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About the medicine

How to use PRIMPERAN 10 mg TABLETS

Contents of the leaflet

  1. Introduction
  2. What is Primperan and what is it used for
  3. What you need to know before you take Primperan
  4. How to take Primperan
  5. Possible side effects
  6. Storage of Primperan
  7. Contents of the pack and other information

Introduction

Package Leaflet: Information for the User

Primperan 10 mg Tablets

Metoclopramide Hydrochloride

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the package leaflet:

  1. What is Primperan and what is it used for
  2. What you need to know before you take Primperan
  3. How to take Primperan
  4. Possible side effects
  5. Storage of Primperan
  1. Contents of the pack and other information

1. What is Primperan and what is it used for

Primperan is an antiemetic. It contains a medicine called metoclopramide. It works in an area of the brain that prevents nausea or vomiting.

Adult Population

Primperan is used in adults:

  • to prevent delayed nausea and vomiting that may occur after chemotherapy
  • to prevent nausea and vomiting caused by radiotherapy
  • to treat nausea and vomiting, including nausea and vomiting that may occur with migraine

Metoclopramide can be taken in combination with oral painkillers in the case of migraine to make the painkillers more effective.

Pediatric Population

Primperan is indicated in children (1-18 years of age) if other treatments do not work or cannot be used to prevent delayed nausea and vomiting that may occur after chemotherapy.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you take Primperan

Do not take Primperan

  • if you are allergic to metoclopramide or any of the other ingredients of this medicine (listed in section 6)
  • if you have bleeding, obstruction or perforation in the stomach or intestine
  • if you have or could have a rare tumor of the adrenal gland, which is near the kidney (pheochromocytoma)
  • if you have ever had involuntary muscle spasms (tardive dyskinesia) when you have been treated with a medicine
  • if you have epilepsy
  • if you have Parkinson's disease
  • if you are taking levodopa (a medicine for Parkinson's disease) or dopaminergic agonists (see below "Using Primperan with other medicines")
  • if you have ever had abnormal levels of blood pigments (methemoglobinemia) or NADH cytochrome b5 reductase deficiency.

Do not give Primperan to children under 1 year of age (see below "Children and adolescents").

Do not take Primperan if any of the above applies to you. If you are not sure, consult your doctor, pharmacist, or nurse before taking Primperan.

Warnings and precautions

Consult your doctor, pharmacist, or nurse before taking Primperan if:

  • you have a history of abnormal heartbeats (prolonged QT interval) or any other heart problem
  • you have problems with salt levels in your blood, such as potassium, sodium, and magnesium
  • you are using other medicines known to affect the way your heart beats
  • you have any neurological problem (brain)
  • you have liver or kidney problems. The dose may need to be reduced (see section 3).

Your doctor may perform blood tests to check your blood pigment levels. In cases of abnormal levels (methemoglobinemia), treatment should be stopped immediately and permanently.

You should wait at least 6 hours between each dose of metoclopramide, even in the case of vomiting or rejection of the dose, to avoid overdose.

Do not exceed 3 months of treatment due to the risk of involuntary muscle spasms.

Children and adolescents

Uncontrollable movements (extrapyramidal disorders) may occur in children and young adults. This medicine should not be used in children under 1 year of age due to the high risk of uncontrollable movements (see above "Do not take Primperan").

Using Primperan with other medicines

Tell your doctor, pharmacist, or nurse if you are taking, have recently taken, or might take any other medicines. This is because some medicines may affect the way Primperan works or Primperan may affect the way other medicines work. These medicines include:

  • levodopa or other medicines used to treat Parkinson's disease (see above "Do not take Primperan")
  • anticholinergics (medicines used to relieve stomach spasms or cramps)
  • opioid derivatives (medicines used to treat severe pain)
  • sedatives
  • any medicine used to treat mental health problems
  • digoxin (a medicine used to treat heart failure)
  • cyclosporin (a medicine used to treat some problems of the immune system)
  • mivacurium and suxamethonium (medicines used to relax muscles)
  • fluoxetine and paroxetine (medicines used to treat depression).
  • rifampicin (a medicine used to treat tuberculosis or other infections), may reduce the amount of metoclopramide in the blood if administered at the same time.

Using Primperan with alcohol

Do not drink alcohol during treatment with metoclopramide because it increases the sedative effect of Primperan.

Pregnancy and breastfeeding

If you are pregnant, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medicine.

Primperan can be taken during pregnancy if necessary. Your doctor will decide whether or not to administer this medicine.

Primperan is not recommended if you are breastfeeding because metoclopramide passes into breast milk and may affect your baby.

Driving and using machines

After taking Primperan, you may feel drowsy, dizzy, or have uncontrollable movements of tics, twitches, or torsion and muscle tone that causes body distortion. This may affect your vision and also interfere with your ability to drive and use machines.

Primperan 10 mg tablets contain lactose

This medicine contains lactose. If your doctor has told you that you have an intolerance to some sugars, consult them before taking this medicine.

3. How to take Primperan

Follow exactly the administration instructions of this medicine indicated by your doctor. In case of doubt, consult your doctor or pharmacist again.

All indications (adult patients)

A single dose of 10 mg is recommended, which can be repeated up to three times a day.

The maximum recommended daily dose is 30 mg or 0.5 mg/kg of body weight.

The maximum treatment duration is 5 days.

To prevent delayed nausea and vomiting that may occur after chemotherapy (children 1-18 years of age)

The recommended dose is 0.1 to 0.15 mg/kg of body weight, which can be repeated up to three times a day, taken orally.

The maximum dose in 24 hours is 0.5 mg/kg of body weight.

Dosing Table

Age

Body weight

Dose

Frequency

1-3 years

10-14 kg

1 mg

Up to 3 times a day

3-5 years

15-19 kg

2 mg

Up to 3 times a day

5-9 years

20-29 kg

2.5 mg

Up to 3 times a day

9-18 years

30-60 kg

5 mg

Up to 3 times a day

15-18 years

Over 60 kg

10 mg

Up to 3 times a day

Do not take this medicine for more than 5 days to prevent delayed nausea and vomiting that may occur after chemotherapy.

Primperan tablets are not suitable for use in children with a weight below 61 kg. Other pharmaceutical forms/doses may be more suitable for administration (e.g., oral solution or injectable solution).

Method of administration

You should wait at least 6 hours between each dose of metoclopramide, even in the case of vomiting or rejection of the dose, to avoid overdose.

Special populations

Elderly population

The dose may need to be reduced depending on kidney problems, liver problems, and general health problems.

Other pharmaceutical forms/doses may be more suitable for administration (e.g., oral solution or injectable solution).

Adults with renal problems

Tell your doctor if you have kidney problems. The dose should be reduced if you have moderate to severe kidney problems.

This presentation is not suitable for administration. Other pharmaceutical forms/doses may be more suitable for administration (e.g., oral solution or injectable solution).

Adults with hepatic problems

Tell your doctor if you have liver problems. The dose should be reduced if you have severe liver problems.

This presentation is not suitable for administration. Other pharmaceutical forms/doses may be more suitable for administration (e.g., oral solution or injectable solution).

Children and adolescents

Metoclopramide should not be used in children under 1 year of age (see section 2).

If you take more Primperan than you should

Contact your doctor or pharmacist immediately. You may experience uncontrollable movements (extrapyramidal disorders), feel drowsy, have some consciousness problems, be confused, have hallucinations, and heart problems. Your doctor may prescribe a treatment for these effects if necessary.

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or call the Toxicological Information Service, phone: 91 562 04 20, indicating the medicine and the amount ingested.

If you forget to take Primperan

Do not take a double dose to make up for forgotten doses.

If you have any other questions about the use of this medicine, ask your doctor, nurse, or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

  • Frequency not known(frequency cannot be estimated from the available data) allergic reactions (such as anaphylaxis, angioedema, and urticaria).

Symptoms may include rash, itching, difficulty breathing, shortness of breath, swelling of the face, lips, throat, or tongue, cold, sweaty skin, palpitations, dizziness, weakness, or fainting.

Contact your doctor or another healthcare professional or go to the emergency department of the nearest hospital immediately.

Stop treatment and inform your doctor, pharmacist, or nurse immediately if you experience one of the following signs while taking this medicine:

  • uncontrollable movements (which often affect the head and neck). These can occur in children and young adults and particularly when high doses are used. These signs usually appear at the beginning of treatment and can even occur after a single administration. These movements will stop when treated properly.
  • high fever, high blood pressure, convulsions, sweating, saliva production. These can be signs of a condition called malignant neuroleptic syndrome.
  • itching and skin rashes, facial swelling, lip or throat swelling, difficulty breathing. These can be signs of an allergic reaction, which can be severe.

Very common(may affect more than 1 in 10 people)

  • feeling drowsy.

Common(may affect up to 1 in 10 people)

  • depression
  • uncontrollable movements such as tics, twitches, torsion movements, or muscle contractions (stiffness, rigidity)
  • symptoms similar to Parkinson's disease (stiffness, tremor)
  • feeling restless
  • decreased blood pressure (particularly with intravenous administration)
  • diarrhea
  • feeling weak.

Uncommon(may affect up to 1 in 100 people)

  • high levels in the blood of a hormone called prolactin that can produce: milk production in men and women who are not breastfeeding
  • irregular periods
  • hallucinations
  • decreased level of consciousness
  • slow heart rate (particularly with intravenous administration)
  • allergy
  • visual disturbances and involuntary deviation of the eyeball.

Rare(may affect up to 1 in 1,000 people)

  • confusion
  • convulsions (especially in patients with epilepsy).

Frequency not known(frequency cannot be estimated from the available data)

  • abnormal levels of blood pigments: which can change the color of your skin
  • abnormal development of the breasts (gynecomastia)
  • involuntary muscle spasms after prolonged use, particularly in elderly patients
  • high fever, high blood pressure, convulsions, sweating, saliva production. These can be signs of a condition called malignant neuroleptic syndrome
  • changes in heartbeats, which can be seen on an ECG (electrocardiogram)
  • cardiac arrest (particularly with intravenous administration)
  • shock (sharp drop in blood pressure) (particularly with intravenous administration)
  • fainting (particularly with intravenous administration)
  • very high blood pressure
  • suicidal thoughts.

Reporting of side effects

If you experience any side effects, consult your doctor or pharmacist, even if it is possible side effects not listed in this leaflet. You can also report them directly through the Spanish Pharmacovigilance System for Human Use Medicines: https://www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Primperan

Keep this medicine out of the sight and reach of children.

Store below 25°C.

Do not use Primperan after the expiration date stated on the packaging after EXP. The expiration date is the last day of the month indicated.

Medicines should not be disposed of via wastewater or household waste. Dispose of the packaging and any unused medicine in the SIGRE collection point at the pharmacy. If in doubt, ask your pharmacist how to dispose of the packaging and any unused medicine. This will help protect the environment.

6. Contents of the pack and other information

Composition of Primperan 10 mg tablets

  • The active ingredient is metoclopramide hydrochloride. Each tablet contains 10 mg of metoclopramide hydrochloride.
  • The other ingredients are: lactose monohydrate, microcrystalline cellulose, corn starch, anhydrous colloidal silica, and magnesium stearate.

Appearance of the product and packaging contents

They are flat, scored, white to off-white tablets.

They are packaged in blister packs of 30 and 60 tablets for oral administration.

Other presentations:

Primperan 1 mg/ml oral solution: Bottle with 200 ml

Primperan 10 mg/2 ml injectable solution: Pack with 12 ampoules of 2 ml

Marketing authorization holder

sanofi-aventis, S.A.

C/ Rosselló i Porcel, 21

08016 Barcelona

Spain

Manufacturer

Famar Health Care Services Madrid, S.A.U.

Avda. de Leganés, 62

28923 - Alcorcón (Madrid)

Spain

or

Delpharm Dijon

6, Boulevard de l’Europe

21800 Quetigny

France

Date of last revision of this leaflet: February 2023

Detailed information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/

Online doctors for PRIMPERAN 10 mg TABLETS

Discuss questions about PRIMPERAN 10 mg TABLETS, including use, safety considerations and whether a prescription is appropriate, subject to medical assessment and local regulations.

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Nuno Tavares Lopes

General medicine18 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

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Jorge Correa Bellido

General medicine7 years of experience
Licence no. 464626297

Dr. Jorge Correa Bellido is a Spanish physician who offers online consultations in Spanish and English. He graduated from the University of La Laguna and has a solid background in clinical practice and international research.

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Anastasiia Shalko

General medicine13 years of experience
Licence no. 52891

Dr. Anastasiia Shalko is a general practitioner with a background in both paediatrics and general medicine. She graduated from Bogomolets National Medical University in Kyiv and completed her paediatric internship at the P.L. Shupyk National Medical Academy of Postgraduate Education. After working as a paediatrician in Kyiv, she relocated to Spain, where she has been practising general medicine since 2015, providing care for both adults and children.Her work focuses on urgent, short-term medical concerns – situations where patients need quick guidance, symptom assessment and clear next steps. She helps people understand whether their symptoms require in-person evaluation, home management or a change in treatment. Common reasons for booking an online consultation include:

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Hocine Lokchiri

General medicine21 years of experience

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

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Chikeluo Okeke

General medicine4 years of experience

Dr Chikeluo Okeke is an internal medicine doctor with extensive international clinical experience. Originally from Nigeria, he has worked across multiple European healthcare systems and currently practises in Sweden. This professional path has given him a strong understanding of different medical approaches and the ability to work effectively with patients from diverse cultural and linguistic backgrounds.

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Lizaveta Trafimchuk Takhvaniuk

DermatologyGeneral medicine10 years of experience
Licence no. 58788

Dr. Lizaveta Trafimchuk Takhvaniuk graduated in Medicine and subsequently specialized in Dermatology and Venereology. She has more than 10 years of clinical experience and is licensed to practice in Spain, where she focuses on the comprehensive diagnosis and treatment of dermatological conditions.

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Cristina Andrada Brazo

General medicineSleep medicine16 years of experience
Licence no. 264505958

Dr. Cristina Andrada Brazo is a highly experienced Spanish physician with more than 15 years of clinical practice in emergency medicine, urgent care, and clinical neurophysiology. She provides professional online medical consultations for patients across Spain, helping both residents and international visitors receive timely medical advice, diagnosis, treatment recommendations, and electronic prescriptions when clinically appropriate.

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Dr. Andrada combines extensive emergency medicine experience with advanced expertise in neurology, epilepsy, sleep medicine, and headache disorders. Her international clinical background includes several years working in Switzerland, where she collaborated with multidisciplinary teams in emergency departments and neurology services. This experience strengthened her commitment to evidence-based medicine, compassionate communication, and high-quality patient care.

She graduated in Medicine from the University of Seville and completed her residency in Clinical Neurophysiology at Hospital Virgen de la Salud and the National Hospital for Paraplegics in Toledo. She currently works as a Clinical Neurophysiology Specialist at Hospital San Pedro in Logroño.

To further expand her expertise, Dr. Andrada completed several postgraduate qualifications, including Master's degrees in Sleep Physiology and Medicine, Medical Professionalism and Clinical Practice, Epilepsy, and Clinical Management.

Patients appreciate her thorough consultations, practical treatment recommendations, and empathetic approach. She speaks Spanish, French, and Portuguese, allowing her to communicate comfortably with patients from different backgrounds.

Conditions Dr. Cristina Andrada Treats Online

Dr. Andrada provides online consultations for a wide range of common medical conditions, including:

  • Fever, flu, COVID-19 symptoms, sore throat and respiratory infections
  • Sinusitis, bronchitis, cough and seasonal allergies
  • Urinary tract infections (UTIs)
  • Migraine and tension headaches
  • Dizziness and vertigo
  • Epilepsy and seizure follow-up
  • Sleep disorders, including insomnia and circadian rhythm disturbances
  • Heartburn, gastritis, diarrhea and constipation
  • Back pain, muscle injuries and joint pain
  • Minor skin infections and allergic reactions
  • Fatigue and general medical assessment
  • Prescription renewals for appropriate chronic treatments
  • Follow-up consultations after surgery or previous medical treatment
  • Travel medicine advice and preventive healthcare
  • Interpretation of laboratory results and medical reports

If your condition requires urgent in-person assessment or emergency care, Dr. Andrada will advise you on the most appropriate next steps.

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Frequently Asked Questions

PRIMPERAN 10 mg TABLETS requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

The active ingredient in PRIMPERAN 10 mg TABLETS is metoclopramide. This information helps identify medicines with the same composition but different brand names.

The average pharmacy price for PRIMPERAN 10 mg TABLETS is around 1.9 EUR. Prices may vary depending on the manufacturer and dosage form.

PRIMPERAN 10 mg TABLETS is manufactured by Sanofi Aventis S.A.. Pharmacy brands and packaging may differ depending on the distributor.

Doctors such as Family doctors, Endocrinologists, Gastroenterologists, Oncologists, Sports medicine specialists, General medicine doctors, Lactation medicine doctors, Intensive care physicians may assess whether PRIMPERAN 10 mg TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

The prescription is issued by a doctor after assessing your health. In Spain, PRIMPERAN 10 mg TABLETS is then dispensed in pharmacies with that prescription. An online consultation does not guarantee that a prescription will be issued: the decision always rests with the doctor.

To request an assessment, you can use Oladoctor:

Other medicines with the same active substance (metoclopramide) include METOCLOPRAMIDE ACCORD 10 mg TABLETS, METOCLOPRAMIDE BASE 5 mg/mL Injectable Solution and Infusion Solution, METOCLOPRAMIDE KERN PHARMA 1 mg/ml ORAL SOLUTION. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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