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BISOLVON CALMATOS 2.13 mg/ml ORAL SOLUTION

Ask a doctor about a prescription for BISOLVON CALMATOS 2.13 mg/ml ORAL SOLUTION

5.0(2)
Doctor

Svetlana Kolomeeva

Cardiology18 years of experience

Dr. Svetlana Kolomeeva is a general practitioner and internal medicine doctor providing online consultations for adults. She helps patients manage acute symptoms, chronic conditions, and preventive care. Her clinical focus includes cardiovascular health, hypertension control, and managing symptoms like fatigue, weakness, sleep issues, and overall low energy.

Patients commonly seek her help for:

  • High blood pressure, headaches, dizziness, swelling, palpitations.
  • Diagnosis and management of hypertension, arrhythmias, and tachycardia.
  • Metabolic syndrome, excess weight, high cholesterol.
  • Chronic fatigue, insomnia, poor concentration, anxiety.
  • Respiratory symptoms: colds, flu, sore throat, cough, fever.
  • Digestive issues: heartburn, bloating, constipation, IBS symptoms.
  • Chronic conditions: diabetes, thyroid disorders.
  • Interpretation of lab tests and medical reports, therapy adjustment.
  • Second opinion and decision-making support.
  • Cardiovascular disease prevention and metabolic risk reduction.
  • Long-term follow-up and dynamic health monitoring.

Dr Kolomeeva combines clinical expertise with personalised care. She clearly explains diagnoses, guides patients through symptoms and treatment options, and provides actionable plans. Her consultations are designed not only to address current complaints but also to stabilise chronic conditions and prevent future complications. She supports patients through every stage of care – from first symptoms to ongoing health management.

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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use BISOLVON CALMATOS 2.13 mg/ml ORAL SOLUTION

Introduction

Package Leaflet: Information for the User

Bisolvon Calmatos 2.13 mg/ml Oral Solution

Pentoxiverine Citrate

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

Follow exactly the administration instructions of the medicine contained in this leaflet or as indicated by your doctor or pharmacist.

  • Keep this leaflet, as you may need to read it again.
  • If you need advice or more information, consult your pharmacist.
  • If you experience side effects, consult your doctor or pharmacist, even if they are not listed in this leaflet. See section 4.
  • You should consult a doctor if your symptoms worsen or do not improve after 7 days.

Contents of the Package Leaflet

  1. What is Bisolvon Calmatos and what is it used for
  2. What you need to know before taking Bisolvon Calmatos
  3. How to take Bisolvon Calmatos
  4. Possible side effects
  5. Storage of Bisolvon Calmatos
  6. Package Contents and Additional Information

1. What is Bisolvon Calmatos and what is it used for

Bisolvon Calmatos is indicated for the treatment of symptoms of dry cough (non-productive cough) in adults and children from 6 years of age. The medicine is an antitussive, reducing the overstimulation of the cough center and thus normalizing the cough reflex.

Contact your doctor if your cough symptoms worsen, you experience chest pain, or your cough persists for more than a week. Pentoxiverine is indicated only for temporary use and should not be used continuously for more than 2 weeks.

2. What you need to know before taking Bisolvon Calmatos

Do not takeBisolvon Calmatos

  • if you are allergic to the active substance or to any of the other components of this medicine (listed in section 6).
  • if you have breathing difficulties
  • if you have symptoms of central nervous system depression, such as drowsiness, low muscle tone, reduced awareness of your surroundings, and response to external stimulation, etc.
  • if you are pregnant or breastfeeding
  • the product should not be used in children under 6 years of age.

Warnings and Precautions

Pentoxiverine is not recommended if you have reduced liver function. Do not take this product unless your doctor has decided that it is safe for you to do so.

Consult your doctor or pharmacist before starting to take pentoxiverine if you have:

  • reduced kidney function,
  • a long-lasting cough (due, for example, to asthma, reduced lung capacity, or smoking) or if the cough produces a large amount of mucus,
  • increased intraocular pressure (glaucoma), enlarged prostate (benign prostatic hyperplasia), urinary flow obstruction, intestinal obstruction, or stomach or duodenal ulcers,
  • high blood pressure or irregular heartbeats,
  • a disease called myasthenia gravis.

Children and Adolescents

Pentoxiverine should not be used in children under 6 years of age. Pentoxiverine is not recommended for children if the cough produces a large amount of mucus.

In particular, children who are prone to seizures should be monitored during treatment.

Other Medicines and Bisolvon Calmatos

Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.

Pentoxiverine may increase the effects of substances that cause central nervous system depression (e.g., sleeping pills, sedating medications, and antihistamines).

Taking Bisolvon Calmatos with Food, Drinks, and Alcohol

Pentoxiverine can be taken with food or on an empty stomach.

This medicine may increase the effects of alcohol.

Pregnancy, Breastfeeding, and Fertility

Pentoxiverine should not be used during pregnancy or breastfeeding due to possible harmful effects on the baby (i.e., breathing difficulties, seizures, symptoms of central nervous system depression) (see section "Do not take Bisolvon Calmatos").

Driving and Using Machines

This medicine may occasionally cause fatigue, even if taken according to the prescription instructions. As fatigue can affect reaction ability, the ability to drive and use machines may be impaired.

Bisolvon Calmatos contains Benzoic Acid, Sorbitol, Propylene Glycol, Benzyl Alcohol, and Sodium.

This medicine contains 11.25 mg of benzoic acid in each 15 ml dose.

This medicine contains 4.5 g of sorbitol in each 15 ml dose.

Sorbitol is a source of fructose. If your doctor has told you (or your child) that you have an intolerance to certain sugars, or you have been diagnosed with hereditary fructose intolerance (HFI), a rare genetic disorder in which the patient cannot break down fructose, consult your doctor before taking this medicine.

Sorbitol may cause gastrointestinal upset and a mild laxative effect.

This medicine contains 1.5 g of propylene glycol in each 15 ml dose.

If you are pregnant or breastfeeding, do not take this medicine unless it is recommended by your doctor. Your doctor may perform additional checks while you are taking this medicine.

If you have liver or kidney failure, do not take this medicine unless it is recommended by your doctor. Your doctor may perform additional checks while you are taking this medicine.

This medicine contains 0.708 mg of benzyl alcohol in each 15 ml dose.

Benzyl alcohol may cause allergic reactions.

Consult your doctor or pharmacist if you are pregnant or breastfeeding. This is because large amounts of benzyl alcohol can accumulate in your body and cause side effects (metabolic acidosis).

Consult your doctor or pharmacist if you have liver or kidney disease. This is because large amounts of benzyl alcohol can accumulate in your body and cause side effects (metabolic acidosis).

This medicine contains less than 23 mg of sodium (1 mmol) per 15 ml dose; it is essentially "sodium-free".

3. How to take Bisolvon Calmatos

Follow exactly the administration instructions of the medicine contained in this leaflet or as indicated by your doctor or pharmacist. If in doubt, ask your doctor or pharmacist.

The recommended dose, based on the user's age and weight, is presented in the following table:

Age

Weight (kg)

Dose (ml)

Children from 6 to 15 years

20 - 26

5 ml 3-4 times a day

27 - 45

7.5 ml 3-4 times a day

46 - 60

15 ml 3-4 times a day

Adolescents from 15 years and Adults

> 60

15 ml 3-4 times a day

If the cough also causes sore throat, it is recommended to gargle with the solution before swallowing the dose.

If the irritating cough causes sleep problems, the last dose should be taken shortly before bedtime.

Use in Children and Adolescents

Read the recommended dose table.

Do not use for children under 6 years of age.

If you take more Bisolvon Calmatos than you should

In case of overdose or accidental ingestion, consult your doctor, pharmacist, or call the Toxicology Information Service, phone 91 562 04 20, indicating the medicine and the amount taken.

If you forget to take Bisolvon Calmatos

Do not take a double dose to make up for forgotten doses.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4. Possible Side Effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Allergic reactionsthat can be serious:

  • Very rare (may affect up to 1 in 10,000 people)
  • These include the following symptoms:

Difficulty breathing or dizziness (anaphylactic shock), hypersensitivity, localized skin swelling, urticaria, blistering rash, itching, skin rash.

  • If you have any of these symptoms, stop using the medicine and seek medical help immediately.

Other possible side effects:

Common (may affect up to 1 in 10 people): upper abdominal pain, diarrhea, dry mouth, nausea, vomiting

Uncommon (may affect up to 1 in 100 people): drowsiness, fatigue.

Very rare (may affect up to 1 in 10,000 people): decreased blood pressure, seizures (especially in small children), apnea, shortness of breath, respiratory depression (especially in small children), breathing difficulties, low white blood cell count.

Frequency not known: restlessness, hallucinations, confusion, blurred vision, temporary rash.

Reporting of Side Effects

If you experience any side effects, consult your doctor or pharmacist, even if they are not listed in this leaflet. You can also report them directly through the Spanish Medicines Monitoring System: www.notificaRAM.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Bisolvon Calmatos

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date stated on the label and carton after EXP. The expiry date is the last day of the month stated.

Do not use after 6 months of first opening.

This medicine does not require any special storage conditions.

Medicines should not be disposed of via wastewater or household waste. Dispose of the packaging and any unused medicine in the pharmacy's SIGRE collection point. If in doubt, ask your pharmacist how to dispose of the packaging and any unused medicine. This will help protect the environment.

6. Package Contents and Additional Information

Composition of Bisolvon Calmatos

  • The active substance is pentoxiverine citrate. Each ml of oral solution contains 2.13 mg of pentoxiverine citrate equivalent to 1.35 mg of pentoxiverine.
  • The other components are: benzoic acid, liquid sorbitol (non-crystallizing) (E420), glycerol, propylene glycol, citric acid monohydrate, sodium citrate, sodium saccharin, pear flavor (contains flavoring substances), juniper flavor (contains flavoring substances, benzyl alcohol [E1519] and alpha-tocopherol [E307]), purified water.

Appearance of the Product and Package Contents

Bisolvon Calmatos is a clear to almost clear, colorless to almost colorless liquid.

It is available in 95 ml and 190 ml amber glass bottles with a child-resistant screw cap.

The bottle is opened by pressing the cap down and turning it counterclockwise. The dosing cup is made of polypropylene and has graduation marks for 5, 7.5, and 15 ml.

Not all pack sizes may be marketed.

Marketing Authorization Holder and Manufacturer

Marketing Authorization Holder

Opella Healthcare Spain S.L.

C/ Rosselló i Porcel 21

08016 Barcelona (Spain)

Sanofi Group

Manufacturer

NextPharma SAS

17, route de Meulan

78520 Limay (France)

This medicine is authorized in the EEA member states under the following names:

Austria: Mucomat Reizhusten 2,13 mg/ml Lösung zum Einnehmen

Belgium: Pentoxyverine Sanofi 2.13 mg/ml drank

Bulgaria: ????????????? ?????? 2,13 mg/ml ????????? ???????

Denmark: Biseltoc

Spain: Bisolvon Calmatos 2,13 mg/ml Solución Oral

Finland: Biseltoc 2.13 mg/ml oraaliliuos

Greece: BISOLDRY 2,13 mg/ml π?σιμο δι?λυμα

Italy: Pentοssiverina Sanofi

Luxembourg: Pentoxyverine Sanofi 2.13 mg/ml Solution buvable

Norway: Biseltoc

Portugal: Pentoxiverina Bisoltussin

Romania: Citrat de pentoxiverina Sanofi 2,13 mg/ml solu?ie orala

Netherlands: Bisolsek pento 2,13 mg/ml drank

Sweden: Biseltoc

Date of the last revision of this leaflet:07/2021

Detailed information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) (http://www.aemps.gob.es/).

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Discuss dosage, side effects, interactions, contraindications, and prescription renewal for BISOLVON CALMATOS 2.13 mg/ml ORAL SOLUTION – subject to medical assessment and local rules.

5.0(2)
Doctor

Svetlana Kolomeeva

Cardiology18 years of experience

Dr. Svetlana Kolomeeva is a general practitioner and internal medicine doctor providing online consultations for adults. She helps patients manage acute symptoms, chronic conditions, and preventive care. Her clinical focus includes cardiovascular health, hypertension control, and managing symptoms like fatigue, weakness, sleep issues, and overall low energy.

Patients commonly seek her help for:

  • High blood pressure, headaches, dizziness, swelling, palpitations.
  • Diagnosis and management of hypertension, arrhythmias, and tachycardia.
  • Metabolic syndrome, excess weight, high cholesterol.
  • Chronic fatigue, insomnia, poor concentration, anxiety.
  • Respiratory symptoms: colds, flu, sore throat, cough, fever.
  • Digestive issues: heartburn, bloating, constipation, IBS symptoms.
  • Chronic conditions: diabetes, thyroid disorders.
  • Interpretation of lab tests and medical reports, therapy adjustment.
  • Second opinion and decision-making support.
  • Cardiovascular disease prevention and metabolic risk reduction.
  • Long-term follow-up and dynamic health monitoring.

Dr Kolomeeva combines clinical expertise with personalised care. She clearly explains diagnoses, guides patients through symptoms and treatment options, and provides actionable plans. Her consultations are designed not only to address current complaints but also to stabilise chronic conditions and prevent future complications. She supports patients through every stage of care – from first symptoms to ongoing health management.

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Mar Tabeshadze

Endocrinology11 years of experience

Dr. Mar Tabeshadze is a licensed endocrinologist and general practitioner in Spain. She provides online consultations for adults, offering medical support for a wide range of endocrine conditions and related health concerns.

  • Diagnostic consultations for suspected endocrine disorders
  • Management of thyroid conditions, including in pregnant women
  • Early detection and treatment of type 1 and type 2 diabetes, with personalised therapy plans
  • Obesity treatment: identifying underlying causes of weight gain, combining medication and non-pharmacological strategies, and long-term support
  • Diagnosis and treatment of endocrine-related skin, hair, and nail issues
  • Ongoing care for patients with osteoporosis, pituitary, and adrenal gland disorders
Dr. Tabeshadze takes a patient-centred approach based on evidence-based medicine. Her goal is to help patients achieve hormonal balance, manage chronic conditions effectively, and improve overall well-being through targeted, personalised care.
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Doctor

Anna Biriukova

General medicine6 years of experience

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

  • High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
  • Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
  • Leg swelling, chronic fatigue, reduced exercise tolerance.
  • EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
  • Post-COVID-19 cardiac monitoring and care.
Endocrinology – Diabetes, thyroid, metabolism:
  • Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
  • Individual treatment plans including oral medications and insulin therapy.
  • GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
  • Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
  • Metabolic syndrome – obesity, lipid disorders, insulin resistance.
Gastroenterology – Digestive health:
  • Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
  • Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
  • Respiratory infections – cough, colds, bronchitis.
  • Lab test analysis, therapy adjustments, medication management.
  • Adult vaccinations – planning, contraindications assessment.
  • Cancer prevention – screening strategies and risk assessment.
  • Holistic approach – symptom relief, complication prevention, and quality of life improvement.
Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
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Taisiya Minorskaya

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Dr Taisiya Minorskaya is a family medicine doctor with an official licence to practise in Spain and over 12 years of clinical experience. She provides online consultations for adults and children, combining evidence-based medicine with a personalised, modern European approach.

She helps with:

  • Viral infections and cold symptoms (flu, sore throat, cough, runny nose)
  • Review and adjustment of antibiotics
  • Skin rashes and allergic reactions
  • Chronic condition flare-ups, high blood pressure, headaches, fatigue
  • Lab and test interpretation
  • Medication review and adaptation to European standards
  • Patient navigation: what tests are needed, which specialists to see, when an in-person visit is required
Dr Minorskaya also specialises in the diagnosis and management of gastrointestinal conditions, including bloating, abdominal pain, chronic nausea, IBS, and SIBO. She supports patients with unexplained physical symptoms that may be linked to somatisation or stress, helping them find relief and improve quality of life.

She offers care for people undergoing GLP-1 therapy (Ozempic, Mounjaro, and others) for weight management. Her support follows Spanish clinical guidelines, from treatment planning and side effect counselling to regular follow-ups and coordination with private or public healthcare providers.

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Antonio Cayatte

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Dr Antonio Cayatte is a physician in General and Acute Medicine with over 30 years of experience across clinical care, medical research, and education. He offers online consultations for adults with a wide range of symptoms, both acute and chronic.

His clinical background includes:

  • assessment of sudden or unclear symptoms
  • ongoing care for chronic conditions
  • follow-up after hospital discharge
  • interpretation of test results
  • medical support while abroad
Dr Cayatte earned his degree from the University of Lisbon and taught internal medicine at Boston University School of Medicine. He holds active medical registrations in both Portugal and the UK and is a Fellow of the American Heart Association.

Consultations are available in English and Portuguese. Patients value his clarity, professionalism, and balanced approach to evidence-based care.

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Lina Travkina

Family medicine13 years of experience

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
  • Post-operative recovery support and pain management.
  • Preconception counselling and postpartum support.
  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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Alexander Nazarchuk

Allergology7 years of experience

Dr. Alexander Nazarchuk is a physician specialising in allergology and internal medicine. He provides online consultations for adults, following the principles of evidence-based medicine — no outdated treatments or unnecessary tests, with clear explanations and a personalised approach. He helps patients with a wide range of allergic and therapeutic conditions, from common day-to-day complaints to complex cases involving allergies, gastrointestinal issues, cardiovascular concerns, respiratory symptoms, and more.

You can consult Dr. Nazarchuk for:

  • Test interpretation and guidance on diagnostic plans.
  • Allergic rhinitis, hay fever, bronchial asthma (including severe cases).
  • Food and drug allergies, skin rashes, angioedema.
  • Atopic dermatitis, urticaria, contact allergies.
  • Allergen-specific immunotherapy (AIT) – initiation and ongoing management.
  • Abdominal pain, bloating, changes in bowel habits, nausea, heartburn.
  • High blood pressure and adjustment of baseline antihypertensive therapy.
  • Hyperlipidaemia and elevated cholesterol.
  • Cough, nasal congestion, fever, sore throat.
  • Anaemia, including iron deficiency and related conditions.
  • Other issues related to allergology and internal medicine.

During consultations, Dr. Nazarchuk takes a thorough, structured approach — analysing symptoms, identifying potential causes, and helping patients make informed decisions. Whether treatment, further investigation, or monitoring is needed, he explains each step clearly so you understand your health and how best to manage it.

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Alina Tsurkan

Family medicine13 years of experience

Dr. Alina Tsurkan is a licensed family medicine physician based in Portugal, offering online consultations for adults and children. She provides professional primary care, with a focus on prevention, accurate diagnosis, and long-term management of acute and chronic conditions.

Dr. Tsurkan supports patients with a wide range of health issues, including:

  • Respiratory infections: cold, flu, bronchitis, pneumonia, and lingering coughs.
  • ENT conditions: sinusitis, tonsillitis, otitis (ear infections), sore throat, allergic rhinitis.
  • Eye conditions: allergic or infectious conjunctivitis, red eyes, irritation.
  • Digestive issues: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), constipation, bloating, nausea.
  • Urinary and reproductive health: urinary tract infections (UTIs), cystitis, prevention of recurrent infections.
  • Chronic diseases: hypertension, elevated cholesterol, weight management.
  • Neurological complaints: headaches, migraines, sleep disturbances, fatigue, general weakness.
  • Children’s health: fever, infections, digestive issues, follow-ups, vaccination guidance.

She also provides:

  • IMT medical certificates for driving licence exchange in Portugal.
  • Personalised preventive care and wellness consultations.
  • Interpretation of test results and medical reports.
  • Follow-up care and medication review.
  • Support in managing multiple coexisting conditions.
  • Remote prescription management and medical documentation.

Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

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