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CARDI-BRAUN REPERFUSION PERFUSION SOLUTION

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Doctor

Tomasz Grzelewski

Dermatology20 years of experience

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques.

For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance.

Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults.

In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions.

Patients commonly seek his care for:

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns
Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.
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Doctor

Hocine Lokchiri

General medicine20 years of experience

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use CARDI-BRAUN REPERFUSION PERFUSION SOLUTION

Introduction

Leaflet: information for theuser

Cardi-Braun Reperfusion solution for perfusion

Read the entire leaflet carefully before starting tousethis medication.

  • Keep this leaflet, as you may need to read it again.
  • If you have any questions, consult your doctor or pharmacist.
  • If you think any of the side effects you are suffering from is serious or if you notice any side effect not mentioned in this leaflet, inform your doctor or pharmacist.

Contents of the leaflet

  1. What Cardi-Braun Reperfusion is and what it is used for
  2. Before using Cardi-Braun Reperfusion
  3. How to use Cardi-Braun Reperfusion
  4. Possible side effects
  5. Storage of Cardi-Braun Reperfusion
  6. Additional information

1. What is Cardi-Braun Reperfusion and what it is used for

The medications Cardi-Braun Maintenance and Cardi-Braun Reperfusion are solutions for intracardiac perfusion (administered directly to the heart through an external device that assumes the functions of the heart) that belong to the group of medications called cardioplegic solutions. The two solutions are used alternately during heart operations.

The cardioplegic solutions of B. Braun Medical are used in open-heart surgery to:

  • stop the heart and protect the heart muscle during the operation,
  • effectively resuscitate the heart function once the operation is finished.

2. Before using Cardi-Braun Reperfusion

Do not use Cardi-Braun Reperfusion

If you are allergic (hypersensitive) to the active ingredients or to any of the other components of Cardi-Braun Reperfusion.

If, in your clinical situation, the technique of stopping the heart with cardioplegic solutions may pose a threat to your life.

Be careful with Cardi-Braun Reperfusion

The cardioplegic solutions Cardi-Braun will only be used by qualified cardiac surgeons and specialists.

The cardioplegic solutions Cardi-Braun are not administered intravenously, they are released directly into the heart through an external device that assumes the functions of the heart during the operation.

During the operation, the medical team that assists you will carefully monitor your vital signs. In particular, they will evaluate:

  • the temperature of your heart,
  • the electrocardiogram (measures the electrical activity of the heart) and
  • the pressure and speed at which these solutions are administered.

For the recovery of the heart once the operation is finished, a defibrillation team (uses electric current to restore the heartbeat) and medications that increase the strength of the heart's contraction must be available.

Adequate intake of vitamins (particularly vitamin B1) must be ensured.

Use of other medications

Certain medications may influence the action of the Cardi-Braun solutions. In these cases, it may be necessary to change the dose or interrupt treatment with one of the medications.

Inform your doctor or pharmacist if you are using or have recently used other medications, including those purchased without a prescription.

Pregnancy and Breastfeeding

Consult your doctor or pharmacist before using any medication.

In case of pregnancy or breastfeeding, the medical team will decide on the convenience of using this medication.

Cardi-Braun Reperfusion contains sodium

This medication contains less than 23 mg of sodium (1 mmol) per 1 milliliter; that is, it is essentially "sodium-free".

3. How to use Cardi-Braun Reperfusion

This medication will always be administered by specialized medical personnel.

Your cardiac surgeon and medical team will decide on the most suitable dose for you.

This medication is injected directly into the heart (intracardiac perfusion) through a device called a heart-lung machine or pulmonary bypass.

This device assumes the functions of the heart and is responsible for pumping and circulating blood. This allows your heart to remain still during the intervention and allows the surgeons to operate on your heart without it moving or being filled with blood.

If you have been administered more Cardi-Braun Reperfusion than you should:

It is unlikely that this will happen because your doctor will determine the most suitable dose for you.

In case of overdose or accidental ingestion, consult the Toxicology Information Service. Phone (91) 562 04 20 indicating the product and the amount administered.

If you have any other questions about the use of this product, ask your doctor or pharmacist.

4. Possible side effects

Like all medications, Cardi-Braun Reperfusion can cause side effects, although not everyone will experience them.

Your surgeon will explain what the possible side effects are derived from the use of Cardi-Braun Reperfusion during the open-heart surgery you will undergo.

The following side effects of unknown frequency have been reported:

Cardiac disorders:

Myocardial infarction, ventricular arrhythmia, ventricular fibrillation.

Complementary tests:

Abnormal electrocardiogram, abnormal acid-base balance.

Metabolic and nutritional disorders:

Electrolyte imbalance, hyperglycemia (in patients receiving solutions with high glucose content; may require insulin administration).

Once the operation is finished and blood circulation is restored, the heartbeat may be delayed, so defibrillation of the heart (use of electric current to restore the heartbeat) and the use of medications to restore normal heart function may be necessary.

If you think any of the side effects you are suffering from is serious or if you notice any side effect not mentioned in this leaflet, inform your doctor or pharmacist.

Reporting side effects

If you experience any type of side effect, consult your doctor or pharmacist, even if it is a possible side effect that is not listed in this leaflet. You can also report them directly through the Spanish Pharmacovigilance System for Human Use Medicines: www.notificaRAM.es. By reporting side effects, you can contribute to providing more information on the safety of this medication.

5. Storage of Cardi-Braun Reperfusion

Keep out of the reach and sight of children.

No special storage conditions are required.

Do not use Cardi-Braun Reperfusion after the expiration date indicated on the packaging. The expiration date is the last day of the month indicated.

Do not use Cardi-Braun Reperfusion if the solution is cloudy or sedimented.

Do not use Cardi-Braun Reperfusion if the packaging shows visible signs of deterioration.

Any unused solution must be disposed of in accordance with local requirements.

Medications should not be thrown away in drains or trash. Ask your pharmacist how to dispose of the packaging and medications you no longer need. This will help protect the environment.

6. Additional information

Composition of Cardi-Braun Reperfusion

The active ingredients are:

Per 1 mlPer 500 ml

Tromethamine 8.5620 mg 4.2810 g

Sodium citrate 6.1963 mg 3.0981 g

Citric acid monohydrate 0.7730 mg 0.3865 g

Sodium dihydrogen phosphate dihydrate 0.5913 mg 0.2956 g

Potassium chloride 2.3419 mg 1.1709 g

Glucose monohydrate 40.5530 mg 20.2765 g

Aspartic acid 7.8970 mg 3.9490 g

Glutamic acid 8.7990 mg 4.4000 g

Electrolyte composition:

Phosphates 3.79 mmol/l

Citrate 24.74 mmol/l

Sodium 186.2 mmol/l

Potassium 31.4 mmol/l

Chloride 31.4 mmol/l

Acetate 11 mmol/l

The other components are: Acetic acid (pH adjustment), sodium hydroxide, and water for injectable preparations.

Appearance of the product and packaging content

Cardi-Braun Reperfusion is a clear and transparent perfusion solution that comes in a single unit package containing a 500 ml flexible plastic bag.

Marketing authorization holder and manufacturer

  • Braun Medical SA

Ctra. de Terrassa, 121

08191-Rubí (Barcelona)

This leaflet was approved in:December 2024

This information is intended only for doctors or healthcare professionals:

Cardi-Braun Reperfusion perfusion solution is a ready-to-use solution.

Its administration is carried out through commercial systems that distribute the solution through the cardiopulmonary bypass device.

The volumes of solution that are perfused depend on the duration or type of open-heart surgical procedure.

The cardioplegic solutions Cardi-Braun can be administered to the coronary circulation through two routes - anterograde and retrograde - or in a mixed manner.

Cardi-Braun Reperfusion requires the addition of potassium chloride 2M for the induction phase.The addition of the potassium chloride solution must be carried out under strict aseptic conditions.

Instructions for the correct use of the Cardi-Braun cardioplegic solutions

Unfold the bag and place it on a hard surface. Open the central joint by pressing with both hands on one of the bag's chambers.

Pre-filled transparent syringe with yellow liquid and gray needle connected, ready for injection

Mix the contents by inverting the bag several times. The homogeneous mixture is ready for use.

Pre-filled transparent syringe with yellow liquid and gray needle connected, ready for injection

The addition of the potassium chloride solution can be incorporated directly into the bag through a syringe in the connector located at the bottom of the bag, using an aseptic procedure.

Pre-filled transparent syringe with yellow liquid and gray needle connected, ready for injection

Remove the white cap from the perfusion connector. Clean the connector and insert the intracardiac perfusion equipment. Perfuse according to protocol.

Pre-filled transparent syringe with yellow liquid and gray needle connected, ready for injection

Once the package is opened, use immediately.

Discard the unused fraction of the solution.

B|BRAUN

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Alternative to CARDI-BRAUN REPERFUSION PERFUSION SOLUTION in Poland

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Online doctors for CARDI-BRAUN REPERFUSION PERFUSION SOLUTION

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for CARDI-BRAUN REPERFUSION PERFUSION SOLUTION – subject to medical assessment and local rules.

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Doctor

Tomasz Grzelewski

Dermatology20 years of experience

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques.

For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance.

Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults.

In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions.

Patients commonly seek his care for:

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns
Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.
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Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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