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APREPITANT ACCORD 125 mg HARD CAPSULES / APREPITANT ACCORD 80 mg HARD CAPSULES

APREPITANT ACCORD 125 mg HARD CAPSULES / APREPITANT ACCORD 80 mg HARD CAPSULES

Ask a doctor about a prescription for APREPITANT ACCORD 125 mg HARD CAPSULES / APREPITANT ACCORD 80 mg HARD CAPSULES

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Doctor

Nuno Tavares Lopes

Family medicine18 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management
  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses
  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment
  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance
  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis
  • Pain management: acute and chronic pain, post-surgical care
  • Public health: prevention, health screenings, long-term monitoring
  • Sick leave (Baixa médica) connected to Segurança Social in Portugal
  • IMT medical certificates for driving licence exchange
Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.

Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use APREPITANT ACCORD 125 mg HARD CAPSULES / APREPITANT ACCORD 80 mg HARD CAPSULES

Introduction

Package Leaflet: Information for the User

Aprepitant Accord 125 mg hard capsules/Aprepitant Accord 80 mg hard capsules EFG

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. If you are the parent of a child who is taking Aprepitant Accord, read this information carefully.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor, pharmacist, or nurse.
  • This medicine has been prescribed for you or your child only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you or your child get any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What is Aprepitant Accord and what is it used for
  2. What you need to know before you take or give Aprepitant Accord
  3. How to take Aprepitant Accord
  4. Possible side effects
  5. Storing Aprepitant Accord
  6. Contents of the pack and other information

1. What is Aprepitant Accord and what is it used for

Aprepitant Accord contains the active substance aprepitant and belongs to a group of medicines called "neurokinin 1 (NK1) receptor antagonists". The brain has a specific area that controls nausea and vomiting. Aprepitant Accord works by blocking the signals to this area, thereby reducing nausea and vomiting.

Aprepitant Accord capsules are used in adults and adolescents from 12 years of age, in combination with other medicines to prevent nausea and vomiting caused by chemotherapy (cancer treatment) that induces strong and moderate nausea and vomiting (such as cisplatin, cyclophosphamide, doxorubicin, or epirubicin).

2. What you need to know before you take or give Aprepitant Accord

Do not take Aprepitant Accord:

  • if you or your child are allergic to aprepitant or any of the other ingredients of this medicine (listed in section 6).
  • with medicines that contain:
    • pimozide (used to treat psychiatric disorders),
    • terfenadine and astemizole (used for allergic rhinitis and other allergic disorders),
    • cisapride (used to treat digestive problems).

Tell your doctor if you or your child are taking these medicines, as treatment needs to be changed before you or your child start taking Aprepitant Accord.

Warnings and precautions

Consult your doctor, pharmacist, or nurse before starting to take Aprepitant Accord or giving it to your child.

Before treatment with Aprepitant Accord, tell your doctor if you or your child have liver disease, as the liver is important for removing the medicine from the body. Therefore, your doctor may need to monitor your liver or your child's liver.

Children and adolescents

Do not give Aprepitant Accord 80 mg and 125 mg capsules to children under 12 years of age, as the 80 mg and 125 mg capsules have not been studied in this population.

Using Aprepitant Accord with other medicines

Aprepitant Accord may affect other medicines during and after treatment with Aprepitant Accord. There are some medicines that should not be taken with Aprepitant Accord (such as pimozide, terfenadine, astemizole, and cisapride) or that require a dose adjustment (see also 'Do not take Aprepitant Accord).

The effects of Aprepitant Accord or other medicines may be influenced if you or your child take Aprepitant Accord with other medicines, including those listed below. Consult your doctor or pharmacist if you or your child are taking any of the following medicines:

  • contraceptives that may include birth control pills, skin patches, implants, and certain intrauterine devices (IUDs) that release hormones; they may not work properly when taken with Aprepitant Accord. During treatment with Aprepitant Accord and up to 2 months after using Aprepitant Accord, non-hormonal methods or additional methods of contraception should be used,
  • cyclosporine, tacrolimus, sirolimus, everolimus (immunosuppressants),
  • alfentanil, fentanyl (used to treat pain),
  • quinidine (used to treat irregular heartbeats),
  • irinotecan, etoposide, vinorelbine, ifosfamide (medicines used to treat cancer),
  • medicines that contain ergot derivatives, such as ergotamine or dihydroergotamine (used to treat migraines),
  • warfarin, acenocoumarol (blood thinners; blood tests may be needed),
  • rifampicin, clarithromycin, telithromycin (antibiotics used to treat infections),
  • phenytoin (a medicine used to treat seizures),
  • carbamazepine (used to treat depression and epilepsy),
  • midazolam, triazolam, phenobarbital (medicines used to calm or help sleep),
  • St. John's Wort (a herbal preparation used to treat depression),
  • protease inhibitors (used to treat HIV infections),
  • ketoconazole, except shampoo (used to treat Cushing's syndrome - when the body produces too much cortisol),
  • itraconazole, voriconazole, posaconazole (antifungals),
  • nefazodone (used to treat depression),
  • corticosteroids (such as dexamethasone and methylprednisolone),
  • anxiety medicines (such as alprazolam),
  • tolbutamide (a medicine used to treat diabetes)

Tell your doctor or pharmacist if you or your child are taking, have recently taken, or might take any other medicines.

Pregnancy and breastfeeding

Do not use this medicine during pregnancy unless clearly necessary. If you or your child are pregnant or breastfeeding, or think you may be pregnant or are planning to have a baby, consult your doctor before using this medicine.

For information on birth control, see 'Using Aprepitant Accord with other medicines'.

It is not known if Aprepitant Accord passes into breast milk; therefore, breastfeeding should not be done during treatment with this medicine. It is important to tell your doctor before taking this medicine if you or your child are breastfeeding or plan to breastfeed.

Driving and using machines

It should be taken into account that some people have dizziness and drowsiness after taking Aprepitant Accord. If you or your child feel dizzy or drowsy, avoid driving, cycling, or using machines or tools after taking this medicine (see 'Possible side effects).

Aprepitant Accord contains sucrose

Aprepitant Accord capsules contain sucrose. If your doctor has told you or your child that you have an intolerance to some sugars, consult with them before taking this medicine.

Aprepitant Accord contains sodium

This medicine contains less than 1 mmol of sodium (23 mg) per capsule, i.e., essentially 'sodium-free'.

3. How to take Aprepitant Accord

Always take Aprepitant Accord exactly as your doctor, pharmacist, or nurse has told you or your child. If you are not sure, ask your doctor, pharmacist, or nurse.

Take Aprepitant Accord always with other medicines to prevent nausea and vomiting. After treatment with Aprepitant Accord, your doctor may ask you or your child to continue taking other medicines to prevent nausea and vomiting, including corticosteroids (such as dexamethasone) and a '5-HT3 antagonist' (such as ondansetron). If in doubt, ask your doctor, pharmacist, or nurse again.

The recommended oral doseof Aprepitant Accord is:

Day 1:

  • one 125 mg capsule 1 hour before starting the chemotherapy session

and

Days 2 and 3:

  • one 80 mg capsule each day.

If you are not receiving chemotherapy, take Aprepitant Accord in the morning.

If you are receiving chemotherapy, take Aprepitant Accord 1 hour before starting your chemotherapy session.

This medicine is taken by mouth. Swallow the capsule whole with some liquid.

Aprepitant Accord can be taken with or without food.

If you take more Aprepitant Accord than you should

Do not take more capsules than your doctor recommends. If you or your child have taken too many capsules, contact your doctor immediately.

If you forget to take Aprepitant Accord

If you or your child have missed a dose, ask your doctor for advice.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Stop taking Aprepitant Accord and contact your doctor immediately if you or your child notice any of the following side effects, which may be serious and require urgent medical attention:

  • Hives, rash, itching, difficulty breathing or swallowing (frequency not known, cannot be estimated from the available data): these are signs of an allergic reaction.

Other side effects that have been reported are listed below.

Common side effects (may affect up to 1 in 10 people) are:

  • constipation, indigestion,
  • headache,
  • fatigue,
  • loss of appetite,
  • hiccups,
  • increased amount of liver enzymes in the blood.

Uncommon side effects (may affect up to 1 in 100 people) are:

  • dizziness, drowsiness,
  • acne, rash,
  • anxiety,
  • belching, nausea, vomiting, heartburn, stomach pain, dry mouth, flatulence,
  • increased painful or burning urination,
  • weakness, general feeling of being unwell,
  • flushing/redness of the face or skin,
  • rapid or irregular heartbeat,
  • fever with a high risk of infection, decrease in red blood cells.

Rare side effects (may affect up to 1 in 1,000 people) are:

  • difficulty thinking, lack of energy, altered taste,
  • sensitivity of the skin to sunlight, excessive sweating, oily skin, skin ulcers, itchy rash, Stevens-Johnson syndrome/toxic epidermal necrolysis (a rare, severe skin reaction),
  • euphoria (feeling of extreme happiness), disorientation,
  • bacterial infection, fungal infection,
  • severe constipation, stomach ulcers, inflammation of the small intestine and colon, mouth ulcers, abdominal swelling,
  • frequent need to urinate, urinating more than usual, presence of sugar or blood in the urine,
  • chest discomfort, swelling, changes in gait,
  • cough, mucous in the back of the throat, throat irritation, sneezing, sore throat,
  • eye discharge and itching,
  • ringing in the ears,
  • muscle spasms, muscle weakness,
  • excessive thirst,
  • slow heartbeat, blood vessel problems,
  • low white blood cell count, low sodium levels in the blood, weight loss

Reporting of side effects

If you or your child experience any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Spanish Pharmacovigilance System for Human Use, www.notificaRAM.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storing Aprepitant Accord

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the carton after EXP. The expiry date refers to the last day of the month shown.

Store in the original package to protect from moisture.

Do not remove the capsule from its blister until the moment of taking it.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help protect the environment.

6. Contents of the pack and other information

Composition of Aprepitant Accord

  • The active substance is aprepitant.

Each 125 mg capsule contains 125 mg of aprepitant.

Each 80 mg capsule contains 80 mg of aprepitant.

  • The other ingredients are: hypromellose, poloxamer, sucrose, microcrystalline cellulose (E-460), gelatin, sodium lauryl sulfate (E-487), titanium dioxide (E-171), lacquer, iron oxide black (E-172), propylene glycol (E-1520). The 125 mg capsule also contains iron oxide red (E-172)

Appearance and packaging

The 125 mg hard capsule is a hard, opaque gelatin capsule with a pink cap and white body, and "125 mg" printed on the body.

The 80 mg hard capsule is a hard, opaque gelatin capsule with a white cap and white body, and "80 mg" printed on the body.

Aprepitant Accord is presented in a cardboard box with an OPA/ALU/PVC-aluminum blister.

Aprepitant Accord 125 mg hard capsules/Aprepitant Accord 80 mg hard capsules are available in the following pack size:

  • Pack for 3-day treatment containing one 125 mg capsule and two 80 mg capsules.

Not all pack sizes may be marketed.

Marketing authorisation holder

Accord Healthcare

World Trade Center

c/ Moll de Barcelona, s/n

Ed. Est, 6ª planta

08039 Barcelona

Spain

Manufacturer

Pharmathen International S.A.

Sapes Industrial Park Block 5

Rodopi, 69300

Greece

or

Pharmathen S.A.

6, Dervenakion Str

Pallini, Attiki, 15351

Greece

This medicine is authorised in the Member States of the European Economic Area under the following names:

Austria:Aprepitant Accord 125mg plus 80mg, Hartkapseln

France:Aprepitant Accord

Ireland:Aprepitant Accord

Italy:Aprepitant Accord

Netherlands:Aprepitant Accord 125 mg harde capsules plus 80 mg harde capsules

Poland:Aprepitant Accord

United Kingdom:Aprepitant Accord

Czech Republic:Aprepitant Accord

Date of last revision of this leaflet:December 2018

Alternatives to APREPITANT ACCORD 125 mg HARD CAPSULES / APREPITANT ACCORD 80 mg HARD CAPSULES in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to APREPITANT ACCORD 125 mg HARD CAPSULES / APREPITANT ACCORD 80 mg HARD CAPSULES in Poland

Dosage form: Capsules, 125 mg/80 mg
Active substance: aprepitant
Prescription required
Dosage form: Capsules, 125 mg; 80 mg
Active substance: aprepitant
Dosage form: Capsules, 125 mg; 80 mg
Active substance: aprepitant
Importer: Merckle GmbH Rontis Hellas Medical And Pharmaceutical Products S.A. Teva Operations Poland Sp. z o.o.
Prescription required
Dosage form: Capsules, 80 mg; 125 mg
Active substance: aprepitant
Importer: Lek Pharmaceuticals d.d. Rontis Hellas Medical And Pharmaceutical Products S.A.
Prescription required
Dosage form: Capsules, 80 mg/125 mg
Active substance: aprepitant
Manufacturer: Ethypharm Ethypharm
Prescription required
Dosage form: Tablets, 50 mg + 50 mg
Prescription not required

Alternative to APREPITANT ACCORD 125 mg HARD CAPSULES / APREPITANT ACCORD 80 mg HARD CAPSULES in Ukraine

Dosage form: capsules, 125 mg + 80 mg capsules
Active substance: aprepitant
Dosage form: capsules, 125 mg and 80 mg
Active substance: aprepitant
Prescription required
Dosage form: capsules, 80mg
Active substance: aprepitant
Prescription required
Dosage form: capsules, 125 mg
Active substance: aprepitant
Prescription required
Dosage form: capsules, 125mg + 80mg capsules
Active substance: aprepitant
Prescription required
Dosage form: lyophilizate, 150 mg in a vial
Active substance: aprepitant
Manufacturer: Aspiro Farma Limited
Prescription required

Online doctors for APREPITANT ACCORD 125 mg HARD CAPSULES / APREPITANT ACCORD 80 mg HARD CAPSULES

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for APREPITANT ACCORD 125 mg HARD CAPSULES / APREPITANT ACCORD 80 mg HARD CAPSULES – subject to medical assessment and local rules.

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Family medicine18 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management
  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses
  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment
  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance
  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis
  • Pain management: acute and chronic pain, post-surgical care
  • Public health: prevention, health screenings, long-term monitoring
  • Sick leave (Baixa médica) connected to Segurança Social in Portugal
  • IMT medical certificates for driving licence exchange
Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.

Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

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Dr. Meneses graduated from the University of Beira Interior and has years of experience working with diverse patient populations. He is fluent in Portuguese, English, Spanish, and French.

His approach is friendly, clear, and focused on delivering practical medical advice tailored to each patient’s needs.

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She has conducted research on the genetic background of stroke and is skilled in communicating with patients from diverse cultural backgrounds. Her approach combines clinical expertise with empathy and clear communication.
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  • viral illnesses such as colds and seasonal infections
  • gastrointestinal complaints (nausea, diarrhoea, abdominal pain, gastroenteritis)
  • sudden changes in how a child or adult feels
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Dr. Shalko works specifically with urgent and short-term problems, providing practical recommendations and helping patients determine the safest next step. She explains symptoms clearly, guides patients through decision-making and offers straightforward medical advice for everyday acute issues.

She does not provide long-term management of chronic conditions, ongoing follow-up or comprehensive care plans for complex long-term illnesses. Her consultations are designed for acute symptoms, sudden concerns and situations where timely medical input is important.

With clinical experience in both paediatrics and general medicine, Dr. Shalko confidently supports adults and children. Her communication style is clear, simple and reassuring, helping patients feel informed and supported throughout the consultation.

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In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions.

Patients commonly seek his care for:

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Main areas of consultation:

  • Diagnosis and treatment of acute and chronic conditions (high blood pressure, diabetes, respiratory infections, cardiovascular symptoms)
  • Evaluation of symptoms and guidance on further diagnostic testing
  • Preventive check-ups and regular health monitoring
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  • Treatment adjustments and lifestyle recommendations based on your personal history
Dr. Agami provides medical support for patients using GLP-1 medications (such as Ozempic or Mounjaro) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Portugal and Israel.

Dr. Agami is committed to evidence-based, patient-centred care, ensuring that each person receives trusted medical support tailored to their health goals.

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Dr. Dmytro Horobets is a licensed family medicine physician in Poland, specialising in endocrinology, diabetology, obesity management, gastroenterology, pediatrics, general surgery, and pain medicine. He offers online consultations for adults and children, providing personalised medical support for a wide range of acute and chronic health concerns.

Areas of expertise:

  • Endocrinology: diabetes type 1 and type 2, prediabetes, thyroid disorders, metabolic syndrome, hormonal imbalance.
  • Obesity medicine: structured weight management plans, nutritional counselling, obesity-related health risks.
  • Gastroenterology: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), liver and biliary conditions.
  • Pediatric care: infections, respiratory symptoms, digestive issues, growth and development monitoring.
  • General surgery support: pre- and post-surgical consultations, wound care, rehabilitation.
  • Pain management: chronic and acute pain, back pain, joint pain, post-traumatic pain syndromes.
  • Cardiovascular health: hypertension, cholesterol control, risk assessment for heart disease.
  • Preventive medicine: regular check-ups, health screenings, long-term management of chronic conditions.

Dr. Horobets combines evidence-based medicine with a patient-centred approach. He carefully evaluates each patient’s medical history and symptoms, offering clear explanations and structured treatment plans adapted to individual needs.

Whether you need help managing diabetes, tackling weight-related health issues, interpreting lab results, or receiving general family medicine support, Dr. Horobets provides professional online care tailored to your specific health goals.

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5.0(32)
Doctor

Sergio Correa

General medicine8 years of experience

Dr. Sergio Correa is a licensed general practitioner, aesthetic medicine specialist, and trichologist with experience in emergency care and preventive health. He offers online consultations in English and Spanish, supporting adult patients with a wide range of medical concerns – from acute symptoms to chronic condition management.

His areas of focus include:

  • General and urgent care: fever, fatigue, infections, digestive issues, respiratory symptoms, and other common concerns
  • Chronic condition support: hypertension, high cholesterol, diabetes, thyroid issues
  • Aesthetic medicine and dermatology: acne, skin ageing, hyperpigmentation, personalised skincare guidance
  • Trichology: hair loss, scalp conditions, treatment strategies for men and women
  • Preventive care: health check-ups, lifestyle advice, second opinions

Dr. Correa combines medical knowledge with an aesthetic and holistic approach to help patients improve both health and quality of life.

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€35
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