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OXIBUPROCA 4 mg /Ml Eye Drops

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Talk to a doctor about this medicine

Discuss your symptoms and possible next steps in a quick online consultation.

Doctor
5.0(38)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a General Practitioner with specialized training in chronic pain. He provides online consultations for adult patients in Spain and other European countries.

Dr. Popov understands that seeking help with weight-related concerns or pain that has persisted for months can be difficult. Many patients come to him after trying different approaches without feeling truly heard. During the consultation, the doctor creates a comfortable and supportive, non-judgmental environment where the patient’s medical history can be discussed in detail, questions can be answered, and the next steps can be decided together.

Weight Management and Metabolic Health

Dr. Popov can help assess overweight, obesity, and related conditions such as hypertension, diabetes, or metabolic disorders. During the consultation, the patient’s medical history, test results, current medications, and previous treatments will be reviewed.

If you would like to learn about possible medication options or have already started treatment, the doctor can assess your situation, review the effectiveness and tolerability of the therapy, and clearly explain its benefits, potential risks, and alternatives.

Not every patient requires the same treatment. A consultation does not guarantee a prescription — it provides an objective medical assessment and a plan tailored to your individual situation.

Pain and General Medicine

You can also consult Dr. Popov regarding:

* chronic pain, migraines, neuralgia, and fibromyalgia;

* back, neck, lower back, or joint pain;

* hypertension, diabetes, and follow-up of chronic conditions;

* review of test results, medical reports, and current treatment;

* preventive medicine and a second medical opinion.

How the Consultation Works

The video consultation lasts up to 30 minutes. The doctor will listen carefully, review the information you provide, and explain the next steps in clear and understandable language.

If additional tests, an in-person consultation, or urgent medical care are required, the doctor will inform you directly.

Dr. Popov’s goal is to make sure the patient feels heard and leaves the consultation with a clear understanding of their condition and the next steps they can take.

Book a video appointment
€86
This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use OXIBUPROCAINE HYDROCHLORIDE AGEPHA 4 MG/ML EYE DROPS IN SOLUTION

Contents of the leaflet

  1. Introduction
  2. What is Oxibuprocaine Hydrochloride Agepha and what is it used for
  3. What you need to know before you start using Oxibuprocaine Hydrochloride Agepha
  4. Other medicines and Oxibuprocaine Hydrochloride
  5. How to use Oxibuprocaine Hydrochloride Agepha
  6. Possible side effects
  7. Storage of Oxibuprocaine Hydrochloride Agepha
  8. Contents of the pack and further information

Introduction

Package Leaflet: Information for the User

Oxibuprocaine Hydrochloride Agepha 4 mg/ml Eye Drops Solution

Read this entire leaflet carefully before you start using this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • If you experience any side effects, talk to your doctor or pharmacist, even if they are not listed in this leaflet. See section 4.

Contents of the Package Leaflet

  1. What is Oxibuprocaine Hydrochloride Agepha and what is it used for
  2. What you need to know before you start using Oxibuprocaine Hydrochloride Agepha
  3. How to use Oxibuprocaine Hydrochloride Agepha
  4. Possible side effects
  5. Storage of Oxibuprocaine Hydrochloride Agepha
  6. Contents of the pack and further information

1. What is Oxibuprocaine Hydrochloride Agepha and what is it used for

This medicine is an external anaesthetic for use in adults.

It acts by locally anaesthetizing the surface of the eye for short ophthalmological procedures.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you start using Oxibuprocaine Hydrochloride Agepha

Do not use Oxibuprocaine Hydrochloride

  • if you are hypersensitive (allergic) to oxibuprocaine or any of the other ingredients of oxibuprocaine hydrochloride (listed in section 6);
  • if you are hypersensitive (allergic) to other local anaesthetics belonging to the same group of active substances (p-aminobenzoic acid).

Warnings and Precautions

Be especially careful with Oxibuprocaine Hydrochloride

If you wear contact lenses. Remove your contact lenses before instillation and wait until the anaesthetic effect has completely worn off before putting them back in your eye (see also 3. How to use Oxibuprocaine Hydrochloride).

In patients with a history of allergies, heart disease, asthma, hyperactive thyroid gland (hyperthyroidism), or liver disease, as well as in elderly patients.

If you have an inflamed eye, as red eyes greatly increase blood flow through the surface of the eyes.

Prolonged and repeated use

Oxibuprocaine Hydrochloride Agepha is intended for use by a doctor only and for a short period of time. Repeated and uncontrolled use can cause serious damage to the cornea of the eye. The same can be said of its long-term use.

Children and adolescents

The safety and efficacy of Oxibuprocaine Hydrochloride in children and adolescents have not been established.

Other medicines and Oxibuprocaine Hydrochloride

Tell your doctor or pharmacist if you are using, have recently used, or might use any other medicines.

Sulphonamides (present in certain antibiotics): The efficacy of these antibiotics may be reduced.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor. He will tell you whether you can be given Oxibuprocaine Hydrochloride or not.

Driving and using machines

This medicine may affect your ability to react, as well as your ability to drive. The use of Oxibuprocaine Hydrochloride may affect your vision and, therefore, also your ability to react when driving or using machines. Do not drive vehicles or use tools or machinery before this effect has worn off.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

3. How to use Oxibuprocaine Hydrochloride Agepha

The recommended dose is 1 drop for the eyes before the examination or procedure; this dose may be repeated if necessary.

Method of administration

For use in the eye. (To be instilled in the eye to be examined)

Your doctor or ophthalmologist will put the drops in your eye. You may be asked to press the inner corners of your eyelid for 1-2 minutes, which prevents the solution from passing into the nose and throat. This measure is especially advisable in elderly patients and at-risk populations.

Your eye will be numb for about an hour, depending on how many drops you have been given. Avoid touching your eye until the anaesthetic effect has worn off.

If you need to instil another eye drop, you should wait at least 15 minutes before administering it.

Although you may have received more oxibuprocaine hydrochloride than you should, it is very unlikely that you will suffer from the effects of an overdose.

If you suddenly feel unwell after the drops have been instilled, inform your doctor or ophthalmologist or contact the nearest emergency department immediately.

Warning for contact lens wearers

Remove your contact lenses before the eye drops are instilled and wait at least one hour after instillation, until the anaesthetic effect has completely worn off, before putting them back in. Failure to follow this recommendation may cause damage to the cornea.

If you use more Oxibuprocaine Hydrochloride than you should

Overdose: Poisoning with local/topical anaesthetics, especially when administered orally, can trigger the following symptoms: muscle spasms, convulsions, drop in blood pressure, fainting, arrhythmias, cardiac arrest caused by conduction problems, respiratory paralysis.

In such cases, consult a doctor immediately.

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or call the Toxicology Information Service, phone: 91 562 04 20, indicating the medicine and the amount ingested.

Instructions for healthcare professionals

You will find information on overdose at the end of this leaflet.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

You should contact a doctor immediately if you experience any of the following symptoms of a severe allergic/anaphylactic reaction: swelling, skin rash, itching, urticaria, difficulty breathing, chills, flushing, headache, general malaise, nausea, restlessness, rapid heartbeat, or low blood pressure (which occurs in an unknown number of patients).

Other side effects that may occur:

Frequent (may affect up to 1 in 10 people):

The most common side effect is local irritation. Other common side effects are: temporary burning after instillation, corneal damage with repeated use.

Rare (may affect up to 1 in 1,000 people):

Tremors, blurred vision, slow heartbeat, low blood pressure, dizziness.

Frequency not known (frequency cannot be estimated from the available data):

Ocular allergy, allergic blepharitis (inflammation of the eyelids). The symptoms of ocular allergy and allergic blepharitis may be: itching, red and swollen eyelids, red eyes, irritated and watery eyes, burning or stinging eyes, scales and crusts on the edge of the eyelashes, similar to dandruff, sensitivity to light.

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist, even if they are not listed in this leaflet.

You can also report side effects directly via the Spanish Medicines Monitoring System for Human Use: https://www.notificaRAM.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Oxibuprocaine Hydrochloride Agepha

This medicine does not require any special storage conditions.

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the carton after EXP. The expiry date is the last day of the month indicated.

To be used within 4 weeks after first opening.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help protect the environment.

6. Contents of the pack and further information

Composition of Oxibuprocaine Hydrochloride Agepha

  • The active substance is oxibuprocaine hydrochloride

Each ml contains 4 mg of oxibuprocaine hydrochloride

  • The other ingredients are: boric acid, chlorhexidine diacetate, hydrochloric acid (for pH adjustment), water for injection.

Appearance and pack contents

Oxibuprocaine Hydrochloride Agepha 4 mg/ml eye drops solution is a clear and colourless solution, presented in a plastic bottle. Each pack contains a 10 ml bottle.

Marketing authorisation holder and manufacturer

AGEPHA Pharma s.r.o.,

Dialnicná cesta 5,

Senec 903 01,

Slovakia

This medicine is authorised in the Member States of the European Economic Area under the following names:

Member State

Medicine name

Austria

Novain 4 mg/ml Augentropfen, Lösung

Denmark

Obupro 4 mg/ml øjendråber, opløsning

Estonia

Novain 4 mg/ml silmatilgad, lahus

Finland

Obupro 4 mg/ml silmätipat, liuos

Ireland

Oxybuprocaine Agepha 4 mg/ml eye drops, solution

Latvia

Obupro 4 mg/ml acu pilieni, šķīdums

Iceland

Obupro 4 mg/ml augndropar, lausn

Croatia

Ophtesia 4 mg/ml kapi za oko, otopina

Lithuania

Novain 4 mg/ml akiu lašai (tirpalas)

Netherlands

Obupro 4 mg/ml oogdruppels, oplossing

Norway

Novain 4 mg/ml øyedråper, løsning

Poland

Obupro 4 mg/ml, krople do oczu, roztwór

Portugal

Novain 4 mg/ml colírio, solução

Sweden

Obupro 4 mg/ml ögondroppar, lösning

Spain

Oxibuprocaine Hydrochloride Agepha 4 mg/ml eye drops solution

Hungary

Obupro 4 mg/ml oldatos szemcsepp

Date of last revision of this leaflet: March 2024

This information is intended only for healthcare professionals:

Treatment in case of poisoning

Immediate management of respiratory and circulatory function (intubation and artificial ventilation), cardiovascular stimulation, perfusions (without adrenaline!). In case of cardiac arrest, external cardiac massage and electrostimulation should be performed. In case of convulsions, ultra-short-acting barbiturates or diazepam should be administered (long-acting barbiturates should not be administered due to the risk of respiratory depression)

Online doctors for OXIBUPROCAINE HYDROCHLORIDE AGEPHA 4 MG/ML EYE DROPS IN SOLUTION

Discuss questions about OXIBUPROCAINE HYDROCHLORIDE AGEPHA 4 MG/ML EYE DROPS IN SOLUTION, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

Doctor
5.0(38)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a General Practitioner with specialized training in chronic pain. He provides online consultations for adult patients in Spain and other European countries.

Dr. Popov understands that seeking help with weight-related concerns or pain that has persisted for months can be difficult. Many patients come to him after trying different approaches without feeling truly heard. During the consultation, the doctor creates a comfortable and supportive, non-judgmental environment where the patient’s medical history can be discussed in detail, questions can be answered, and the next steps can be decided together.

Weight Management and Metabolic Health

Dr. Popov can help assess overweight, obesity, and related conditions such as hypertension, diabetes, or metabolic disorders. During the consultation, the patient’s medical history, test results, current medications, and previous treatments will be reviewed.

If you would like to learn about possible medication options or have already started treatment, the doctor can assess your situation, review the effectiveness and tolerability of the therapy, and clearly explain its benefits, potential risks, and alternatives.

Not every patient requires the same treatment. A consultation does not guarantee a prescription — it provides an objective medical assessment and a plan tailored to your individual situation.

Pain and General Medicine

You can also consult Dr. Popov regarding:

* chronic pain, migraines, neuralgia, and fibromyalgia;

* back, neck, lower back, or joint pain;

* hypertension, diabetes, and follow-up of chronic conditions;

* review of test results, medical reports, and current treatment;

* preventive medicine and a second medical opinion.

How the Consultation Works

The video consultation lasts up to 30 minutes. The doctor will listen carefully, review the information you provide, and explain the next steps in clear and understandable language.

If additional tests, an in-person consultation, or urgent medical care are required, the doctor will inform you directly.

Dr. Popov’s goal is to make sure the patient feels heard and leaves the consultation with a clear understanding of their condition and the next steps they can take.

Book a video appointment
€86
Doctor
5.0(12)

Yevgen Yakovenko

General medicine12 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

Book a video appointment
€72
Doctor
5.0(3)

Lina Travkina

General medicine13 years of experience

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.

  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.

  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.

  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.

  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.

  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.

  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.

  • Medical advice and follow-up consultations.

  • Test interpretation and diagnostic guidance.

  • Structured support for undiagnosed complaints.

  • Second opinion on diagnoses and treatment plans.

  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.

  • Post-operative recovery support and pain management.

  • Preconception counselling and postpartum support.

  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

Book a video appointment
€75
Doctor
5.0(21)

Nuno Tavares Lopes

General medicine18 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies

  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management

  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses

  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment

  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance

  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis

  • Pain management: acute and chronic pain, post-surgical care

  • Public health: prevention, health screenings, long-term monitoring

  • Sick leave (Baixa médica) connected to Segurança Social in Portugal

  • IMT medical certificates for driving licence exchange

Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

Book a video appointment
€70
Doctor
0.0(0)

Hocine Lokchiri

General medicine21 years of experience

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
Book a video appointment
€64

Get OXIBUPROCAINE HYDROCHLORIDE AGEPHA 4 MG/ML EYE DROPS IN SOLUTION Prescription Online

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Frequently Asked Questions

OXIBUPROCAINE HYDROCHLORIDE AGEPHA 4 MG/ML EYE DROPS IN SOLUTION requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

The active ingredient in OXIBUPROCAINE HYDROCHLORIDE AGEPHA 4 MG/ML EYE DROPS IN SOLUTION is oxybuprocaine. This information helps identify medicines with the same composition but different brand names.

OXIBUPROCAINE HYDROCHLORIDE AGEPHA 4 MG/ML EYE DROPS IN SOLUTION is manufactured by Agepha Pharma S.R.O.. Pharmacy brands and packaging may differ depending on the distributor.

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether OXIBUPROCAINE HYDROCHLORIDE AGEPHA 4 MG/ML EYE DROPS IN SOLUTION is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy OXIBUPROCAINE HYDROCHLORIDE AGEPHA 4 MG/ML EYE DROPS IN SOLUTION in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

Other medicines with the same active substance (oxybuprocaine) include COLIROFTA ANESTHETIC 5 mg/ml + 0.5 mg/ml EYE DROPS SOLUTION, COLIROFTA ANESTHETIC DOUBLE 1 mg/ml + 4 mg/ml EYE DROPS SOLUTION, OPHTESIC 20 mg/g OPHTHALMIC GEL SINGLE-DOSE CONTAINER. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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