Nitrocard

When not to use Nitrocardan

If the patient is hypersensitive to glyceryl trinitrate (Nitroglycerin) or any of the other ingredients of this medicine (listed in section 6).
If the patient has found that they are unable to raise their systolic blood pressure above 90 mm Hg, if the patient has been diagnosed with aortic stenosis, if the patient has been diagnosed with hypertrophic cardiomyopathy or other serious heart rhythm disorders.
If the patient has recently had a myocardial infarction, if the patient has been diagnosed with increased intracranial pressure.
If the patient has severe weakness, hypotension (systolic blood pressure below 100 mm Hg), if the patient has been diagnosed with hypovolemia or if the patient is dehydrated.

Important information before using Nitrocardan

Nitrocardan is used to prevent angina pectoris, as a medication or in combination with other anti-anginal medications.

What to observe and for what purpose it is used

1. Nitrocardan is an active substance of glyceryl trinitrate (Nitroglycerin), causing vasodilation, reducing the heart's workload and oxygen demand.
2. The action of the medication causes a decrease in arterial blood pressure.
3. Nitroglycerin dilates coronary vessels, increasing blood flow and oxygen supply to the heart muscle.
4. The use of the medication reduces angina symptoms, such as chest pain, feeling of pressure, shortness of breath, and fatigue.
5. Nitroglycerin also dilates cerebral vessels, restoring normal blood flow.
6. Possible side effects
7. Package contents and other information

How to use Nitrocardan

This medication is intended for use under medical supervision.
Always keep this leaflet, so that you can read it again if necessary.
Caution should be exercised to prevent the medication from getting into the hands of children.
In case of any doubts, you should consult a doctor or pharmacist.
This medication has been prescribed strictly individually. Do not pass it on to others. The medication may harm them, even if the symptoms of the disease are the same.
If the patient experiences any side effects, they should inform their doctor or pharmacist.

Nitrocardan 20 mg/ml - patient information

Glyceryl trinitrate
You should carefully read the contents of the leaflet before using the medication, as it contains important information for the patient.

Warnings and precautions: Caution should be exercised:

• In patients with acute renal failure, acute hepatitis, cholestasis, or bile duct obstruction.
• In patients with severe renal failure, treatment should be carried out with caution, taking into account the reduction of the dose.
• In patients with liver failure, nitrofuranshould be avoided due to the risk of accumulation.
• In patients with a deficiency of glucose-6-phosphate dehydrogenase.
• In patients with porphyria (not tolerant to light).
• In patients with hematopoietic disorders, including aplastic anemia, nitrofuranmay cause toxic effects.

In case of suspected hypersensitivity, the administration of the medication should be discontinued. In rare cases, after the use of nitrofuran, the occurrence of hypersensitivity reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis, has been observed. In case of symptoms of hypersensitivity, treatment should be discontinued immediately and a doctor consulted.
Nitrofuranmay cause symptoms of overdose, including nausea, vomiting, headaches, and dizziness. In case of these symptoms, the dose should be reduced or treatment discontinued. In case of overdose, a doctor should be contacted immediately.
Nitrofuranshould be avoided during pregnancy and breastfeeding. The medication passes through the placental barrier and may be excreted in breast milk. The use of nitrofuranduring pregnancy and breastfeeding may cause harmful effects on the fetus or infant.
Concomitant use of nitrofuranwith other medications that may enhance its toxic effects, including other antibiotics, sulfonamides, and metronidazole, should be avoided. Concomitant use of nitrofuranwith other medications may increase the risk of side effects.
A doctor should be informed about all medications being taken, including over-the-counter medications, dietary supplements, and herbs. The doctor will assess the risk of interactions and make appropriate decisions.
Low concentrations of nitrofuranin urine may lead to the development of bacterial resistance to the medication. Therefore, it is essential to use nitrofuranaccording to the doctor's recommendations and not to discontinue treatment prematurely.
Exposure to sunlight should be avoided during the use of nitrofuran, as the medication may increase skin sensitivity to UV radiation. In case of necessity to stay in the sun, a UV filter cream should be used and protective clothing worn.
The use of nitrofuranmay cause gastrointestinal disorders, such as nausea, vomiting, diarrhea, and abdominal pain. In case of these symptoms, a doctor should be consulted.
In rare cases, the use of nitrofuranmay cause peripheral neuropathy, manifested by pain, numbness, and weakness of the limbs. In case of these symptoms, treatment should be discontinued immediately and a doctor consulted.
The use of nitrofuranmay cause changes in blood tests, such as anemia, leukopenia, and thrombocytopenia. In case of these symptoms, a doctor should be consulted.
The medication may cause liver and kidney function disorders. Therefore, it is essential to monitor liver and kidney function during the use of nitrofuran.
Caution should be exercised when driving vehicles and operating machinery, as nitrofuranmay cause dizziness and drowsiness.
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Pregnancy and breastfeeding

Nifedipine(used in a dose of 20 mg twice a day) is not a reason to refuse breastfeeding. Nifedipinemay cause a decrease in lactation, which should be taken into account. Nifedipineis excreted in breast milk. Nitrocardshould not be used during pregnancy or breastfeeding.
If the patient is pregnant or breastfeeding, they should inform their doctor before taking this medication.

How to use Nitrocard

This medication should always be used according to the doctor's recommendations. In case of doubts, a doctor should be consulted.
The medication is intended for use on the skin.
The maximum dose of Nifedipinein the form of a patch is 10 mg per day. To prevent excessive lowering of blood pressure, the smallest effective dose should be used. Usually, 5 mg per day is sufficient.
The Nitrocardpatch should be applied once a day, at the same time, to clean, dry, and intact skin (e.g., on the buttocks, abdomen, or arm). Areas with skin irritation or scars should be avoided.
In case of skin irritation at the patch application site, the old patch should be removed and a new patch applied to a different area.
To achieve optimal medication effects, hot baths, saunas, and excessive sun exposure should be avoided.
The medication should be used for 3 to 4 weeks, followed by a 2- to 3-day break. If necessary, the treatment cycle should be repeated.
To achieve the best results, the medication should be used regularly, at the same time of day. If a patch is forgotten, it should be applied as soon as possible. Do not apply two patches at the same time.

Side effects

Like any medication, this medication may cause side effects, although not everyone will experience them.

• Common side effects: dizziness, headache, feeling of fatigue, edema (especially of the ankles and feet), flushing of the face.
• Uncommon side effects: palpitations, shortness of breath.
• Rare side effects: allergic reactions, angioedema.

Treatment should be discontinued and a doctor consulted in case of severe side effects, such as facial, tongue, or throat edema, difficulty breathing.

Contraindications

Do not use Nitrocardin the following cases:

• Hypersensitivity to nifedipine or any of the ingredients of the preparation.
• Acute myocardial infarction.
• Heart failure in the phase of acute deterioration.
• Liver disease.
• Severe kidney function disorders.
• Aortic stenosis.

Caution should be exercised when using the medication in patients with heart failure, kidney or liver disease.
Alcohol consumption should be avoided during medication use.
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Use

The use of Nimecradis indicated for the treatment of acute, moderate, or severe pain, e.g., after injuries, surgeries, in headache, toothache, menstrual pain, muscle and joint pain. The medication may also be used to treat fever.

Dosage

Adults and children over 12 years:

• Usually 1 to 2 tablets (500 mg to 1000 mg) every 4 to 6 hoursdepending on the severity of the pain.
• Maximum single dose: 1000 mg (2 tablets).
• Maximum daily dose: 4000 mg (8 tablets).

The smallest effective dose should be used for the shortest possible duration of pain.

Possible side effects

1. Very common (occurring in 1 in 10 patients):

Common (occurring in 1 to 10 in 100 patients): These symptoms usually resolve after a few days. Possible side effects, if related to the gastrointestinal tract, should be treated by continuing treatment, following a diet, or in case of headache, are usually mild and short-term. If they persist or worsen, a doctor should be consulted.

2. Uncommon (occurring in 1 to 10 in 1000 patients):

Contact dermatitis, skin redness at the injection site, itching, burning, irritation.

3. Rare (occurring in 1 to 10 in 10,000 patients):

Hypersensitivity reactions (e.g., urticaria, angioedema, bronchospasm). In case of hypersensitivity reactions, the medication should be discontinued immediately and a doctor consulted.

4. Possible side effects related to the use of this medication should be reported to a doctor or pharmacist.

Like any medication, this medication may cause side effects, although not everyone will experience them.

In case of using a higher dose than recommended

Remember! The use of a Nimecraddose to supplement a missed dose. Discontinuation of Nimecradtreatment. In case of doubts, a doctor or pharmacist should be consulted.
In case of using a higher dose than recommended, a doctor should be contacted.

CHEMA-ELEKTROMET

Cooperative
ul. Jerzego Waszyngtona 9
05-105 Rzeszów
tel. 17 8602 090
e-mail: [email protected]
To obtain more detailed information, you should contact the representative of the responsible entity.

Date of the last update of the leaflet:

5. How to store Nitrocard

Store at a temperature below 25°C.
The medication should be stored in a place inaccessible and invisible to children.
Shelf life after first opening: 2 years.
Particular attention should be paid to the expiration date stated on the packaging. The medication should not be used after the expiration date stated on the packaging.
The medication should be stored in its original packaging to protect it from light and moisture.
A pharmacist should be asked how to dispose of unused medications and how to dispose of unused medications. Protect the environment.

6. Package contents and other information

The active substance of the medication is glyceryl trinitrate (Nitroglycerin).
1 g of ointment contains 20 mg of glyceryl trinitrate.
Other ingredients: anhydrous lanolin, butylhydroxytoluene (E 320), purified water.
Nitrocard is a uniform, fatty ointment of light yellow color.
Packaging: aluminum tube containing 30 g of ointment, placed in a cardboard box.

Responsible entity and manufacturer

CHEMA-ELEKTROMET
Cooperative
ul. Jerzego Waszyngtona 9
05-105 Rzeszów

Address of the Registration Authority:

Office for Registration of Medicinal Products, Medical Devices, and Biocidal Products
Al. Jerozolimskie 181C
02-222 Warsaw
tel.: +48 22 49 21 309
Website: https://smz.zdrowie.gov.pl
Further detailed information on side effects can be collected and more information obtained on