OSTINE 1250 mg /400 Iu Chewable Tablets

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Talk to a doctor about this medicine

Discuss your symptoms and possible next steps in a quick online consultation.

Doctor
5.0(36)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

Book a video appointment
€86
This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use OSTINE Chewable Tablets

Contents of the leaflet

  1. Introduction
  2. What is Ostine and what is it used for
  3. What you need to know before taking Ostine
  4. How to take Ostine
  5. Possible side effects
  6. Storage of Ostine
  7. Contents of the pack and further information

Introduction

Package Leaflet: Information for the User

Ostine 500 mg/ 400 UI Chewable Tablets

Calcium Carbonate/Cholecalciferol

Read the entire package leaflet carefully before starting to take the medicine.

  • Keep this package leaflet, as you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed to you and you should not pass it on to others. It may harm them, even if their symptoms are the same as yours.
  • If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this package leaflet. See section 4.

Contents of the Package Leaflet

  1. What is Ostine and what is it used for
  2. What you need to know before taking Ostine
  3. How to take Ostine
  4. Possible side effects

5 Storage of Ostine

  1. Contents of the pack and further information

1. What is Ostine and what is it used for

Ostine is a fixed combination of calcium and vitamin D. The high concentration of calcium and vitamin D in each dose unit facilitates the absorption of a sufficient amount of calcium with a limited number of doses. This is why the product is useful as a vitamin and calcium supplement, associated with other treatments, for osteoporosis and as a correction of vitamin D and calcium deficiency in the elderly.

Ostine is indicated for:

  • Correction of vitamin D and calcium deficiency, especially in elderly individuals.
  • Vitamin D and calcium supplement associated with certain treatments for osteoporosis.
Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before taking Ostine

Do not take Ostine

  • if you are allergic to the active substances or to any of the other components of this medicine (listed in section 6).
  • if you have abnormally high levels of calcium in the blood (hypercalcemia).
  • if you have high levels of calcium in the urine (hypercalciuria).
  • if you have any disease that increases calcium levels in the blood or urine, such as hyperthyroidism, myeloma, or bone metastases.
  • if you have kidney stones (kidney lithiasis) or calcium deposits in the kidneys (nephrocalcinosis).
  • if you have severe kidney problems (renal insufficiency).
  • if you have taken too much vitamin D (hypervitaminosis D)

Warnings and precautions

Talk to your doctor or pharmacist before taking Ostine:

  • if you have sarcoidosis, a disease whose most common symptoms are fatigue, increased size of the nodes, and inflammation of the lungs and other organs,
  • if you have kidney disease (renal insufficiency).
  • if you are already taking additional calcium doses (e.g., nutritional supplements or calcium-enriched foods) and are using carbonate-containing medications (e.g., anti-acids) at the same time, you should monitor your serum and urine calcium levels.
  • if you have a long period of immobilization and if you have high calcium levels in the blood and/or urine. Your doctor will allow you to take this medicine when you start walking again.
  • if you are undergoing long-term treatment, it is necessary to perform periodic blood and urine tests to monitor calcium levels. This monitoring is particularly important in elderly people and when treatment is being taken at the same time as cardiac glycosides (e.g., digoxin) or diuretics. Depending on the result, your doctor may decide to reduce or even interrupt your treatment.
  • if you take other medicines or products that contain calcium and/or vitamin D. High levels of calcium and vitamin D can be harmful to your health.

In case of doubts, consult your doctor or pharmacist.

Children and adolescents

This medicine is not intended for use in children or adolescents under 18 years of age.

Other medicines and Ostine

Tell your doctor or pharmacist if you are using or have recently used other medicines, including those obtained without a prescription.

Ostine may interact (i.e., its effects may be altered) with the following medicines:

  • Digoxin (a medicine used to treat heart problems), as it may cause more side effects,
  • Bisphosphonates or medicines containing strontium (used in osteoporosis),
  • Antibiotics (medicines used to treat bacterial infections): oral tetracycline, rifampicin, and some fluoroquinolones (ciprofloxacin and norfloxacin),
  • Dolutegravir (a medicine used to treat HIV infection).
  • Medicines or supplements that contain iron or zinc,
  • Estramustine (a medicine used to treat certain types of prostate cancer),
  • Thyroid hormones, used in cases of thyroid disease,
  • Carbamazepine, phenytoin, phenobarbital, primidone: medicines used to treat epileptic seizures.
  • Orlistat (a medicine used to treat obesity), as it may reduce the amount of vitamin D3 absorbed.
  • Thiazide diuretics (medicines used to treat high blood pressure or edema), as they may increase the amount of calcium in the blood

You should wait 30 minutes or more between taking Ostine and bisphosphonates, and more than two hours between taking Ostine and the following medicines: medicines containing strontium, iron, or zinc, estramustine, thyroid hormones, some fluoroquinolones (ciprofloxacin, norfloxacin), and tetracyclines. It is also recommended to take Ostine at least 2 hours after or 6 hours before taking dolutegravir.

Taking Ostine with food, drinks, or alcohol

There may be interactions with food. You should take Ostine 2 hours before or after the following foods:

  • oxalic acid (present in spinach or rhubarb, coconut, tea...),
  • phosphates (pork, ham, sausages, processed cheese, dessert cream, cola drinks),
  • phytic acid (present in whole grains, dried vegetables, oilseeds, chocolate...).

Pregnancy, breastfeeding, and fertility

The use of Ostine is not recommended during pregnancy and breastfeeding.

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medicine.

Driving and using machines

Ostine does not affect the ability to drive or use machines.

Ostine contains sorbitol

This medicine contains 475 mg of sorbitol in each chewable tablet. Sorbitol is a source of fructose. If your doctor has told you that you have an intolerance to certain sugars, or you have been diagnosed with hereditary fructose intolerance (HFI), a rare genetic disease in which the patient cannot break down fructose, consult your doctor before taking this medicine.

3. How to take Ostine

Follow the administration instructions of this medicine exactly as indicated by your doctor. In case of doubt, consult your doctor or pharmacist.

Only for adults.

Take one tablet twice a day.

The tablets can be dissolved in the mouth or chewed.

If you take more Ostine than you should

The following clinical signs may occur: loss of appetite, intense thirst, nausea, vomiting, constipation, abdominal pain, muscle weakness, fatigue, mental disorders, increased urine production, bone pain, kidney stones, and high blood pressure.

These symptoms may be part of the milk-alkali syndrome that can occur when, for example, large amounts of calcium and carbonate-containing medications (so-called anti-acids) are taken at the same time (see "Warnings and precautions" and "If you take more Ostine than you should").

In these cases, stop taking Ostine and consult your doctor immediately to take measures (who will perform the necessary procedures).

If you take too much Ostine for a long time, calcium deposits may appear in the blood vessels or body tissues.

In case of overdose or accidental ingestion, call the Toxicology Information Service. Phone 91 562 04 20.

If you forget to take Ostine

Do not take a double dose to make up for forgotten doses.

If you have any further questions about the use of this medicine, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Uncommon side effects (may affect up to 1 in 100 people):

  • Increased calcium in the blood and urine.

Rare side effects (may affect up to 1 in 1,000 people):

  • Gastrointestinal disorders such as constipation, flatulence, nausea, abdominal pain, diarrhea
  • Skin disorders such as itching, rash, or irritation.

Side effects of unknown frequency (cannot be estimated from the available data):

  • Hypersensitivity reactions such as angioedema and laryngeal edema (swelling of the face, tongue, lips, throat with difficulty breathing).
  • Milk-alkali syndrome (renal failure due to excess calcium in the blood). There may be high blood pH (alkalosis) and renal insufficiency with high doses (see "Warnings and precautions" and "If you take more Ostine than you should").

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this package leaflet. You can also report them directly through the Spanish Medicines and Healthcare Products Agency (AEMPS) website: https://www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Ostine

Store below 25°C.

Keep out of sight and reach of children.

Do not use Ostine after the expiration date stated on the packaging after CAD. The expiration date is the last day of the month indicated.

Medicines should not be disposed of via wastewater or household waste. Place the packaging and any unused medicines in the pharmacy's SIGRE collection point. If in doubt, ask your pharmacist how to dispose of the packaging and any unused medicines. This will help protect the environment.

6. Contents of the pack and further information

Composition of Ostine

  • The active substances are calcium and cholecalciferol (vitamin D3). Each tablet contains 1,250 mg of calcium carbonate (equivalent to 500 mg of calcium) and 400 UI of cholecalciferol (equivalent to 0.01 mg of vitamin D3).
  • The other components are xylitol, sorbitol, povidone, lemon flavor, and magnesium stearate. (*lemon flavor composition: lemon essential oils, orange, litsea cubeba, maltodextrin, acacia gum, and sodium citrate).

Appearance of the product and pack contents

Cardboard box with 2 or 4 polypropylene tubes and a polyethylene cap. Each tube contains 15 chewable tablets.

30 and 60 chewable tablet formats are available.

Marketing authorization holder and manufacturer

Holder:

QUALIX PHARMA, S.L.

c/ Botánica 137-139

08908 L'Hospitalet de Llobregat

(Barcelona) Spain

Manufacturer:

Innothera Chouzy

Rue René Chantereau, Chouzy-Sur-Cisse.

41150 Valloire-Sur-Cisse (France)

Date of last revision of this package leaflet: April 2022

Detailed information about this medicine is available on the website of the Spanish Agency for Medicines and Healthcare Products (AEMPS) (http://www.aemps.gob.es/)

Online doctors for OSTINE Chewable Tablets

Discuss questions about OSTINE Chewable Tablets, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

Doctor
5.0(36)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

Book a video appointment
€86
Doctor
5.0(12)

Yevgen Yakovenko

Family medicine12 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

Book a video appointment
€72
Doctor
5.0(3)

Lina Travkina

Family medicine13 years of experience

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
  • Post-operative recovery support and pain management.
  • Preconception counselling and postpartum support.
  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

Book a video appointment
€75
Doctor
5.0(19)

Nuno Tavares Lopes

Family medicineGeneral medicine18 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management
  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses
  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment
  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance
  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis
  • Pain management: acute and chronic pain, post-surgical care
  • Public health: prevention, health screenings, long-term monitoring
  • Sick leave (Baixa médica) connected to Segurança Social in Portugal
  • IMT medical certificates for driving licence exchange
Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.

Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

Book a video appointment
€70

Get OSTINE Chewable Tablets Prescription Online

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Tell us your symptoms, history, and what medicine you're requesting.

2

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3

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Usually within 30 minutes. They may ask follow-up questions via chat.

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Electronic prescription sent to your email — valid across Spain.

Frequently Asked Questions

Is a prescription required for OSTINE Chewable Tablets?

OSTINE Chewable Tablets requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

What is the active substance in OSTINE Chewable Tablets?

The active ingredient in OSTINE Chewable Tablets is Calcium, combinations with vitamin D and/or other drugs. This information helps identify medicines with the same composition but different brand names.

How much does OSTINE Chewable Tablets cost in pharmacies?

The average pharmacy price for OSTINE Chewable Tablets is around 3.61 EUR. Prices may vary depending on the manufacturer and dosage form.

Who manufactures OSTINE Chewable Tablets?

OSTINE Chewable Tablets is manufactured by Qualix Pharma S.L.. Pharmacy brands and packaging may differ depending on the distributor.

Which doctors can assess the use of OSTINE Chewable Tablets online?

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether OSTINE Chewable Tablets is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

How to buy OSTINE Chewable Tablets in Spain?

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy OSTINE Chewable Tablets in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

What are the alternatives to OSTINE Chewable Tablets?

Other medicines with the same active substance (Calcium, combinations with vitamin D and/or other drugs) include ADIAVAL 1000 mg/880 IU CHEWABLE TABLETS, BONESIL D FLAS 1500 mg/400 IU ORALLY DISINTEGRATING TABLETS, CADELIUS D 600 MG/2000 IU ORALLY DISINTEGRATING TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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