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MIGLUSTAT DIPHARMA 100 mg HARD CAPSULES

MIGLUSTAT DIPHARMA 100 mg HARD CAPSULES

Ask a doctor about a prescription for MIGLUSTAT DIPHARMA 100 mg HARD CAPSULES

5.0(39)
Doctor

Yevgen Yakovenko

General surgery11 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use MIGLUSTAT DIPHARMA 100 mg HARD CAPSULES

Introduction

Package Leaflet: Information for the User

Miglustat Dipharma 100 mg Hard Capsules EFG

miglustat

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What is Miglustat Dipharma and what is it used for.
  2. What you need to know before you take Miglustat Dipharma.
  3. How to take Miglustat Dipharma.
  4. Possible side effects.
  5. Storing Miglustat Dipharma.
  6. Contents of the pack and other information.

1. What is Miglustat Dipharma and what is it used for

Miglustat Dipharma contains the active substance miglustat, which belongs to a group of medicines that have an effect on metabolism. It is used to treat two disorders:

  • Miglustat Dipharma is used to treat mild to moderate type 1 Gaucher disease in adults.

In type 1 Gaucher disease, your body cannot break down a substance called glucosylceramide. As a result, it builds up in some cells of your immune system. This can lead to an enlarged liver and spleen, changes in the blood, and bone disease.

The usual treatment for type 1 Gaucher disease is enzyme replacement therapy (ERT). Miglustat Dipharma will only be used in cases where enzyme replacement therapy is not suitable for the patient.

  • Miglustat Dipharma is also used to treat the progressive neurological symptoms of Niemann-Pick disease type C in adults and children.

If you have Niemann-Pick disease type C, lipids such as glycosphingolipids can build up in the cells of your brain. This can lead to impaired neurological functions such as slow eye movements, balance, swallowing, memory, or seizures.

Miglustat Dipharma works by inhibiting the enzyme called glucosylceramide synthase, which is responsible for the first step in the synthesis of most glycosphingolipids.

2. What you need to know before you take Miglustat Dipharma

Do not take Miglustat Dipharma:

  • if you are allergic to miglustat or any of the other ingredients of this medicine (listed in section 6).

Warnings and precautions

Consult your doctor or pharmacist before starting treatment with Miglustat Dipharma

  • if you have kidney disease
  • if you have liver disease

Your doctor will perform the following tests before and during treatment with Miglustat Dipharma:

  • physical examination of the nerves in your arms and legs
  • measurement of vitamin B12 levels
  • monitoring of growth in children or adolescents with Niemann-Pick disease type C
  • monitoring of platelet count in blood

These tests are necessary because some patients have reported symptoms such as tingling or numbness in hands and feet, or weight loss during treatment with Miglustat Dipharma. The tests will help your doctor determine if these effects are due to your disease or pre-existing conditions or are side effects of Miglustat Dipharma (see section 4 for more details).

If you have diarrhea, your doctor may ask you to modify your diet to reduce lactose and carbohydrate intake, such as sucrose (cane sugar), or not to take Miglustat Dipharma with food, or to temporarily reduce the dose. In some cases, your doctor may prescribe medications to treat diarrhea, such as loperamide. Consult your doctor if the diarrhea does not respond to these measures or if you experience any other abdominal discomfort. In this case, your doctor may decide to perform additional tests.

Male patients are advised to use reliable contraceptive methods during treatment with Miglustat Dipharma and for up to three months after stopping treatment.

Children and adolescents

Do not give this medicine to children and adolescents (under 18 years of age) with type 1 Gaucher disease because it is not known if it works in this disease.

Other medicines and Miglustat Dipharma

Tell your doctor or pharmacist if you are taking or have recently taken or might take any other medicines.

Tell your doctor if you are taking medicines that contain imiglucerase, which are sometimes used at the same time as Miglustat Dipharma. They may decrease the amount of Miglustat Dipharma in your body.

Pregnancy, breastfeeding, and fertility

Do not take Miglustat Dipharma if you are pregnant or plan to become pregnant. For more information, consult your doctor or pharmacist. You must use an effective contraceptive method while taking Miglustat Dipharma. You should not breastfeed while taking Miglustat Dipharma.

Male patients must use a reliable contraceptive method during treatment with Miglustat Dipharma and for three months after stopping treatment.

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medicine.

Driving and using machines

Miglustat Dipharma may cause dizziness. Do not drive or operate tools or machines if you feel dizzy.

3. How to take Miglustat Dipharma

Follow the instructions for administration of this medicine exactly as prescribed by your doctor. If you are unsure, consult your doctor or pharmacist again.

  • For type 1 Gaucher disease: In adults, the usual dose is one capsule (100 mg) three times a day (morning, afternoon, evening), which is a maximum daily dose of three capsules (300 mg).
  • For Niemann-Pick disease type C: In adults and adolescents (over 12 years), the usual dose is 2 capsules (200 mg) three times a day (morning, afternoon, and evening). This is a maximum daily dose of six capsules (600 mg).

For children under 12 years, your doctor will adjust the dose for Niemann-Pick disease type C.

If you have kidney problems, your doctor may prescribe a lower initial dose. It is possible that your doctor will reduce the dose of Miglustat Dipharma to one capsule (100 mg) one or two times a day if you experience diarrhea during treatment with Miglustat Dipharma (see section 4). Your doctor will tell you how long to take the treatment.

Miglustat Dipharma can be taken with or without food. The capsule should be swallowed whole with a glass of water.

If you take more Miglustat Dipharma than you should

If you take more capsules than prescribed, consult your doctor immediately. In clinical trials, miglustat has been used at doses of up to 3000 mg: this caused a reduction in white blood cell counts and other side effects similar to those described in section 4.

If you forget to take Miglustat Dipharma

Take the next capsule when it is due. Do not take a double dose to make up for forgotten doses.

If you stop taking Miglustat Dipharma

Do not stop treatment with Miglustat Dipharma without consulting your doctor.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

More serious side effects

Some patients have reported tingling or numbness in hands and feet (this is a common side effect). These could be signs of peripheral neuropathy, due to side effects of Miglustat Dipharma or could be due to pre-existing conditions. Your doctor will perform tests before and during treatment with Miglustat Dipharma to assess your case (see section 2).

If you experience any of these effects, tell your doctor as soon as possible.

If you experience a slight tremor, usually tremor in the hands, informyour doctor as soon as possible. Often the tremor resolves without the need to stop treatment. In some cases, your doctor may need to reduce the dose and even stop treatment with Miglustat Dipharma to control the tremor.

Very common– may affect more than 1 in 10 people

The most common side effects include diarrhea, flatulence (gas), abdominal pain (stomach pain), weight loss, and decreased appetite.

If you lose some weightwhen starting treatment with Miglustat Dipharma, do not worry, people usually stop losing weight with continued treatment.

Common– may affect up to 1 in 10 people

Common side effects include headache, dizziness, paresthesia (tingling or numbness), coordination disorders, hypoesthesia (reduced sensation to touch), dyspepsia (heartburn), nausea (feeling sick), constipation, and vomiting, abdominal swelling or discomfort (stomach) and thrombocytopenia (reduced platelet count). Neurological symptoms and thrombocytopenia may be due to the underlying disease.

Other possible side effects are muscle spasms or weakness, fatigue, chills, and general malaise, difficulty sleeping, memory loss, and decreased libido.

Most patients experience one or more of these side effects, usually when starting treatment or at different times during treatment. Most are mild and resolve quickly. If any of these side effects cause you problems, consult your doctor. He or she may reduce the dose of Miglustat Dipharma or prescribe other medicines to control the side effects.

Reporting of side effects

If you experience side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storing Miglustat Dipharma

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the blister and carton after “EXP/CAD”. The expiry date is the last day of the month stated.

This medicine does not require any special storage conditions.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help protect the environment.

6. Contents of the pack and other information

  • The active substance is miglustat. Each hard capsule contains 100 mg of miglustat.
  • The other ingredients are magnesium stearate, gelatin, titanium dioxide (E171), printing ink (which consists of iron oxide black (E172), propylene glycol (E1520), potassium hydroxide, shellac).

Appearance and packaging

Miglustat Dipharma is a white, opaque capsule of 100 mg, printed in black ink with “DPH02” on the top and “100” on the body. The capsules are presented in PCTFE/PVC and aluminum blister packs, in pack sizes of 84 capsules in non-perforated blisters and 84x1 capsules in perforated unit-dose blisters.

Not all pack sizes may be marketed.

Marketing authorisation holder

Dipharma Arzneimittel GmbH

Offheimer Weg 33

65549 Limburg a. d. Lahn

Germany

Manufacturer

Doppel Farmaceutici S.r.l

Via Volturno 48

20089 Quinto di Stampi - Rozzano (MI)

Italy

Date of last revision of this leaflet:{MM/AAAA}.

Other sources of information

Detailed information on this medicine is available on the European Medicines Agency website: http://www.ema.europa.eu.

Alternatives to MIGLUSTAT DIPHARMA 100 mg HARD CAPSULES in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to MIGLUSTAT DIPHARMA 100 mg HARD CAPSULES in Poland

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Alternative to MIGLUSTAT DIPHARMA 100 mg HARD CAPSULES in Ukraine

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Dosage form: suppositories, 0.35 g
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Online doctors for MIGLUSTAT DIPHARMA 100 mg HARD CAPSULES

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for MIGLUSTAT DIPHARMA 100 mg HARD CAPSULES – subject to medical assessment and local rules.

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Dr. Andrei Popov is a licensed pain management specialist and general practitioner based in Spain. He provides expert online care for adults dealing with both chronic and acute pain, as well as a wide range of everyday health concerns.

He specialises in diagnosing and treating pain conditions that affect quality of life, including:

  • Chronic pain lasting more than 3 months.
  • Migraines and recurring headaches.
  • Neck, back, lower back, and joint pain.
  • Post-traumatic pain following injury or surgery.
  • Nerve-related pain, fibromyalgia, and neuralgia.
In addition to pain management, Dr. Popov helps patients with:
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  • High blood pressure and metabolic conditions such as diabetes.
  • Preventive care and routine health check-ups.

Online consultations last up to 30 minutes and include a detailed symptom review, personalised treatment planning, and medical follow-up when needed.

Dr. Popov’s approach is rooted in evidence-based medicine, combined with individualised care tailored to each patient’s history, lifestyle, and clinical needs.

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Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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  • Individual treatment plans including oral medications and insulin therapy.
  • GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
  • Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
  • Metabolic syndrome – obesity, lipid disorders, insulin resistance.
Gastroenterology – Digestive health:
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  • Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
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