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SELEXID 400 mg FILM-COATED TABLETS

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About the medicine

How to use SELEXID 400 mg FILM-COATED TABLETS

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

Selexid 400 mg film-coated tabletsEFG

Pivmecillinam hydrochloride

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor, pharmacist, or nurse.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What is Selexid and what is it used for
  2. What you need to know before you take Selexid
  3. How to take Selexid
  4. Possible side effects
  5. Storage of Selexid
  6. Contents of the pack and other information

1. What is Selexid and what is it used for

Selexid belongs to a group of medicines called penicillins. It is a type of antibiotic. Selexid works by killing the bacteria that cause infections.

Antibiotics are used to treat bacterial infections and are not effective against viral infections.

It is important that you follow the instructions regarding the dose, administration interval, and treatment duration indicated by your doctor.

Do not store or reuse this medicine. If you have any leftover antibiotic after finishing the treatment, return it to the pharmacy for proper disposal. Do not throw away medicines via wastewater or household waste.

Selexid is used to treat bladder infections (cystitis) in adults.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you take Selexid

Your doctor may have prescribed a different use or dose than what is indicated in this information. Follow your doctor's instructions exactly.

Do not take Selexid:

  • If you are allergic (hypersensitive) to pivmecillinam or any of the other ingredients of this medicine (listed in section 6).
  • If you are allergic (hypersensitive) to other antibiotics. These antibiotics include penicillins and cephalosporins.
  • If you have ever experienced a severe skin rash, skin peeling, blisters, and/or mouth ulcers after taking Selexid 400 mg film-coated tablets EFG or other beta-lactam antibiotics (such as amoxicillin, penicillin V, and flucloxacillin).
  • If you have a narrowing of the digestive tract.
  • If you have a disorder that can reduce the amount of a substance called carnitine in your body. These disorders include a carnitine transporter defect, methylmalonic aciduria, and propionic acidemia.

Warnings and precautions

Consult your doctor, pharmacist, or nurse before starting to take Selexid. The tablets should be taken with at least half a glass of liquid to avoid the tablets getting stuck in the digestive tract.

Before starting treatment, inform your doctor:

  • If you have porphyria.
  • If you have recently used Selexid, as prolonged use can reduce the amount of carnitine in your body.

During treatment:

  • Severe skin reactions (SSR), including Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS), have been reported in relation to treatment with Selexid 400 mg film-coated tablets EFG. Stop treatment with Selexid 400 mg film-coated tablets EFG and seek immediate medical attention if you experience any of the symptoms related to severe skin reactions described in section 4.
  • If you experience sudden diarrhea while taking Selexid, inform your doctor immediately. This may be due to inflammation of the intestine (colitis).
  • Taking pivmecillinam shortly before birth may affect the results of neonatal tests for detecting hereditary metabolic disorders and give a false positive result. A "false positive" means that the result incorrectly indicates that the baby has a disorder. There is no risk to the neonate, but you should inform your doctor that you have taken Selexid shortly before birth.

Children and adolescents

Do not give this medicine to children and adolescents under 18 years of age, as the potential benefits may not outweigh the risks.

Taking Selexid with other medicines

Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.

Inform your doctor or pharmacist if you are taking any of the following medicines:

  • Probenecid (for the treatment of gout). This may enhance the effect of Selexid.
  • Methotrexate (for the treatment of rheumatism and cancer). The excretion of methotrexate from your body may be slower if used with Selexid.
  • Valproate or valproic acid (for the treatment of epilepsy). This increases the risk of having too low a level of carnitine in your body if used with Selexid.
  • Other antibiotics (e.g., tetracyclines, erythromycin, other beta-lactam antibiotics).

This may affect the effect of Selexid.

Taking Selexid with food and drinks

You can take the medicine with or immediately after a meal. Selexid should be taken with at least half a glass of water. It is important that you take your medicine with plenty of liquid and a long time before going to bed. This will prevent digestive tract disorders.

Pregnancy, breastfeeding, and fertility

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Pregnancy

Selexid can be used during pregnancy.

There have been reports of false positives in neonatal screening tests, where it has simulated the presence of isovaleric acidemia. Taking pivmecillinam shortly before birth may affect the results of neonatal tests for detecting hereditary metabolic disorders and give a false positive result. A "false positive" means that the result incorrectly indicates that the baby has a disorder. There is no risk to the neonate, but you should inform your doctor that you have taken Selexid shortly before birth.

Breastfeeding

Selexid can be used during breastfeeding.

Fertility

No clinical studies have been conducted regarding fertility.

Driving and using machines

The influence of Selexid on the ability to drive and use machines is negligible.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

3. How to take Selexid

Follow the instructions for administration of this medicine exactly as stated in this leaflet or as directed by your doctor or pharmacist. If you are unsure, ask your doctor, pharmacist, or nurse. You should take the medicine at equal intervals of time during the day. For example, if you need to take it three times a day, take it at breakfast, lunch, and dinner time. Selexid should be taken with at least half a glass of liquid. Your doctor will tell you how long you need to use Selexid tablets.

The recommended dose is 400 mg 3 times a day.

Elderly patients: No dose adjustment is necessary.

In case of renal or hepatic insufficiency, no dose adjustment is necessary.

If you take more Selexid than you should

Inform your doctor immediately. You may need to stop taking this medicine. You may feel nauseous, vomit, or have stomach disorders.

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or call the Toxicology Information Service, phone: 91 562 04 20, indicating the medicine and the amount ingested.

If you forget to take Selexid

If you forget to take the medicine, take it as soon as you remember. You should take it with at least half a glass of water or other liquid. Then, take the next dose at the usual time.

If you stop taking Selexid

It is very important that you take all the medicine that your doctor has indicated. You should finish this medicine even if you feel better, otherwise, you may become ill again.

If you have any further questions on the use of this medicine, ask your doctor, pharmacist, or nurse.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Serious side effects:

Stop treatment with Selexid and seek immediate medical attention if you notice any of the following symptoms:

  • Severe allergic reactions (anaphylactic reactions, angioedema, anaphylactic shock): symptoms can include skin rash, swelling of the face, lips, tongue, or throat, difficulty breathing or swallowing, fainting due to hypersensitivity. These reactions can be life-threatening.
  • Red, non-raised, target-like or circular patches on the trunk, often with central blisters, skin peeling, mouth ulcers, and/or genital and eye ulcers. These severe skin reactions can be preceded by fever and flu-like symptoms (Stevens-Johnson syndrome or toxic epidermal necrolysis).
  • Widespread rash, high body temperature, and enlarged lymph nodes (DRESS or drug hypersensitivity syndrome).
  • Severe, bloody diarrhea with stomach pain and fever (Clostridium difficile colitis).

Anaphylactic reactions and Clostridium difficile colitis are rare and may affect up to 1 in 100 people. The occurrence of angioedema and anaphylactic shock is unknown.

Contact your doctor if you notice the following seriousside effects:

  • Bleeding from the skin and mucous membranes, as well as bruising of the skin caused by changes in the blood (low platelet count) (thrombocytopenia). Uncommon: may affect up to 1 in 100 people.

Other side effects:

Frequent (may affect up to 1 in 10 people)

  • Fungal infection of the vagina
  • Diarrhea
  • Feeling of nausea

Uncommon (may affect up to 1 in 100 people)

  • Headache
  • Dizziness
  • Feeling of vertigo
  • Vomiting
  • Stomach pain
  • Indigestion (digestive problems)
  • Ulcers in the mouth or digestive tract, inflammation of the digestive tract
  • Disorders of liver function
  • Changes in hematological or hepatic values
  • Weakness or muscle loss. Fatigue or lack of energy. A low level of carnitine in your body can cause these symptoms.
  • Hives
  • Itching
  • Fatigue

Reporting of side effects

If you experience any side effects, talk to your doctor, pharmacist, or nurse, even if it is possible that the side effects are not listed in this leaflet. You can also report side effects directly through the Spanish Medicines Monitoring System: https://www.notificaram.es.

By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Selexid

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the carton after EXP. The expiry date is the last day of the month stated.

No special storage conditions are required.

Medicines should not be disposed of via wastewater or household waste. Dispose of the packaging and any unused medicine in the pharmacy's SIGRE collection point. If you are unsure, ask your pharmacist how to dispose of the packaging and any unused medicine. This will help protect the environment.

6. Contents of the pack and other information

Composition of Selexid

  • The active substance is pivmecillinam hydrochloride. One Selexid tablet contains 400 mg of pivmecillinam hydrochloride.
  • The other ingredients are hydroxypropylcellulose, hypromellose 6 cps, magnesium stearate, microcrystalline cellulose, simethicone emulsion 30%, and synthetic paraffin.

Appearance and packaging of the product

Selexid is a white, capsule-shaped, film-coated tablet, 8 x 17 mm in size.

Pack sizes:

9, 10, 15, and 20 tablets in blisters.

Not all pack sizes may be marketed.

Marketing authorization holder and manufacturer

Marketing authorization holder:

Karo Pharma AB

Box 16184

103 24 Stockholm

Sweden

Manufacturer:

Recipharm Strängnäs AB, Mariefredsvägen 35, S-645 41 Strängnäs, Sweden

You can obtain further information on this medicine by contacting the local representative of the marketing authorization holder:

Laboratorios Gebro Pharma, S.A.

Avenida Tibidabo n° 29

08022 Barcelona

Spain

Phone: +34 93 205 86 86

This medicine is authorized in the Member States of the European Economic Area under the following names:

Belgium: Selexid® 400 mg Tabletten

Denmark: Pivmecillinamhydrochlorid Karo Pharma

Netherlands: Selexid® 400 mg Filmomhulde tabletten

Ireland: Pivmecillinam hydrochloride Karo Pharma 400 mg film-coated tablets

Italy: XSYSTO®

Luxembourg: Selexid® 400 mg Comprimés pelliculés

Poland: X-SYSTO® 400 mg Tabletki powlekane

Spain: Selexid® 400 mg Comprimidos recubiertos con película

Germany: X-SYSTO® 400 mg Filmtabletten

Date of last revision of this leaflet: February 2024

Detailed information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/.

Online doctors for SELEXID 400 mg FILM-COATED TABLETS

Discuss questions about SELEXID 400 mg FILM-COATED TABLETS, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Tarek Agami

General medicine 11 years exp.

Dr. Tarek Agami is a general practitioner registered in both Portugal and Israel, with broad experience in family and preventive medicine. He offers online consultations for adults and children, providing personalised support for primary care needs, chronic disease management, and everyday health concerns.

Dr. Agami received clinical training and worked in leading medical institutions in Israel (Kaplan Medical Center, Barzilai Medical Center, Wolfson Medical Center) and Portugal (European Healthcare City, Viscura Internacional, Hospital Dr. José Maria Grande, Hospital Vila Franca de Xira). His approach combines international medical standards with individualised attention to each patient.

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Dr. Agami provides medical support for patients using GLP-1 medications (such as Ozempic or Mounjaro) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Portugal and Israel.

Dr. Agami is committed to evidence-based, patient-centred care, ensuring that each person receives trusted medical support tailored to their health goals.

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Nuno Tavares Lopes

Family medicine 18 years exp.

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
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Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.

Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

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Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
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Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

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He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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Anastasiia Shalko

Family medicine 13 years exp.

Dr. Anastasiia Shalko is a general practitioner with a background in both paediatrics and general medicine. She graduated from Bogomolets National Medical University in Kyiv and completed her paediatric internship at the P.L. Shupyk National Medical Academy of Postgraduate Education. After working as a paediatrician in Kyiv, she relocated to Spain, where she has been practising general medicine since 2015, providing care for both adults and children.Her work focuses on urgent, short-term medical concerns – situations where patients need quick guidance, symptom assessment and clear next steps. She helps people understand whether their symptoms require in-person evaluation, home management or a change in treatment. Common reasons for booking an online consultation include:

  • acute respiratory symptoms (cough, sore throat, runny nose, fever)
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Dr. Shalko works specifically with urgent and short-term problems, providing practical recommendations and helping patients determine the safest next step. She explains symptoms clearly, guides patients through decision-making and offers straightforward medical advice for everyday acute issues.She does not provide long-term management of chronic conditions, ongoing follow-up or comprehensive care plans for complex long-term illnesses. Her consultations are designed for acute symptoms, sudden concerns and situations where timely medical input is important.With clinical experience in both paediatrics and general medicine, Dr. Shalko confidently supports adults and children. Her communication style is clear, simple and reassuring, helping patients feel informed and supported throughout the consultation.

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Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques. For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance. Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults. In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions. Patients commonly seek his care for: 

  • seasonal and perennial allergies
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Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.

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Doctor

Daniel Cichi

Family medicine 24 years exp.

Dr Daniel Cichi is a family medicine doctor with over 20 years of clinical experience. He provides online consultations for adults, supporting patients with acute symptoms, chronic conditions, and everyday health concerns that require timely medical guidance. His background includes work in emergency care, ambulance services, and family medicine, which allows him to assess symptoms quickly, identify warning signs, and help patients choose the safest next steps – whether that means home care, treatment adjustment, or in-person evaluation. Patients commonly consult Dr Daniel Cichi for: 

  • acute symptoms: fever, infections, flu-like illness, cough, sore throat, shortness of breath;
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  • sexually transmitted infections, erectile dysfunction;
  • muscle, joint, and back pain, minor injuries, post-traumatic symptoms;
  • chronic conditions: hypertension, diabetes, high cholesterol, thyroid disorders, weight loss, hair loss;
  • review and interpretation of lab tests, imaging reports, and medical documents;
  • medication review and treatment adjustment;
  • medical advice while travelling or living abroad;
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Dr Cichi’s consultations are structured and practical. He focuses on clear explanations, risk assessment, and actionable recommendations, helping patients understand their symptoms and make informed decisions about their health.

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€55

Frequently Asked Questions

Is a prescription required for SELEXID 400 mg FILM-COATED TABLETS?
SELEXID 400 mg FILM-COATED TABLETS requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in SELEXID 400 mg FILM-COATED TABLETS?
The active ingredient in SELEXID 400 mg FILM-COATED TABLETS is pivmecillinam. This information helps identify medicines with the same composition but different brand names.
Who manufactures SELEXID 400 mg FILM-COATED TABLETS?
SELEXID 400 mg FILM-COATED TABLETS is manufactured by Karo Pharma Ab. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of SELEXID 400 mg FILM-COATED TABLETS online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether SELEXID 400 mg FILM-COATED TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to SELEXID 400 mg FILM-COATED TABLETS?
Other medicines with the same active substance (pivmecillinam) include AMITRON 1 g POWDER FOR INJECTABLE SOLUTION, AMITRON 500 mg HARD CAPSULES, AMOXICILLIN ALMUS 1000 mg DISPERSIBLE TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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