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PALONOSETRON SALA 250 micrograms Injectable Solution

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About the medicine

How to use PALONOSETRON SALA 250 micrograms Injectable Solution

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

Palonosetron Sala 250 micrograms solution for injection EFG

Read all of this leaflet carefully before you are given this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor, pharmacist, or nurse.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.
  • If you get any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What Palonosetron Sala is and what it is used for
  2. What you need to know before you are given Palonosetron Sala
  3. How Palonosetron Sala will be given to you
  4. Possible side effects
  5. Storage of Palonosetron Sala
  6. Contents of the pack and further information

1. What Palonosetron Sala is and what it is used for

Palonosetron Sala contains the active substance palonosetron, which belongs to a group of medicines called 'serotonin (5HT3) antagonists'.

Palonosetron Sala is used in adults, adolescents, and children over 1 month of age to prevent nausea and vomiting when they receive cancer treatment (chemotherapy).

This medicine works by blocking the action of a chemical called serotonin, which can cause nausea or vomiting.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you are given Palonosetron Sala

Do not take Palonosetron Sala:

  • if you are allergic to palonosetron or any of the other ingredients of this medicine (listed in section 6).

You will not be given Palonosetron Sala if any of the above applies to you. If you are unsure, consult your doctor, pharmacist, or nurse before you are given this medicine.

Warnings and precautions

Tell your doctor, pharmacist, or nurse before you are given Palonosetron Sala if:

  • you have a blockage in your intestine or have had repeated constipation in the past;
  • you have had heart problems or have a family history of heart problems, such as changes in your heartbeat ('prolonged QT interval');
  • you have an imbalance of certain minerals in your blood that has not been treated, such as potassium and magnesium.

If any of the above applies to you (or if you are unsure), consult your doctor or nurse before you are given this medicine.

Other medicines and Palonosetron Sala

Tell your doctor, pharmacist, or nurse if you are taking, have recently taken, or might take any other medicines. In particular, tell them if you are taking any of the following medicines:

Medicines for depression or anxiety

Tell your doctor or nurse if you are taking any medicines for depression or anxiety, including:

  • medicines called SSRIs ('selective serotonin reuptake inhibitors'), such as fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, and escitalopram;
  • medicines called SNRIs ('serotonin and noradrenaline reuptake inhibitors'), such as venlafaxine and duloxetine (may cause serotonin syndrome and should be used with caution).

Medicines that may affect your heartbeat

Tell your doctor, pharmacist, or nurse if you are taking any medicines that affect your heartbeat. This is because these medicines may cause heart problems when taken with Palonosetron Sala. These medicines include:

  • medicines for heart problems, such as amiodarone, nicardipine, and quinidine;
  • medicines for infections, such as moxifloxacin and erythromycin;
  • medicines for severe mental health problems, such as haloperidol, chlorpromazine, quetiapine, and thioridazine;
  • a medicine for nausea and vomiting called domperidone.

If any of the above applies to you (or if you are unsure), consult your doctor or nurse before you are given Palonosetron Sala. This is because these medicines may cause heart problems when taken with Palonosetron Sala.

Pregnancy

If you are pregnant or think you may be pregnant, your doctor will not give you Palonosetron Sala unless it is clearly necessary. This is because we do not know if Palonosetron Sala can harm the baby.

Tell your doctor, pharmacist, or nurse before you are given this medicine if you are pregnant or think you may be pregnant.

Breast-feeding

It is not known if Palonosetron Sala passes into breast milk.

Tell your doctor, pharmacist, or nurse before you are given this medicine if you are breast-feeding.

Driving and using machines

You may feel dizzy or tired after you are given this medicine. If this happens, do not drive or use tools or machines.

Palonosetron Sala contains sodium

This medicine contains less than 1 mmol of sodium (23 mg) per vial; this is essentially 'sodium-free'.

3. How you will be given Palonosetron Sala

A doctor or nurse will usually give you Palonosetron Sala.

  • You will be given the medicine about 30 minutes before the start of chemotherapy.

Adults

  • The recommended dose of Palonosetron Sala is 250 micrograms.
  • It is given as an injection into a vein.

Children and adolescents (from 1 month to 17 years of age)

  • Your doctor will calculate the dose based on your weight.
  • The maximum dose is 1500 micrograms.
  • Palonosetron Sala will be given as a drip (a slow infusion into a vein).

It is not recommended that you are given Palonosetron Sala on the days following chemotherapy unless you are going to receive another cycle of chemotherapy.

If you have any further questions about the use of this medicine, ask your doctor, pharmacist, or nurse.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

The following side effects may happen with this medicine:

Serious side effects

Tell your doctor immediately if you notice any of the following serious side effects:

  • allergic reaction: the signs may include swelling of the lips, face, tongue, or throat, difficulty breathing or collapse, skin rash with itching and hives (urticaria). This reaction is very rare: it may affect up to 1 in 10,000 people.

Tell your doctor immediately if you notice any of the serious side effects mentioned above.

Other side effects

Tell your doctor if you notice any of the following side effects:

Adults

Common:may affect up to 1 in 10 people

  • headache, dizziness;
  • constipation, diarrhea.

Uncommon:may affect up to 1 in 100 people

  • change in the color of the vein and enlarged veins;
  • feeling unusually happy or feeling anxious;
  • drowsiness or sleep problems;
  • decreased or lost appetite;
  • weakness, tiredness, fever, or flu-like symptoms;
  • numbness, burning, itching, or tingling of the skin;
  • skin rash with itching;
  • vision changes or eye irritation;
  • movement disorders;
  • ringing in the ears;
  • hiccups, gas (flatulence), dry mouth, or indigestion;
  • abdominal pain (stomach pain);
  • difficulty urinating;
  • joint pain.

Tell your doctor if you notice any of the side effects mentioned above.

Uncommon side effects seen in clinical trials:may affect up to 1 in 100 people

  • high or low blood pressure;
  • abnormal heartbeat or lack of blood flow to the heart;
  • high or low levels of potassium in the blood;
  • high levels of sugar in the blood or sugar in the urine;
  • low levels of calcium in the blood;
  • high levels of bilirubin in the blood;
  • high levels of certain liver enzymes;
  • abnormalities in the electrocardiogram ('prolonged QT interval).

Very rare:may affect up to 1 in 10,000 people

  • burning, pain, or redness at the injection site.

Children and adolescents

Common:may affect up to 1 in 10 people

  • headache

Uncommon:may affect up to 1 in 100 people

  • dizziness;
  • spasms;
  • abnormal heartbeat;
  • cough or shortness of breath;
  • nosebleeds;
  • skin rash with itching or hives;
  • fever;
  • pain at the infusion site.

Tell your doctor if you notice any of the side effects mentioned above.

Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Spanish Medicines Agency's website: https://www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

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5. Storage of Palonosetron Sala

  • Keep this medicine out of the sight and reach of children.
  • Do not use this medicine after the expiry date which is stated on the vial and carton after EXP. The expiry date is the last day of the month stated.
  • No special storage conditions are required.
  • For single use, any unused solution should be discarded.

6. Contents of the pack and further information / Further information

Composition of Palonosetron Sala

  • The active substance is palonosetron (as hydrochloride). Each ml of solution contains 50 micrograms of palonosetron. Each 5 ml vial of solution contains 250 micrograms of palonosetron.
  • The other ingredients are mannitol, disodium edetate (dihydrate), sodium citrate (dihydrate), citric acid monohydrate, and water for injections.

Appearance and packaging

Palonosetron Sala solution for injection is a clear and colorless solution and is presented in a type I glass vial with a siliconized chlorobutyl rubber stopper and an aluminum cap, which contains 5 ml of the solution. Each vial contains a single dose.

It is presented in packs of 1 vial containing 5 ml of solution.

Marketing authorization holder and manufacturer:

Laboratorio Reig Jofre, S.A.

Gran Capitán, 10

08970 Sant Joan Despí (Barcelona)

Spain

Date of last revision of this leaflet: February 2022

Detailed information on this medicine is available on the Spanish Medicines Agency's website: http://www.aemps.gob.es/

Online doctors for PALONOSETRON SALA 250 micrograms Injectable Solution

Discuss questions about PALONOSETRON SALA 250 micrograms Injectable Solution, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Doctor

Bulat Garipov

General medicine 15 years exp.

Dr. Bulat Garipov is a radiologist with more than 15 years of experience, specializing in magnetic resonance imaging (MRI). Throughout his professional career, he has worked in leading diagnostic imaging centers, both in on-site practice and teleradiology, which has allowed him to develop a broad and versatile approach to radiology.

Over the years, he has gained solid experience in interpreting MRI studies in various areas, including:

  •  Neuroimaging
  •  Musculoskeletal system (MSK)
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Additionally, Dr. Garipov is open to new collaboration opportunities in radiology and teleradiology projects. He offers his expertise in MRI, providing both first and second readings of studies, as well as advanced image interpretation, ensuring accurate and high-quality diagnostics.

You could consult Dr. Bulat Garipov in cases where accurate interpretation of MRI studies or a second expert opinion is required. His expertise is especially valuable in cases of suspected neurological conditions, back and joint pain, vascular disorders, as well as in the diagnosis of abdominal and pelvic diseases. The doctor also provides support in complex or unclear clinical situations, including the review of previously performed studies, which helps improve diagnostic accuracy and determine the optimal treatment strategy. A teleradiology format is available, allowing you to receive a professional opinion remotely.

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Doctor

Lina Travkina

Family medicine 13 years exp.

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
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  • Test interpretation and diagnostic guidance.
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  • Second opinion on diagnoses and treatment plans.
  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
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  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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Doctor

Anna Biriukova

General medicine 6 years exp.

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

  • High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
  • Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
  • Leg swelling, chronic fatigue, reduced exercise tolerance.
  • EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
  • Post-COVID-19 cardiac monitoring and care.
Endocrinology – Diabetes, thyroid, metabolism:
  • Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
  • Individual treatment plans including oral medications and insulin therapy.
  • GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
  • Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
  • Metabolic syndrome – obesity, lipid disorders, insulin resistance.
Gastroenterology – Digestive health:
  • Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
  • Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
  • Respiratory infections – cough, colds, bronchitis.
  • Lab test analysis, therapy adjustments, medication management.
  • Adult vaccinations – planning, contraindications assessment.
  • Cancer prevention – screening strategies and risk assessment.
  • Holistic approach – symptom relief, complication prevention, and quality of life improvement.
Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
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Doctor

Alina Tsurkan

Family medicine 13 years exp.

Dr. Alina Tsurkan is a licensed family medicine physician based in Portugal, offering online consultations for adults and children. She provides professional primary care, with a focus on prevention, accurate diagnosis, and long-term management of acute and chronic conditions.

Dr. Tsurkan supports patients with a wide range of health issues, including:

  • Respiratory infections: cold, flu, bronchitis, pneumonia, and lingering coughs.
  • ENT conditions: sinusitis, tonsillitis, otitis (ear infections), sore throat, allergic rhinitis.
  • Eye conditions: allergic or infectious conjunctivitis, red eyes, irritation.
  • Digestive issues: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), constipation, bloating, nausea.
  • Urinary and reproductive health: urinary tract infections (UTIs), cystitis, prevention of recurrent infections.
  • Chronic diseases: hypertension, elevated cholesterol, weight management.
  • Neurological complaints: headaches, migraines, sleep disturbances, fatigue, general weakness.
  • Children’s health: fever, infections, digestive issues, follow-ups, vaccination guidance.

She also provides:

  • IMT medical certificates for driving licence exchange in Portugal.
  • Personalised preventive care and wellness consultations.
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  • Remote prescription management and medical documentation.

Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

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Doctor

Andrei Popov

General medicine 7 years exp.

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

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Doctor

Alexander Nazarchuk

Allergology 7 years exp.

Dr. Alexander Nazarchuk is a physician specialising in allergology and internal medicine. He provides online consultations for adults, following the principles of evidence-based medicine — no outdated treatments or unnecessary tests, with clear explanations and a personalised approach. He helps patients with a wide range of allergic and therapeutic conditions, from common day-to-day complaints to complex cases involving allergies, gastrointestinal issues, cardiovascular concerns, respiratory symptoms, and more.

You can consult Dr. Nazarchuk for:

  • Test interpretation and guidance on diagnostic plans.
  • Allergic rhinitis, hay fever, bronchial asthma (including severe cases).
  • Food and drug allergies, skin rashes, angioedema.
  • Atopic dermatitis, urticaria, contact allergies.
  • Allergen-specific immunotherapy (AIT) – initiation and ongoing management.
  • Abdominal pain, bloating, changes in bowel habits, nausea, heartburn.
  • High blood pressure and adjustment of baseline antihypertensive therapy.
  • Hyperlipidaemia and elevated cholesterol.
  • Cough, nasal congestion, fever, sore throat.
  • Anaemia, including iron deficiency and related conditions.
  • Other issues related to allergology and internal medicine.

During consultations, Dr. Nazarchuk takes a thorough, structured approach — analysing symptoms, identifying potential causes, and helping patients make informed decisions. Whether treatment, further investigation, or monitoring is needed, he explains each step clearly so you understand your health and how best to manage it.

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€55

Frequently Asked Questions

Is a prescription required for PALONOSETRON SALA 250 micrograms Injectable Solution?
PALONOSETRON SALA 250 micrograms Injectable Solution requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in PALONOSETRON SALA 250 micrograms Injectable Solution?
The active ingredient in PALONOSETRON SALA 250 micrograms Injectable Solution is palonosetron. This information helps identify medicines with the same composition but different brand names.
Who manufactures PALONOSETRON SALA 250 micrograms Injectable Solution?
PALONOSETRON SALA 250 micrograms Injectable Solution is manufactured by Laboratorio Reig Jofre, S.A.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of PALONOSETRON SALA 250 micrograms Injectable Solution online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether PALONOSETRON SALA 250 micrograms Injectable Solution is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to PALONOSETRON SALA 250 micrograms Injectable Solution?
Other medicines with the same active substance (palonosetron) include ALOXI 250 micrograms INJECTABLE SOLUTION, FERANT 250 micrograms injectable solution, PALONOSETRON ACCORD 250 micrograms Injectable Solution. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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