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SIGNIFOR 40 mg POWDER AND SOLVENT FOR INJECTABLE SUSPENSION

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About the medicine

How to use SIGNIFOR 40 mg POWDER AND SOLVENT FOR INJECTABLE SUSPENSION

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the Patient

Signifor 10mg powder and solvent for injectable suspension

Signifor 20mg powder and solvent for injectable suspension

Signifor 30mg powder and solvent for injectable suspension

Signifor 40mg powder and solvent for injectable suspension

Signifor 60mg powder and solvent for injectable suspension

pasireotide

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor, nurse or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor, nurse or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What is Signifor and what is it used for
  2. What you need to know before you use Signifor
  3. How to use Signifor
  4. Possible side effects
  5. Storage of Signifor
  6. Contents of the pack and other information

1. What is Signifor and what is it used for

Signifor is a medicine that contains the active substance pasireotide. It is used to treat acromegaly in adult patients. It is also used to treat Cushing's disease in adult patients for whom surgery is not an option or for whom surgery has failed.

Acromegaly

Acromegaly is caused by a type of tumor called a pituitary adenoma, which occurs in the pituitary gland at the base of the brain. The adenoma causes the body to produce too much of the hormones that control the growth of tissues, organs, or bones, resulting in an increase in the size of bones and tissues, especially in the hands and feet.

Signifor reduces the production of these hormones and may also reduce the size of the adenoma. As a result, it reduces the symptoms of acromegaly, which include headache, increased sweating, numbness of the hands and feet, fatigue, and joint pain.

Cushing's disease

Cushing's disease is caused by an increase in the size of the pituitary gland (a gland located at the base of the brain) called a pituitary adenoma. This causes the body to produce too much of a hormone called adrenocorticotropic hormone (ACTH), which in turn causes an increase in the production of another hormone called cortisol.

The human body naturally produces a substance called somatostatin, which blocks the production of certain hormones, including ACTH. Pasireotide works in a very similar way to somatostatin. Signifor is therefore able to block the production of ACTH, helping to control the overproduction of cortisol and improve the symptoms of Cushing's disease.

If you have any questions about how Signifor works or why you have been prescribed this medicine, ask your doctor.

Doctor consultation

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2. What you need to know before you use Signifor

Do not use Signifor:

  • if you are allergic to pasireotide or any of the other ingredients of this medicine (listed in section 6).
  • if you have severe liver problems.

Warnings and precautions

Tell your doctor before you start using Signifor if you have or have ever had:

  • problems with blood sugar levels, either too high (as in hyperglycemia/diabetes) or too low (hypoglycemia);
  • heart problems such as a recent heart attack, congestive heart failure (a type of heart disease where the heart cannot pump enough blood through the body) or sudden and severe chest pain (usually felt as pressure, heaviness, tightness, or pain in the chest);
  • a heart rhythm disorder, such as an irregular heartbeat or an abnormal electrical signal called "prolonged QT interval" or "QT prolongation";
  • low levels of potassium or magnesium in the blood;
  • gallstones;
  • or if you are taking anticoagulants (medicines used to reduce the blood's ability to clot), your doctor will monitor your coagulation parameters and may adjust your anticoagulant dose.

During your treatment with Signifor

  • Signifor may cause an increase in blood sugar. Your doctor may monitor your blood sugar level and start treatment or adjust your antidiabetic medicine.
  • Signifor controls the overproduction of cortisol. The control may be too strong and you may experience signs or symptoms associated with a lack of cortisol, such as extreme weakness, fatigue, weight loss, nausea, vomiting, or low blood pressure. If this happens, tell your doctor immediately.
  • Signifor may reduce your heart rate. Your doctor may monitor your heart rate using a machine that measures the electrical activity of the heart (an "ECG" or electrocardiogram). If you are using a medicine to treat a heart problem, your doctor may also need to adjust your dose.
  • your doctor may also periodically monitor your gallbladder, liver enzymes, and pituitary hormones, as they may be affected by this medicine.

Children and adolescents

Do not give this medicine to children and adolescents under 18 years of age because there is no data available for this age group.

Other medicines and Signifor

Signifor may affect the way other medicines work. If you are using other medicines at the same time as Signifor (including non-prescription medicines), your doctor may need to monitor your heart more closely or change the dose of Signifor or the other medicines. Tell your doctor or pharmacist if you are using, have recently used, or might use any other medicines. In particular, tell your doctor if you are using:

  • medicines used in organ transplantation to reduce the activity of the immune system (cyclosporine);
  • medicines to treat high blood sugar levels (such as in diabetes) or low blood sugar levels (hypoglycemia), such as:
  • insulin
  • metformin, liraglutide, vildagliptin, nateglinide (antidiabetic medicines);
  • medicines to treat irregular heart rhythm, such as those containing disopyramide, procainamide, quinidine, sotalol, dofetilide, ibutilide, amiodarone, or dronedarone;
  • medicines to treat bacterial infections (by mouth: clarithromycin, moxifloxacin; by injection: erythromycin, pentamidine);
  • medicines to treat fungal infections (ketoconazole, except in shampoo);
  • medicines to treat certain psychiatric disorders (chlorpromazine, thioridazine, fluphenazine, pimozide, haloperidol, tiapride, amisulpride, sertindol, methadone);
  • medicines to treat hay fever and other allergies (terfenadine, astemizole, mizolastine);
  • medicines used to prevent or treat malaria (chloroquine, halofantrine, lumefantrine);
  • medicines to control blood pressure, such as:
  • beta blockers (metoprolol, carteolol, propranolol, sotalol)
  • calcium channel blockers (bepridil, verapamil, diltiazem)
  • cholinesterase inhibitors (rivastigmine, physostigmine);
  • medicines to control the balance of electrolytes (potassium, magnesium) in the body.

Pregnancy, breastfeeding, and fertility

Ask your doctor or pharmacist for advice before taking any medicine.

  • Do not use Signifor during pregnancy unless clearly necessary. If you are pregnant or think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.
  • If you are breastfeeding, ask your doctor for advice before taking this medicine, as it is not known whether Signifor passes into breast milk.
  • If you are a sexually active woman, you should use an effective method of contraception during treatment. Ask your doctor about the need for contraception before using this medicine.

Driving and using machines

Signifor may have a minor effect on your ability to drive and use machines, as some of the side effects you may experience while using Signifor, such as headache, dizziness, and fatigue, may reduce your ability to drive and use machines safely.

Important information about some of the ingredients of Signifor

Signifor contains less than 1 mmol of sodium (23 mg) per dose; i.e., it is essentially "sodium-free".

3. How to use Signifor

This medicine will only be administered by a trained healthcare professional.

How much Signifor to use

Acromegaly

The recommended starting dose of Signifor for acromegaly is 40 mg every 4 weeks. After starting treatment, your doctor may reassess your dose. This may involve measuring the levels of growth hormone or other hormones in your body. Depending on the results and how you feel, it may be necessary to reduce or increase the dose of Signifor administered in each injection. The dose should not exceed 60 mg. If you have liver disease before starting treatment with Signifor, your doctor may decide to start treatment with a dose of 20 mg.

Cushing's disease

The normal starting dose of Signifor for Cushing's disease is 10 mg every 4 weeks. After starting treatment, your doctor may review the dose. This may involve measuring the levels of cortisol in the blood or urine. Depending on the results and how you feel, it may be necessary to reduce or increase the dose of Signifor administered in each injection. The dose should not exceed 40 mg.

Your doctor will regularly monitor how you respond to treatment with Signifor and decide what dose is best for you.

How to use Signifor

Your doctor or nurse will inject Signifor. If you have any questions, ask your doctor, nurse, or pharmacist.

Signifor is used by intramuscular injection. This means it is injected through a needle into the muscles of your buttocks.

For how long to use Signifor

This is a long-term treatment, possibly lasting years. Your doctor will regularly monitor your disease to check that the treatment is having the desired effect. Your treatment with Signifor should continue as long as your doctor tells you it is necessary.

If you stop treatment with Signifor

If you stop your treatment with Signifor, your symptoms may come back. Therefore, do not stop your treatment with Signifor unless your doctor tells you to.

If you have any other questions about the use of this medicine, ask your doctor, nurse, or pharmacist.

Medicine questions

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4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Some side effects may be serious. Tell your doctor immediately if you experience any of the following:

Very common (may affect more than 1 in 10 people)

  • High blood sugar level. You may notice excessive thirst, urination, increased appetite with weight loss, fatigue, nausea, vomiting, abdominal pain.
  • Gallstones or associated complications. You may experience fever, chills, yellowing of the skin/eyes, sudden back pain or pain in the right side of the abdomen.

Common (may affect up to 1 in 10 people)

  • Low levels of cortisol. You may experience extreme weakness, fatigue, weight loss, nausea, vomiting, and low blood pressure.
  • Slow heart rate.
  • Prolonged QT interval (an abnormal electrical signal in your heart that can be seen on tests).
  • Bile flow problems (cholestasis). You may experience yellowing of the skin, dark urine, pale stools, and itching.
  • Inflammation of the gallbladder (cholecystitis).

Other side effects of Signifor may include:

Very common (may affect more than 1 in 10 people)

  • Diarrhea
    • Nausea
    • Abdominal pain
    • Fatigue

Common (may affect up to 1 in 10 people)

  • Fatigue, weakness, pale skin (signs of low red blood cell count)
  • Loss of appetite
  • Headache
  • Swelling
  • Vomiting
  • Dizziness
  • Pain, discomfort, itching, and swelling at the injection site
  • Changes in liver function test results
  • Abnormal blood test results (sign of elevated creatine phosphokinase, hemoglobin A1c, lipase in the blood)
  • Hair loss

Uncommon (may affect up to 1 in 100 people)

  • Changes in blood test results of pancreatic function (amylase)
  • Abnormal blood coagulation properties

Frequency not known (cannot be estimated from the available data)

  • High levels of ketone bodies (a group of substances produced in the liver) in the urine or blood (diabetic ketoacidosis) as a complication of high blood sugar. You may experience fruity breath odor, breathing problems, and confusion.

Reporting of side effects

If you experience any side effects, talk to your doctor, pharmacist, or nurse, even if it is possible side effects not listed in this leaflet. You can also report side effects directly through the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Signifor

  • Keep this medicine out of the sight and reach of children.
  • Do not use this medicine after the expiry date which is stated on the carton, vial, and pre-filled syringe after "EXP"/"CAD". The expiry date is the last day of the month shown.
  • Store in a refrigerator (between 2°C and 8°C). Do not freeze.
  • Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help protect the environment.

6. Container Contents and Additional Information

Composition of Signifor

  • The active substance is pasireotide.

Signifor 10 mg: each vial contains 10 mg of pasireotide (as pasireotide pamoate)

Signifor 20 mg: each vial contains 20 mg of pasireotide (as pasireotide pamoate)

Signifor 30 mg: each vial contains 30 mg of pasireotide (as pasireotide pamoate)

Signifor 40 mg: each vial contains 40 mg of pasireotide (as pasireotide pamoate)

Signifor 60 mg: each vial contains 60 mg of pasireotide (as pasireotide pamoate)

  • The other components are:
    • In the powder: poly(D,L-lactide-co-glycolide) (50-60:40.50), poly(D,L-lactide-co-glycolide) (50:50).
    • In the solvent: sodium carmellose, mannitol, poloxamer 188, water for injectable preparations.

Appearance of Signifor and Container Contents

Signifor powder is a slightly yellowish to yellowish powder in a vial. The solvent is a clear, colorless to slightly yellow or slightly brown solution in a pre-filled syringe.

Signifor 10 mg is available in single-unit containers that contain a vial of powder with 10 mg of pasireotide and a pre-filled syringe with 2 ml of solvent.

Signifor 20 mg is available in single-unit containers that contain a vial of powder with 20 mg of pasireotide and a pre-filled syringe with 2 ml of solvent.

Signifor 30 mg is available in single-unit containers that contain a vial of powder with 30 mg of pasireotide and a pre-filled syringe with 2 ml of solvent.

Signifor 40 mg is available in single-unit containers that contain a vial of powder with 40 mg of pasireotide and a pre-filled syringe with 2 ml of solvent.

Signifor 60 mg is available in single-unit containers that contain a vial of powder with 60 mg of pasireotide and a pre-filled syringe with 2 ml of solvent.

Each single-unit container contains the vial and the pre-filled syringe in a sealed blister tray with a vial adapter and a safety injection needle.

Signifor 40 mg and Signifor 60 mg are also available in multiple-unit containers that contain 3 intermediate containers.

In your country, only some doses and container sizes may be marketed.

Marketing Authorization Holder

Recordati Rare Diseases

Immeuble Le Wilson

70 avenue du Général de Gaulle

92800 Puteaux

France

Manufacturer

Recordati Rare Diseases

Immeuble Le Wilson

70 avenue du Général de Gaulle

92800 Puteaux

France

Recordati Rare Diseases

Eco River Parc

30 rue des Peupliers

92000 Nanterre

France

You can request more information about this medicinal product by contacting the local representative of the marketing authorization holder:

Belgium

Recordati

Tel: +32 2 46101 36

Lithuania

Recordati AB.

Tel: +46 8 545 80 230

Sweden

Greece

Recordati Rare Diseases

Tel: +33 (0)1 47 73 64 58

France

Luxembourg

Recordati

Tel: +32 2 46101 36

Belgium

Czech Republic

Recordati Rare Diseases

Tel: +33 (0)1 47 73 64 58

France

Hungary

Recordati Rare Diseases

Tel: +33 (0)1 47 73 64 58

France

Denmark

Recordati AB.

Tel: +46 8 545 80 230

Sweden

Malta

Recordati Rare Diseases

Tel: +33 1 47 73 64 58

France

Germany

Recordati Rare Diseases Germany GmbH

Tel: +49 731 140 554 0

Netherlands

Recordati

Tel: +32 2 46101 36

Belgium

Estonia

Recordati AB.

Tel: +46 8 545 80 230

Sweden

Norway

Recordati AB.

Tel: +46 8 545 80 230

Sweden

Greece

Recordati Hellas

Tel: +30 210 6773822

Austria

Recordati Rare Diseases Germany GmbH

Tel: +49 731 140 554 0

Germany

Spain

Recordati Rare Diseases Spain S.L.U.

Tel: +34 91 659 28 90

Poland

Recordati Rare Diseases

Tel: +33 (0)1 47 73 64 58

France

France

Recordati Rare Disease s

Tel: +33 (0)1 47 73 64 58

Portugal

Jaba Recordati S.A.

Tel: +351 21 432 95 00

Croatia

Recordati Rare Diseases

Tel: +33 (0)1 47 73 64 58

France

Romania

Recordati Rare Diseases

Tel: +33 (0)1 47 73 64 58

France

Ireland

Recordati Rare Diseases

Tel: +33 (0)1 47 73 64 58

France

Slovenia

Recordati Rare Diseases

Tel: +33 (0)1 47 73 64 58

France

Iceland

Recordati AB.

Tel: +46 8 545 80 230

Sweden

Slovakia

Recordati Rare Diseases

Tel: +33 (0)1 47 73 64 58

France

Italy

Recordati Rare Diseases Italy Srl

Tel: +39 02 487 87 173

Finland

Recordati AB.

Tel: +46 8 545 80 230

Sweden

Cyprus

Recordati Rare Diseases

Tel: +33 1 47 73 64 58

France

Sweden

Recordati AB.

Tel: +46 8 545 80 230

Latvia

Recordati AB.

Tel: +46 8 545 80 230

Sweden

United Kingdom (Northern Ireland)

Recordati Rare Diseases UK Ltd.

Tel: +44 (0)1491 414333

Date of Last Revision of this Leaflet:

Other Sources of Information

Detailed information on this medicinal product is available on the European Medicines Agency website: http://www.ema.europa.eu. There are also links to other websites on rare diseases and orphan medicines.

This information is intended only for healthcare professionals:

INSTRUCTIONS FOR USE OF SIGNIFOR POWDER AND SOLVENT FOR INJECTABLE SUSPENSION

FOR INTRAMUSCULAR INJECTION ONLY

ATTENTION:

In the process of reconstituting Signifor, there are two critical steps. If these are not performed correctly, this may result in the injection not being administered correctly.

  • The injection kit must reach room temperature.Remove the injection kit from the refrigerator and let it reach room temperature for at least 30 minutes before reconstitution, but not more than 24 hours.
  • After adding the solvent, shake the vialmoderatelyfor at least 30 seconds until a uniform suspension is formed.

The injection kit includes:

Vial with liquid, filter, pre-filled syringe, and protective cap on a flat surface with alphabetical labels

a A vial containing the powder

b A pre-filled syringe containing the solvent

c A vial adapter for reconstitution of the medicinal product

d A safety injection needle (20G x 1.5”)

Follow the detailed instructions below to ensure the correct reconstitution of Signifor powder and solvent for injectable suspension before intramuscular injection.

Signifor suspension should only be prepared immediately before administration.

Signifor should only be administered by a healthcare professional with experience.

Instructions showing vial with lyophilized powder and adapter, arrows indicating preparation and assembly steps of the device

Pre-filled syringe connected to a vial with arrows indicating plunger pressure and moderate shaking to suspend powder

Hand inverting syringe and vial with clear liquid, arrow indicating direction of plunger withdrawal and unscrewing vial from adapter

Syringe with safety needle in use, showing steps of cap removal and injection angle of 90 degrees

Hand pressing the safety mechanism of a syringe with needle, showing two activation methods and a discarded syringe in a container

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Nuno Tavares Lopes

Family medicine 18 years exp.

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management
  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses
  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment
  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance
  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis
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  • Public health: prevention, health screenings, long-term monitoring
  • Sick leave (Baixa médica) connected to Segurança Social in Portugal
  • IMT medical certificates for driving licence exchange
Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.

Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

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Anastasiia Shalko

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Dr. Anastasiia Shalko is a general practitioner with a background in both paediatrics and general medicine. She graduated from Bogomolets National Medical University in Kyiv and completed her paediatric internship at the P.L. Shupyk National Medical Academy of Postgraduate Education. After working as a paediatrician in Kyiv, she relocated to Spain, where she has been practising general medicine since 2015, providing care for both adults and children.Her work focuses on urgent, short-term medical concerns – situations where patients need quick guidance, symptom assessment and clear next steps. She helps people understand whether their symptoms require in-person evaluation, home management or a change in treatment. Common reasons for booking an online consultation include:

  • acute respiratory symptoms (cough, sore throat, runny nose, fever)
  • viral illnesses such as colds and seasonal infections
  • gastrointestinal complaints (nausea, diarrhoea, abdominal pain, gastroenteritis)
  • sudden changes in how a child or adult feels
  • questions about existing treatment and whether adjustments are needed
  • renewal of prescriptions when clinically appropriate

Dr. Shalko works specifically with urgent and short-term problems, providing practical recommendations and helping patients determine the safest next step. She explains symptoms clearly, guides patients through decision-making and offers straightforward medical advice for everyday acute issues.She does not provide long-term management of chronic conditions, ongoing follow-up or comprehensive care plans for complex long-term illnesses. Her consultations are designed for acute symptoms, sudden concerns and situations where timely medical input is important.With clinical experience in both paediatrics and general medicine, Dr. Shalko confidently supports adults and children. Her communication style is clear, simple and reassuring, helping patients feel informed and supported throughout the consultation.

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Lizaveta Trafimchuk Takhvaniuk

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Dr. Lizaveta Trafimchuk Takhvaniuk graduated in Medicine and subsequently specialized in Dermatology and Venereology. She has more than 10 years of clinical experience and is licensed to practice in Spain, where she focuses on the comprehensive diagnosis and treatment of dermatological conditions.

Throughout her education and professional career, Dr. Trafimchuk has gained extensive experience in managing diseases of the skin, hair, and nails, as well as in the diagnosis, treatment, and prevention of sexually transmitted infections (STIs). Her clinical approach is based on evidence-based medicine, combined with personalized care tailored to each patient’s needs.

In her daily practice, she treats a wide range of dermatological conditions, including chronic inflammatory dermatoses such as acne, rosacea, atopic dermatitis, psoriasis, and eczema. She also has experience in treating pigmentation disorders, including melasma, post-inflammatory hyperpigmentation, and dyschromia.

She has developed a particular interest in trichology, treating various types of alopecia, chronic hair loss, and scalp disorders. In addition, she has experience in managing infectious dermatoses of fungal, viral, and bacterial origin, as well as in evaluating benign and suspicious skin lesions, with referral to specialized care when necessary.

With a strong interest in a comprehensive approach to skin health, she also treats scars, post-procedural skin changes, and conditions related to hormonal factors and aging, including those associated with pregnancy, menopause, and age-related skin changes.

Thanks to her experience and continuous professional development, Dr. Trafimchuk provides high-quality medical care that is professional, confidential, and aligned with modern dermatology standards.

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Joao Silva

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Dr. João Silva is a physician with training and experience in the field of General and Family Medicine, dedicated to providing healthcare focused on the well-being and quality of life of his patients. Throughout his professional career, he has developed broad clinical competencies, striving to maintain a medical practice based on scientific evidence and continuous knowledge updates.

Between 2013 and 2019, he completed the Integrated Master's Degree in Medicine at the Abel Salazar Institute of Biomedical Sciences in Porto, where he acquired a solid academic and clinical education.

Subsequently, between January 2021 and December 2021, he completed the General Internship at the Entre Douro e Vouga Hospital Center in Santa Maria da Feira, where he had the opportunity to work in different hospital settings and deepen his competencies in several areas of medicine.

From January 2022 until March 2026, he works as a Resident Physician in General and Family Medicine at USF Salvador Machado in Oliveira de Azeméis, developing clinical activities in primary healthcare, follow-up of chronic patients, and health promotion in the community.

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Daniel Cichi

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Dr Daniel Cichi is a family medicine doctor with over 20 years of clinical experience. He provides online consultations for adults, supporting patients with acute symptoms, chronic conditions, and everyday health concerns that require timely medical guidance. His background includes work in emergency care, ambulance services, and family medicine, which allows him to assess symptoms quickly, identify warning signs, and help patients choose the safest next steps – whether that means home care, treatment adjustment, or in-person evaluation. Patients commonly consult Dr Daniel Cichi for: 

  • acute symptoms: fever, infections, flu-like illness, cough, sore throat, shortness of breath;
  • chest discomfort, palpitations, dizziness, fatigue, and blood pressure concerns;
  • digestive problems: abdominal pain, nausea, diarrhoea, constipation, reflux;
  • sexually transmitted infections, erectile dysfunction;
  • muscle, joint, and back pain, minor injuries, post-traumatic symptoms;
  • chronic conditions: hypertension, diabetes, high cholesterol, thyroid disorders, weight loss, hair loss;
  • review and interpretation of lab tests, imaging reports, and medical documents;
  • medication review and treatment adjustment;
  • medical advice while travelling or living abroad;
  • second opinions and guidance on whether in-person care is needed.

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Andreea Mateescu

Paediatrics 8 years exp.

Dr Andreea Mateescu is a board-certified paediatrician with 7 years of clinical experience. She graduated from Carol Davila University of Medicine and Pharmacy in Bucharest, Romania, and completed her paediatric residency at INSMC Alessandrescu-Rusescu. She also holds additional training in general ultrasound diagnostics.

Dr Mateescu focuses on providing high-quality, evidence-based medical care for children, with a strong emphasis on prevention, healthy development, and long-term wellbeing. She believes that clear, empathetic communication with both children and parents is essential for building trust and ensuring effective care.

Online consultations with Dr Mateescu are suitable for:

  • preventive check-ups and monitoring of growth and development;
  • vaccination planning, including personalised and catch-up schedules;
  • assessment of psychomotor, emotional, and physical development;
  • diagnosis and management of acute and chronic paediatric conditions;
  • nutritional guidance for infants and children, including formula selection when medically indicated;
  • care for children with complex or rare conditions;
  • practical guidance and ongoing support for parents.
Dr Mateescu works with patience, empathy, and professionalism, ensuring that each child receives attentive, individualised care. Her goal is to support healthy, balanced development while helping parents feel confident and well-informed at every stage of their child’s care.
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Lina Travkina

Family medicine 13 years exp.

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
  • Post-operative recovery support and pain management.
  • Preconception counselling and postpartum support.
  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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€70
0.0 (1)
Doctor

Lisa Drigo

Paediatrics 34 years exp.

Dr Lisa Drigo is an experienced paediatrician based in Italy with over 30 years of clinical practice. She graduated from Università Cattolica del Sacro Cuore in Rome and has spent decades working within the Italian healthcare system, supporting children and families with both acute care and long-term prevention.

She is well familiar with Italian paediatric standards, including local vaccination schedules, preventive check-ups, growth monitoring, and everyday medical issues faced by families living in Italy. This makes her consultations especially valuable for parents who want guidance that aligns with local medical practice.

Her primary focus is paediatrics, with additional support in family medicine when a child’s health needs to be assessed in a broader family or preventive context.

Patients most often consult her for:

  • Acute infections in children (fever, cough, sore throat, runny nose).
  • Viral and bacterial illnesses, frequent colds.
  • Digestive symptoms such as abdominal pain, nausea, diarrhoea or constipation.
  • Monitoring of growth, weight, and developmental milestones.
  • Vaccination advice according to Italian schedules.
  • Allergic reactions, skin rashes, food sensitivities.
  • General health concerns and everyday questions from parents.
  • Preventive care, nutrition advice, and healthy lifestyle guidance.

Dr Drigo communicates in a clear, calm, and reassuring way, helping parents understand what is happening and what steps to take next. Online consultations allow families to receive reliable paediatric guidance aligned with Italian medical practice, without unnecessary stress or waiting.

Camera Book a video appointment
€180

Get SIGNIFOR 40 mg POWDER AND SOLVENT FOR INJECTABLE SUSPENSION Prescription Online

1

Fill in a 2-min form

Tell us your symptoms, history, and what medicine you're requesting.

2

Pick a doctor or let us assign

Choose a specialist or we'll match you with the next available doctor.

3

Doctor reviews your case

Usually within 30 minutes. They may ask follow-up questions via chat.

4

Collect from any pharmacy

Electronic prescription sent to your email — valid across Spain.

Frequently Asked Questions

Is a prescription required for SIGNIFOR 40 mg POWDER AND SOLVENT FOR INJECTABLE SUSPENSION?
SIGNIFOR 40 mg POWDER AND SOLVENT FOR INJECTABLE SUSPENSION requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in SIGNIFOR 40 mg POWDER AND SOLVENT FOR INJECTABLE SUSPENSION?
The active ingredient in SIGNIFOR 40 mg POWDER AND SOLVENT FOR INJECTABLE SUSPENSION is pasireotide. This information helps identify medicines with the same composition but different brand names.
Who manufactures SIGNIFOR 40 mg POWDER AND SOLVENT FOR INJECTABLE SUSPENSION?
SIGNIFOR 40 mg POWDER AND SOLVENT FOR INJECTABLE SUSPENSION is manufactured by Recordati Rare Diseases. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of SIGNIFOR 40 mg POWDER AND SOLVENT FOR INJECTABLE SUSPENSION online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether SIGNIFOR 40 mg POWDER AND SOLVENT FOR INJECTABLE SUSPENSION is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to SIGNIFOR 40 mg POWDER AND SOLVENT FOR INJECTABLE SUSPENSION?
Other medicines with the same active substance (pasireotide) include SIGNIFOR 0.3 mg INJECTABLE SOLUTION, SIGNIFOR 0.3 mg INJECTABLE SOLUTION, SIGNIFOR 0.6 mg INJECTABLE SOLUTION. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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