medicine as soon as your doctor decides that you need it to prevent severe side effects of methotrexate.

This medicine cannot on its own prevent or stop all side effects of high doses of methotrexate, and you will also be given other treatments and supportive care as needed.

It is important that your doctor knows how much methotrexate is in your blood and how well your kidneys are working.

You will have tests to check this before and after treatment with this medicine.

Children and adolescents

This medicine can be given to children over 28 days. The safety and efficacy of this medicine in children under 28 days have not been established.

Other medicines and Voraxaze

This medicine may affect the amount of folinic acid in your body, another product that your doctor may give you to reduce the toxicity of methotrexate. As a precaution, your doctor will adjust the schedule of your folinic acid and your doses of Voraxaze to ensure that at least 2 hours pass between the administration of the two medicines. Your doctor will restart the administration of folinic acid no less than 2 hours after the administration of glucarpidase.

No other interactions between this and other medicines have been reported during clinical studies.

Pregnancy and breast-feeding

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor.

Since this medicine is only used in people who have already received methotrexate, which is known to cause harmful effects on the developing baby, no studies have been done to determine if this medicine alone can cause harmful effects on a developing fetus during pregnancy or if it is excreted in breast milk.

Driving and using machines

The influence of this medicine on the ability to drive and use machines is negligible.

3. How to take Voraxaze

This medicine is given by injection into a vein over a 5-minute period. Your doctor will decide the right dose for you, based on your weight. The recommended dose is 50 units per kilogram of body weight.

Because the medicine is given under medical supervision, it is unlikely that you will be given too much. If you think you have been given too much, talk to your doctor or nurse.

You will be monitored to detect changes in the amount of methotrexate in your blood after treatment with this medicine.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Tell your doctor or medical staff immediately if you experience any of the following:

  • swelling of the throat, chest tightness, difficulty breathing
  • swelling of the hands, feet, face, lips or mouth
  • rash, with or without redness or swelling of the face
  • shaking or chills without fever

If you experience any of the above symptoms, you may be having a severe allergic reaction and may need immediate medical attention. These side effects (allergic reactions) are very rare, and if they occur, they usually occur on the day of treatment.

You should tell your doctor or medical staff as soon as possible if you experience any of the following side effects, which are also rare, but have been reported during treatment with this medicine:

  • fever
  • headache
  • tingling or prickling sensation on the skin ("pins and needles" sensation)
  • burning sensation on the skin

If you experience any other side effect not mentioned in this leaflet, tell your doctor or medical staff.

Reporting of side effects

If you experience any side effects, talk to your doctor, even if they are not listed in this leaflet. You can also report side effects directly through the Spanish Pharmacovigilance System for Human Use Medicines: https://www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Voraxaze

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the carton and vial after EXP. The expiry date is the last day of the month shown.

This medicine will be given to you under medical supervision. Store in a refrigerator (between 2°C and 8°C).

Do not freeze.

Expiry date: This medicine will not be used after the expiry date shown on the vial or outer packaging. The pharmacist will check this before dispensing.

6. Contents of the pack and other information

What Voraxaze contains

The active substance is glucarpidase.

The other ingredients are lactose, trometamol, and zinc acetate dihydrate.

Appearance and packaging

Each pack contains a vial with a white or off-white lyophilized powder, which is reconstituted with 1 ml of sterile sodium chloride 0.9% solution (not included).

Marketing authorisation holder and manufacturer

Name and address of the marketing authorisation holder

SERB SAS

40 Avenue George V

75008 Paris

France

Name and address of the manufacturer responsible for batch release

Almac Pharma Services Limited

Seagoe Industrial Estate,

Portadown,

Craigavon,

BT63 5UA, UK (Northern Ireland)

Date of last revision of this leaflet

Other sources of information

Detailed information on this medicine is available on the European Medicines Agency website: http://www.ema.europa.eu.

----------------------------------------------------------------------------------------------------------------

The following information is intended for healthcare professionals only:

Each vial of Voraxaze should be reconstituted in 1 ml of sterile sodium chloride 0.9% solution.

Reconstitution should be performed immediately prior to use (do not dilute further). It should be administered by intravenous injection over a 5-minute period.

After reconstitution in 1 ml of sterile sodium chloride 0.9% solution, it will contain 1,000 units of glucarpidase. A suitable syringe should be used to extract small volumes to extract the solution from the vials. It may not always be possible to extract a full 1 ml from the vial, but extracting at least 0.90 ml from the vial will provide an adequate amount of glucarpidase for administration.

Disposal of unused medicine and all materials that have come into contact with it should be done in accordance with local regulations.

Online doctors for VORAXAZE 1000 UNITS POWDER FOR INJECTABLE SOLUTION

Discuss questions about VORAXAZE 1000 UNITS POWDER FOR INJECTABLE SOLUTION, including use, safety considerations and whether a prescription is appropriate, subject to medical assessment and local regulations.

Doctor
5.0(12)

Yevgen Yakovenko

General medicine12 years of experience
Licence no. 35/35/09707

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

Book a video appointment
€72
Doctor
5.0(3)

Lina Travkina

General medicine13 years of experience

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.

  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.

  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.

  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.

  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.

  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.

  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.

  • Medical advice and follow-up consultations.

  • Test interpretation and diagnostic guidance.

  • Structured support for undiagnosed complaints.

  • Second opinion on diagnoses and treatment plans.

  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.

  • Post-operative recovery support and pain management.

  • Preconception counselling and postpartum support.

  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

Book a video appointment
€75
Doctor
5.0(21)

Nuno Tavares Lopes

General medicine18 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies

  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management

  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses

  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment

  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance

  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis

  • Pain management: acute and chronic pain, post-surgical care

  • Public health: prevention, health screenings, long-term monitoring

  • Sick leave (Baixa médica) connected to Segurança Social in Portugal

  • IMT medical certificates for driving licence exchange

Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

Book a video appointment
€70
Doctor
0.0(0)

Hocine Lokchiri

General medicine21 years of experience

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
Book a video appointment
€64
Doctor
4.7(11)

Anastasiia Shalko

General medicine13 years of experience
Licence no. 52891

Dr. Anastasiia Shalko is a general practitioner with a background in both paediatrics and general medicine. She graduated from Bogomolets National Medical University in Kyiv and completed her paediatric internship at the P.L. Shupyk National Medical Academy of Postgraduate Education. After working as a paediatrician in Kyiv, she relocated to Spain, where she has been practising general medicine since 2015, providing care for both adults and children.Her work focuses on urgent, short-term medical concerns – situations where patients need quick guidance, symptom assessment and clear next steps. She helps people understand whether their symptoms require in-person evaluation, home management or a change in treatment. Common reasons for booking an online consultation include:

  • acute respiratory symptoms (cough, sore throat, runny nose, fever)
  • viral illnesses such as colds and seasonal infections
  • gastrointestinal complaints (nausea, diarrhoea, abdominal pain, gastroenteritis)
  • sudden changes in how a child or adult feels
  • questions about existing treatment and whether adjustments are needed
  • renewal of prescriptions when clinically appropriate

Dr. Shalko works specifically with urgent and short-term problems, providing practical recommendations and helping patients determine the safest next step. She explains symptoms clearly, guides patients through decision-making and offers straightforward medical advice for everyday acute issues.She does not provide long-term management of chronic conditions, ongoing follow-up or comprehensive care plans for complex long-term illnesses. Her consultations are designed for acute symptoms, sudden concerns and situations where timely medical input is important.With clinical experience in both paediatrics and general medicine, Dr. Shalko confidently supports adults and children. Her communication style is clear, simple and reassuring, helping patients feel informed and supported throughout the consultation.

Book a video appointment
€56

Frequently Asked Questions

VORAXAZE 1000 UNITS POWDER FOR INJECTABLE SOLUTION requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

The active ingredient in VORAXAZE 1000 UNITS POWDER FOR INJECTABLE SOLUTION is glucarpidase. This information helps identify medicines with the same composition but different brand names.

VORAXAZE 1000 UNITS POWDER FOR INJECTABLE SOLUTION is manufactured by Serb. Pharmacy brands and packaging may differ depending on the distributor.

Doctors such as Family doctors, Endocrinologists, Allergists, Oncologists, General medicine doctors, Immunologists may assess whether VORAXAZE 1000 UNITS POWDER FOR INJECTABLE SOLUTION is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

The prescription is issued by a doctor after assessing your health. In Spain, VORAXAZE 1000 UNITS POWDER FOR INJECTABLE SOLUTION is then dispensed in pharmacies with that prescription. An online consultation does not guarantee that a prescription will be issued: the decision always rests with the doctor.

To request an assessment, you can use Oladoctor:

Other medicines with the same active substance (glucarpidase) include CARDIOXANE 500 mg POWDER FOR SOLUTION FOR INFUSION, FASTURTEC 1.5 mg/ml POWDER AND SOLVENT FOR CONCENTRATE FOR INFUSION SOLUTION, FASTURTEC 1.5 mg/ml POWDER AND SOLVENT FOR CONCENTRATE FOR PERFUSION SOLUTION. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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