Product Information for the Patient

Fiasp 100units/mL FlexTouch pre-filled injectable solution

insulin aspart

Read this entire product information carefully before starting to use this medicine, as it contains important information for you.

–Keep this product information, as you may need to read it again.

–If you have any questions, consult your doctor, pharmacist, or nurse.

–This medicine has been prescribed only for you, and you should not give it to others even if they have the same symptoms as you, as it may harm them.

–If you experience any side effects, consult your doctor, pharmacist, or nurse, even if they are not listed in this product information. See section 4.

1.What is Fiasp and what it is used for

2.What you need to know before starting to use Fiasp

3.How to use Fiasp

4.Possible side effects

5.Storage of Fiasp

6.Contents of the pack and additional information

Fiasp is an insulin that is administered at mealtime with a rapid effect in reducing blood sugar levels. Fiasp is an injectable solution of insulin aspart and is used to treat type 2 diabetes in adults, adolescents, and children aged 1 year and older. Diabetes is a diseasein which the bodydoes not produce enough insulin to controlthe level of blood sugar. Treatment with Fiasp helps to prevent diabetes complications. Fiasp should be injected 2 minutes before starting to eat, with the possibility of administration up to 20 minutes after the start of the meal. This medication reaches its maximum effect between 1 and 3 hours after injection and its effect lasts between 3 and 5 hours.

This medication should be used normally in combination with intermediate-acting or long-acting insulins.

No use Fiasp

•If you are allergic to insulin aspart or any of the other ingredients of this medicine (listed in section 6).

Warnings and precautions

Consult your doctor, pharmacist or nurse before starting to use Fiasp. It is important that you know the following:

•Low blood sugar (hypoglycemia): if your blood sugar level is too low, follow the instructions for low blood sugar that are listed in section 4 “Possible side effects”. Compared to other insulins that are taken at mealtime, Fiasp starts to lower blood sugar faster. If you have hypoglycemia, you may feel it sooner after an injection of Fiasp.

•High blood sugar (hyperglycemia): if your blood sugar level is too high, follow the instructions for high blood sugar that are listed in section 4 “Possible side effects”.

•Switching from other insulins. Your doctor may need to advise you on your insulin dose.

•If you are taking insulin with pioglitazone (an oral anti-diabetic medication used to treat type 2 diabetes), talk to your doctor as soon as possible if you experience symptoms of heart failure such as unusual difficulty breathing or rapid weight gain or localized swelling caused by fluid retention (edema).

•Eye disorders: a sudden improvement in blood sugar control may cause a temporary worsening of visual disorders related to diabetes such as diabetic retinopathy.

•Nerve damage: if your blood sugar level improves very quickly, you may experience nerve-related pain that is usually transient.

•Swelling of the joints: when starting to use the medicine, the body may retain more fluid than it should, causing inflammation of the ankles and other joints. This effect usually disappears quickly.

•Make sure you use the correct type of insulin, always check the label of the insulin before each injection to avoid accidental mix-ups between insulins.

•The treatment with insulins may cause the body to produce antibodies to insulin (a substance that acts against insulin). However, only in very rare cases, this will require a change in your insulin dose.

In case of reduced vision, see section 3 “How to use Fiasp”.

Some conditions and activities may affect your insulin requirement. Consult your doctor:

•If you have kidney, liver, adrenal gland, pituitary gland or thyroid gland problems.

•If you are doing more physical exercise than usual or if you want to change your usual diet, as this may affect your blood sugar level.

•If you are ill, continue your insulin treatment and consult your doctor.

•If you are traveling abroad, traveling to different time zones may affect your insulin needs and injection times.

When using Fiasp, it is recommended to record the name and batch number of each pack to keep a record of the batches used.

Changes in the skin at the injection site

Rotate the injection site to help avoid changes in the fatty tissue, such as thickening of the skin, shrinking of the skin or lumps under the skin. Insulin may not work very well if injected in a swollen, shrunk or thickened area (see section 3 “How to use Fiasp”). Inform your doctor if you detect any changes in the injection site. Inform your doctor if you are currently injecting in these affected areas, before starting to inject in a different area. Your doctor may advise you to check your blood sugar levels more closely, and adjust the insulin or the dose of your other anti-diabetic medications.

Children and adolescents

This medicine is not recommended for children under 1 year of age.

Other medicines and Fiasp

Inform your doctor or pharmacist if you are using, have used recently or may need to use any other medicine. Some medicines affect your blood sugar level and this may mean that you need to change your insulin dose.

The following are the main medicines that may affect your insulin treatment:

Your blood sugar level may decrease (hypoglycemia) if you take:

•other diabetes medicines (oral and injectable)

•sulfonamide antibiotics (used to treat infections)

•anabolic steroids (such as testosterone)

•beta-blockers (used to treat high blood pressure or angina)

•salicylates (used to relieve pain and reduce fever)

•monoamine oxidase inhibitors (MAOIs) (used to treat depression)

•angiotensin-converting enzyme inhibitors (ACEIs) (to treat certain heart problems or high blood pressure)

Your blood sugar level may increase (hyperglycemia) if you take:

•danazol (a medicine that acts on ovulation)

•oral contraceptives (birth control pills)

•thyroid hormones (to treat thyroid gland problems)

•growth hormone (to treat a deficiency of this hormone)

•glucocorticoids (such as “cortisone”, to treat inflammation)

•sympathomimetics (such as adrenaline, salbutamol or terbutaline, to treat asthma)

•thiazides (to treat high blood pressure or if the body retains too much fluid (fluid retention)).

Octreotide and lanreotide, used to treat acromegaly, a rare disorder characterized by excessive production of growth hormone. These medicines may increase or decrease your blood sugar level.

If you are in any of the above situations (or are unsure), consult your doctor or pharmacist.

Use of Fiasp with alcohol

If you drink alcohol, it may change your insulin needs, as your blood sugar level may be increased or decreased. Therefore, you should monitor your blood sugar level more frequently than usual.

Pregnancy and breastfeeding

If you are pregnant, think you may be pregnant or are planning to become pregnant, consult your doctor before using this medicine. This medicine can be used during pregnancy, however, you may need to modify your insulin dose while pregnant and after delivery. The amount of insulin you normally need decreases during the first 3 months of pregnancy and increases during the remaining 6 months. During pregnancy, careful control of your diabetes is necessary. Avoiding low blood sugar (hypoglycemia) is especially important for the health of your baby. After having your baby, your insulin requirements will probably return to what you needed before pregnancy.

There are no restrictions on the use of Fiasp during breastfeeding.

Driving and operating machines

Low blood sugar may affect your ability to drive or use tools or machines. If you have low blood sugar, your concentration and reaction times may be affected. This could put your life or the lives of others at risk. Ask your doctor if you can drive if:

•You have frequent episodes of hypoglycemia

•You find it difficult to recognize the symptoms of hypoglycemia.

Important information about one of the components of Fiasp

This medicine contains less than 1 mmol of sodium (23 mg) per dose; this is, essentially “sodium-free”.

Follow exactly the administration instructions of this medication as indicated by your doctor. In case of doubt, consult your doctor or pharmacist again.

If you are blind or have reduced vision and cannot read the dose counter on the pen, do not use this pen without help. Ask for help from a person with normal vision and trained in the use of the FlexTouch pre-filled pen.

The pre-filled pen can provide a dose of 1–80 units in a single injection, in increments of 1 unit.

When to use Fiasp

Fiasp is an insulin that is administered with meals.

Adults: Fiasp should be injected just before (0 to 2 minutes) starting to eat, with the possibility of administering up to 20 minutes after the start of the meal.

Children: Fiasp should be injected just before (0 to 2 minutes) starting to eat, with the possibility of administering up to 20 minutes after the start of the meal in situations where it is uncertain when the child will eat. Consult your doctor about these situations.

This medication reaches its maximum effect between 1 and 3 hours after injection and its effect lasts between 3 and 5 hours.

Fiasp Dosage

Dosage for type 1 and type 2 diabetes

Your doctor will decide with you:

• What amount of Fiasp you need for each meal

• When to check your blood sugar level and if you need a higher or lower dose.

If you want to modify your usual diet, consult your doctor, pharmacist, or nurse beforehand, as a change in diet may alter your insulin needs.

When using other medications, ask your doctor if you need to adjust your treatment.

Adjustment of dosage for type 2 diabetes

The daily dose depends on your blood sugar level at mealtime the day before and at night before.

• Before breakfast: the dose should be adjusted according to the blood sugar level before lunch the day before.

• Before lunch: the dose should be adjusted according to the blood sugar level before dinner the day before.

• Before dinner: the dose should be adjusted according to the blood sugar level at night before.

Use in elderly patients (65 years or older)

This medication can be used in elderly patients. Talk to your doctor about possible changes in your dose.

If you have kidney or liver problems

If you have kidney or liver problems, you may need to monitor your blood sugar level more frequently. Talk to your doctor about possible changes in your dose.

Injecting Fiasp

This medication is only indicated for subcutaneous injection.

Before using Fiasp for the first time, your doctor or nurse will show you how to use the pre-filled pen. Consult your doctor if you need to inject insulin by another method.

Where to inject

• The best areas for injection are the front of the abdomen or the upper arm.

• Do not inject into a vein or muscle.

• Change the injection site every day within the area where you inject to reduce the risk of developing skin changes (see section 4).

Do not use Fiasp

• If the pen is damaged or not stored properly (see section 5 "Storage of Fiasp").

• If the insulin does not have a transparent (e.g. cloudy) and colorless appearance.

On the other side of this leaflet, detailed instructions are provided on how to use the FlexTouch pen.

If you use more Fiasp than you should

If you use too much insulin, your blood sugar level may become very low (hypoglycemia), see section 4 "Low blood sugar level".

If you forget to use Fiasp

If you forget to inject insulin, your blood sugar level may become very high (hyperglycemia). See section 4 "High blood sugar level".

Three simple steps that may help you avoid low or high blood sugar levels:

• Always carry a spare pen in case you lose or damage the one you have.

• Always carry something that indicates you are diabetic.

• Always carry something sweet with you. See section 4 "What to do if your blood sugar level is low".

If you interrupt treatment with Fiasp

Do not interrupt your insulin treatment without consulting your doctor. Stopping insulin administration could lead to very high blood sugar levels (severe hyperglycemia) and ketoacidosis (a condition that consists of an excessive amount of acid in the blood that is potentially fatal). See symptoms and recommendations in section 4 "High blood sugar level".

Like all medicines, this medicine can cause side effects, although not everyone will experience them.

Low blood sugar (hypoglycemia)is a very common side effect of insulin treatment (can affect more than 1 in 10 people). It can be very serious. A severe drop in blood sugar can lead to loss of consciousness. A severe hypoglycemia can cause brain damage and put your life at risk. If you have symptoms of low blood sugar, take measures to increase your blood sugar level immediately.immediately. See recommendations “Low blood sugar” later.

If you suffer a severe allergic reaction(including anaphylactic shock) to insulin or any of the components of Fiasp (the frequency of this is unknown), discontinue treatment with this medicine and contact the emergency medical service immediately.

The symptoms of a severe allergic reaction may include:

•local reactions (e.g. rash, redness and itching) spreading to other parts of the body

•feeling suddenly unwell with sweating

•starting to vomit

•experiencing difficulty breathing

•having palpitations or feeling dizzy.

Reactions such as generalized skin rash and facial swelling may occur.These are rare and may affect up to 1 in 100 people.Consult a doctor if symptoms worsen or if no improvement is seen in a few weeks.

Changes in skin at the injection site:If insulin is injected in the same place, the fatty tissue may shrink (lipoatrophy) or become thicker (lipohypertrophy) (these are rare and may affect up to 1 in 100 people). Blisters under the skin may also occur due to the accumulation of a protein called amyloid (cutaneous amyloidosis; the frequency of this is unknown). Insulin may not work well if injected in a swollen, shrunk or thickened area. Change the injection site to help prevent these skin changes.

Other side effects include:

Common(may affect up to 1 in 10 people)

Reaction at the administration site:Local reactions may occur at the injection site. Symptoms may include: rash, redness, inflammation, bruises, irritation, pain and itching. These reactions usually disappear after a few days.

Reactions on the skin:Signs of allergy on the skin such as eczema, rash, itching, hives and dermatitis may occur.

General effects of insulin treatment including Fiasp

•Low blood sugar (hypoglycemia)(very common)

Low blood sugar may occur if:

You drink alcohol, inject too much insulin, exercise more than usual, eat very little or skip a meal.

Warning signs of low blood sugar, which may appear suddenly:Headache, difficulty speaking, palpitations, cold sweat, pale and cold skin, nausea, excessive hunger, tremors, nervousness or concern, unusual fatigue, weakness and drowsiness, confusion, difficulty concentrating, temporary changes in vision.

What to do if your blood sugar level is low

•If you are conscious, treat your low blood sugar immediately with 15–20 g of rapid-acting carbohydrates: take glucose tablets or a sweet product, such as fruit juice, candies or cookies (always carry glucose tablets or sweet products with you in case you need them).

•It is recommended that you recheck your blood glucose levels after 15–20 minutes and re-treat if your blood glucose levels are still below 4 mmol/l.

•Wait until the symptoms of hypoglycemia have disappeared or your blood sugar level has stabilized. Continue with insulin treatment as usual.

What to do if you lose consciousness

Inform people you spend time with that you have diabetes. Tell them what the consequences of a drop in blood sugar level may be, including the risk of losing consciousness.

Inform them that, if you become unconscious, they should:

•lay you on your side to prevent asphyxiation

•seek immediate medical assistance

•do notgive you anything to eat or drink, as you may asphyxiate.

You may recover consciousness more quickly if someone who knows how to administer it gives you a glucagon injection.

•If you are given glucagon, you should take glucose or a sweet product as soon as you regain consciousness.

•If you do not respond to glucagon treatment, you should be treated in a hospital.

If severe hypoglycemia is not treated, it may cause brain damage over time. This may be temporary or permanent. It may even cause death.

Talk to your doctor if:

•You have had blood sugar levels so low that you have lost consciousness

•You have been given a glucagon injection

•You have recently had several drops in blood sugar levels.

You may need to adjust the dose or frequency of your insulin injections, diet or exercise.

•High blood sugar (hyperglycemia)

High blood sugar may occur if:

You eat more or exercise less than usual, drink alcohol, have an infection or fever, do not inject enough insulin, repeatedly inject less insulin than you need, forget to inject insulin or interrupt insulin treatment.

Warning signs of high blood sugar, which usually appear gradually:Redness of the skin, dry skin, feeling ofsomnolence or fatigue, dry mouth, breath with a fruity odor (acetone), increased need to urinate, thirst, loss of appetite, nausea or vomiting.

These may be symptoms of a very serious condition called ketoacidosis. This is a buildup of acid in the blood due to the body metabolizing fat instead of sugar. If not treated, it may cause diabetic coma and even death.

What to do if your blood sugar level is high

•Check your blood sugar level.

•Administer a corrective dose of insulin if you have been taught how to do so.

•Check the level of ketones in your urine.

•If you have ketones, seek immediate medical assistance.

Reporting side effects

If you experience any type of side effect, consult your doctor, pharmacist or nurse, even if it is a side effect that does not appear in this prospectus.You can also report them directlythrough the Spanish System for the Vigilance of Medicines for Human Use: https://www.notificaram.es. By reporting side effects, you can contribute to providing more information on the safety of this medicine.

Keep this medication out of the sight and reach of children.

Do not use this medication after the expiration date that appears on the label and on the packaging after CAD. The expiration date is the last day of the month indicated.

Before first use

Store in refrigerator (between 2°C and 8°C). Do not freeze. Keep away from freezer. Store the pen with the cap on to protect it from light.

Once opened or when carrying as a spare

You may carry your preloaded pen (FlexTouch) with you and store it at room temperature (not above 30°C) or in the refrigerator (between 2°C and 8°C) for 4 weeks. Always store the pen with the cap on when not in use to protect it from light.

Medicines should not be disposed of through drains or in the trash. Ask your pharmacist how to dispose of the packaging and the medication that you no longer need. This will help protect the environment.

Composition of Fiasp

•The active ingredient is insulin aspart. 1ml of solution contains 100units of insulin aspart. Each pre-filled pen contains 300units of insulin aspart in 3ml of solution.

•The other components are phenol, metacresol, glycerol, zinc acetate, disodium phosphate dihydrate, arginine hydrochloride, nicotinamide (vitamin B3), hydrochloric acid (for pH adjustment), sodium hydroxide (for pH adjustment) (see end of section 2 “Important information about some of the components of Fiasp”) and water for injection.

Appearance of Fiasp and contents of the pack

Fiasp is presented as a transparent, colourless and aqueous injectable solution in a pre-filled pen.

Pack sizes of 1, 5 or multiple pack with 2x5pre-filled pens of 3ml. Some pack sizes may only be marketed.

Marketing authorisation holder and manufacturer

Novo Nordisk A/S,

Novo Allé,

DK-2880 Bagsværd, Denmark

Date of the last revision of this leaflet:

Other sources of information

The detailed information on this medicine is available on the website of the European Medicines Agency:http://www.ema.europa.eu.

Instructions for use of Fiasp FlexTouch

Read these instructions carefullybefore using your Fiasp FlexTouch pen. If you do not follow the instructions carefully, you may administer too little or too much insulin, which could result in an increase or decrease in your blood sugar level.

Do not use the pen without proper training from your doctor or nurse.

Start by checking the pen toensure that it contains Fiasp 100units/mland then observe the illustrations to familiarize yourself with the different parts of the pen and the needle.

If you are blind or have reduced vision and cannot read the dose counter on the pen, do not use this pen without assistance.Seek the help of a person with normal vision and who is trained in the use of the Fiasp FlexTouch pen.

Your pen is an insulin dosing pen that contains 300units of insulin. You can select amaximum of 80units per dose in increments of 1unit.Your pen is designed to be used with single-use disposable needles of between 4 mm and 8mm in length and a gauge of between 30 G and 32 G. The needles are not included in the pack.

Important information

Pay special attention to these notes because they are important for the correct use of the pen.

1 Preparation of the pen with a new needle

•Check the label on your pen to ensure that it contains Fiasp 100units/ml. This is especially important if you use more than one type of insulin. If you use the wrong type of insulin, your blood sugar level may be too high or too low.

•Remove the cap from the pen.

•Check that the insulin in the pen has a transparent and colourless appearance.

Look through the insulin window. If the insulin has a cloudy appearance, do not use the pen.

•Take a new needleand remove the paper tab.

Make sure to place the needle correctly.

•Place the needlestraightinto the pen.

•Push it in until it isfirmlyseated.

The needles are covered by two caps. You must remove both caps.If you forget to remove both, you will not inject any insulin.

•Remove the outer cap from the needle and keep it for later use.You will need it after the injection to safely remove the needle from the pen.

•Remove the inner cap from the needle and discard it.If you try to put it back on, you may damage or accidentally prick yourself with the needle.

You may see a drop of insulin at the tip of the needle. This is normal, but despite this, you must check the insulin flow.

Do not place a new needlein the pen until you are ready to administer the injection.

Always use a new needle for each injection.

This reduces the risk of contamination, infection, insulin loss, needle blockage and inaccurate dosing.

Never use a bent or damaged needle.

2 Checking the insulin flow

•Always check the insulin flow before starting.

This will help you ensure that you receive the full dose of insulin.

•Turn the dose selector until2units are selected. Make sure that 2 appears on the dose counter.

•Hold the pen with the needle pointing upwards.

Gently tap the top of the penseveral times to allow any air bubbles to rise.

•Press and hold the dose buttonuntil the dose counter returns to 0.

The 0 must be aligned with the dose marker.

You should see a drop of insulin at the tip of the needle.

You may see a small air bubble at the tip of the needle, but it will not be injected.

If no drop appears,repeat steps 2Ato 2Cup to 6times. If it still does not appear, change the needle and repeat steps 2Ato 2Conce more.

If, despite this, no drop of insulin appears, discard the pen and use a new one.

Always make sure that a dropappears at the tip of the needle before injecting. This ensures that the insulin flows correctly.

If no drop appears, no insulin will be injected, although the dose counter may move. This may indicate that the needle is blocked or damaged.

Always check the insulin flow before injecting.If you do not check the flow, you may receive an insufficient or non-existent dose of insulin. This could result in an increase in your blood sugar level.

3 Selecting the dose

•Check that the dose counter shows 0 before starting.

The 0 must be aligned with the dose marker.

•Turn the dose selector to select the dose you need,following the instructions of your doctor or nurse.

If you have selected the wrong dose, you can turn the dose selector forward or backward until you select the correct dose.

The pen can select up to a maximum of 80units.

The dose selector changes the number of units. Only the dose counter and the dose marker show how many units you have selected for each administration.

You can select up to 80units per administration. When the pen contains less than 80units, the dose counter stops when it reaches the number of units remaining.

Before injecting the insulin, always use the dose counter and the dose marker to see how many units you have selected.

Do not count the clicks of the pen to set the dose.If you select the wrong dose and inject it, your blood sugar level may become too high or too low.

Do not use the insulin scale, as it only indicates the approximate amount of insulin remaining in the pen.

The dose selector makes a different click when turned forward, backward or when passing the number of units remaining.

4 Injecting the dose

•Insert the needle under the skin,as explained by your doctor or nurse.

•Check that you can see the dose counter.

Do not touch the dose counter with your fingers. This may interrupt the injection.

•Press and hold the dose button. Observe how the dose counter returns to 0.

The 0 must be aligned with the dose marker. At this point, you may hear or feel a click.

•Continue pressing the dose button while keeping the needle in the skin.

•Count slowly to 6 while keeping the dose button pressed.

•If you remove the needle before, you may see insulin coming out of the tip of the needle. This means that the full dose has not been administered, so you should check your blood sugar level more frequently.

•Remove the needle from the skin.You can then release the dose button.

If you see blood at the injection site, press the skin gently for a few minutes to stop the bleeding. Do not rub the area.

You may see a drop of insulin at the tip of the needle after the injection. This is normal and does not affect the dose.

Always observe the dose counter to know how many units you inject.Keep the dose button pressed until the dose counter indicates 0. If the dose counter does not return to 0, it means that the full dose has not been administered, which could result in an increase in your blood sugar level.

How to detect if the needle is blocked or damaged?

•If the dose counter does not return to 0 after pressing the dose button continuously, you may have used a blocked or damaged needle.

•In this case,you will not have receivedany medication, although the dose counter may have moved from the original dose you set.

What to do if the needle is blocked?

Remove the needle as described in section 5 and repeat all the steps from section 1: Preparation of the pen with a new needle. Make sure to select the full dose you need.

Do not touch the dose counter while injecting.This may interrupt the injection.

5 After the injection

Always discard the needle after each injection.

This reduces the risk of contamination, infection, insulin loss, needle blockage and inaccurate dosing. If the needle is blocked,no insulin will be injected.

•Insert the tip of the needle into the outer cap,placed on a flat surface, without touching the needle or the outer cap.

•When the needle is covered,press the outer cap firmly and carefully.

•Twist the needleand discard it carefully, as instructed by your doctor, nurse, pharmacist or local authorities.

•Put the cap back on the pen after each use to protect the insulin from light.

When the pen is empty, discard itwithoutthe needle attached, following the instructions of your doctor, nurse, pharmacist or local authorities.

Never try to put the inner cap back on the needle.You may prick or damage yourself with it.

Always remove the needle from the pen after each injectionand store your pen without the needle attached. This reduces the risk of contamination, infection, insulin loss, needle blockage and inaccurate dosing.

6 How much insulin is left?

•Theinsulin scaleshows the approximate amount of insulin remaining in the pen.

•To know exactly how much insulin is left,use the dose counter:

Turn the dose selector until thedose counter stops.

If it indicates 80, it means that there areat least 80units remaining in the pen.

If it indicatesless than 80,the number shows the amount of units remaining in the pen.

•Turn the dose selector backward until the dose counter shows 0.

•If you need more insulin than the units remaining in the pen, you can divide the dose between two pens.

Be very careful to make the calculation correctly if you divide your dose.

If you are unsure, inject the full dose with a new pen. If you divide incorrectly, you may inject too little or too much insulin, which could result in an increase or decrease in your blood sugar level.

More important information

•Always carry the pen with you.

•Always carry a spare pen and new needles,in case of loss or breakage.

•Always keep the pen and needlesout of sight and reach of other people,especially children.

•Never sharethe pen or needles with other people. Infections may occur.

•Never sharethe pen with other people. Your medication may be harmful to others.

•People who care for patients mustbe very careful when handling used needlesto reduce the risk ofneedlestick injuryand infection.

Care of the pen

•Treat your pen with care. Rough handling or misuse may cause inaccurate dosing, which may result in an increase or decrease in your blood sugar level.

•Do not leave the pen in the caror in any other place where it may become too hot or too cold.

•Do not expose the pen to dust, dirt or liquids.

•Do not wash, soak or lubricate the pen.If necessary, wipe it with a damp cloth and a mild detergent.

•Make sure the pen does not fallor hit against hard surfaces.

If the pen falls or you suspect a problem, put a new needle on and check the insulin flow before injecting.

• Do not try to refill the pen.Once empty, it must be discarded.

Do not try to repair the penor disassemble it.