APRETUDE 600 mg PROLONGED-RELEASE INJECTABLE SUSPENSION

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

Preventive consultations and check-up planning.
Medical advice and follow-up consultations.
Test interpretation and diagnostic guidance.
Structured support for undiagnosed complaints.
Second opinion on diagnoses and treatment plans.
Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
Post-operative recovery support and pain management.
Preconception counselling and postpartum support.
Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

General medicine2 years of experience

Muhammad Tayyab Altaf

Dr. Muhammad Tayyab Altaf is a primary care physician with extensive international experience, offering online consultations for adults and children. His background includes clinical practice in Italy, the United States and other healthcare settings, allowing him to manage a wide range of acute and chronic medical conditions with confidence and clarity. He trained at leading institutions such as IRCCS Policlinico San Matteo in Pavia, Mount Sinai Hospital in New York, Baptist Hospital in Texas and a private practice in Dallas, working across outpatient care, inpatient medicine, intensive care, hospice and nursing home management.

His clinical expertise spans multi-system conditions, preventive care and long-term management of chronic diseases. Dr. Altaf combines hands-on experience with a strong research background in both medical and surgical fields, enabling him to provide accurate assessments and structured, evidence-based treatment plans. Patients value his ability to explain diagnoses clearly, outline next steps and support them in making informed healthcare decisions.

Online consultations with Dr. Altaf are suitable for many everyday and acute situations where a timely medical opinion can help determine the safest next steps. He evaluates and treats conditions affecting the cardiovascular, respiratory, gastrointestinal, neurological, haematological and endocrine systems. Common examples include:

hypertension and other blood pressure issues
ischaemic heart disease and angina
asthma, COPD and emphysema
pneumonia and lung fibrosis
gastroenteritis and digestive infections
liver conditions, including alcohol-related disease
epilepsy, seizures and post-stroke symptoms
dementia and cognitive decline
anaemia and other haematological changes
diabetes, thyroid disorders and pituitary disease

Many patients reach out when they experience new or worsening symptoms, fluctuations in blood pressure, non-severe chest discomfort, breathing symptoms, digestive issues, suspected infections, chronic fatigue or concerns that affect daily life. He also helps patients understand test results, adjust existing treatment plans and navigate long-term health strategies safely and effectively.

When clinically appropriate, Dr. Altaf can also provide health and fitness certificates, including documentation required for physical activity, sports participation or gym use, based on the patient’s health status and medical indications.

Some conditions are not suitable for online care. Severe chest pain, loss of consciousness, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack require immediate attention from local emergency services. Dr. Altaf prioritises patient safety and will guide you accordingly if your situation needs urgent in-person care.

In all consultations, Dr. Muhammad Tayyab Altaf focuses on clear communication, accurate diagnosis and patient-centred decision-making. His approach ensures that individuals and families feel informed, supported and confident in their next steps, no matter where they are.

Lina Travkina

Areas of medical care include:

Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

Preventive consultations and check-up planning.
Medical advice and follow-up consultations.
Test interpretation and diagnostic guidance.
Structured support for undiagnosed complaints.
Second opinion on diagnoses and treatment plans.
Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
Post-operative recovery support and pain management.
Preconception counselling and postpartum support.
Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

General medicine2 years of experience

Muhammad Tayyab Altaf

hypertension and other blood pressure issues
ischaemic heart disease and angina
asthma, COPD and emphysema
pneumonia and lung fibrosis
gastroenteritis and digestive infections
liver conditions, including alcohol-related disease
epilepsy, seizures and post-stroke symptoms
dementia and cognitive decline
anaemia and other haematological changes
diabetes, thyroid disorders and pituitary disease

This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.

How to use APRETUDE 600 mg PROLONGED-RELEASE INJECTABLE SUSPENSION

Introduction

Package Leaflet: Information for the Patient

Apretude 600 mg prolonged-release injectable suspension

cabotegravir

This medicine is subject to additional monitoring, which will help to quickly identify new safety information. You can contribute by reporting any side effects you may have. The last part of section 4 will include information on how to report side effects.

Read all of this leaflet carefully before you start using this medicine, because it contains important information for you.

Keep this leaflet, you may need to read it again.
If you have any further questions, ask your doctor or nurse.
If you experience any side effects, talk to your doctor or nurse, even if they are not listed in this leaflet. See section 4.

Contents of the pack

What is Apretude and what is it used for
What you need to know before you are given Apretude
How Apretude is given
Possible side effects
Storage of Apretude
Contents of the pack and other information

1. What is Apretude and what is it used for

Apretude contains cabotegravir as the active substance. Cabotegravir belongs to a group of antiretroviral medicines called integrase inhibitors (INI).

Apretude is used to help prevent infection with HIV-1 in adults and adolescents who weigh at least 35 kg and are at high risk of infection. This is called pre-exposure prophylaxis: PrEP(see section 2).

It must be used in combination with safer sex practices, such as using condoms.

2. What you need to know before you are given Apretude

Do not use Apretude

if you have ever developed a severe skin rash, skin peeling, blisters, and/or sores in the mouth.
if you are allergic(hypersensitive) to cabotegravir or any of the other ingredients of this medicine (listed in section 6).
If you are HIV positiveor you do not know if you are HIV positive. Apretude can only help reduce the risk of getting HIV before you become infected. You must get testedto make sure you are HIV negative before taking Apretude.
if you are taking any of the following medicines:

carbamazepine, oxcarbazepine, phenytoin, phenobarbital(medicines to treat epilepsy and prevent seizures).
rifampicin or rifapentine(medicines to treat some bacterial infections, such as tuberculosis).

These medicines reduce the effectiveness of Apretude by decreasing the amount of Apretude in your blood.

If you think this applies to you, or if you are not sure, tell your doctor.

Warnings and precautions

Using Apretude on its own may not prevent HIV infection.

HIV infection is spread by sexual contact with someone who is HIV positive or by transfer of infected blood. Although Apretude reduces the risk of infection, you can still get HIV even if you are taking this medicine.

You must take other measures to reduce your risk of getting HIV:

Get testedfor other sexually transmitted diseases when your doctor tells you to. These infections make it easier for you to get HIV.
Use condomswhen you have oral or penetrative sex.
Do not share or reuse needles or other injection equipment or medical equipment.
Do not share personal items that may contain blood or body fluids (such as razors or toothbrushes).

Talk to your doctor about what other precautions you need to take to reduce your risk of getting HIV.

Reduce your risk of getting HIV:

There is a risk of developing resistance to this medicine if you get HIV. This means the medicine may not prevent you from getting HIV. To minimize this risk and prevent HIV infection, it is essential that you:

attend your scheduled appointmentsto receive your Apretude injection. Tell your doctor if you are thinking of stopping treatment, as this may increase your risk of getting HIV. If you stop getting your Apretude injection or delay it, you may need to take other medicines or precautions to reduce your risk of getting HIV and possibly develop viral resistance.
get tested for HIVwhen your doctor tells you to. You should get tested regularly to make sure you are still HIV-1 negative while taking Apretude.
tell your doctor immediatelyif you think you may have gotten HIV (you may have flu-like symptoms). You may need to get more tests to make sure you are still HIV negative.

Apretude injectable is a long-acting medicine

If you stop getting Apretude injections, cabotegravir may stay in your body for more than a year after your last injection, but this will not be enough to protect you from possible infection.

It is essential that you attend your scheduled appointments to receive your Apretude injections. Talk to your doctor if you are thinking of stopping PrEP.

Once you stop Apretude injectable, you may need to take other medicines to reduce your risk of getting HIV or use other precautions like safe sex.

Liver problems

Tell your doctor if you have liver problems. You may need to be monitored more closely. (See also ‘Uncommon side effects’ in section 4).

Adolescents

Your doctor will talk to you about your mental health before and while you are taking Apretude. Tell your doctor if you have mental health problems. You may need to be monitored more closely (See also section 4).

Severe skin reaction

Very rare cases of severe skin reactions, Stevens-Johnson syndrome, and toxic epidermal necrolysis have been reported with Apretude. If you notice any of the symptoms related to these severe skin reactions, do not receive your next Apretude injection and seek medical attention immediately.

Read the informationin section 4 of this leaflet (“Possible side effects”).

Allergic reactions

Apretude contains cabotegravir, which is an integrase inhibitor. Integrase inhibitors, including cabotegravir, can cause a severe allergic reaction known as a hypersensitivity reaction. You need to know what the important signs and symptoms are to look out for while taking Apretude.

Read the informationin ‘Possible side effects’ in section 4 of this leaflet.

Children and adolescents

This medicine must not be used in children and adolescents who weigh less than 35 kg, as it has not been studied in these users.

Other medicines and Apretude

Tell your doctor if you are taking, have recently taken, or might take any other medicines, including medicines bought without a prescription.

Some medicines may affect how Apretude works or increase your chance of side effects. Apretude may also affect how other medicines work.

Apretude must not be givenwith other medicines that may affect the effectiveness of the medicine (see ‘Do not use Apretude’ in section 2). These include:

carbamazepine, oxcarbazepine, phenytoin, phenobarbital(medicines to treat epilepsy and prevent seizures).
rifampicin or rifapentine(medicines to treat some bacterial infections, such as tuberculosis).

Tell your doctorif you are taking:

rifabutin(to treat some bacterial infections, such as tuberculosis). You may need to receive Apretude injections more frequently.

Tell your doctor or pharmacistif you are taking this medicine. Your doctor may decide that you need extra monitoring.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.

Pregnancy

Apretude is not recommended during pregnancy. The effect of Apretude on pregnancy is unknown. Talk to your doctor: if you can be pregnant, if you plan to have a baby, or if you become pregnant. Do not stop attending appointments to receive Apretude without talking to your doctor. Your doctor will consider the benefit to you and the risk to your baby before starting/continuing Apretude.

Breastfeeding

It is unknown if the components of Apretude can pass into breast milk. However, it is possible that cabotegravir may pass into breast milk during the 12 months following the last Apretude injection. If you are breastfeeding or think you may breastfeed, talk to your doctor. Your doctor will consider the benefit and risk of breastfeeding for you and your baby.

Driving and using machines

Apretude may cause dizziness and have other side effects that may make you less alert.

Do not drive or use machinesunless you are sure it won’t affect you.

3. How Apretude is given

This medicine is given as a 600 mg injection. A nurse or doctor will give you Apretude in the muscle of your buttock.

You must have an HIV test and be negativebefore receiving Apretude.

You will be given your first and second doses of Apretude one month apart. After the second dose, you will be given a single injection of Apretude every 2 months.

Before starting treatment with Apretude injectable, you and your doctor may decide to start with oral cabotegravir tablets (called an oral lead-in period) first. The oral lead-in period allows you and your doctor to see if it is suitable to switch to injections.

If you decide to start with the tablets:

You must take one 30 mg Apretude tablet once a day for about a month.

You must receive your first injection on the same day you take your last tablet or within 3 days after.

After that, you will receive an injection every 2 months.

Injection schedule for every 2 months

When	Which medicine
First and second injection, one month apart	Apretude 600 mg
Third injection onwards, every 2 months	Apretude 600 mg

If you are given too much Apretude injectable

This medicine will be given to you by a doctor or nurse, so it is unlikely that you will be given too much. If you are concerned, talk to your doctor or nurse and you will receive the necessary treatment.

If you miss an appointment to receive an Apretude injection

Contact your doctor immediatelyto schedule a new appointment.

It is essential that you attend your scheduled appointments to receive your injection and reduce your risk of getting HIV (see section 2). Talk to your doctor if you are thinking of stopping Apretude.

Talk to your doctor if you think you will not be able to receive your Apretude injection as scheduled. Your doctor may recommend that you take cabotegravir tablets instead until you can receive your Apretude injection again.

Do not stop receiving Apretude injections without your doctor’s advice.

Keep receiving Apretude injections for as long as your doctor recommends. Do not stop unless your doctor tells you to. If you stop treatment and you are still at risk of getting HIV, your doctor should start you on another medicine for PrEP during the 2 months after your last Apretude injection.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Do not receive your next Apretude injection and seek medical attention immediatelyif you notice any of the following symptoms:

red patches that are not raised, target-like or circular patches on the trunk, often with blisters in the center, skin peeling, sores in the mouth, throat, nose, genitals, and eyes. These severe skin reactions can be preceded by fever and flu-like symptoms (Stevens-Johnson syndrome, toxic epidermal necrolysis). These severe skin reactions are very rare (they may affect up to 1 in 10,000people).

Allergic reactions

Apretude contains cabotegravir, which is an integrase inhibitor. Integrase inhibitors, including cabotegravir, can cause a severe allergic reaction known as a hypersensitivity reaction.

If you experience any of the following symptoms:

skin reaction
high temperature (fever)
lack of energy (fatigue)
swelling, sometimes of the face or mouth (angioedema), which can cause difficulty breathing
muscle or joint pain.

See a doctor immediately.Your doctor may consider it necessary to do tests to check your liver, kidneys, or blood and may tell you to stop taking Apretude.

Very common side effects(may affect more than 1 in 10 people)

headache
diarrhea
injection site reactions

very common: pain (which can rarely include temporary difficulty walking) and discomfort, a lump or hardened area
common: redness (erythema), itching (pruritus), swelling, warmth, numbness (anesthesia), or bruising (which can include discoloration or blood accumulation under the skin)
uncommon: pus accumulation (abscess)

feeling hot (pyrexia)
changes in liver function (increased transaminases), measured in blood tests.

Common side effects(may affect up to 1 in 10 people)

depression
anxiety
abnormal dreams
difficulty sleeping (insomnia)
dizziness
feeling sick (nausea)
vomiting
stomach pain (abdominal pain)
gas (flatulence)
rash
muscle pain (myalgia)
lack of energy (fatigue)
general discomfort.

Uncommon side effects(may affect up to 1 in 100 people)

suicidal thoughts and attempts (especially in users with a history of depression or mental health problems)
allergic reaction (hypersensitivity)
hives (urticaria)
swelling, sometimes of the face or mouth (angioedema), which can cause difficulty breathing
feeling drowsy (somnolence)
weight gain
feeling dizzy during or after an injection (vasovagal reactions). This can lead to fainting
liver damage (hepatotoxicity). The signs may include yellowing of the skin and the whites of the eyes, loss of appetite, itching, stomach tenderness, pale stools, or unusually dark urine
increased bilirubin in the blood, a breakdown product of red blood cells, measured in blood tests.

Reporting of side effects

If you experience any side effects, talk to your doctor or nurse, even if they are not listed in this leaflet. You can also report side effects directly through the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Apretude

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the label and carton after EXP. The expiry date is the last day of the month shown.

The doctor or nurse is responsible for storing this medicine correctly.

Do not freeze.

6. Container Content and Additional Information

Apretude Composition

The active ingredient is cabotegravir

Each 3 ml vial contains 600 mg of cabotegravir.

The other components are:

Mannitol (E421)

Polysorbate 20 (E432)

Macrogol (E1521)

Water for injectable preparations

Product Appearance and Container Content

Cabotegravir is a white to light pink suspension, presented in a topaz-colored glass vial with a rubber stopper and an aluminum seal with a flip-off plastic cap.

Marketing Authorization Holder

ViiV Healthcare BV

Van Asch van Wijckstraat 55H,

3811 LP Amersfoort

Netherlands

Manufacturer

GlaxoSmithKline Manufacturing S.p.A.

Strada Provinciale Asolana 90

Torrile

43056

Italy

You can request more information about this medication by contacting the local representative of the marketing authorization holder:

Belgium/Belgique/Belgien

ViiV Healthcare srl/bv

Tel: + 32 (0) 10 85 65 00

Lithuania

ViiV Healthcare BV

Tel: + 370 80000334

Bulgaria

ViiV Healthcare BV

Tel: + 359 80018205

Luxembourg/Luxemburg

ViiV Healthcare srl/bv

Belgium/Belgien

Tel: + 32 (0) 10 85 65 00

Czech Republic

GlaxoSmithKline, s.r.o.

Tel: + 420 222 001 111

Hungary

ViiV Healthcare BV

Tel: + 36 80088309

Denmark

GlaxoSmithKline Pharma A/S

Tel: + 45 36 35 91 00

Malta

ViiV Healthcare BV

Tel: + 356 80065004

Germany

ViiV Healthcare GmbH

Tel: + 49 (0)89 203 0038-10

Netherlands

ViiV Healthcare BV

Tel: + 31 (0) 33 2081199

Estonia

ViiV Healthcare BV

Tel: + 372 8002640

Norway

GlaxoSmithKline AS

Tel: + 47 22 70 20 00

Greece

GlaxoSmithKline Μονοπρóσωπη A.E.B.E.

Tel: + 30 210 68 82 100

Austria

GlaxoSmithKline Pharma GmbH

Tel: + 43 (0)1 97075 0

Spain

Laboratorios ViiV Healthcare, S.L.

Tel: + 34 900 923 501

Poland

GSK Services Sp. z o.o.

Tel: + 48 (0)22 576 9000

France

ViiV Healthcare SAS

Tel: + 33 (0)1 39 17 69 69

Portugal

VIIVHIV HEALTHCARE, UNIPESSOAL, LDA

Tel: + 351 21 094 08 01

Croatia

ViiV Healthcare BV

Tel: + 385 800787089

Romania

ViiV Healthcare BV

Tel: + 40 800672524

Ireland

GlaxoSmithKline (Ireland) Limited

Tel: + 353 (0)1 4955000

Slovenia

ViiV Healthcare BV

Tel: + 386 80688869

Iceland

Vistor hf.

Tel: +354 535 7000

Slovak Republic

ViiV Healthcare BV

Tel: + 421 800500589

Italy

ViiV Healthcare S.r.l

Tel: + 39 (0)45 7741600

Finland

GlaxoSmithKline Oy

Tel: + 358 (0)10 30 30 30

Cyprus

ViiV Healthcare BV Tel: + 357 80070017

Sweden

GlaxoSmithKline AB

Tel: + 46 (0)8 638 93 00

Latvia

ViiV Healthcare BV

Tel: + 371 80205045

United Kingdom (Northern Ireland)

ViiV Healthcare BV

Tel: + 44 (0)800 221441

Date of Last Revision of this Leaflet:{MM/YYYY}.

Other Sources of Information

Detailed information on this medicinal product is available on the European Medicines Agency website: http://www.ema.europa.eu

This information is intended only for healthcare professionals:


Overview One injection is required per visit; 3 ml of cabotegravir (600 mg). Cabotegravir is a suspension that does not require additional dilution or reconstitution. Cabotegravir is for intramuscular use only. It should be administered in the gluteal area. Note:The ventrogluteal area is recommended.
Storage Information
Storage conditions are detailed on the packaging. Do notfreeze.
To Prepare the Injection
1 Luer-Lock syringe (5 ml) 1 Luer-Lock aspiration needle or an aspiration device (to withdraw the suspension)
To Administer the Injection
1 additional Luer-Lock needle (use the safety needle if available) 23 gauge; 1.5 inches. Consider the patient's constitution and medical judgment to choose the appropriate needle length.
You Will Also Need
Non-sterile gloves 2 alcohol-impregnated swabs 1 gauze A suitable container for disposing of sharp objects
Preparation
Inspect the vial
	Check the expiration date Do not useif the expiration date has passed Inspect the vial. If you notice any foreign matter, do not use the product. Note:The cabotegravir vial is made of topaz-colored glass.
Shake vigorously
	Hold the vial firmly and shake vigorously for 10 seconds as shown. Invert the vial and check the resuspension. It should appear uniform. If the suspension is not uniform, shake the vial again. It is normal to see small air bubbles. Remove the vial cap. Clean the rubber stopper with an alcohol-impregnated swab.
	Do notallow anything to touch the rubber stopper after cleaning.
Prepare the syringe and needle
	Continue preparing the injection according to local guidelines. Example: Attach the aspiration needle to the syringe. It is recommended to inject 1 ml of air into the vial to allow the required volume to be withdrawn.
Withdraw the dose slowly
	Invert the syringe and vial and slowly withdraw as much liquid as possible with the syringe. The amount of liquid may be greater than the dose.
	Note:Check that the suspension appears uniform and is white to light pink in color.
Attach the injection needle
	Open the needle wrapper halfway to expose the needle cone. Holding the syringe upright, firmly screw the syringe into the injection needle. Attach the injection needle. Completely remove the needle wrapper.
Injection
Prepare the injection site
	Injections should be administered in the gluteal area. Choose between the following areas for injection: Ventrogluteal (recommended) Dorsogluteal (upper outer quadrant)
	Note:For intramuscular use in the gluteal area only. Do notadminister intravenously.
Discard excess liquid
	Remove the injection needle cap. Hold the syringe with the needle pointing upwards. Press the plunger until the 3 ml dose to eliminate excess liquid and any air bubbles.
	Note:Clean the injection site with an alcohol-impregnated swab. Allow the skin to air dry before proceeding.
Stretch the skin
	Use the Z-track injection technique to minimize medication dripping at the injection site. Firmly stretch the skin covering the injection site, moving it approximately 2.5 cm (1 inch). Hold it in this position for the injection.
Inject the dose
	Insert the needle completely, or as necessary to reach the muscle. Keep the skin stretched – slowly press the plunger to the bottom. Make sure the syringe is empty. Remove the needle and immediately release the stretched skin.
Examine the injection site
	Apply pressure to the injection site using a gauze. If bleeding occurs, a small dressing can be used. Dispose of the used needle, syringe, and vial according to local health and safety regulations. Do notmassage the area.
Questions and Answers
If the container has been stored in the refrigerator, is it safe to rapidly bring the vial to room temperature? You should wait at least 15 minutes before administering the injection to allow the medication to reach room temperature. It is best to let the vial reach room temperature naturally. However, you can use the heat from your hands to speed up the warming time, but make sure the vial does not exceed 30°C. Do not use any other heating method. How long can the medication remain in the syringe? It is best to inject the medication (at room temperature) as soon as possible after withdrawal. However, the medication can remain in the syringe for up to 2 hours before injection. If the medication remains in the syringe for more than 2 hours, the filled syringe and needle must be discarded. Why is air injected into the vial? Injecting 1 ml of air into the vial facilitates the withdrawal of the dose with the syringe. Without the air, some of the liquid may return to the vial unintentionally, leaving less medication in the syringe than intended. Why is administration in the ventrogluteal area recommended? Administration in the ventrogluteal area is recommended because it is farther from major nerves and blood vessels. Administration in the dorsogluteal area, in the gluteus maximus muscle, is also acceptable if preferred by the healthcare professional. The injection should not be administered in any other area.

Country of registration
Spain
Active substance
cabotegravir
Prescription required
Yes
Manufacturer
Viiv Healthcare B.V.
This information is for reference only and does not constitute medical advice. Always consult a licensed doctor before taking any medication. Oladoctor is not responsible for medical decisions based on this content.
Alternatives to APRETUDE 600 mg PROLONGED-RELEASE INJECTABLE SUSPENSION
APRETUDE 30 mg FILM-COATED TABLETS
Dosage form: TABLET, 30 mg
Active substance: cabotegravir
Manufacturer: Viiv Healthcare B.V.
Prescription required
VOCABRIA 30 mg FILM-COATED TABLETS
Dosage form: TABLET, 30 mg
Active substance: cabotegravir
Manufacturer: Viiv Healthcare B.V.
Prescription required
VOCABRIA 600 mg PROLONGED-RELEASE INJECTABLE SUSPENSION
Dosage form: INJECTABLE, 600 mg
Active substance: cabotegravir
Manufacturer: Viiv Healthcare B.V.
Prescription required

Alternatives to APRETUDE 600 mg PROLONGED-RELEASE INJECTABLE SUSPENSION in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to APRETUDE 600 mg PROLONGED-RELEASE INJECTABLE SUSPENSION in Ucrania

APRETUD

Dosage form: tabletas, 30 mg

Active substance: Cabotegravir

Manufacturer: Glakso Operejsns UK Limited, so vede dial'nist' ak Glakso Vellkom Operejsns

Prescription required

APRETUD

Dosage form: suspensión, 200 mg/ml; 3 ml en un vial

Active substance: Cabotegravir

Manufacturer: Sterigeniks Bel'gia (Fl'orus) SA (Sotera Hels Kampani)

Prescription required

Online doctors for APRETUDE 600 mg PROLONGED-RELEASE INJECTABLE SUSPENSION

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for APRETUDE 600 mg PROLONGED-RELEASE INJECTABLE SUSPENSION – subject to medical assessment and local rules.

5.0(1)

Lina Travkina

Areas of medical care include:

Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

Preventive consultations and check-up planning.
Medical advice and follow-up consultations.
Test interpretation and diagnostic guidance.
Structured support for undiagnosed complaints.
Second opinion on diagnoses and treatment plans.
Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
Post-operative recovery support and pain management.
Preconception counselling and postpartum support.
Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

General medicine2 years of experience

Muhammad Tayyab Altaf

hypertension and other blood pressure issues
ischaemic heart disease and angina
asthma, COPD and emphysema
pneumonia and lung fibrosis
gastroenteritis and digestive infections
liver conditions, including alcohol-related disease
epilepsy, seizures and post-stroke symptoms
dementia and cognitive decline
anaemia and other haematological changes
diabetes, thyroid disorders and pituitary disease

General medicine6 years of experience

Andrei Popov

Dr. Andrei Popov is a licensed pain management specialist and general practitioner based in Spain. He provides expert online care for adults dealing with both chronic and acute pain, as well as a wide range of everyday health concerns.

He specialises in diagnosing and treating pain conditions that affect quality of life, including:

Chronic pain lasting more than 3 months.
Migraines and recurring headaches.
Neck, back, lower back, and joint pain.
Post-traumatic pain following injury or surgery.
Nerve-related pain, fibromyalgia, and neuralgia.

In addition to pain management, Dr. Popov helps patients with:

Respiratory infections (colds, bronchitis, pneumonia).
High blood pressure and metabolic conditions such as diabetes.
Preventive care and routine health check-ups.

Online consultations last up to 30 minutes and include a detailed symptom review, personalised treatment planning, and medical follow-up when needed.

Dr. Popov’s approach is rooted in evidence-based medicine, combined with individualised care tailored to each patient’s history, lifestyle, and clinical needs.

General surgery11 years of experience

Yevgen Yakovenko

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

12+ years of clinical experience in university hospitals in Germany and Spain.
International education: Ukraine – Germany – Spain.
Member of the German Society of Surgeons (BDC).
Certified in radiological diagnostics and robotic surgery.
Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

General medicine29 years of experience

Tetiana Fedoryshyn

Dr Tetiana Fedoryshyn is a senior general practitioner, certified nutritionist, and psychologist with over 29 years of clinical experience. She combines classical internal medicine with modern approaches in lifestyle medicine, functional nutrition, and emotional health support.

Her focus is on helping patients regain health through deep understanding of symptoms, personalised nutrition plans, and evidence-based correction of deficiencies, stress-related conditions, and metabolic imbalances. Dr Fedoryshyn works with adults experiencing chronic conditions, fatigue, hormonal disruption, and post-stress exhaustion.

She integrates medical analysis, psychological insight, and real-life behaviour change tools to offer treatment plans tailored to each patient’s biochemistry, mental state, and lifestyle.

Main areas of practice:

Chronic condition management and medical counselling
Weight loss programmes based on metabolic profiling
Diagnosis and treatment of micronutrient deficiencies
Recovery from stress, burnout, and hormonal imbalances
Emotional support and psychosomatic symptom care

Her approach is never one-size-fits-all – each consultation begins with a deep dive into your unique health history, test results, and emotional landscape. Consultations are available in Ukrainian, Polish, and Russian.

Taisiya Minorskaya

Dr Minorskaya also specialises in the diagnosis and management of gastrointestinal conditions, including bloating, abdominal pain, chronic nausea, IBS, and SIBO. She supports patients with unexplained physical symptoms that may be linked to somatisation or stress, helping them find relief and improve quality of life.

Dr Taisiya Minorskaya is a family medicine doctor with an official licence to practise in Spain and over 12 years of clinical experience. She provides online consultations for adults and children, combining evidence-based medicine with a personalised, modern European approach.

She helps with:

Viral infections and cold symptoms (flu, sore throat, cough, runny nose)
Review and adjustment of antibiotics
Skin rashes and allergic reactions
Chronic condition flare-ups, high blood pressure, headaches, fatigue
Lab and test interpretation
Medication review and adaptation to European standards
Patient navigation: what tests are needed, which specialists to see, when an in-person visit is required

She offers care for people undergoing GLP-1 therapy (Ozempic, Mounjaro, and others) for weight management. Her support follows Spanish clinical guidelines, from treatment planning and side effect counselling to regular follow-ups and coordination with private or public healthcare providers.

General medicine5 years of experience

Anna Biriukova

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
Leg swelling, chronic fatigue, reduced exercise tolerance.
EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
Post-COVID-19 cardiac monitoring and care.

Endocrinology – Diabetes, thyroid, metabolism:

Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
Individual treatment plans including oral medications and insulin therapy.
GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
Metabolic syndrome – obesity, lipid disorders, insulin resistance.

Gastroenterology – Digestive health:

Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).

General internal medicine and preventive care:

Respiratory infections – cough, colds, bronchitis.
Lab test analysis, therapy adjustments, medication management.
Adult vaccinations – planning, contraindications assessment.
Cancer prevention – screening strategies and risk assessment.
Holistic approach – symptom relief, complication prevention, and quality of life improvement.

Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.

Cardiology16 years of experience

Maryna Kuznetsova

Dr Marina Kuznetsova is an internal medicine doctor and cardiologist with a PhD in medicine. She provides online consultations for adults with chronic and acute conditions, with a strong focus on cardiovascular health. Her approach is based on current clinical guidelines and evidence-based treatment strategies.

Areas of expertise:

dyslipidaemia and lipid metabolism disorders
prevention and management of atherosclerosis
blood pressure monitoring and antihypertensive therapy
arrhythmias: diagnosis, follow-up, and treatment adjustment
cardiovascular care and recovery support after Covid-19

Dr Kuznetsova helps patients manage cardiovascular risk factors, optimise long-term treatment, and gain clarity in complex health situations – all through accessible and structured online care.

General medicine43 years of experience

Antonio Cayatte

Dr Antonio Cayatte is a physician in General and Acute Medicine with over 30 years of experience across clinical care, medical research, and education. He offers online consultations for adults with a wide range of symptoms, both acute and chronic.

His clinical background includes:

assessment of sudden or unclear symptoms
ongoing care for chronic conditions
follow-up after hospital discharge
interpretation of test results
medical support while abroad

Dr Cayatte earned his degree from the University of Lisbon and taught internal medicine at Boston University School of Medicine. He holds active medical registrations in both Portugal and the UK and is a Fellow of the American Heart Association.

Consultations are available in English and Portuguese. Patients value his clarity, professionalism, and balanced approach to evidence-based care.

Family medicine6 years of experience

Dmytro Horobets

Dr. Dmytro Horobets is a licensed family medicine physician in Poland, specialising in endocrinology, diabetology, obesity management, gastroenterology, pediatrics, general surgery, and pain medicine. He offers online consultations for adults and children, providing personalised medical support for a wide range of acute and chronic health concerns.

Areas of expertise:

Endocrinology: diabetes type 1 and type 2, prediabetes, thyroid disorders, metabolic syndrome, hormonal imbalance.
Obesity medicine: structured weight management plans, nutritional counselling, obesity-related health risks.
Gastroenterology: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), liver and biliary conditions.
Pediatric care: infections, respiratory symptoms, digestive issues, growth and development monitoring.
General surgery support: pre- and post-surgical consultations, wound care, rehabilitation.
Pain management: chronic and acute pain, back pain, joint pain, post-traumatic pain syndromes.
Cardiovascular health: hypertension, cholesterol control, risk assessment for heart disease.
Preventive medicine: regular check-ups, health screenings, long-term management of chronic conditions.

Dr. Horobets combines evidence-based medicine with a patient-centred approach. He carefully evaluates each patient’s medical history and symptoms, offering clear explanations and structured treatment plans adapted to individual needs.

Whether you need help managing diabetes, tackling weight-related health issues, interpreting lab results, or receiving general family medicine support, Dr. Horobets provides professional online care tailored to your specific health goals.