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SILARINE 80 mg HARD CAPSULES

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About the medicine

How to use SILARINE 80 mg HARD CAPSULES

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

Silarine 80 mg Hard Capsules

Silymarin

Read the entire package leaflet carefully before starting to use this medication, as it contains important information for you.

  • Keep this package leaflet, as you may need to read it again. If you have any questions, consult your doctor or pharmacist.
  • This medication has been prescribed to you only, and you should not give it to others, even if they have the same symptoms as you, as it may harm them.
  • If you experience side effects, consult your doctor or pharmacist, even if they are not listed in this package leaflet. See section 4.

Contents of the Package Leaflet

  1. What Silarine is and what it is used for
  2. What you need to know before taking Silarine
  3. How to take Silarine
  4. Possible side effects
  5. Storage of Silarine
  6. Package Contents and Additional Information

1. What Silarine is and what it is used for

Silarine is a preparation with antitoxic and hepatoprotective action due to its active ingredient silymarin present in the dry extract of milk thistle (Silybum marianum).

It is indicated for supportive treatment in adults of chronic liver lesions caused by chronic alcohol consumption or hepatotoxic medications, steatosis (fatty liver) or cirrhosis.

Doctor consultation

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2. What you need to know before taking Silarine

Do not take Silarine

If you are allergic to silymarin or any of the other components of this medication (listed in section 6).

Warnings and Precautions

Consult your doctor or pharmacist before starting to take Silarine.

Treatment with dry extract of milk thistle fruit does not replace abstinence from the causes of liver damage (e.g., alcohol).

In case of jaundice (yellowish discoloration of the skin, yellowish discoloration of the whites of the eyes), you should consult your doctor.

The use of this medication for long periods of time should be monitored by a doctor.

Cautions should be taken in patients with known sensitivity to plants of the Asteraceae/Compositae family (such as chrysanthemum, daisy, calendula, or ragweed).

Children

There is no experience with the use of this medication in children, so its administration is not recommended.

Other Medications and Silarine

Tell your doctor or pharmacist if you are taking, have recently taken, or may need to take any other medication. In particular, inform them if you are taking:

  • Metronidazole or losartan; special precautions may be required.
  • Domperidone: its use with Silarine is not recommended.

Pregnancy and Breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medication.

Driving and Using Machines

According to experience with Silarine, it is unlikely that your ability to drive vehicles or operate hazardous machinery will be impaired. However, at the start of treatment, be cautious when performing these tasks until you know how you tolerate the treatment.

This medication contains lactose

If your doctor has told you that you have an intolerance to certain sugars, consult them before taking this medication.

Medicine questions

Started taking the medicine and have questions?

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3. How to take Silarine

Follow the administration instructions for this medication exactly as indicated by your doctor or pharmacist. If in doubt, consult your doctor or pharmacist again.

Silarine is presented in the form of hard capsules for oral administration. The capsules should be swallowed without chewing, with the help of a little water, and can be taken with or without food.

The recommended starting dose is 1 capsule 3 times a day, after meals, for 1 month, and then continue with 2 capsules per day.

If you take more Silarine than you should

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or call the Toxicology Information Service, phone 91 562 04 20, indicating the medication and the amount ingested. You may observe nausea, diarrhea, dyspepsia, flatulence, abdominal pain, or a feeling of fullness and anorexia.

If you forget to take Silarine

Do not take a double dose to make up for forgotten doses. Take your dose as soon as you remember and continue the treatment as before.

If you stop treatment with Silarine

Your doctor will indicate the duration of your treatment with this medication. Do not stop the treatment before, as your symptoms may worsen. If you think the effect of Silarine is too strong or too weak, tell your doctor or pharmacist.

If you have any other questions about the use of this medication, ask your doctor or pharmacist.

4. Possible side effects

Like all medications, this medication can cause side effects, although not everyone will experience them.

Side effects are mild and transient.

The following side effects* have been observed in products containing the active ingredient silymarin:

Uncommon (affecting 1 to 10 out of 1000 patients)

Gastrointestinal disorders: stomach pain and diarrhea.

Very rare (affecting less than 1 in 10,000 patients)

Immune system disorders: allergic reactions.

Respiratory, thoracic, and mediastinal disorders: dyspnea.

Skin and subcutaneous tissue disorders: skin rash.

  • Side effects and their frequencies have been extrapolated from other medications containing the same active ingredient but at different doses. Due to the lack of clinical data specific to this medication, both side effects and frequencies should be interpreted with caution.

Reporting side effects

If you experience any side effects, consult your doctor, pharmacist, or nurse, even if they are not listed in this package leaflet. You can also report them directly through the Spanish Medication Surveillance System for Human Use: https://www.notificaram.es. By reporting side effects, you can contribute to providing more information on the safety of this medication.

5. Storage of Silarine

Keep this medication out of the sight and reach of children.

No special storage conditions are required.

Do not use this medication after the expiration date shown on the blister pack and the packaging after "EXP". The expiration date is the last day of the month indicated.

Medications should not be disposed of through wastewater or household waste. Deposit the packaging and any unused medications at the SIGRE collection point in your pharmacy. If in doubt, ask your pharmacist how to dispose of the packaging and medications you no longer need. This will help protect the environment.

6. Package Contents and Additional Information

Composition of Silarine

The active ingredient is silymarin. Each capsule contains 100 mg of dry extract of milk thistle, equivalent to 80 mg of silymarin.

The other ingredients are lactose and magnesium stearate.

The capsule shell contains gelatin, indigo carmine (E-132), quinoline yellow (E-104), and titanium dioxide (E-171).

Appearance of the Product and Package Contents

Hard gelatin capsules with a white opaque body and a green opaque cap, packaged in aluminum/PVC blister packs containing 30 hard capsules.

Marketing Authorization Holder and Manufacturer

Industria Química y Farmacéutica VIR, S.A.

C/Laguna 66-68-70. Polígono Industria Urtinsa II

28923 Alcorcón (Madrid)

Spain

Date of the Last Revision of this Package Leaflet:June 2025.

Detailed information about this medication is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS).

Online doctors for SILARINE 80 mg HARD CAPSULES

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Chikeluo Okeke

General medicine 4 years exp.

Dr Chikeluo Okeke is an internal medicine doctor with extensive international clinical experience. Originally from Nigeria, he has worked across multiple European healthcare systems and currently practises in Sweden. This professional path has given him a strong understanding of different medical approaches and the ability to work effectively with patients from diverse cultural and linguistic backgrounds.

Dr Okeke focuses on general internal medicine and adult primary care, combining clinical accuracy with careful attention to lifestyle, personal context, and everyday health concerns. His consultations are particularly well suited for people who seek medical advice online, live abroad, or need clear guidance without unnecessary complexity.

He provides online consultations covering symptom assessment, prevention, and long-term management of chronic conditions, helping patients understand what is happening and decide on appropriate next steps.

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Dr Okeke is known for his clear communication, calm approach, and cultural awareness. He listens carefully, explains medical decisions in a structured way, and supports patients in making informed choices about their health.

Online consultations with Dr Chikeluo Okeke offer reliable internal medicine care without geographic limitations, focused on medical relevance, clarity, and patient comfort.

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Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques. For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance. Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults. In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions. Patients commonly seek his care for: 

  • seasonal and perennial allergies
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Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.

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Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

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Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
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If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Joao Silva

General medicine 6 years exp.

Dr. João Silva is a physician with training and experience in the field of General and Family Medicine, dedicated to providing healthcare focused on the well-being and quality of life of his patients. Throughout his professional career, he has developed broad clinical competencies, striving to maintain a medical practice based on scientific evidence and continuous knowledge updates.

Between 2013 and 2019, he completed the Integrated Master's Degree in Medicine at the Abel Salazar Institute of Biomedical Sciences in Porto, where he acquired a solid academic and clinical education.

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From January 2022 until March 2026, he works as a Resident Physician in General and Family Medicine at USF Salvador Machado in Oliveira de Azeméis, developing clinical activities in primary healthcare, follow-up of chronic patients, and health promotion in the community.

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Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

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Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

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Dr. Lokchiri’s professional training includes:

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He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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Bulat Garipov

General medicine 15 years exp.

Dr. Bulat Garipov is a radiologist with more than 15 years of experience, specializing in magnetic resonance imaging (MRI). Throughout his professional career, he has worked in leading diagnostic imaging centers, both in on-site practice and teleradiology, which has allowed him to develop a broad and versatile approach to radiology.

Over the years, he has gained solid experience in interpreting MRI studies in various areas, including:

  •  Neuroimaging
  •  Musculoskeletal system (MSK)
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  •  Abdomen and pelvis
  •  Soft tissues

Additionally, Dr. Garipov is open to new collaboration opportunities in radiology and teleradiology projects. He offers his expertise in MRI, providing both first and second readings of studies, as well as advanced image interpretation, ensuring accurate and high-quality diagnostics.

You could consult Dr. Bulat Garipov in cases where accurate interpretation of MRI studies or a second expert opinion is required. His expertise is especially valuable in cases of suspected neurological conditions, back and joint pain, vascular disorders, as well as in the diagnosis of abdominal and pelvic diseases. The doctor also provides support in complex or unclear clinical situations, including the review of previously performed studies, which helps improve diagnostic accuracy and determine the optimal treatment strategy. A teleradiology format is available, allowing you to receive a professional opinion remotely.

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Frequently Asked Questions

Is a prescription required for SILARINE 80 mg HARD CAPSULES?
SILARINE 80 mg HARD CAPSULES requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in SILARINE 80 mg HARD CAPSULES?
The active ingredient in SILARINE 80 mg HARD CAPSULES is silymarin. This information helps identify medicines with the same composition but different brand names.
Who manufactures SILARINE 80 mg HARD CAPSULES?
SILARINE 80 mg HARD CAPSULES is manufactured by Industria Quimica Y Farmaceutica Vir S.A.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of SILARINE 80 mg HARD CAPSULES online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether SILARINE 80 mg HARD CAPSULES is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to SILARINE 80 mg HARD CAPSULES?
Other medicines with the same active substance (silymarin) include LEGALON 150 mg CAPSULES, CHENODEOXYCHOLIC ACID LEADIANT 250 mg HARD CAPSULES, URSODESOXYCHOLIC ACID GRINDEKS 250 mg HARD CAPSULES. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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