Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

12+ years of clinical experience in university hospitals in Germany and Spain.
International education: Ukraine – Germany – Spain.
Member of the German Society of Surgeons (BDC).
Certified in radiological diagnostics and robotic surgery.
Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.

How to use VARIDASA COMPRESSES

Introduction

PACKAGE LEAFLET: INFORMATION FOR THE USER

VARIDASA Tablets

Streptokinase and Streptodornase

Read all of this leaflet carefully before you start taking this medicine.

Keep this leaflet, you may need to read it again.
If you have any further questions, ask your doctor or pharmacist.
This medicine has been prescribed for you, do not pass it on to others. It may harm them, even if their symptoms are the same as yours.
If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.

Contents of the pack:

What VARIDASA Tablets are and what they are used for
Before you take VARIDASA Tablets
How to take VARIDASA Tablets
Possible side effects
Storing VARIDASA Tablets
Further information

1. What VARIDASA Tablets are and what they are used for

Varidasa belongs to a group of medicines called antithrombotics.

Varidasa is indicated for the treatment of acute or chronic inflammation, infectious in combination with antibiotics or traumatic (with edema and/or hematoma).

2. BEFORE YOU TAKE VARIDASA Tablets

Do not take Varidasa

If you are allergic (hypersensitive) to streptokinase, streptodornase or any of the other ingredients of this medicine.
If you have bleeding disorders (known hemorrhagic diathesis).
If you have severe uncontrolled hypertension.
If you have low fibrinogen levels.
If you have low platelet counts in the blood (thrombocytopenia).

Be careful with Varidasa

In case of an allergic reaction, including anaphylactic shock, dyspnea (difficulty breathing) and urticaria, treatment with Varidasa should be discontinued.

Special precautions should be taken when administering Varidasa to patients with the following conditions:

Recent severe gastrointestinal bleeding.
Recent major surgery (6th to 10th postoperative day, depending on the severity of the surgery).
Recent trauma and cardiopulmonary resuscitation.
Recent biopsy of any organ, punctures in non-compressible vessels, intramuscular injections or intubation.
Recent childbirth, abortion.
Patients with concomitant treatment with oral anticoagulants (INR>1.3).
Severe liver or kidney damage.
Organic lesions that may bleed (e.g. active peptic ulcer).
Acute pericarditis and/or subacute bacterial endocarditis.
Active internal bleeding, existing or recent.
Recent stroke; intracranial or intraspinal surgery.
Intracranial neoplasia.
Recent head trauma.
Known neoplasia with risk of bleeding.
Acute pancreatitis.
Hypertensive retinopathy grade III/IV.

Varidasa should be used with caution in patients with a history of decreased liver function.

Using other medicines

Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including those obtained without a prescription.

Prior or simultaneous treatment with Varidasa and anticoagulants or substances that act on platelet formation or function (e.g. platelet aggregation inhibitors, dextran, antifibrinolytics such as aminocaproic acid, aprotinin and tranexamic acid, non-steroidal anti-inflammatory analgesics especially acetylsalicylic acid, indomethacin, phenylbutazone and other platelet aggregation inhibitors especially sulfinpyrazone) could increase the risk of bleeding.

Pregnancy and breastfeeding

Consult your doctor or pharmacist before taking any medicine.

The safety and efficacy of Varidasa during pregnancy and breastfeeding have not been established, so its use is not recommended in these situations.

Use in children

Varidasa is not recommended for use in patients under 18 years of age, as its safety and efficacy have not been established in these patients.

Driving and using machines

No effects on the ability to drive or operate machinery have been described.

Important information about some of the ingredients of Varidasa:

Varidasa contains the yellow-orange S dye (E-110), which may cause allergic reactions.

3. HOW TO TAKE VARIDASA Tablets

Follow exactly the administration instructions of Varidasa indicated by your doctor. Consult your doctor or pharmacist if you have any doubts.

Your doctor will indicate the duration of your treatment with Varidasa. Do not stop treatment before, as it may not have the desired effect.

Varidasa tablets are for oral administration.

The recommended average dose is one tablet, four times a day, for 4-6 days.

In acute conditions, higher doses may be used as a therapeutic attack measure, consisting of two tablets three times a day, and if necessary, the dose may be increased to two tablets four times a day.

If you take more Varidasa than you should

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately, or call the Toxicology Information Service, phone 91 562 04 20 (indicating the medicine and the amount ingested).

If you forget to take Varidasa

If you forget a dose of the medicine, take the next dose when it is due. Do not take a double dose to make up for the forgotten doses.

4. Possible side effects

Like all medicines, Varidasa can have side effects, although not everybody gets them.

The following side effects have been described, according to the frequency categories indicated below:

Very common:at least 1 in 10 patients

Common:at least 1 in 100 patients

Uncommon:at least 1 in 1,000 patients

Rare:at least 1 in 10,000 patients

Very rare:less than 1 in 10,000 patients

Immune system disorders

Common:Development of anti-streptokinase antibodies.

Uncommon:Hypersensitivity and allergic reactions including anaphylactic shock, dyspnea (difficulty breathing) and urticaria.

Gastrointestinal disorders

Uncommon:Nausea, diarrhea, epigastric pain, vomiting.

Skin and subcutaneous tissue disorders

Very rare:Erythematous exanthema (inflammatory lesion at the site of administration), dermatitis, pruritus.

Hepatobiliary disorders

Uncommon:Transient increase in liver enzymes (transaminases) and bilirubin.

General disorders

Uncommon:Headache, back pain (dorsalgia), muscle pain (myalgia), chills and/or increased body temperature, feeling of weakness (asthenia), general malaise.

If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.

5. Storing VARIDASA Tablets

Keep Varidasa out of the reach and sight of children.

Store in the original packaging to protect from light and moisture.

Do not store above 30°C.

Do not use Varidasa after the expiry date stated on the carton. The expiry date is the last month indicated.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. FURTHER INFORMATION

Composition of Varidasa Tablets

The active ingredients are streptokinase and streptodornase. Each tablet contains 10,000 International Units and 2,500 Units of streptodornase.
The other ingredients are dibasic calcium phosphate dihydrate, corn starch, acacia, magnesium stearate, and yellow-orange S dye (E-110).

Appearance and packaging of the product

Varidasa are orange-colored scored tablets. They are available in packs of 20 or 40 tablets.

Marketing authorization holder

INDUSTRIAL FARMACEUTICA CANTABRIA, S.A.

Carretera Cazoña-Adarzo, s/n.

39011 – Santander

Manufacturer

Toll Manufacturing Services S.L.

Aragoneses, 2

28108 – Alcobendas (Madrid)

This leaflet was approved in: May 2007

How much does VARIDASA COMPRESSES cost in Spain ( 2025)?

The average price of VARIDASA COMPRESSES in October, 2025 is around 2.5 EUR. Prices may vary depending on the region, pharmacy, and whether a prescription is required. Always check with a local pharmacy or online source for the most accurate information.

VARIDASA COMPRESSES

Yevgen Yakovenko

Nuno Tavares Lopes

Yevgen Yakovenko

Nuno Tavares Lopes