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QUADRAMET Injectable Solution

Prescription review online

Prescription review online

A doctor will review your case and decide whether a prescription is medically appropriate.

Talk to a doctor about this medicine

Talk to a doctor about this medicine

Discuss your symptoms and possible next steps in a quick online consultation.

This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use QUADRAMET Injectable Solution

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introducción

Prospecto: información para el paciente

Quadramet 1,3 GBq/ml solución inyectable

Samario (153Sm) lexidronam pentasódico

Lea todo el prospecto detenidamente antes de empezar a usar este medicamento, porque contiene información importante para usted.

  • Conserve este prospecto, ya que puede tener que volver a leerlo.
  • Si tiene alguna duda, consulte a su médico o farmacéutico.
  • Si experimenta efectos adversos, consulte a su médico o farmacéutico, incluso si se trata de efectos adversos que no aparecen en este prospecto. Ver sección 4.

Contenido del prospecto:

  1. Qué es Quadramet y para qué se utiliza
  2. Qué necesita saber antes de empezar a usar Quadramet
  3. Cómo usar Quadramet
  4. Posibles efectos adversos
  5. Conservación de Quadramet
  6. Contenido del envase e información adicional

1. Qué es Quadramet y para qué se utiliza

Quadramet es un medicamento para uso exclusivamente terapéutico.

Este radiofármaco se emplea para el tratamiento del dolor óseo que le ocasiona su enfermedad.

Quadramet tiene gran afinidad por el tejido óseo. Una vez inyectado se concentra en las lesiones óseas. Como Quadramet contiene pequeñas cantidades de un elemento radiactivo, el samario 153, administra radiación local a las lesiones óseas, lo que permite desarrollar una acción paliativa sobre el dolor óseo.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. Qué necesita saber antes de empezar a usar Quadramet

No use Quadramet:

  • Si es alérgico al ácido etilendiaminotetrametilenofosfónico (EDTMP), a compuestos similares con fosfonatos o a cualquiera de los demás componentes de este medicamento (incluidos en la sección 6).
  • Si está embarazada,
  • Si ha recibido quimioterapia o radioterapia externa hemicorporal en las 6 semanas previas a la administración del medicamento.

Advertencias y precauciones

Consulte a su médico antes de empezar a tomar Quadramet.

Su médico le extraerá sangre todas las semanas durante 8 semanas como mínimo para medirle la cifra de plaquetas, glóbulos rojos y glóbulos blancos, que pueden disminuir ligeramente debido al tratamiento.

En las 6 horas siguientes a la administración de Quadramet su médico le indicará que debe beber y orinar tan a menudo como le sea posible. Él decidirá en qué momento puede abandonar el departamento de medicina nuclear.

En caso de incontinencia urinaria o de obstrucción urinaria se le colocará una sonda urinaria durante 6 horas aproximadamente. En el resto de los pacientes la orina será recogida durante al menos 6 horas.

Si presenta una reducción de la función renal se ajustará la cantidad del medicamento a administrar.

Niños y adolescentes

QUADRAMET no está recomendado para uso en niños menores de 18 años.

Uso de Quadramet con otros medicamentos

Informe a su médico si está utilizando, ha utilizado recientemente o podría tener que utilizar cualquier otro medicamento.

Embarazo y lactancia

Si está embarazada o en período de lactancia, cree que podría estar embarazada o tiene intención de quedarse embarazada, consulte a su médico antes de utilizar este medicamento.

Quadramet no debe administrarse a mujeres embarazadas.

Si se considera necesaria la administración de Quadramet a una mujer que está en periodo de lactancia, dicho periodo de lactancia debe ser interrumpido.

3. Cómo usar Quadramet

Antes de administrarle Quadramet su médico querrá someterle a una exploración diagnóstica especial (gammagrafía) para determinar si es posible que se beneficie de Quadramet.

Posología

Debe inyectarse una sola dosis de 37 megabequerelios (el bequerelio es la unidad en que se mide la radiactividad) de Quadramet por kilogramo de peso corporal.

Si tiene la impresión de que el efecto de Quadramet es demasiado fuerte o débil, consulte a su médico o farmacéutico.

Método y vía de administración

Quadramet debe ser administrado mediante inyección lenta en una vena.

Frecuencia de administración

La inyección de este medicamento no se realiza de forma regular o continua. No obstante, la administración puede ser repetida después de 8 semanas de la última inyección, dependiendo de la evolución de su enfermedad.

Duración del tratamiento

Podrá abandonar el departamento de medicina nuclear tras someterse a un seguimiento dosimétrico (generalmente en las 6 horas siguientes a la inyección de Quadramet).

Si usa más Quadramet del que debiera

Como Quadramet se suministra en un vial de dosis única, es poco probable que se produzca una sobredosis accidental.

Se puede limitar la dosis de radiación recibida por el organismo aumentando la ingesta de fluidos y orinando frecuentemente.

Si tiene cualquier otra duda sobre el uso de este producto, pregunte a su médico o farmacéutico.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Posibles efectos adversos

Al igual que todos los medicamentos, Quadramet puede producir efectos adversos, aunque no todas las personas los sufran.

Los efectos adversos que produce la administración de Quadramet tienen que ver con una disminución de los glóbulos rojos y blancos y de las plaquetas. Se han informado casos de hemorragias, algunos de ellos graves.

Por este motivo sus recuentos sanguíneos serán controlados de forma rigurosa durante algunas semanas tras la inyección de Quadramet.

Excepcionalmente puede notar un ligero aumento del dolor óseo unos días después de la inyección de Quadramet. No debe alarmarse por ello; en ese caso se le aumentará ligeramente el medicamento para el dolor. Es un efecto breve y moderado que desaparecerá en unas horas.

Se han comunicado reacciones adversas del fármaco tales como náuseas, vómitos, diarrea y sudoración.

Se han comunicado reacciones de hipersensibilidad que incluyen casos raros de reacción anafiláctica tras la administración de Quadramet.

En casos raros se han observado las siguientes reacciones adversas: neuralgia, trastornos de la coagulación y accidentes cerebrovasculares. Se consideró que estos efectos estaban relacionados con el avance de la enfermedad.

Si experimenta dolor de espalda o anomalías de la sensibilidad, informe a su médico cuanto antes.

Comunicación de efectos adversos

Si experimenta cualquier tipo de efecto adverso, consulte a su médico o farmacéutico, incluso si se trata de posibles efectos adversos que no aparecen en este prospecto. También puede comunicarlos directamente a través del sistema nacional de notificación incluido en el Anexo V. Mediante la comunicación de efectos adversos usted puede contribuir a proporcionar más información sobre la seguridad de este medicamento.

5. Conservación de Quadramet

Mantener este medicamento fuera del alcance y de la vista de los niños.

No utilizar Quadramet después de la fecha de caducidad que aparece en el envase.

Quadramet caduca al día siguiente de la hora de referencia de actividad que figura en la etiqueta.

Conservar entre -10ºC y -20ºC en congelador en su envase original.

Quadramet debe ser utilizado en las 6 horas siguientes a la descongelación. Después de descongelado no congelar de nuevo.

En la etiqueta del medicamento se señalan las condiciones adecuadas de conservación y la fecha de caducidad para el lote del medicamento. El personal del hospital se asegurará que el producto se conserva correctamente y no se administra después de la fecha de caducidad señalada.

Los procedimientos de conservación deben cumplir las normas nacionales sobre materiales radiactivos.

6. Contenido del envase e información adicional

Composición de Quadramet

El principio activo es samario (153Sm) lexidronam pentasódico.

Cada ml de solución contiene 1,3 GBq/ml de Samario (153Sm) lexidronam pentasódico en la fecha de referencia (que corresponden a 20 - 80 µg/ml de samario por vial).

Los demás componentes son EDTMP total (como EDTMP.H2O), sal sódica de calcio-EDTMP (como Ca), sodio total (como Na), agua para inyectables.

Aspecto de Quadramet y contenido del envase

Quadramet es una solución inyectable.

Este medicamento es una solución transparente, entre incolora y de color ámbar claro envasada en un vial de vidrio incoloro tipo I de la Farmacopea Europea, de 15 ml, cerrado con tapón de caucho natural/clorobutilo recubierto de teflón y cápsula de aluminio

Cada vial contiene 1,5 ml (2 GBq en la fecha de referencia) a 3,1 ml (4 GBq en la fecha de referencia) de solución inyectable.

Titular de la autorización de comercialización y responsable de la fabricación

CIS bio international

Boîte Postale 32

F-91192 Gif-sur-Yvette cedex

Francia

Fecha de la última revisión de este prospecto: {MM/AAAA}

La información detallada de este medicamento está disponible en la página web de la Agencia Europea del Medicamento (EMEA) http://www.ema.europa.eu/

Esta información está destinada únicamente a médicos o profesionales del sector sanitario:Para información detallada referirse al Resumen de Características del Producto de QUADRAMET. Con el fin de ofrecer a los profesionales sanitarios información científica y práctica adicional sobre la administración y el uso de este radiofármaco, se incluye el Resumen de las Características del Producto de Quadramet como un documento aparte en el envase del producto.

Consulte el Resumen de las Características del Producto (que debe incluirse en el envase)

Online doctors for QUADRAMET Injectable Solution

Discuss questions about QUADRAMET Injectable Solution, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

5.0 (1056)
Doctor

Andrei Popov

General medicine 7 years exp.

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

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€80
5.0 (94)
Doctor

Tarek Agami

General medicine 11 years exp.

Dr. Tarek Agami is a general practitioner registered in both Portugal and Israel, with broad experience in family and preventive medicine. He offers online consultations for adults and children, providing personalised support for primary care needs, chronic disease management, and everyday health concerns.

Dr. Agami received clinical training and worked in leading medical institutions in Israel (Kaplan Medical Center, Barzilai Medical Center, Wolfson Medical Center) and Portugal (European Healthcare City, Viscura Internacional, Hospital Dr. José Maria Grande, Hospital Vila Franca de Xira). His approach combines international medical standards with individualised attention to each patient.

Main areas of consultation:

  • Diagnosis and treatment of acute and chronic conditions (high blood pressure, diabetes, respiratory infections, cardiovascular symptoms)
  • Evaluation of symptoms and guidance on further diagnostic testing
  • Preventive check-ups and regular health monitoring
  • Medical support during travel or after relocation
  • Treatment adjustments and lifestyle recommendations based on your personal history
Dr. Agami provides medical support for patients using GLP-1 medications (such as Ozempic or Mounjaro) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Portugal and Israel.

Dr. Agami is committed to evidence-based, patient-centred care, ensuring that each person receives trusted medical support tailored to their health goals.

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€69
5.0 (130)
Doctor

Nuno Tavares Lopes

Family medicine 18 years exp.

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management
  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses
  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment
  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance
  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis
  • Pain management: acute and chronic pain, post-surgical care
  • Public health: prevention, health screenings, long-term monitoring
  • Sick leave (Baixa médica) connected to Segurança Social in Portugal
  • IMT medical certificates for driving licence exchange
Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.

Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

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€59
5.0 (38)
Doctor

Jorge Correa Bellido

General medicine 7 years exp.

Dr. Jorge Correa Bellido is a Spanish physician who offers online consultations in Spanish and English. He graduated from the University of La Laguna and has a solid background in clinical practice and international research.

Throughout his career, he has participated in various medical and academic projects, including a research fellowship in Spain, where he contributed to evidence-based studies in the field of family medicine. This experience allowed him to broaden his global perspective on healthcare and comprehensive patient care.

Dr. Correa Bellido has worked with several healthcare providers in Spain, focusing particularly on patient-centered care and public health initiatives aimed at communities with limited access to healthcare services.

In addition, he actively participates in international medical conferences and workshops, which allows him to stay up to date with the latest medical advances and collaborate with healthcare professionals from different countries.

Dr. Correa Bellido provides comprehensive care for a wide variety of medical conditions, including:

  • respiratory infections
  • gastrointestinal disorders
  • cardiovascular problems
  • endocrine and metabolic diseases
  • musculoskeletal and dermatological conditions
  • as well as mental health conditions such as anxiety and depression.

He also treats infectious and allergic diseases, general health concerns, and provides guidance on prevention and healthy lifestyle habits.

His services include virtual consultations, diagnosis and management of acute and chronic diseases, prescription renewals, and personalized medical advice.

With a patient-centered approach and a strong commitment to continuous learning, Dr. Correa Bellido provides accessible and high-quality healthcare to patients both in Spain and around the world.

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€55
5.0 (49)
Doctor

Anastasiia Shalko

Family medicine 13 years exp.

Dr. Anastasiia Shalko is a general practitioner with a background in both paediatrics and general medicine. She graduated from Bogomolets National Medical University in Kyiv and completed her paediatric internship at the P.L. Shupyk National Medical Academy of Postgraduate Education. After working as a paediatrician in Kyiv, she relocated to Spain, where she has been practising general medicine since 2015, providing care for both adults and children.Her work focuses on urgent, short-term medical concerns – situations where patients need quick guidance, symptom assessment and clear next steps. She helps people understand whether their symptoms require in-person evaluation, home management or a change in treatment. Common reasons for booking an online consultation include:

  • acute respiratory symptoms (cough, sore throat, runny nose, fever)
  • viral illnesses such as colds and seasonal infections
  • gastrointestinal complaints (nausea, diarrhoea, abdominal pain, gastroenteritis)
  • sudden changes in how a child or adult feels
  • questions about existing treatment and whether adjustments are needed
  • renewal of prescriptions when clinically appropriate

Dr. Shalko works specifically with urgent and short-term problems, providing practical recommendations and helping patients determine the safest next step. She explains symptoms clearly, guides patients through decision-making and offers straightforward medical advice for everyday acute issues.She does not provide long-term management of chronic conditions, ongoing follow-up or comprehensive care plans for complex long-term illnesses. Her consultations are designed for acute symptoms, sudden concerns and situations where timely medical input is important.With clinical experience in both paediatrics and general medicine, Dr. Shalko confidently supports adults and children. Her communication style is clear, simple and reassuring, helping patients feel informed and supported throughout the consultation.

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€50
5.0 (5)
Doctor

Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques. For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance. Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults. In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions. Patients commonly seek his care for: 

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns

Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.

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€80

Frequently Asked Questions

Is a prescription required for QUADRAMET Injectable Solution?
QUADRAMET Injectable Solution requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in QUADRAMET Injectable Solution?
The active ingredient in QUADRAMET Injectable Solution is samarium (153Sm) lexidronam. This information helps identify medicines with the same composition but different brand names.
Who manufactures QUADRAMET Injectable Solution?
QUADRAMET Injectable Solution is manufactured by Cis Bio International. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of QUADRAMET Injectable Solution online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether QUADRAMET Injectable Solution is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to QUADRAMET Injectable Solution?
Other medicines with the same active substance (samarium (153Sm) lexidronam) include ERBIUM CITRATE (169Er) colloidal CIS BIO INTERNACIONAL 111 MBq/ML INJECTABLE SUSPENSION, Yttrium Citrate (90 Y) Colloidal CIS BIO INTERNATIONAL 37-370 MBq/ml Injectable Suspension, SODIUM IODIDE (I131) CURIUM PHARMA SPAIN 37-7400 MBq CAPSULES. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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