Background pattern

Anaclosil 500 mg capsulas

About the medicine

About the medication

Introduction

Package Leaflet: Information for the User

Anaclosil 500 mg Hard Capsules

Cloxacillin (as sodium salt)

Read this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, as you may need to read it again.
  • If you have any questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others even if they have similar symptoms to you, as it may harm them.
  • If you experience any side effects, talk to your doctor or pharmacist, even if they are not listed in this leaflet. See section 4.

1. What is Anaclosil 500 mg Hard Capsules and what it is used for

2. Before taking Anaclosil 500 mg Hard Capsules

3. How to take Anaclosil 500 mg Hard Capsules

4. Possible side effects

5. Storage of Anaclosil 500 mg Hard Capsules

6. Contents of the pack and additional information

1. What is Anaclosil 500 mg hard capsules and what is it used for

This medicine contains cloxacillin, which is an antibiotic belonging to the family of penicillins.

Antibiotics are used to treat bacterial infections and do not work for viral infections such as the flu or a cold.

It is essential that you follow the instructions regarding the dose, administration interval, and treatment duration indicated by your doctor.

Do not store or reuse this medication. If you have leftover antibiotics after treatment, return them to the pharmacy for proper disposal. Do not dispose of medications through the drain or in the trash.

It is indicated for adults and children to treat uncomplicated skin and soft tissue infections, such as impetigo.

2. Before taking Anaclosil 500 mg hard capsules

Do not take Anaclosil 500mg hard capsules

- If you are allergic (hypersensitive) to the active ingredient or to any of the other components of Anaclosil 500mg hard capsules.

- If you are allergic (hypersensitive) to penicillins.

If you are allergic (hypersensitive) to cephalosporins. Although an allergy to cephalosporins does not imply the existence of an allergy to this penicillin, it should be determined whether the patient has previously experienced immediate, moderate, or severe allergic reactions to a cephalosporin, in which case it would be advisable to avoid the use of this penicillin.

Warnings and precautions

Consult your doctor or pharmacist before starting to take this medication if:

- You are allergic to penicillins or cephalosporins. In hypersensitive patients to cephalosporins, the possibility of cross-allergic reactions should be taken into account.

- During treatment, you suffer from pseudomembranous colitis (persistent and/or severe diarrhea during or after the administration of cloxacillin). In the event of these symptoms appearing, treatment should be interrupted.

- During a previous antibiotic treatment (even with another family of antibiotics), you have had some type of allergic reaction such as urticaria or other rashes, itching, sudden swelling of the face and neck.

- You have kidney or liver disease.

- You have a history of seizures and/or epilepsy, especially in patients with renal or hepatic impairment.

- If you are taking oral contraceptives, it is recommended to use an alternative, effective, and safe method during treatment and for one week after, as the concomitant use of Cloxacillin and combined oral contraceptives may reduce the effectiveness of the contraceptive.

This medication may interfere with diagnostic tests: If you are to undergo any diagnostic test (including blood, urine, etc... tests) inform your doctor that you are taking this medication, as it may alter the test results.

Children and adolescents

This medication should be administered with caution in neonates, due to the risk of hyperbilirubinemia by competition at the binding sites of bilirubin to serum proteins. See section 3 for the dose in this population.

Administration of ANACLOSIL 500 mg hard capsules with food and beverages

It is advisable to take the capsules outside of the digestive phases.

Other medications and Anaclosil 500mg hard capsules

Inform your doctor or pharmacist if you are taking, have taken recently, or may need to take any other medication, including those purchased without a prescription. It is especially important to inform your doctor if you are taking:

• Methotrexate, which is a medication used for some forms of arthritis and for the treatment of psoriasis.

• Other antibiotics (medications used for infections caused by bacteria), such as chloramphenicol, tetracyclines, macrolides, or sulfonamides. These antibiotics may reduce the effect of Anaclosil.

• Aminoglycosides, as the treatment should be administered separately from Anaclosil.

• Probenecid, which is a medication for the treatment of gout, as it may increase the effect of Anaclosil.

• Warfarin or other anticoagulant medications.

Pregnancy, breastfeeding, and fertility

If you are pregnant or breastfeeding, or think you may be pregnant, consult your doctor before using this medication.

This medication passes into breast milk. Consult your doctor before breastfeeding your baby. The treatment should be interrupted in case of diarrhea, candidiasis, or skin rashes in the baby.

Driving and operating machinery

There is no evidence of effects on the ability to drive or operate machinery.

ANACLOSIL 500 mg hard capsules contain sodium

Consult your doctor if you are taking a low-sodium diet, as this medication contains 26.4 mg (equivalent to 1.15 mmol) of sodium per capsule.

3. How to Take Anaclosil 500 mg Hard Capsules

Follow exactly the administration instructions for this medication as indicated by your doctor. Consult your doctor or pharmacist if you have any doubts.

The dose depends on body weight, as well as the functioning of the kidneys and liver.

Adults

The usual recommended dose in adults with normal kidney function is 500 mg every 4-6 hours, depending on the severity and location of the infection.

The treatment duration should not exceed 14 days.

The dose may be adjusted in case of severe kidney and liver function problems. The usual recommended dose in children with normal kidney function ranges from 50 to 100 mg/kg/day in divided doses.

It should be administered preferably on an empty stomach (1 hour before or 2 hours after meals).

As with antibiotic therapy in general, the administration of cloxacillin will continue for 48 to 72 hours after the disappearance of fever, or after obtaining evidence of eradication of bacteria.

Children and adolescents:

-Normal renal function

In children, the recommended doses range from 50 to 100 mg/kg/day, in divided doses.

-Altered renal function

The dosage in children with renal and/or hepatic insufficiency has not been sufficiently studied.

If you take more Anaclosil 500mg capsules than you should

If you (or someone) ingest many capsules at once or if you think a child has swallowed some capsules, contact your doctor or pharmacist immediately.

In case of overdose or accidental ingestion, consult your doctor or pharmacist or call the Toxicological Information Service, phone 91 562 04 20 indicating the medication and the amount ingested.

If you forgot to take Anaclosil 500 mg capsules

Do not take a double dose to make up for the missed doses of Anaclosil 500mg capsules.

If you have any other questions about the use of this product, ask your doctor or pharmacist.

4. Possible Adverse Effects

Like all medications, Anaclosil may produce adverse effects, although not everyone will experience them.

Very rare frequency (may affect up to 1 in 10,000 people): Severe skin redness, Stevens-Johnson syndrome, toxic epidermal necrolysis

Unknown frequency (frequency cannot be estimated from the available data).

Oral administration of this medication (cloxacillin) may produce gastrointestinal disturbances (diarrhea, nausea, and vomiting), generally mild and resolving upon discontinuation of the medication.

In subjects sensitized to penicillins, allergic reactions such as facial swelling, lips, mouth, tongue, or throat may occur, causing difficulty swallowing or breathing (angioedema).

Other adverse effects may include:

-Skin allergic reactions (pruritus, cutaneous rash, urticaria).

-Decreased neutrophil and platelet counts in the blood.

-Neurological symptoms: seizures (this effect is more frequent in individuals with significant renal dysfunction).

-Jaundice (yellow discoloration of the skin), elevated liver enzyme values, and hepatitis (inflammation of the liver).

Reporting Adverse Effects

If you experience any type of adverse effect, consult your doctor or pharmacist, even if it is a possible adverse effect not listed in this prospectus. You can also report them directly through the Spanish System for Pharmacovigilance of Medicinal Products for Human Use https://www.notificaram.es. By reporting adverse effects, you can contribute to providing more information on the safety of this medication.

5. Conservation of Anaclosil 500 mg Hard Capsules

Store below 25°C. Store in the original packaging.

Keep this medication out of the sight and reach of children.

Do not use this medication after the expiration date that appears on the packaging, after CAD. The expiration date is the last day of the month indicated.

Medications should not be disposed of through drains or in the trash. Dispose of packaging and medications you no longer need at the SIGRE collection point at the pharmacy. If in doubt, ask your pharmacist how to dispose of packaging and medications you no longer need. By doing so, you will help protect the environment.

6. Content of the packaging and additional information

Composition of Anaclosil 500 mg hard capsules

The active ingredient is cloxacillin (as sodium salt). Each capsule contains 500mg of cloxacillin (as sodium salt).

The other components are magnesium stearate, colloidal silica, and sodium carboxymethylcellulose (type A) (derived from potato starch).

Appearance of the product and content of the packaging

Box containing 20, 40, or 500 hard gelatin capsules, with colored body and cap, with the name Anaclosil 500mg printed.

Holder of the marketing authorization and responsible for manufacturing

Holder of the marketing authorization

Reig Jofré, S.A. Laboratory

Gran Capitán, 10

08970 Sant Joan Despí (Barcelona)

Responsible for manufacturing

Reig Jofré, S.A. Laboratory

Jarama, 111 – 45007

Toledo (Spain)

Last review date of this leaflet: May 2020

The detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Medical Devices (AEMPS) http://www.aemps.es/

Country of registration
Active substance
Prescription required
Yes
Composition
Carboximetilalmidon sodico (22,66 mg mg)
This information is for reference only and does not constitute medical advice. Always consult a licensed doctor before taking any medication. Oladoctor is not responsible for medical decisions based on this content.

Talk to a doctor online

Have questions about this medication or your symptoms? Connect with a licensed doctor for guidance and personalized care.

5.01 review
Doctor

Anna Moret

Dermatology18 years of experience

Dr. Anna Moret is a board-certified dermatologist and dermatovenereologist. She specialises in adult and pediatric dermatology, venereology, aesthetic skin care, and general medicine. Her consultations are evidence-based and tailored to each patient’s dermatological needs.

Dr. Moret provides expert evaluation and treatment for: • Skin conditions such as eczema, acne, rosacea, dermatitis, and psoriasis • Hair and scalp issues including hair loss, dandruff, and seborrheic dermatitis • Pediatric skin problems — from newborns to adolescents • Sexually transmitted infections (STIs) and dermatovenereology • Aesthetic concerns: skin ageing, non-invasive cosmetic treatments • Skin allergies and hypersensitivity reactions • Mole checks, lesion evaluation, and skin cancer screening • Skincare advice and personalised cosmeceutical routines

Combining dermatology with general medical knowledge, Dr. Moret offers comprehensive care that addresses both skin health and underlying conditions. She also holds certification from the Canadian Board of Aesthetic Medicine, ensuring an internationally aligned approach to aesthetic dermatology.

CameraBook a video appointment
5.05 reviews
Doctor

Alina Tsurkan

Family medicine12 years of experience

Dr. Alina Tsurkan is a licensed family medicine physician based in Portugal, offering online consultations for adults and children. She provides professional primary care, with a focus on prevention, accurate diagnosis, and long-term management of acute and chronic conditions.

Dr. Tsurkan supports patients with a wide range of health issues, including: • Respiratory infections: cold, flu, bronchitis, pneumonia, and lingering coughs • ENT conditions: sinusitis, tonsillitis, otitis (ear infections), sore throat, allergic rhinitis • Eye conditions: allergic or infectious conjunctivitis, red eyes, irritation • Digestive issues: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), constipation, bloating, nausea • Urinary and reproductive health: urinary tract infections (UTIs), cystitis, prevention of recurrent infections • Chronic diseases: hypertension, diabetes, thyroid disorders, elevated cholesterol, weight management • Neurological complaints: headaches, migraines, sleep disturbances, fatigue, general weakness • Women’s health: menstrual irregularities, perimenopausal symptoms, preventive screening • Children’s health: fever, infections, digestive issues, follow-ups, vaccination guidance

She also provides: • IMT medical certificates for driving licence exchange in Portugal • Personalised preventive care and wellness consultations • Interpretation of test results and medical reports • Follow-up care and medication review • Support in managing multiple coexisting conditions • Remote prescription management and medical documentation

Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

CameraBook a video appointment
5.04 reviews
Doctor

Andrei Popov

General medicine6 years of experience

Dr. Andrei Popov is a licensed pain management specialist and general practitioner based in Spain. He provides expert online care for adults dealing with both chronic and acute pain, as well as a wide range of everyday health concerns.

He specialises in diagnosing and treating pain conditions that affect quality of life, including: • Chronic pain lasting more than 3 months • Migraines and recurring headaches • Neck, back, lower back, and joint pain • Post-traumatic pain following injury or surgery • Nerve-related pain, fibromyalgia, and neuralgia In addition to pain management, Dr. Popov helps patients with: • Respiratory infections (colds, bronchitis, pneumonia) • High blood pressure and metabolic conditions such as diabetes • Preventive care and routine health check-ups

Online consultations last up to 30 minutes and include a detailed symptom review, personalised treatment planning, and medical follow-up when needed.

Dr. Popov’s approach is rooted in evidence-based medicine, combined with individualised care tailored to each patient’s history, lifestyle, and clinical needs.

CameraBook a video appointment
5.03 reviews
Doctor

Yevgen Yakovenko

General surgery11 years of experience

Dr. Yevhenii Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise: • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan. • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions. • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies. • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries. • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required. • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up. • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data. • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications: • 12+ years of clinical experience in university hospitals in Germany and Spain • International education: Ukraine – Germany – Spain • Member of the German Society of Surgeons (BDC) • Certified in radiological diagnostics and robotic surgery • Active participant in international medical conferences and research

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

CameraBook a video appointment
See all doctors

Stay informed and save on care

Get health tips, platform updates, and exclusive promos for subscribers.

Follow us on social media
FacebookInstagramTikTok