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ANACLOSIL 500 mg CAPSULES

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About the medicine

How to use ANACLOSIL 500 mg CAPSULES

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

Anaclosil 500 mg Hard Capsules

Cloxacillin (as sodium salt)

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the Package Leaflet

  1. What Anaclosil 500 mg Hard Capsules are and what they are used for
  2. Before you take Anaclosil 500 mg Hard Capsules
  3. How to take Anaclosil 500 mg Hard Capsules
  4. Possible side effects
  5. Storage of Anaclosil 500 mg Hard Capsules
  6. Contents of the pack and further information

1. What Anaclosil 500 mg Hard Capsules are and what they are used for

This medicine contains cloxacillin, which is an antibiotic belonging to the penicillin family.

Antibiotics are used to treat bacterial infections and are not effective against viral infections such as flu or common cold.

It is important that you follow the instructions regarding dosage, administration interval, and treatment duration as indicated by your doctor.

Do not store or reuse this medicine. If you have any leftover antibiotic after completing the treatment, return it to the pharmacy for proper disposal. Do not throw away medicines via wastewater or household waste.

It is indicated in adults and children to treat uncomplicated skin and soft tissue infections, such as impetigo.

Doctor consultation

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2. Before you take Anaclosil 500 mg Hard Capsules

Do not take Anaclosil 500mg Hard Capsules

  • If you are allergic (hypersensitive) to the active substance or any of the other ingredients of Anaclosil 500mg Hard Capsules.
  • If you are allergic (hypersensitive) to penicillins.

If you are allergic (hypersensitive) to cephalosporins. Although allergy to cephalosporins does not necessarily imply an allergy to this penicillin, it should be determined whether the patient has previously experienced immediate, moderate, or severe allergic reactions to a cephalosporin, in which case it would be advisable to avoid the use of this penicillin.

Warnings and Precautions

Consult your doctor or pharmacist before starting to take this medicine if:

-you are allergic to penicillins or cephalosporins. In patients hypersensitive to cephalosporins, the possibility of cross-allergic reactions should be taken into account.

-during treatment, you suffer from pseudomembranous colitis (persistent and/or severe diarrhea during or after the administration of cloxacillin). In the event of these symptoms, treatment should be discontinued.

-during a previous antibiotic treatment (even with another family of antibiotics), you have had any type of allergic reaction such as urticaria or other rashes, itching, sudden swelling of the face and neck.

-you have kidney or liver disease.

-you have a history of seizures and/or epilepsy, especially in patients with renal or hepatic impairment.

-if you are taking oral contraceptives, it is recommended to use an alternative, effective, and safe method during treatment and until one week after, as the concomitant use of Cloxacillin and combined oral contraceptives may decrease the effectiveness of the contraceptive.

This medicine may interfere with laboratory tests: If you are going to undergo any diagnostic test (including blood tests, urine tests, etc.), inform your doctor that you are taking this medicine, as it may alter the test results.

Children and Adolescents

This medicine should be administered with caution in neonates, due to the risk of hyperbilirubinemia due to competition at the bilirubin binding sites to serum proteins. See section 3 for the dose in this population.

Taking ANACLOSIL 500 mg Hard Capsules with Food and Drinks

It is recommended that the intake of the capsules be done outside of the digestive phases.

Other Medicines and Anaclosil 500mg Hard Capsules

Inform your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including those obtained without a prescription. It is especially important that you inform your doctor if you are taking:

  • Methotrexate, which is a medicine indicated for some forms of arthritis and for the treatment of psoriasis.
  • Other antibiotics (medicines used for infections caused by bacteria), such as chloramphenicol, tetracyclines, macrolides, or sulfonamides. These antibiotics may decrease the effect of Anaclosil.
  • Aminoglycosides, as the treatment should be administered separately from Anaclosil.
  • Probenecid, which is a medicine for the treatment of gout, as it may increase the effect of Anaclosil.
  • Warfarin or other anticoagulant medicines.

Pregnancy, Breastfeeding, and Fertility

If you are pregnant or breastfeeding, or think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.

This medicine passes into breast milk. Consult your doctor before breastfeeding your baby. Treatment should be discontinued in case of diarrhea, candidiasis, or skin rashes in the baby.

Driving and Using Machines

There is no evidence of effects on the ability to drive or use machines.

ANACLOSIL 500 mg Hard Capsules contain Sodium

Consult your doctor in case you are on a low-sodium diet, as this medicine contains 26.4 mg (equivalent to 1.15 mmol) of sodium per capsule.

3. How to take Anaclosil 500 mg Hard Capsules

Follow exactly the administration instructions of this medicine as indicated by your doctor. Consult your doctor or pharmacist if you have any doubts.

The dose depends on the body weight, as well as the state of kidney and liver function.

Adults

The usual recommended dose in adults with normal kidney function is 500 mg every 4-6 hours, depending on the severity and site of the infection.

The treatment duration should not exceed 14 days.

The dose may be adjusted in case of severe kidney or liver function problems. The usual recommended dose in children with normal kidney function ranges from 50 to 100 mg/kg/day in divided doses.

It should be administered preferably on an empty stomach (1 hour before or 2 hours after meals).

As with antibiotic therapy in general, the administration of cloxacillin will continue for 48 to 72 hours after the disappearance of fever, or after obtaining evidence of eradication of the bacteria.

Children and Adolescents:

-Normal Renal Function

In children, the recommended doses range from 50 to 100 mg/kg/day, in divided doses.

-Impaired Renal Function

The dosage in children with renal and/or hepatic insufficiency has not been sufficiently studied.

If you take more Anaclosil 500mg Hard Capsules than you should

If you (or someone else) swallow many capsules at the same time or if you think a child has swallowed some, contact your doctor or pharmacist immediately.

In case of overdose or accidental ingestion, consult your doctor or pharmacist or call the Toxicology Information Service, phone 91 562 04 20, indicating the medicine and the amount ingested.

If you forget to take Anaclosil 500 mg Hard Capsules

Do not take a double dose to make up for forgotten doses of Anaclosil 500mg Hard Capsules.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

Medicine questions

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Discuss your symptoms and treatment with a doctor online.

4. Possible Side Effects

Like all medicines, Anaclosil can cause side effects, although not everybody gets them.

Very rare (may affect up to 1 in 10,000 people): Severe skin redness, Stevens-Johnson syndrome, toxic epidermal necrolysis

Frequency not known (cannot be estimated from the available data).

The oral administration of this medicine (cloxacillin) may cause gastrointestinal disorders (diarrhea, nausea, and vomiting), which are usually mild and disappear when the medication is discontinued.

In subjects sensitized to penicillins, allergic reactions such as swelling of the face, lips, mouth, tongue, or throat may occur, which can cause difficulty swallowing or breathing (angioedema).

Other side effects may include:

-Allergic reactions on the skin (itching, skin rash, urticaria).

-Decrease in the number of neutrophils and platelets in the blood.

-Neurological symptoms: seizures (this effect is more frequent in people with significantly impaired kidney function).

-Jaundice (yellowing of the skin), increased liver enzyme values, and hepatitis (inflammation of the liver).

Reporting of Side Effects

If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly through the Spanish Medicines Surveillance System for Human Use https://www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Anaclosil 500 mg Hard Capsules

Keep below 25°C. Store in the original package.

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the carton, after EXP. The expiry date is the last day of the month stated.

Medicines should not be disposed of via wastewater or household waste. Place the empty packaging and any unused medicinal products in the SIGRE collection point at your pharmacy. If you have any doubts, ask your pharmacist how to dispose of the packaging and any unused medicinal products. This will help protect the environment.

6. Contents of the Pack and Further Information

Composition of Anaclosil 500 mg Hard Capsules

The active substance is cloxacillin (as sodium salt). Each capsule contains 500mg of cloxacillin (as sodium salt).

The other ingredients are magnesium stearate, colloidal silica, and sodium carboxymethylcellulose (type A) (derived from potato starch).

Appearance of the Product and Contents of the Pack

Box containing 20, 40, or 500 hard gelatin capsules, with a body and cap of color, with the name Anaclosil 500mg printed.

Marketing Authorization Holder and Manufacturer

Marketing Authorization Holder

Laboratorio Reig Jofré, S.A.

Gran Capitán, 10

08970 Sant Joan Despí (Barcelona)

Manufacturer

Laboratorio Reig Jofré, S.A.

Jarama, 111 – 45007

Toledo (Spain)

Date of the Last Revision of this Leaflet: May 2020

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.es/

Online doctors for ANACLOSIL 500 mg CAPSULES

Discuss questions about ANACLOSIL 500 mg CAPSULES, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Doctor

Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

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Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
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Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Anna Biriukova

General medicine 6 years exp.

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

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Endocrinology – Diabetes, thyroid, metabolism:
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Gastroenterology – Digestive health:
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General internal medicine and preventive care:
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Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
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Dmytro Horobets

Family medicine 7 years exp.

Dr. Dmytro Horobets is a licensed family medicine physician in Poland, specialising in endocrinology, diabetology, obesity management, gastroenterology, pediatrics, general surgery, and pain medicine. He offers online consultations for adults and children, providing personalised medical support for a wide range of acute and chronic health concerns.

Areas of expertise:

  • Endocrinology: diabetes type 1 and type 2, prediabetes, thyroid disorders, metabolic syndrome, hormonal imbalance.
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  • Gastroenterology: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), liver and biliary conditions.
  • Pediatric care: infections, respiratory symptoms, digestive issues, growth and development monitoring.
  • General surgery support: pre- and post-surgical consultations, wound care, rehabilitation.
  • Pain management: chronic and acute pain, back pain, joint pain, post-traumatic pain syndromes.
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Doctor

Svetlana Kolomeeva

Cardiology 18 years exp.

Dr. Svetlana Kolomeeva is a general practitioner and internal medicine doctor providing online consultations for adults. She helps patients manage acute symptoms, chronic conditions, and preventive care. Her clinical focus includes cardiovascular health, hypertension control, and managing symptoms like fatigue, weakness, sleep issues, and overall low energy.

Patients commonly seek her help for:

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  • Respiratory symptoms: colds, flu, sore throat, cough, fever.
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  • Chronic conditions: diabetes, thyroid disorders.
  • Interpretation of lab tests and medical reports, therapy adjustment.
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Dr Kolomeeva combines clinical expertise with personalised care. She clearly explains diagnoses, guides patients through symptoms and treatment options, and provides actionable plans. Her consultations are designed not only to address current complaints but also to stabilise chronic conditions and prevent future complications. She supports patients through every stage of care – from first symptoms to ongoing health management.

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Doctor

Alexander Nazarchuk

Allergology 7 years exp.

Dr. Alexander Nazarchuk is a physician specialising in allergology and internal medicine. He provides online consultations for adults, following the principles of evidence-based medicine — no outdated treatments or unnecessary tests, with clear explanations and a personalised approach. He helps patients with a wide range of allergic and therapeutic conditions, from common day-to-day complaints to complex cases involving allergies, gastrointestinal issues, cardiovascular concerns, respiratory symptoms, and more.

You can consult Dr. Nazarchuk for:

  • Test interpretation and guidance on diagnostic plans.
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During consultations, Dr. Nazarchuk takes a thorough, structured approach — analysing symptoms, identifying potential causes, and helping patients make informed decisions. Whether treatment, further investigation, or monitoring is needed, he explains each step clearly so you understand your health and how best to manage it.

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Frequently Asked Questions

Is a prescription required for ANACLOSIL 500 mg CAPSULES?
ANACLOSIL 500 mg CAPSULES requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in ANACLOSIL 500 mg CAPSULES?
The active ingredient in ANACLOSIL 500 mg CAPSULES is cloxacillin. This information helps identify medicines with the same composition but different brand names.
How much does ANACLOSIL 500 mg CAPSULES cost in pharmacies?
The average pharmacy price for ANACLOSIL 500 mg CAPSULES is around 5.06 EUR. Prices may vary depending on the manufacturer and dosage form.
Who manufactures ANACLOSIL 500 mg CAPSULES?
ANACLOSIL 500 mg CAPSULES is manufactured by Laboratorio Reig Jofre, S.A.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of ANACLOSIL 500 mg CAPSULES online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether ANACLOSIL 500 mg CAPSULES is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to ANACLOSIL 500 mg CAPSULES?
Other medicines with the same active substance (cloxacillin) include ANACLOSIL 1000 mg powder for injectable solution and for infusion, ANACLOSIL 500 mg powder for injectable solution and for infusion, CLOXACILLIN NORMON 1 g POWDER FOR INJECTION AND INFUSION SOLUTION. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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