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RAYVOW 50 mg Film-Coated Tablets

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About the medicine

How to use RAYVOW 50 mg FILM-COATED TABLETS

Contents of the leaflet

  1. Introduction
  2. What is RAYVOW and what is it used for
  3. What you need to know before you take RAYVOW
  4. How to take RAYVOW
  5. Possible side effects
  6. Storage of RAYVOW
  7. Contents of the pack and further information

Introduction

Package Leaflet: Information for the Patient

RAYVOW 50 mg film-coated tablets

RAYVOW 100 mg film-coated tablets

RAYVOW 200 mg film-coated tablets

lasmiditan

This medicine is subject to additional monitoring, which will allow for quick identification of new safety information. You can help by reporting any side effects you may get. The last section of section 4 will tell you how to report side effects.

Read all of this leaflet carefully before you start taking this medicine, because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack and other information

  1. What is RAYVOW and what is it used for
  2. What you need to know before you take RAYVOW
  3. How to take RAYVOW
  4. Possible side effects
  5. Storage of RAYVOW
  6. Contents of the pack and further information

1. What is RAYVOW and what is it used for

RAYVOW contains the active substance lasmiditan, which is used to treat the headache phase of migraine attacks with or without aura in adults.

RAYVOW helps to reduce or eliminate the pain and other symptoms associated with migraine. Pain relief can be felt even 30 minutes after taking RAYVOW.

Doctor consultation

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2. What you need to know before you take RAYVOW

Do not take RAYVOW

  • if you are allergic to lasmiditan or any of the other ingredients of this medicine (listed in section 6).

Warnings and precautions

Do not engage in activities that require your full attention, such as driving or operating machinery, within 8 hours after taking each dose of RAYVOW, even if you feel well enough to do so, because it may affect your ability to drive or operate machinery safely. If you cannot do so, you should not take RAYVOW.

Consult your doctor or pharmacist before starting to take RAYVOW if:

  • you are taking medicines that increase serotonin levels (see “Other medicines and RAYVOW”). These medicines increase the risk of side effects such as serotonin syndrome (a rare reaction that can cause mental changes, such as seeing things that do not exist (hallucinations), agitation or coma; rapid heartbeat; changes in blood pressure; high body temperature; muscle stiffness; difficulty walking; nausea, vomiting or diarrhea).
  • you are taking other medicines or substances that cause drowsiness, such as sleeping pills, medicines for psychiatric disorders or alcohol.
  • you have ever been addicted to prescription medicines, alcohol or other drugs.

If you repeatedly use any medicine for the treatment of migraine for several days or weeks, this may cause you to have daily headaches in the long term. Tell your doctor if you experience this, as it may be necessary to interrupt treatment for a while.

Children and adolescents

RAYVOW should not be given to patients under 18 years of age because there is not enough information on how it works in this age group.

Other medicines and RAYVOW

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.

In particular, tell your doctor or pharmacist before taking RAYVOW if you are taking:

  • medicines that reduce heart rate, such as propranolol
  • medicines that increase serotonin levels (including SSRIs, SNRIs, tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs) or triptans)
  • digoxin (used to treat heart disorders)

Taking RAYVOW with alcohol

Caution should be exercised if you drink alcohol while taking RAYVOW.

Pregnancy, breastfeeding and fertility

If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine. It is not known whether RAYVOW will harm your unborn baby. RAYVOW is not recommended during pregnancy.

If you are breastfeeding, ask your doctor for advice before taking this medicine. It is not known whether lasmiditan passes into breast milk. Breastfeeding should be avoided for 24 hours after treatment to minimize the amount of lasmiditan that is passed to your baby.

It is not known whether RAYVOW affects fertility.

Driving and using machines

RAYVOW affects your ability to drive and use machines. Do not engage in activities that require your full attention, such as driving or operating machinery, for at least 8 hours after taking each dose of lasmiditan, even if you feel well enough to do so. If you cannot do so, you should not take RAYVOW.

RAYVOW contains sodium

This medicine contains less than 1 mmol of sodium (23 mg) per tablet; this is essentially “sodium-free”.

3. How to take RAYVOW

Follow exactly the administration instructions of this medicine given by your doctor or pharmacist. In case of doubt, consult your doctor or pharmacist again.

  • The recommended initial dose is 100 mg of lasmiditan. Your doctor will decide which dose of lasmiditan is suitable for you.
  • If you do not stop feeling pain after the first tablet, do not take a second tablet for the same attack as it is unlikely to be effective.
  • If after a first tablet of 50 mg or 100 mg your migraine is completely resolved and then recurs, you can take a second tablet of the same dose no earlier than 2 hours after the first dose.
  • Do not take more than 200 mg in 24 hours.
  • If your dose of 100 mg does not relieve your migraine or causes side effects, talk to your doctor, who may recommend a higher dose (200 mg) or a lower dose (50 mg).

Use in children and adolescents and patients with hepatic impairment

RAYVOW is not recommended in children and adolescents (under 18 years of age) or in patients with severe liver problems.

Method of administration

RAYVOW is for oral use. You should swallow your tablet with a little water during the headache phase of your migraine attack. You can take the tablet with or without food.

If you take more RAYVOW than you should

If you take more RAYVOW than you should, contact your doctor immediately. You may develop some of the side effects described in section 4.

If you forget to take RAYVOW

RAYVOW is indicated for the acute treatment of migraines and should only be taken when needed.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Tell your doctor immediatelyif you experience any of the following serious side effects after taking this medicine:

  • allergic reactions including rash and swelling of the eyelids, face or lips (uncommon)
  • signs and symptoms of serotonin syndrome, a rare reaction that can cause mental changes, such as seeing things that do not exist (hallucinations), agitation or coma; rapid heartbeat; changes in blood pressure; high body temperature; muscle stiffness; difficulty walking; gastrointestinal symptoms such as nausea, vomiting or diarrhea.

Other side effects may include:

Very common(may affect more than 1 in 10 people):

  • Dizziness

Common(may affect up to 1 in 10 people):

  • Feeling sleepy
  • Feeling tired
  • Pins and needles or tingling in the skin
  • Feeling sick
  • Numbness
  • General feeling of being unwell
  • Feeling of spinning or loss of balance
  • Muscle weakness
  • Difficulty controlling movement, e.g. lack of coordination
  • Abnormal sensation
  • Vomiting
  • Poor quality sleep
  • Feeling your heart beating in your chest, e.g. palpitations
  • Vision problems, e.g. blurred vision

Uncommon(may affect up to 1 in 100 people):

  • Feeling restless or unable to sit or stand still
  • Agitation or tremors
  • Feeling anxious
  • Feeling hot or cold
  • Muscle cramp
  • Slowing down
  • Pain in arms or legs
  • Difficulty concentrating
  • Changes in thinking, such as memory loss or confused thinking
  • Feeling that your head is not working properly
  • Speech problems, e.g. stuttering
  • Feeling confused
  • Chest pain
  • Feeling extremely happy or excited
  • Seeing or hearing things that do not exist
  • Shortness of breath or difficulty breathing

In the hours following administration, lasmiditan has been associated with a decrease in heart rate (an average of around 5 to 10 beats per minute) and a small increase in blood pressure.

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of RAYVOW

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the blister and carton after “EXP”. The expiry date refers to the last day of the month shown.

This medicine does not require any special storage conditions.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help protect the environment.

6. Contents of the pack and further information

Composition of RAYVOW

  • The active substanceis lasmiditan.
  • RAYVOW 50 mg film-coated tablets

Each film-coated tablet contains 50 mg of lasmiditan (as succinate).

  • RAYVOW 100 mg film-coated tablets

Each film-coated tablet contains 100 mg of lasmiditan (as succinate).

  • RAYVOW 200 mg film-coated tablets

Each film-coated tablet contains 200 mg of lasmiditan (as succinate).

  • The otheringredients are: croscarmellose sodium, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate, pregelatinized starch
  • For the gray color mixture of 50 mg and 200 mg: polyvinyl alcohol, titanium dioxide (E171), macrogol 3350, talc, iron oxide black (E172)
  • For the purple color mixture of 100 mg: polyvinyl alcohol, titanium dioxide (E171), macrogol 3350, talc, iron oxide black (E172), iron oxide red (E172)

Appearance and packaging

RAYVOW is available in 3 doses: 50 mg, 100 mg and 200 mg

  • The 50 mg film-coated tablets are oval, light gray, with “4312” on one side and “L-50” on the other.
  • The 100 mg film-coated tablets are oval, light purple, with “4491” on one side and “L-100” on the other.
  • The 200 mg film-coated tablets are oval, gray, with “4736” on one side and “L-200” on the other.

RAYVOW is available in single-dose precut blisters of polychlorotrifluoroethylene/polyvinyl chloride (PCTFE/PVC) and polyvinyl chloride (PVC) sealed with an aluminum foil in packs of 2 x 1, 4 x 1, 6 x 1, 12 x 1 and 16 x 1 film-coated tablets. Not all pack sizes may be marketed.

Marketing authorization holder

Eli Lilly Nederland B.V.,

Papendorpseweg 83,

3528 BJ Utrecht,

Netherlands

Manufacturer

Lilly S.A.,

Avda. de la Industria, 30,

28108 Alcobendas,

Madrid,

Spain

You can request more information about this medicine from the local representative of the marketing authorization holder:

Belgium/Belgique/Belgien

Eli Lilly Benelux S.A./N.V.

Tel: + 32-(0)2 548 84 84

Lithuania

Eli Lilly Lietuva

Tel: +370 (5) 2649600

Text in Bulgarian language with contact information of a pharmaceutical company and phone number

Luxembourg/Luxemburg

Eli Lilly Benelux S.A./N.V.

Tel: + 32-(0)2 548 84 84

Czech Republic

ELI LILLY CR, s.r.o.

Tel: + 420 234 664 111

Hungary

Lilly Hungária Kft.

Tel: + 36 1 328 5100

Denmark

Eli Lilly Danmark A/S

Tel: +45 45 26 60 00

Malta

Charles de Giorgio Ltd.

Tel: + 356 25600 500

Germany

Lilly Deutschland GmbH

Tel: + 49-(0) 6172 273 2222

Netherlands

Eli Lilly Nederland B.V.

Tel: + 31-(0) 30 60 25 800

Estonia

Eli Lilly Nederland B.V.

Tel: +372 6 817 280

Norway

Eli Lilly Norge A.S.

Tel: + 47 22 88 18 00

Greece

ΦΑΡΜΑΣΕΡΒ-ΛΙΛΛΥ Α.Ε.Β.Ε.

Tel: +30 210 629 4600

Austria

Eli Lilly Ges.m.b.H.

Tel: + 43-(0) 1 711 780

Spain

Organon Salud, S.L.

Tel: +34 91 591 12 79

Poland

Eli Lilly Polska Sp. z o.o.

Tel: +48 22 440 33 00

France

Organon France

Tel: +33-(0) 1 57 77 32 00

Portugal

Lilly Portugal Produtos Farmacêuticos, Lda

Tel: + 351-21-4126600

Croatia

Eli Lilly Hrvatska d.o.o.

Tel: +385 1 2350 999

Romania

Eli Lilly România S.R.L.

Tel: + 40 21 4023000

Ireland

Eli Lilly and Company (Ireland) Limited

Tel: + 353-(0) 1 661 4377

Slovenia

Eli Lilly farmacevtska družba, d.o.o.

Tel: +386 (0)1 580 00 10

Iceland

Icepharma hf.

Tel: + 354 540 8000

Slovakia

Eli Lilly Slovakia s.r.o.

Tel: + 421 220 663 111

Italy

Eli Lilly Italia S.p.A.

Tel: + 39- 055 42571

Finland

Oy Eli Lilly Finland Ab

Tel: + 358-(0) 9 85 45 250

Cyprus

Phadisco Ltd

Tel: +357 22 715000

Sweden

Eli Lilly Sweden AB

Tel: + 46-(0) 8 7378800

Latvia

Eli Lilly (Suisse) S.A Parstavnieciba Latvija

Tel: +371 67364000

United Kingdom (Northern Ireland)

Eli Lilly and Company (Ireland) Limited

Tel: + 353-(0) 1 661 4377

Date of last revision of this leaflet:

Other sources of information

Detailed information on this medicine is available on the European Medicines Agency website: http://www.ema.europa.eu, and on the website of the Spanish Agency for Medicines and Health Products (AEMPS) (http://www.aemps.gob.es/).

Online doctors for RAYVOW 50 mg FILM-COATED TABLETS

Discuss questions about RAYVOW 50 mg FILM-COATED TABLETS, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

Doctor
5.0(38)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a General Practitioner with specialized training in chronic pain. He provides online consultations for adult patients in Spain and other European countries.

Dr. Popov understands that seeking help with weight-related concerns or pain that has persisted for months can be difficult. Many patients come to him after trying different approaches without feeling truly heard. During the consultation, the doctor creates a comfortable and supportive, non-judgmental environment where the patient’s medical history can be discussed in detail, questions can be answered, and the next steps can be decided together.

Weight Management and Metabolic Health

Dr. Popov can help assess overweight, obesity, and related conditions such as hypertension, diabetes, or metabolic disorders. During the consultation, the patient’s medical history, test results, current medications, and previous treatments will be reviewed.

If you would like to learn about possible medication options or have already started treatment, the doctor can assess your situation, review the effectiveness and tolerability of the therapy, and clearly explain its benefits, potential risks, and alternatives.

Not every patient requires the same treatment. A consultation does not guarantee a prescription — it provides an objective medical assessment and a plan tailored to your individual situation.

Pain and General Medicine

You can also consult Dr. Popov regarding:

* chronic pain, migraines, neuralgia, and fibromyalgia;

* back, neck, lower back, or joint pain;

* hypertension, diabetes, and follow-up of chronic conditions;

* review of test results, medical reports, and current treatment;

* preventive medicine and a second medical opinion.

How the Consultation Works

The video consultation lasts up to 30 minutes. The doctor will listen carefully, review the information you provide, and explain the next steps in clear and understandable language.

If additional tests, an in-person consultation, or urgent medical care are required, the doctor will inform you directly.

Dr. Popov’s goal is to make sure the patient feels heard and leaves the consultation with a clear understanding of their condition and the next steps they can take.

Book a video appointment
€86
Doctor
5.0(12)

Yevgen Yakovenko

General medicine12 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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€72
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5.0(3)

Lina Travkina

General medicine13 years of experience

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.

  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.

  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.

  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.

  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.

  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.

  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.

  • Medical advice and follow-up consultations.

  • Test interpretation and diagnostic guidance.

  • Structured support for undiagnosed complaints.

  • Second opinion on diagnoses and treatment plans.

  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.

  • Post-operative recovery support and pain management.

  • Preconception counselling and postpartum support.

  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

Book a video appointment
€75
Doctor
5.0(21)

Nuno Tavares Lopes

General medicine18 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies

  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management

  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses

  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment

  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance

  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis

  • Pain management: acute and chronic pain, post-surgical care

  • Public health: prevention, health screenings, long-term monitoring

  • Sick leave (Baixa médica) connected to Segurança Social in Portugal

  • IMT medical certificates for driving licence exchange

Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

Book a video appointment
€70

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Frequently Asked Questions

RAYVOW 50 mg FILM-COATED TABLETS requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

The active ingredient in RAYVOW 50 mg FILM-COATED TABLETS is lasmiditan. This information helps identify medicines with the same composition but different brand names.

The average pharmacy price for RAYVOW 50 mg FILM-COATED TABLETS is around 15.61 EUR. Prices may vary depending on the manufacturer and dosage form.

RAYVOW 50 mg FILM-COATED TABLETS is manufactured by Eli Lilly Nederland B.V.. Pharmacy brands and packaging may differ depending on the distributor.

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether RAYVOW 50 mg FILM-COATED TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy RAYVOW 50 mg FILM-COATED TABLETS in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

Other medicines with the same active substance (lasmiditan) include RAYVOW 100 mg FILM-COATED TABLETS, ALMOGRAN 12.5 mg FILM-COATED TABLETS, ALMOTRIPTAN CINFA 12.5 mg FILM-COATED TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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