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FOLINATE CALCIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION

FOLINATE CALCIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION

Ask a doctor about a prescription for FOLINATE CALCIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION

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Doctor

Yevgen Yakovenko

General surgery11 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use FOLINATE CALCIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION

Introduction

Package Leaflet: Information for the User

Calcium Folinate Hikma 10 mg/ml Solution for Injection/Infusion

Folinic Acid

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.

If you have any further questions, ask your doctor, pharmacist, or nurse.

  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.
  • If you get any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the Package Leaflet

  1. What is Calcium Folinate Hikma and what is it used for
  2. What you need to know before you use Calcium Folinate Hikma
  3. How to use Calcium Folinate Hikma
  4. Possible side effects
  5. Storage of Calcium Folinate Hikma
  6. Contents of the pack and other information

1. What is Calcium Folinate Hikma and what is it used for

Calcium Folinate Hikma contains calcium folinate, which belongs to a group of medicines called detoxifying agents. It is the calcium salt of folinic acid, which is related to folic acid vitamin.

Calcium Folinate Hikma is used to:

  • reduce the harmful effects and to treat overdose of certain cancer medicines, such as methotrexate and other folic acid antagonists. This process is known as "calcium folinate rescue".
  • treat cancer in combination with 5-fluorouracil (a cancer medicine). 5-fluorouracil works better when given with Calcium Folinate Hikma.

2. What you need to know before you use Calcium Folinate Hikma

Calcium Folinate Hikma must not be administered intrathecally (in the spine).

Do not use Calcium Folinate Hikma:

  • if you are allergic to calcium folinate or any of the other ingredients of this medicine (listed in section 6).
  • if you have a type of anemia caused by having very low vitamin B12.

Warnings and Precautions

Consult your doctor, pharmacist, or nurse before starting treatment with Calcium Folinate Hikma.

If you are receiving treatment with calcium folinate and fluorouracil at the same time, be particularly careful if:

  • you have had radiotherapy
  • you have stomach or intestine problems

Special care is also needed if you are over 65 years old and are going to receive treatment with calcium folinate and fluorouracil at the same time.

Using Calcium Folinate Hikma with other medicines

Tell your doctor if you are using, have recently used, or might use any other medicines.

Special care is needed if you are taking/using other medicines as they may interact with Calcium Folinate Hikma, for example:

  • folic acid antagonists (see section 1) - the effectiveness of these medicines will be reduced by calcium folinate;
  • fluorouracil (cancer medicine) - the effectiveness and side effects of this medicine will be increased with calcium folinate;
  • medicines used to treat epilepsy (phenobarbital, phenytoin, primidone, or succinimides) - the effectiveness of these medicines may be reduced with calcium folinate. Your doctor may monitor the blood levels of these medicines and change the dose to prevent an increase in seizures (epilepsy).

Pregnancy and Breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.

It is unlikely that your doctor will ask you to take/use a folic acid antagonist or fluorouracil during pregnancy or breastfeeding. However, if you have taken/used a folic acid antagonist while pregnant or breastfeeding, this medicine (calcium folinate) may be used to reduce side effects.

Calcium Folinate Hikma contains sodium

This medicine contains less than 23 mg (1 mmol) of sodium per vial, and is therefore essentially "sodium-free".

3. How to use Calcium Folinate Hikma

This medicine can be administered by injection (using a syringe) into the muscle. Alternatively, it can also be administered by injection or infusion (drip) into a vein. If administered by infusion, Calcium Folinate Hikma must be diluted first.

Your doctor will decide the correct dose of Calcium Folinate Hikma for you and how often you should receive it. The decision will depend on the medical condition being treated.

If you use more Calcium Folinate Hikma than you should

This medicine is administered in a hospital, under the supervision of a doctor.

It is unlikely that you will be given too much or too little, but talk to your doctor or nurse if you have any questions.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Very rare: may affect up to 1 in 10,000 people

  • severe allergic reaction - you may feel a sudden itchy rash (urticaria), swelling of hands, feet, ankles, face, lips, mouth, or throat (which may cause difficulty in swallowing or breathing) and you may feel weak. This is a serious side effect. You may need medical attention.

Uncommon: may affect up to 1 in 100 people

  • fever

Rare: may affect up to 1 in 1,000 people

  • an increase in seizures (epilepsy) in patients with epilepsy
  • depression
  • agitation
  • gastrointestinal disorders
  • difficulty sleeping (insomnia)

Combination therapy with 5-fluorouracil:

If you receive calcium folinate in combination with a cancer medicine that contains fluoropyrimidines, you are more likely to have the following side effects of the other medicine:

Very common: may affect more than 1 in 10 people

  • nausea
  • vomiting
  • severe diarrhea
  • dehydration that may be due to diarrhea
  • inflammation of the intestinal and oral mucosa (life-threatening situations have occurred)
  • reduction in the number of blood cells (including life-threatening situations)

Common: may affect up to 1 in 10 people

  • redness and swelling of the palms of the hands and soles of the feet, which can cause skin peeling (hand-foot syndrome)

Frequency not known: cannot be estimated from the available data

  • high levels of ammonia in the blood

Reporting of side effects

If you experience any side effects, talk to your doctor, pharmacist, or nurse, even if it is possible side effects not listed in this leaflet. You can also report side effects directly through the Spanish Pharmacovigilance System for Human Use Medicines: https://www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Calcium Folinate Hikma

Keep in the refrigerator (2°C – 8°C).

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the label and carton after EXP. The expiry date is the last day of the month stated.

Store the vials in the outer packaging to protect them from light.

Unopened vials: 18 months.

After opening: 28 days at room temperature or at 2-8°C.

After dilution: the chemical and physical stability during use after dilution between 0.5 mg/ml and 4 mg/ml in 0.9% sodium chloride or 5% glucose has been demonstrated for 28 days at both room temperature and 2-8°C.

From a microbiological point of view, the product should be used immediately.

If not used immediately, the in-use storage times and conditions are the responsibility of the user and normally should not be longer than 24 hours at 2 to 8°C, unless the dilution has been carried out in a controlled and validated aseptic environment.

6. Contents of the pack and other information

Composition of Calcium Folinate Hikma

  • The active substance is calcium folinate. Each ml contains 10 mg of folinic acid as calcium folinate.
  • Each 5, 10, 30, and 50 ml of solution contains 50, 100, 300, and 500 mg of folinic acid, respectively (as calcium folinate).
  • The other ingredients are sodium chloride, hydrochloric acid, sodium hydroxide, and water for injection.

Appearance and packaging of the product

Calcium Folinate Hikma is a clear, pale yellow solution, which comes in glass containers called vials.

It is available in packs containing:

1 or 5 vials of 10 ml with 5 ml of calcium folinate

1 or 5 vials of 10 ml with 10 ml of calcium folinate

1 or 5 vials of 50 ml with 30 ml of calcium folinate

1 or 5 vials of 50 ml with 50 ml of calcium folinate

Marketing Authorisation Holder and Manufacturer

Marketing Authorisation Holder

Hikma Farmacêutica (Portugal) S.A.

Estrada do Rio da Mó, nº8, 8A e 8B, Fervença

2705-906 Terrugem SNT

Portugal

Manufacturer

Hikma Italia S.p.A

Viale Certosa, 10

27100 - Pavia

Italy

You can ask for more information about this medicine from the local representative of the Marketing Authorisation Holder:

Hikma España, S.L.U.

Calle Anabel Segura nº11, Edificio A, planta 1ª, oficina 2

28108 - Alcobendas, Madrid

Spain

This medicine is authorised in the Member States of the European Economic Area under the following names:

Germany Calciumfolinat Hikma 10 mg/ml Injektions-/Infusionslösung

Spain Folinato Cálcico Hikma 10 mg/ml Solución inyectable y para perfusión

France Folinate de Calcium Hikma 10 mg/ml solution injectable/pour perfusion

United Kingdom Calcium Folinate 10 mg/ml Solution for injection/infusion

Date of last revision of this leaflet: February 2024

------------------------------------------------------------------------------------------------------------------

This information is intended only for healthcare professionals:

In addition to the information included in section 3, practical information on the preparation/handling of this product is available here.

Incompatibilities

Incompatibilities have been observed between injectable forms of calcium folinate and injectable forms of droperidol, fluorouracil, foscarnet, and methotrexate.

Droperidol

Droperidol 1.25 mg/0.5 ml with calcium folinate 5 mg/0.5 ml, immediate precipitation after direct mixing in a syringe for 5 minutes at 25°C followed by 8 minutes of centrifugation.

Droperidol 2.5 mg/0.5 ml with calcium folinate 10 mg/0.5 ml, immediate precipitation when the medicines are injected sequentially into a Y-piece without flushing one arm of the equipment between injections.

Fluorouracil

Calcium folinate must not be mixed in the same infusion as 5-fluorouracil because a precipitate may form. 50 mg/ml of fluorouracil with 20 mg/ml of calcium folinate, with or without 5% dextrose in water, have been shown to be incompatible when mixed in different amounts and stored at 4°C, 23°C, or 32°C in polyvinyl chloride containers.

Foscarnet

24 mg/ml of Foscarnet with 20 mg/ml of calcium folinate: the formation of a yellowish turbid solution has been reported.

Special precautions for disposal and other handling

Calcium Folinate Hikma is intended for single use. Disposal of unused medicine and all materials that have come into contact with it should be done in accordance with local regulations.

Before administration, calcium folinate should be visually inspected. The solution for injection or infusion should be clear and pale yellow in color. If it is cloudy in appearance or particles are observed, the solution should be discarded.

Alternatives to FOLINATE CALCIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to FOLINATE CALCIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION in Poland

Dosage form: Solution, 10 mg/ml
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Alternative to FOLINATE CALCIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION in Ukraine

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Active substance: calcium folinate
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Discuss dosage, side effects, interactions, contraindications, and prescription renewal for FOLINATE CALCIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION – subject to medical assessment and local rules.

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Abdullah Alhasan

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Main areas of consultation:

  • Chest pain, shortness of breath, heart palpitations, high blood pressure
  • Hypertension control and cardiovascular disease prevention
  • Interpretation of ECG, blood tests, and Holter monitor results
  • Management of heart failure and coronary artery disease
  • General medical issues: infections, fever, fatigue, gastrointestinal symptoms
  • Guidance on diagnostics, treatment plans, and medication adjustments
Dr. Alhasan’s approach is based on thorough assessment, clear communication, and personalised care – helping patients understand their health and make informed decisions about their treatment.
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Yevgen Yakovenko

General surgery11 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management
  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses
  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment
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  • Pain management: acute and chronic pain, post-surgical care
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Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.
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  • Common symptoms such as fever, sore throat, cough, fatigue, or digestive issues
  • Chronic conditions including hypertension, diabetes, high cholesterol, and thyroid problems
  • Mental health concerns such as stress, sleep issues, anxiety, and burnout
  • Preventive care: health check-ups, lifestyle advice, and follow-up for existing conditions
  • Work-related health questions, sick leave documentation, and medical guidance for returning to work
Dr. Meneses graduated from the University of Beira Interior and has years of experience working with diverse patient populations. He is fluent in Portuguese, English, Spanish, and French.

His approach is friendly, clear, and focused on delivering practical medical advice tailored to each patient’s needs.

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Key areas of consultation:

  • Preventive and family medicine
  • Women’s health, including gynaecology and obstetrics
  • Chronic disease management: hypertension, diabetes, and more
  • Mental health support, anxiety, and counselling
  • Postoperative care and lab test interpretation
She has conducted research on the genetic background of stroke and is skilled in communicating with patients from diverse cultural backgrounds. Her approach combines clinical expertise with empathy and clear communication.
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Patients commonly seek her help for:

  • High blood pressure, headaches, dizziness, swelling, palpitations.
  • Diagnosis and management of hypertension, arrhythmias, and tachycardia.
  • Metabolic syndrome, excess weight, high cholesterol.
  • Chronic fatigue, insomnia, poor concentration, anxiety.
  • Respiratory symptoms: colds, flu, sore throat, cough, fever.
  • Digestive issues: heartburn, bloating, constipation, IBS symptoms.
  • Chronic conditions: diabetes, thyroid disorders.
  • Interpretation of lab tests and medical reports, therapy adjustment.
  • Second opinion and decision-making support.
  • Cardiovascular disease prevention and metabolic risk reduction.
  • Long-term follow-up and dynamic health monitoring.

Dr Kolomeeva combines clinical expertise with personalised care. She clearly explains diagnoses, guides patients through symptoms and treatment options, and provides actionable plans. Her consultations are designed not only to address current complaints but also to stabilise chronic conditions and prevent future complications. She supports patients through every stage of care – from first symptoms to ongoing health management.

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  • General and urgent care: fever, fatigue, infections, digestive issues, respiratory symptoms, and other common concerns
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  • Aesthetic medicine and dermatology: acne, skin ageing, hyperpigmentation, personalised skincare guidance
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  • Preventive care: health check-ups, lifestyle advice, second opinions

Dr. Correa combines medical knowledge with an aesthetic and holistic approach to help patients improve both health and quality of life.

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Dr. Tsurkan supports patients with a wide range of health issues, including:

  • Respiratory infections: cold, flu, bronchitis, pneumonia, and lingering coughs.
  • ENT conditions: sinusitis, tonsillitis, otitis (ear infections), sore throat, allergic rhinitis.
  • Eye conditions: allergic or infectious conjunctivitis, red eyes, irritation.
  • Digestive issues: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), constipation, bloating, nausea.
  • Urinary and reproductive health: urinary tract infections (UTIs), cystitis, prevention of recurrent infections.
  • Chronic diseases: hypertension, elevated cholesterol, weight management.
  • Neurological complaints: headaches, migraines, sleep disturbances, fatigue, general weakness.
  • Children’s health: fever, infections, digestive issues, follow-ups, vaccination guidance.

She also provides:

  • IMT medical certificates for driving licence exchange in Portugal.
  • Personalised preventive care and wellness consultations.
  • Interpretation of test results and medical reports.
  • Follow-up care and medication review.
  • Support in managing multiple coexisting conditions.
  • Remote prescription management and medical documentation.

Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

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You can consult Dr. Ben Harbi for:

  • General health concerns, prevention, and primary care.
  • Hypertension, type 1 and type 2 diabetes, metabolic issues.
  • Cold, cough, flu, respiratory infections, sore throat, fever.
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  • Skin rashes, mild allergic reactions, basic dermatological complaints.
  • Medication guidance, treatment adjustments, prescription review.
  • Paediatric concerns — fever, infections, general well-being.
  • Lifestyle optimisation: stress, sleep, weight, and diet counselling.

Dr. Ben Harbi offers reliable, accessible medical support through online consultations, helping patients make informed decisions about their health with a clear, structured, and compassionate approach.

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