This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.

How to use KONAKION 10 mg/ml ORAL SOLUTION/INJECTABLE SOLUTION

Introduction

Package Leaflet: Information for the User

Konakion 10mg/ml oral solution/injectable solution

Phytomenadione

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

Keep this leaflet, you may need to read it again.
If you have any further questions, ask your doctor or pharmacist.
This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

What is Konakion 10 mg/ml and what is it used for
What you need to know before you use Konakion 10 mg/ml
How to use Konakion 10 mg/ml
Possible side effects
Storage of Konakion 10 mg/ml
Contents of the pack and other information

1. What is Konakion 10 mg/ml and what is it used for

Konakion contains the active substance phytomenadione, Vitamin K that intervenes in the blood coagulation mechanism. The lack of Vitamin K1 causes an increase in the tendency to bleed.

It is used for the treatment and prevention of bleeding (hemorrhages).

Konakion 10 mg/ml is indicated in:

Prevention and treatment of hypoprothrombinemia (lack of a substance, prothrombin, needed for blood to clot) caused by Vitamin K deficiency.

Therefore, it is indicated in hemorrhages or risk of hemorrhages due to severe hypoprothrombinemia caused by:

overdose of anticoagulant medications derived from coumarin in patients taking them (medications that prevent the formation of blood clots)
lack of Vitamin K (hypovitaminosis K) caused by factors that decrease the absorption or synthesis of Vitamin K, such as obstructive jaundice (disorder of bile secretion to the intestine), intestinal or hepatic disorders, and after prolonged treatment with antibiotics, sulfonamides (chemical substances that can be used as antibiotics), or salicylates (e.g., acetylsalicylic acid).

For the prevention and treatment of hemorrhagic disease of the newborn, Konakion 2 mg/0.2 ml pediatric is used.

2. What you need to know before you use Konakion 10 mg/ml

Do not useKonakion

If you are allergic to phytomenadione or any of the other components of this medicine (listed in section 6)
It should not be administered intramuscularly if you are being treated with anticoagulants, as this route may hinder the establishment of anticoagulant therapy. Additionally, intramuscular injections have a risk of causing hematomas (bruises) if you are being treated with anticoagulants.

Warnings and precautions

Consult your doctor before starting to use Konakion 10 mg/ml.

If you have severe liver disease, make sure your doctor knows, as you may need to have blood tests to monitor certain parameters during treatment
if you have other diseases
if you have allergies

Children

For newborns and children under 1 year of age, another medicine of the same brand but with a lower dose, Konakion 2 mg/0.2 ml pediatric, should be used.

Use of Konakion 10 mg/ml with other medicines

Tell your doctor or pharmacist if you are using, have recently used, or may need to use any other medicine.

This is very important, as the use of several medicines at the same time can increase or decrease their effect.

The following medicines may interact with Konakion:

Anticoagulants such as warfarin or acenocoumarol (medicines that help prevent the formation of blood clots in blood vessels)

Medicines for epilepsy.

Pregnancy, breastfeeding, and fertility

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor before using this medicine
Pregnancy
Konakion can be administered during pregnancy if the benefit to the mother outweighs the risk to the fetus.
Breastfeeding
If you are breastfeeding, you can be treated with Konakion.

It is not recommended to administer Konakion for the prevention of hemorrhagic disease of the newborn to women in advanced gestation or during breastfeeding.

Driving and using machines

The influence of Konakion on the ability to drive or operate machinery is negligible or insignificant.

Konakion10 mg/ml contains sodium hydroxide

This medicine contains less than 23 mg (1 mmol) of sodium per ampoule, so it is considered essentially "sodium-free".

3. How to use Konakion 10 mg/ml

Follow exactly the administration instructions of this medicine indicated by your doctor. In case of doubt, consult your doctor or pharmacist again. Depending on the nature of your illness, your doctor will administer the correct dose of this medicine.

The route of administration will depend on the severity of your illness and the risks associated with administration by each route. Konakion 10 mg/ml can be administered orally or intravenously, the latter may be indicated when the oral route is not feasible or useful.

Usual dose for adults

Severe or very severe bleeding, e.g., during anticoagulant therapy:

After discontinuation of treatment with the coumarin anticoagulant you are taking, a dose of 5-10 mg of Konakion will be administered slowly (for at least 30 seconds) intravenously, along with fresh frozen plasma (FFP) or prothrombin complex concentrate (PCC). The dose of Vitamin K1 may be repeated as needed.

Recommended doses of Vitamin K1for the treatment of patients with asymptomatic elevation of the International Normalized Ratio (INR) with or without mild bleeding:

Anticoagulant	INR	Vitamin K1 orally	Vitamin K1 intravenously
Warfarin	5-9	1 to 2.5 mg for initial reversal 2 to 5 mg for rapid neutralization (additional dose of 1 to 2 mg if INR remains elevated after 24 hours)	0.5 to 1 mg 0.5 to 1 mg
>9	2.5 to 5 mg (up to 10 mg)	1 mg
Acenocoumarol	5-8	1 to 2 mg	1 to 2 mg
>8	3 to 5 mg	1 to 2 mg
Fenprocoumon	5-9	2 to 5 mg	2 to 5 mg
>9	2 to 5 mg	2 to 5 mg
>10	Not recommended	Individualized dose for each patient

For small doses, one or more ampoules of another presentation of Konakion can be used: Konakion 2 mg/0.2 ml pediatric.

Recommended doses of Vitamin K1for the treatment of patients with severe or very severe bleeding:

Anticoagulant	Situation	Vitamin K1 intravenously	Concomitant treatment
Warfarin	Severe bleeding	5 to 10 mg	FFP or PCC
Very severe bleeding	10 mg	FFP, PCC, or recombinant factor VIIa
Acenocoumarol	Severe bleeding	5 mg	FFP, PCC, or prothrombin and factor VII concentrates
Fenprocoumon	Severe bleeding with INR <5	5 mg	PCC
Severe bleeding with INR >5	10 mg	PCC

FFP, fresh frozen plasma

PCC, prothrombin complex concentrate

Hypoprothrombinemia due to other causes

In hypoprothrombinemia due to absorption disorders or treatment with antibiotics, salicylates, or sulfonamides, an oral or injectable dose of 2 mg of Konakion 10 mg/ml can be administered in adults. Konakion should be administered at the lowest effective dose.

The dose and route of administration will depend on the severity of the deficiency and the response to the medicine.

Elderly patients

Elderly patients tend to be more sensitive to the effect of this medicine. Therefore, the dose in this group should be at the lower limits of the recommended values. It has been shown that small doses of 0.5 to 1 mg of Vitamin K1 intravenously or orally effectively reduce the INR to <5 within 24 hours of administration.

Use in children

Children over 1 year of age

The doctor will decide the appropriate dose based on the indication and patient weight. It has been reported that a single dose corresponding to one-tenth of the total intravenous dose of Vitamin K1 in adults is effective in reversing asymptomatic elevations of INR (>8) in clinically well children.

Newborns and children under 1 year of age

For this group of patients, due to the small dose required, Konakion 2 mg/0.2 ml pediatric should be used.

Normally, you will be administered Konakion as a single dose, but if your response is not sufficient, administrations may be repeated.

Instructions for correct administration of the preparation

The Konakion solution should be clear at the time of use. If the ampoules have not been stored correctly, they may be cloudy or have phase separation. If this occurs, the ampoule should be discarded.

Oral route: Konakion can be administered with a syringe as follows: Break the neck of the ampoule and extract the necessary amount from the ampoule using a syringe with a needle. Remove the needle from the syringe and administer the contents of the syringe directly into the patient's mouth. Rinse the syringe with liquid.

Parenteral route: Konakion should not be diluted or mixed with other parenteral medicines, but it can be injected into the lower part of an infusion set.

If you use more Konakion 10 mg/ml than you should

Cases of intoxication with Vitamin K1 (phytomenadione) are unknown. It may affect the resumption of treatment with anticoagulants.

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or go to a medical center or call the Toxicology Information Service. Phone 91 562.04.20 indicating the medicine and the amount administered.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Very rare side effects, which may affect up to 1 in 10,000 people: severe allergic reaction (anaphylactic reaction) and inflammation at the injection site. Venous irritation or phlebitis with intravenous administration of Konakion 10 mg/ml.

Reporting of side effects

If you experience any side effects, consult your doctor or pharmacist, even if it is a possible side effect not listed in this leaflet. You can also report them directly through the Spanish Pharmacovigilance System for Human Use Medicines: www.notificaRAM.es.

By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Konakion

Store below 25°C.

Keep the ampoules in the outer packaging to protect them from light.

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiration date stated on the packaging after EXP. The expiration date is the last day of the month indicated.

Do not use this medicine if you notice that the solution is cloudy or has phase separation.

For stability reasons, the unused contents of opened ampoules cannot be used and should be discarded.

Medicines should not be disposed of via wastewater or household waste. Deposit the packaging and medicines you no longer need at the SIGRE collection point in the pharmacy. If in doubt, ask your pharmacist how to dispose of the packaging and medicines you no longer need. This will help protect the environment.

6. Contents of the pack and other information

Composition of Konakion 10 mg/ml oral solution/injectable solution

The active substance is phytomenadione (synthetic Vitamin K1). Each ampoule contains 10 mg of phytomenadione (Vitamin K1) in 1 ml.
The other components are glycolic acid, sodium hydroxide, lecithin, 25% hydrochloric acid, and water for injectable preparations.

Appearance of the product and contents of the pack

Konakion is an oral and injectable solution contained in ampoules. Clear to slightly opalescent liquid.

Each pack contains 5 amber glass ampoules of 1 ml.

How much does KONAKION 10 mg/ml ORAL SOLUTION/INJECTABLE SOLUTION cost in Spain ( 2025)?

The average price of KONAKION 10 mg/ml ORAL SOLUTION/INJECTABLE SOLUTION in December, 2025 is around 9.37 EUR. Prices may vary depending on the region, pharmacy, and whether a prescription is required. Always check with a local pharmacy or online source for the most accurate information.

Country of registration
Spain
Average pharmacy price
9.37 EUR
Active substance
phytomenadione
Prescription required
Yes
Manufacturer
Cheplapharm Arzneimittel Gmbh
This information is for reference only and does not constitute medical advice. Always consult a licensed doctor before taking any medication. Oladoctor is not responsible for medical decisions based on this content.
Alternatives to KONAKION 10 mg/ml ORAL SOLUTION/INJECTABLE SOLUTION
KONAKION 2 mg/0.2 ml PEDIATRIC ORAL SOLUTION/INJECTABLE SOLUTION
Dosage form: ORAL/INJECTABLE SOLUTION/SUSPENSION, 2 mg phytomenadione/0.2ml
Active substance: phytomenadione
Manufacturer: Cheplapharm Arzneimittel Gmbh
Prescription required
ADVATE 1,000 IU POWDER AND SOLVENT FOR INJECTABLE SOLUTION
Dosage form: INJECTABLE, 1,000 IU
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Prescription required
ADVATE 1500 IU POWDER AND SOLVENT FOR INJECTABLE SOLUTION
Dosage form: INJECTABLE, 1500 IU
Active substance: coagulation factor VIII
Manufacturer: Takeda Manufacturing Austria Ag
Prescription required

Alternatives to KONAKION 10 mg/ml ORAL SOLUTION/INJECTABLE SOLUTION in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to KONAKION 10 mg/ml ORAL SOLUTION/INJECTABLE SOLUTION in Polonia

Vitacon

Dosage form: Comprimidos, 10 mg

Active substance: Todo-rac- fitomenadiona

Importer: Zakłady Farmaceutyczne POLPHARMA S.A. Oddział Produkcyjny w Nowej Dębie

Prescription required

Vitacon

Dosage form: Solución, 10 mg/ml

Active substance: Todo-rac- fitomenadiona

Manufacturer: Warszawskie Zakłady Farmaceutyczne POLFA S.A.

Prescription required

Alternative to KONAKION 10 mg/ml ORAL SOLUTION/INJECTABLE SOLUTION in Ucrania

KANAVIT

Dosage form: emulsión, 10 mg/ml; 1 ml

Active substance: Todo-rac- fitomenadiona

Manufacturer: EjcBiEm Farma s.r.o.

Prescription required

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