This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.

How to use PRODERMA 200 mg HARD CAPSULES

Introduction

Package Leaflet: Information for the User

Proderma 200 mg Hard Capsules

Doxycycline

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

Keep this leaflet, you may need to read it again.
If you have any further questions, ask your doctor or pharmacist.
This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.

Contents of the pack

What Proderma 200 mg Hard Capsules is and what it is used for
What you need to know before you take Proderma 200 mg Hard Capsules
How to take Proderma 200 mg Hard Capsules
Possible side effects
Storage of Proderma 200 mg Hard Capsules
Contents of the pack and other information

1. What Proderma 200 mg Hard Capsules is and what it is used for

Doxycycline belongs to a group of medicines called tetracyclines, which are broad-spectrum antibiotics, active against multiple microorganisms.

Text on a white background explaining the use of antibiotics and the importance of following medical instructions Doxycycline is indicated primarily in infections of the skin and soft tissues, respiratory tract infections, and genitourinary infections, such as:

Atypical pneumonia.
Psittacosis (disease transmitted to humans by certain birds that occurs as pneumonia accompanied by fever and cough).
Typhus and other infections caused by microorganisms called rickettsias.
Sexually transmitted diseases.
Brucellosis (Malta fever).
Cholera.
Early stages of Lyme disease (disease transmitted by ticks).

Fever transmitted by lice and ticks.
Malaria.
Severe acne vulgaris.

2. What you need to know before you take Proderma 200 mg Hard Capsules

Do not take Proderma 200 mg Hard Capsules

If you are allergic to doxycycline, tetracyclines, or any of the other components of Proderma 200 mg (listed in section 6).

Warnings and precautions

Consult your doctor or pharmacist before starting to take Proderma 200 mg.

Children

Proderma 200 mg should not be administered during the dentition period (second half of pregnancy, lactation, and children under 8 years), as it may cause permanent tooth discoloration, as well as delayed bone development.

General

Bulging of the fontanelles (unossified space in the skull) has been reported in children and intracranial hypertension (increased pressure of the cerebrospinal fluid in the brain) in both children and adults (see section 4. Possible side effects).
If you experience diarrhea while receiving treatment with doxycycline, consult your doctor.
If you take this medication while lying down, or without sufficient water, ulcers may appear in the digestive system, so it is essential to follow the administration instructions (see section 3. How to take Proderma 200 mg Hard Capsules and section 4. Possible side effects).
If you have liver or kidney disease, consult your doctor.
In prolonged treatments, the doctor will perform checks on renal and hepatic function.
If you have systemic lupus erythematosus, you should avoid using this medication.
In case of direct exposure to the sun, skin redness may occur; if this happens, you should consult your doctor.
If you suffer from myasthenia gravis (a form of muscle weakness), consult your doctor before taking this medication.
If you are going to have any urine tests, you should inform the healthcare staff that you are being treated with this medication, as doxycycline may interfere with the results.

Using Proderma 200 mg Hard Capsules with other medicines

Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including those obtained without a prescription.

Like all medicines, Proderma 200 mg can interact with some medicines, such as:

Aluminum, calcium, and magnesium antacids, as they decrease the absorption of Proderma 200 mg.
Antibiotics, as they may decrease the effectiveness of Proderma 200 mg.
Methoxyflurane, along with tetracyclines and Proderma 200 mg, may produce kidney toxicity, which can be severe.
Anticoagulants (such as warfarin), as Proderma 200 mg may alter the effect of these anticoagulants, so you should consult your doctor.
Medicines for the treatment of epilepsy, such as carbamazepine and phenytoin.
Oral contraceptives and barbiturates, as Proderma 200 mg may decrease their effectiveness.
Chronic alcohol consumption may decrease the effectiveness of Proderma 200 mg.

In case of doubt, consult your doctor or pharmacist.

Taking Proderma 200 mg Hard Capsules with food and drinks:

During treatment with doxycycline, alcohol consumption should be avoided.
Proderma 200 mg should be administered with food or water to avoid esophageal irritation (see section 3. How to take Proderma 200 mg Hard Capsules and section 4. Possible side effects).

Pregnancy and lactation

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medicine.

Breastfeeding

You should avoid taking this medication during breastfeeding.

Driving and using machines

There is no evidence that Proderma 200 mg alters the ability to drive or use machines.

Proderma 200 mg Hard Capsules contains sucrose.If your doctor has told you that you have an intolerance to certain sugars, consult with them before taking this medicine.

3. How to take Proderma 200 mg Hard Capsules

Follow the administration instructions of Proderma 200 mg exactly as indicated by your doctor. In case of doubt, consult your doctor or pharmacist again.

Remember to take your medicine.

Consult your doctor or pharmacist if you think the effect of doxycycline is too strong or too weak.

IMPORTANT:

This medication should be taken during a meal, accompanied by a large glass of water.

It is essential that, after taking the medication, you wait at least one hour before lying down or going to bed to sleep.

The above recommendations are intended to prevent the appearance of digestive problems, especially stomach ulcers.

Your doctor will indicate the duration of treatment with Proderma 200 mg. Do not stop treatment early, even if you have started to improve.

Adults:the usual dose of doxycycline is 200 mg in one or two doses on the first day of treatment, followed by a maintenance dose of 100 mg/day. For the treatment of more severe infections, 200 mg/day should be administered throughout the treatment period. In general, treatment should continue until at least 24 to 48 hours after the disappearance of symptoms and fever.

Children over 8 years old:children over 8 years old who weigh 45 kg or less, the usual dose is 4 mg/kg body weight on the first day of treatment, administered in a single dose or in two equal doses every 12 hours. In severe infections: 4 mg/kg body weight every 24 hours, maintaining the same dose throughout treatment. Treatment should continue for 24 to 48 hours after symptoms have disappeared.

If you take more Proderma 200 mg Hard Capsules than you should

If you have taken more capsules than you should, consult your doctor or pharmacist immediately.

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or call the Toxicology Information Service. Phone (91) 562 04 20, indicating the medication and the amount ingested.

If you forget to take Proderma 200 mg Hard Capsules

If you forget to take a dose, take the next one when it is due. Do not take a double dose to make up for the forgotten dose.

4. Possible side effects

Like all medicines, Proderma 200 mg can cause side effects, although not everybody gets them.

The following side effects have been detected after taking Proderma 200 mg:

Blood and lymphatic system disorders:blood disorders after administration of tetracyclines are very rare. However, cases of hemolytic anemia (consequence of high destruction of red blood cells), thrombocytopenia (decrease in the number of platelets), neutropenia (decrease in the number of neutrophils), and eosinophilia (increase in the number of eosinophils) have been reported.

Nervous system disorders:infrequently, intracranial hypertension characterized by headache, nausea, vomiting, dizziness, tinnitus, and visual disturbances occurs. These symptoms resolve after withdrawal of the drug. Bulging of the fontanelles in children has also been reported.

Gastrointestinal disorders:it is possible to experience digestive alterations such as esophageal ulcers (see section 3. How to take Proderma 200 mg Hard Capsules), nausea, stomach pain, diarrhea, loss of appetite, tongue inflammation, intestinal inflammation, and anogenital candidiasis (infection by a microscopic fungus).

Permanent tooth discoloration may also occur if doxycycline is used during dental development (second half of pregnancy, lactation, and children under 8 years).

Liver disorders:treatment with high doses may produce hepatitis and liver function disorders.

Skin and subcutaneous tissue disorders:urticaria, maculopapular rash (spots and small elevations of the skin), exudative erythema (redness and spots on the skin), multiform eruptions (redness and swelling of the skin), photosensitivity skin reactions, exceptionally exfoliative dermatitis (inflammation and peeling of the skin), and rarely Stevens-Johnson syndrome.

Frequency not known: photoonycholysis (nail pigmentation).

Musculoskeletal and connective tissue disorders:joint pain and muscle pain may occur, as well as delayed growth in children.

Kidney disorders:like all tetracyclines, doxycycline may produce elevated blood urea nitrogen.

General disorders:occasionally, severe hypersensitivity reactions (allergies) may occur, exceptionally urticaria, angioedema (fluid retention in the vessels), hypotension (decrease in blood pressure), pericarditis (inflammation of the tissue surrounding the heart), worsening of systemic lupus erythematosus, angioedema, serum sickness (allergic reaction to serum), and very rarely anaphylactic shock (unusual or exaggerated allergic reaction).

Jarisch-Herxheimer reaction: which occurs with fever, chills, headache, muscle pain, and skin rash, and usually resolves spontaneously. It occurs shortly after starting treatment with doxycycline for spirochetal infections, such as Lyme disease.

If you think any of the side effects you are experiencing is serious, or if you notice any side effect not mentioned in this leaflet, tell your doctor or pharmacist.

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist, even if they are not listed in this leaflet. You can also report them directly through the Spanish Medicines and Healthcare Products Agency Website: www.notificaRAM.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Proderma 200 mg Hard Capsules

Keep out of the sight and reach of children.

No special storage conditions are required.

Do not use this medicine after the expiry date stated on the carton after EXP. The expiry date is the last day of the month indicated.

Medicines should not be disposed of via wastewater or household waste. Place the empty packaging and any unused medication in the SIGRE collection point at your pharmacy. If you have any doubts, ask your pharmacist how to dispose of the packaging and any unused medication. This will help protect the environment.

6. Contents of the pack and other information

Composition of Proderma 200 mg Hard Capsules

The active ingredient is doxycycline. Each capsule contains 200 mg of doxycycline (as hyclate).

The other ingredients (excipients) are: sucrose, cornstarch, crospovidone, polyaminomethacrylate (Eudragit E100), talc, gelatin, carmine indigo (E132), erythrosine (E127), and titanium dioxide (E171).

Appearance of the product and contents of the pack

Proderma 200 mg is presented in packs of 42 capsules.

How much does PRODERMA 200 mg HARD CAPSULES cost in Spain ( 2025)?

The average price of PRODERMA 200 mg HARD CAPSULES in December, 2025 is around 14.42 EUR. Prices may vary depending on the region, pharmacy, and whether a prescription is required. Always check with a local pharmacy or online source for the most accurate information.

Country of registration
Spain
Average pharmacy price
14.42 EUR
Active substance
doxycycline
Prescription required
Yes
Manufacturer
Industrial Farmaceutica Cantabria S.A.
This information is for reference only and does not constitute medical advice. Always consult a licensed doctor before taking any medication. Oladoctor is not responsible for medical decisions based on this content.
Alternatives to PRODERMA 200 mg HARD CAPSULES
DOSIL 100 mg HARD CAPSULES
Dosage form: CAPSULE, 100 mg
Active substance: doxycycline
Manufacturer: Laboratorios Llorens S.L.
Prescription required
DOXICICLINA NORMON 100 mg FILM-COATED TABLETS
Dosage form: TABLET, 100 mg
Active substance: doxycycline
Manufacturer: Laboratorios Normon S.A.
Prescription required
DOXICLAT 100 mg FILM-COATED TABLETS
Dosage form: TABLET, 100 mg
Active substance: doxycycline
Manufacturer: Pierre Fabre Iberica S.A.
Prescription required

Alternatives to PRODERMA 200 mg HARD CAPSULES in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to PRODERMA 200 mg HARD CAPSULES in Poland

Efracea

Dosage form: Capsules, 40 mg

Active substance: doxycycline

Marketing authorisation holder (MAH): Galderma International

Prescription required

Doxicicline Genoptim

Dosage form: Capsules, 100 mg

Active substance: doxycycline

Importer: Synoptis Industrial Sp. z o.o.

Prescription not required

Doxiciclinum Polfarmex

Dosage form: Capsules, 100 mg

Active substance: doxycycline

Manufacturer: Polfarmex S.A.

Prescription required

Efracea

Dosage form: Capsules, 40 mg

Active substance: doxycycline

Manufacturer: Galderma Laboratorium GmbH Laboratorios Galderma Patheon France

Prescription required

Doxiciclinum Tzf

Dosage form: Solution, 20 mg/ml

Active substance: doxycycline

Manufacturer: Tarchomińskie Zakłady Farmaceutyczne "Polfa" S.A.

Prescription not required

Unidox Solutab

Dosage form: Tablets, 100 mg

Active substance: doxycycline

Manufacturer: Astellas Pharma Europe B.V. Dragenopharm Apotheker Pueschl GmbH

Prescription required

Alternative to PRODERMA 200 mg HARD CAPSULES in Ukraine

DOKSICIKLINU GIDROHLORID

Dosage form: capsules, 100 mg

Active substance: doxycycline

Manufacturer: Tovaristvo z obmezenou vidpovidal'nistu "Harkivs'ke farmacevticne pidpriemstvo "Zdorov'a narodu" (vipusk serii)

Prescription required

DOKSICIKLIN-TEVA

Dosage form: tablets, 100mg

Active substance: doxycycline

Manufacturer: Merkle GmbH

Prescription required

DOKSICIKLIN-DARNICA

Dosage form: capsules, 100 mg capsules in blister packs

Active substance: doxycycline

Manufacturer: PrAT "Farmacevticna firma "Darnica

Prescription required

DOKSICIKLIN

Dosage form: capsules, 100mg capsules in blister

Active substance: doxycycline

Manufacturer: Publicne akcionerne tovaristvo "Naukovo-virobnicij centr "Borsagivs'kij himiko-farmacevticnij zavod

Prescription required

UNIDOKS SOLUTAB

Dosage form: tablets, 100 mg

Active substance: doxycycline

Manufacturer: Astellas Farma Urop B.V.

Prescription required

Online doctors for PRODERMA 200 mg HARD CAPSULES

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for PRODERMA 200 mg HARD CAPSULES – subject to medical assessment and local rules.

5.0(8)

Iryna Reznychenko

Gynecology25 years of experience

Dr Iryna Reznychenko is an obstetrician-gynaecologist, paediatric gynaecologist, and certified lactation consultant. She provides online consultations for women at all stages of life – from adolescence to menopause. Her work combines medical care for gynaecological conditions with dedicated support for breastfeeding challenges, both physical and emotional.

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support during the postpartum and lactation period

Dr Reznychenko offers a clear, attentive and professional approach. Her consultations help prevent minor discomforts from developing into more serious concerns – all in a convenient online format.

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Hocine Lokchiri

General medicine20 years of experience

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

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Tomasz Grzelewski

Dermatology20 years of experience

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques.

For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance.

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Lina Travkina

Family medicine12 years of experience

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

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If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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Antonio Cayatte

General medicine43 years of experience

Dr Antonio Cayatte is a physician in General and Acute Medicine with over 30 years of experience across clinical care, medical research, and education. He offers online consultations for adults with a wide range of symptoms, both acute and chronic.

His clinical background includes:

assessment of sudden or unclear symptoms
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Dr Cayatte earned his degree from the University of Lisbon and taught internal medicine at Boston University School of Medicine. He holds active medical registrations in both Portugal and the UK and is a Fellow of the American Heart Association.

Consultations are available in English and Portuguese. Patients value his clarity, professionalism, and balanced approach to evidence-based care.

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Jonathan Marshall Ben Ami

Family medicine8 years of experience

Dr. Jonathan Marshall Ben Ami is a licensed family medicine doctor in Spain. He provides comprehensive care for adults and children, combining general medicine with emergency care expertise to address both acute and chronic health concerns.

Dr. Ben Ami offers expert diagnosis, treatment, and follow-up for:

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ENT conditions such as sinusitis, ear infections, and tonsillitis.
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Andrei Popov

General medicine6 years of experience

Dr. Andrei Popov is a licensed pain management specialist and general practitioner based in Spain. He provides expert online care for adults dealing with both chronic and acute pain, as well as a wide range of everyday health concerns.

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Respiratory infections (colds, bronchitis, pneumonia).
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Preventive care and routine health check-ups.

Online consultations last up to 30 minutes and include a detailed symptom review, personalised treatment planning, and medical follow-up when needed.

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Yevgen Yakovenko

General surgery11 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

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Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
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General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
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Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
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Experience and qualifications:

12+ years of clinical experience in university hospitals in Germany and Spain.
International education: Ukraine – Germany – Spain.
Member of the German Society of Surgeons (BDC).
Certified in radiological diagnostics and robotic surgery.
Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Tetiana Fedoryshyn

General medicine29 years of experience

Dr Tetiana Fedoryshyn is a senior general practitioner, certified nutritionist, and psychologist with over 29 years of clinical experience. She combines classical internal medicine with modern approaches in lifestyle medicine, functional nutrition, and emotional health support.

Her focus is on helping patients regain health through deep understanding of symptoms, personalised nutrition plans, and evidence-based correction of deficiencies, stress-related conditions, and metabolic imbalances. Dr Fedoryshyn works with adults experiencing chronic conditions, fatigue, hormonal disruption, and post-stress exhaustion.

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Main areas of practice:

Chronic condition management and medical counselling
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Her approach is never one-size-fits-all – each consultation begins with a deep dive into your unique health history, test results, and emotional landscape. Consultations are available in Ukrainian, Polish, and Russian.

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Dmytro Horobets

Family medicine6 years of experience

Dr. Dmytro Horobets is a licensed family medicine physician in Poland, specialising in endocrinology, diabetology, obesity management, gastroenterology, pediatrics, general surgery, and pain medicine. He offers online consultations for adults and children, providing personalised medical support for a wide range of acute and chronic health concerns.

Areas of expertise:

Endocrinology: diabetes type 1 and type 2, prediabetes, thyroid disorders, metabolic syndrome, hormonal imbalance.
Obesity medicine: structured weight management plans, nutritional counselling, obesity-related health risks.
Gastroenterology: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), liver and biliary conditions.
Pediatric care: infections, respiratory symptoms, digestive issues, growth and development monitoring.
General surgery support: pre- and post-surgical consultations, wound care, rehabilitation.
Pain management: chronic and acute pain, back pain, joint pain, post-traumatic pain syndromes.
Cardiovascular health: hypertension, cholesterol control, risk assessment for heart disease.
Preventive medicine: regular check-ups, health screenings, long-term management of chronic conditions.

Dr. Horobets combines evidence-based medicine with a patient-centred approach. He carefully evaluates each patient’s medical history and symptoms, offering clear explanations and structured treatment plans adapted to individual needs.

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