
Ask a doctor about a prescription for LAPRYSTA 10 mg/ml SYRUP
Package Leaflet: Information for the Patient
Laprysta 10 mg/ml Oral Solution EFG
lacosamide
Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.
Contents of the pack
What isLaprysta oral solution
Laprysta oral solution contains lacosamide, which belongs to a group of medicines called “antiepileptic medicines”. These medicines are used to treat epilepsy.
WhatLaprysta oral solutionis used for
Do not takeLaprysta oral solution
Do not take this medicine if any of the above applies to you. If you are not sure, consult your doctor or pharmacist before taking this medicine.
Warnings and precautions
Consult your doctor before starting to use Laprysta oral solution if:
If any of the above applies to you (or you are not sure), consult your doctor or pharmacist before taking this medicine.
If you are taking lacosamide and experience symptoms of abnormal heartbeat (such as slow, fast or irregular heartbeat, palpitations, shortness of breath, feeling of dizziness, fainting), consult your doctor immediately (see section 4).
Children
This medicine is not recommended for children under 2 years of age with epilepsy characterized by the occurrence of partial-onset seizures and is not recommended for children under 4 years of age with primary generalized tonic-clonic seizures. This is because it is not yet known if it is effective and safe for children in this age group.
Other medicines and Laprysta oral solution
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
In particular, tell your doctor or pharmacist if you are taking any of the following medicines that affect the heart, as lacosamide may also affect the heart:
If any of the above applies to you (or you are not sure), talk to your doctor or pharmacist before taking this medicine.
Tell your doctor or pharmacist if you are taking any of the following medicines, as they may also increase or decrease the effect of lacosamide in your body:
If any of the above applies to you (or you are not sure) talk to your doctor or pharmacist before taking this medicine.
TakingLaprysta oral solutionwith alcohol
As a precaution, do not take this medicine with alcohol.
Pregnancy and breast-feeding
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Lacosamide is not recommended during pregnancy or breast-feeding, as its effects on pregnancy and the fetus or newborn are not known. Additionally, it is not known if this medicine passes into breast milk. Ask your doctor for advice immediately if you are pregnant or planning to become pregnant. Your doctor will help you decide whether to take this medicine or not.
Do not stop treatment without talking to your doctor first, as this may increase the risk of seizures (fits). Worsening of your condition may also harm the fetus.
Driving and using machines
Do not drive, ride a bicycle or use any tools or machines until you know if this medicine affects you. The reason is that this medicine may cause dizziness or blurred vision.
Laprysta oral solution contains sorbitol (E 420), propylene glycol (E 1520), sodium, methyl parahydroxybenzoate (E 219), aspartame (E 951) and potassium.
Sorbitol is a source of fructose. If your doctor has told you (or your child) that you have an intolerance to some sugars, or if you (or your child) have been diagnosed with hereditary fructose intolerance (HFI), a rare genetic disorder in which the patient cannot break down fructose, consult your doctor before taking this medicine. Sorbitol may cause gastrointestinal upset and a mild laxative effect.
Follow the administration instructions for this medication exactly as indicated by your doctor or pharmacist. If in doubt, consult your doctor or pharmacist again.
Taking Laprysta syrup
Normally, you will start taking a low dose every day and your doctor will gradually increase the dose over several weeks. When you reach the dose that works well for you, called the "maintenance dose," you will take the same amount every day. When the recommended dose cannot be achieved with the dosing device in a single administration, the required dose must be achieved with multiple administrations (e.g., for a dose of 300 ml (30 ml) with a 25 ml dosing cup: one 25 ml cup + one 5 ml cup.
Laprysta syrup is used as long-term treatment. You will need to continue taking this medication until your doctor tells you to stop.
How much to take
The following are the normal recommended doses of lacosamide for different age groups and weights.
Your doctor may prescribe a different dose if you have kidney or liver problems.
Use the 10 ml oral syringe or the 25 ml measuring cup provided in the outer box, as appropriate, according to the necessary dose. See the instructions for use below.
Adolescents and children who weigh 50 kg or more and adults
When taking Laprysta syrup alone:
The usual starting dose is 50 mg (5 ml), twice a day.
Your doctor may prescribe a starting dose of 100 mg (10 ml) of this medication twice a day.
Your doctor may increase the dose you take twice a day by 50 mg (5 ml) each week, until you reach a maintenance dose between 100 mg (10 ml) and 300 mg (30 ml) twice a day.
When taking Laprysta syrup with other antiepileptic medications
The usual starting dose is 50 mg (5 ml) twice a day.
Your doctor may increase the dose you take twice a day by 50 mg (5 ml) each week, until you reach a maintenance dose between 100 mg (10 ml) and 200 mg (20 ml) twice a day.
If you weigh 50 kg or more, your doctor may decide to start lacosamide treatment with a single "loading" dose of 200 mg (20 ml). Then you will start taking the continuous maintenance dose 12 hours later.
Children and adolescents who weigh less than 50 kg
When taking Laprysta syrup alone
To be taken twice a day,for children from 2 years of age who weighfrom 10 to less than 40kg
Weight | Week 1 Initial Dose: 0.1 ml/kg | Week 2 0.2 ml/kg | Week 3 0.3 ml/kg | Week 4 0.4 ml/kg | Week 5 0.5 ml/kg | Week 6 Maximum Recommended Dose: 0.6 ml/kg |
Use of the 10 ml syringe (black graduation marks) for a volume between 1 ml and 20 ml * Use of the 25 ml measuring cup (black graduation marks) for a volume of more than 20 ml | ||||||
10 kg | 1 ml | 2 ml | 3 ml | 4 ml | 5 ml | 6 ml |
15 kg | 1.5 ml | 3 ml | 4.5 ml | 6 ml | 7.5 ml | 9 ml |
20 kg | 2 ml | 4 ml | 6 ml | 8 ml | 10 ml | 12 ml |
25 kg | 2.5 ml | 5 ml | 7.5 ml | 10 ml | 12.5 ml | 15 ml |
30 kg | 3 ml | 6 ml | 9 ml | 12 ml | 15 ml | 18 ml |
35 kg | 3.5 ml | 7 ml | 10.5 ml | 14 ml | 17.5 ml | 21 ml* |
To be taken twice a day,for children and adolescents who weigh from 40 kg to less than 50 kg
Weight | Week 1 Initial Dose: 0.1 ml/kg | Week 2 0.2 ml/kg | Week 3 0.3 ml/kg | Week 4 0.4 ml/kg | Week 5 Maximum Recommended Dose: 0.5 ml/kg |
Use of the 10 ml syringe for a volume between 1 ml and 20 ml
| |||||
40 kg | 4 ml | 8 ml | 12 ml | 16 ml | 20 ml |
45 kg | 4.5 ml | 9 ml | 13.5 ml | 18 ml | 22.5 ml* |
When taking Laprysta syrup with other antiepileptic medications
To be taken twice a day,for children from 2 years of age who weigh from 10 kg to less than 20 kg
Week | Week 1 Initial Dose: 0.1 ml/kg | Week 2 0.2 ml/kg | Week 3 0.3 ml/kg | Week 4 0.4 ml/kg | Week 5 0.5 ml/kg | Week 6 Maximum Recommended Dose: 0.6 ml/kg |
Use of the 10 ml syringe (black graduation marks) for a volume between 1 ml and 20 ml | ||||||
10 kg | 1 ml | 2 ml | 3 ml | 4 ml | 5 ml | 6 ml |
12 kg | 1.2 ml | 2.4 ml | 3.6 ml | 4.8 ml | 6 ml | 7.2 ml |
14 kg | 1.4 ml | 2.8 ml | 4.2 ml | 5.6 ml | 7 ml | 8.4 ml |
15 kg | 1.5 ml | 3 ml | 4.5 ml | 6 ml | 7.5 ml | 9 ml |
16 kg | 1.6 ml | 3.2 ml | 4.8 ml | 6.4 ml | 8 ml | 9.6 ml |
18 kg | 1.8 ml | 3.6 ml | 5.4 ml | 7.2 ml | 9 ml | 10.8 ml |
To be taken twice a day,for adolescents and children who weigh from 20 kg to less than 30 kg:
Weight | Week 1 Initial Dose: 0.1 ml/kg | Week 2 0.2 ml/kg | Week 3 0.3 ml/kg | Week 4 0.4 ml/kg | Week 5 Maximum Recommended Dose: 0.5 ml/kg |
Use of the 10 ml syringe (black graduation marks) for a volume between 1 ml and 20 ml | |||||
20 kg | 2 ml | 4 ml | 6 ml | 8 ml | 10 ml |
22 kg | 2.2 ml | 4.4 ml | 6.6 ml | 8.8 ml | 11 ml |
24 kg | 2.4 ml | 4.8 ml | 7.2 ml | 9.6 ml | 12 ml |
25 kg | 2.5 ml | 5 ml | 7.5 ml | 10 ml | 12.5 ml |
26 kg | 2.6 ml | 5.2 ml | 7.8 ml | 10.4 ml | 13 ml |
28 kg | 2.8 ml | 5.6 ml | 8.4 ml | 11.2 ml | 14 ml |
To be taken twice a day,for adolescents and children who weigh from 30 kg to less than 50 kg:
Weight | Week 1 Initial Dose: 0.1 ml/kg | Week 2 0.2 ml/kg | Week 3 0.3 ml/kg | Week 4 Maximum Recommended Dose: 0.4 ml/kg |
Use of the 10 ml syringe (black graduation marks) for a volume between 1 ml and 20 ml | ||||
30 kg | 3 ml | 6 ml | 9 ml | 12 ml |
35 kg | 3.5 ml | 7 ml | 10.5 ml | 14 ml |
40 kg | 4 ml | 8 ml | 12 ml | 16 ml |
45 kg | 4.5 ml | 9 ml | 13.5 ml | 18 ml |
Instructions for use
It is essential that you use the correct device to measure your dose. Your doctor or pharmacist will indicate which device you should use based on the dose prescribed for you.
10 ml oral syringe | 25 ml measuring cup |
The 10 ml oral syringe has graduations in increments of 0.25 ml. If the necessary dose is between 1 ml and 10 ml, you should use the 10 ml oral syringe and the adapter provided in this package. If the necessary dose is between 10 ml and 20 ml, you should use the 10 ml syringe twice. | The 25 ml measuring cup has graduations in increments of 5 ml. If the necessary dose is more than 20 ml, you should use the 25 ml measuring cup included in this package. |
Instructions for use: measuring cup
Instructions for use: oral syringe
Your doctor will show you how to use the oral syringe before you use it for the first time. If you have any questions, consult your doctor or pharmacist.
Children andadolescentswho weigh less than 50kg
Shake the bottle well before using it.
Open the bottle by pressing the cap while turning it counterclockwise (figure 1).

Follow these steps the first time you take Laprysta syrup:


Follow these steps each time you take this medication:







There are two ways you can choose to take the medication:



If you take more Laprysta syrup than you should
If you have taken more lacosamide than you should, consult your doctor immediately. Do not try to drive.
You may experience:
In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or call the Toxicology Information Service, phone 91 562 04 20, indicating the medication and the amount ingested.
If you forget to take Laprysta syrup
If you stop treatment with Laprysta syrup
If you have any other questions about the use of this product, ask your doctor or pharmacist.
Like all medicines, this medicine may cause adverse effects, although not all people suffer from them.
Adverse effects on the nervous system, such as dizziness, may be greater after a single "loading" dose.
Tell your doctor or pharmacist if you experience any of the following effects:
Very common: may affect more than 1 in 10 patients
Common: may affect up to 1 in 10 patients
Uncommon: may affect up to 1 in 100 patients
Frequency not known: cannot be estimated from the available data
Other adverse effects in children
Additional adverse effects observed in children were fever (pyrexia), runny nose (nasopharyngitis), sore throat (pharyngitis), eating less than usual (decreased appetite), behavioral changes, not acting as they normally do (abnormal behavior) and lack of energy (lethargy). Sleepiness (somnolence) is a very common side effect in children and may affect more than 1 in 10 children .
Reporting of adverse effects
If you experience any type of adverse effect, consult your doctor or pharmacist, even if it is a possible adverse effect that is not listed in this leaflet. You can also report them directly through the Spanish Pharmacovigilance System for Human Use Medicines: www.notificaram.es.
By reporting adverse effects, you can contribute to providing more information on the safety of this medicine.
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiration date that appears on the box and on the bottle, after CAD/EXP. The expiration date is the last day of the month indicated.
Do not refrigerate.
Once the syrup bottle is opened, do not use it after 2 months.
Medicines should not be thrown away through wastewater or household waste. Deposit the packaging and medicines you no longer need at the SIGRE Point in the pharmacy. Ask your pharmacist how to dispose of the packaging and medicines you no longer need. This way, you will help protect the environment.
Composition ofLaprysta syrup
Appearance of the product and package contents
The box of Laprysta syrup includes a 25 ml measuring cup with graduated marks and a 10 ml oral syringe.
The measuring cup shows three different non-linear scales on three different sides, to allow for precise graduation of different doses. Each graduation mark is accompanied by the mention of the corresponding volume in ml. The minimum extractable volume is 2 ml, which is 20 mg of lacosamide. The maximum extractable volume is 25 ml, which is 250 mg of lacosamide.
Marketing authorization holder and manufacturer
Marketing authorization holder
Neuraxpharm Spain, S.L.U.
Avda. Barcelona 69,
08970 Sant Joan Despí – Barcelona
Spain
Manufacturer
neuraxpharm Arzneimittel GmbH
Elisabeth-Selbert-Strasse 23
40764 Langenfeld
Germany
This medicine is authorized in the EEA member states with the following names:
Italy: Laprysta
Spain: Laprysta 10 mg/ml syrup EFG
Date of the last revision of this leaflet: July 2023
Other sources of information
Detailed information about this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/.
The average price of LAPRYSTA 10 mg/ml SYRUP in November, 2025 is around 23.49 EUR. Prices may vary depending on the region, pharmacy, and whether a prescription is required. Always check with a local pharmacy or online source for the most accurate information.
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