Bg pattern

OCTOSTIM 1.5 mg/ml NASAL SPRAY SOLUTION

Prescription review online

Prescription review online

A doctor will review your case and decide whether a prescription is medically appropriate.

Talk to a doctor about this medicine

Talk to a doctor about this medicine

Discuss your symptoms and possible next steps in a quick online consultation.

This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use OCTOSTIM 1.5 mg/ml NASAL SPRAY SOLUTION

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

Show original

Introduction

Package Leaflet: Information for the User

Octostim 1.5 mg/ml Nasal Spray Solution

Desmopressin Acetate

Read the entire package leaflet carefully before starting to use this medication, as it contains important information for you.

  • Keep this package leaflet, as you may need to read it again.
  • If you have any questions, consult your doctor or pharmacist.
  • This medication has been prescribed to you only, and you should not give it to others, even if they have the same symptoms, as it may harm them.
  • If you experience side effects, consult your doctor or pharmacist, even if they are not listed in this package leaflet. See section 4.

Contents of the Package Leaflet:

  1. What is Octostim and what is it used for
  2. What you need to know before taking Octostim
  3. How to use Octostim
  4. Possible side effects
  5. Storage of Octostim
  6. Package Contents and Additional Information

1. What is Octostim and what is it used for

Octostim contains desmopressin, a natural analogue of the hypophysial hormone arginine-vasopressin, which, when administered at the appropriate dose, modifies the factors involved in blood coagulation and, as a consequence, shortens or normalizes the prolonged bleeding time (bleeding) caused by various causes.

It is indicated for:

  • therapeutic treatment and prevention of bleeding (bleeding) in patients with mild Hemophilia A and von Willebrand disease who respond positively to the test dose. In exceptional cases, moderate cases of these diseases can also be treated.
  • in patients who respond positively to the test dose, it decreases and normalizes the prolonged bleeding time (bleeding) due to a platelet disorder (platelet disorder).
Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before taking Octostim

Do not use Octostim if you have wounds or irritation in the nasal mucosa, as you may not obtain the desired effect.

Do not use Octostim:

  • if you are allergic to desmopressin or any of the other components of this medication (listed in section 6),
  • if you have excessive prolonged thirst or thirst due to a mental disorder
  • if you have heart failure and other diseases that require treatment with diuretic medications (those that increase urine production),
  • in von Willebrand disease Type IIB (blood coagulation disorders), Hemophilia A, and von Willebrand disease type I with coagulant activity of factor VII below 5%, Hemophilia B, and hemophiliacs with anti-factor VIII antibodies
  • if you have sodium deficiency in the blood (known hyponatremia)
  • if you have inappropriate antidiuretic hormone secretion syndrome (SIADH)
  • if you have uncontrolled high blood pressure.

Warnings and Precautions

Consult your doctor or pharmacist before starting to use Octostim.

Be particularly careful with Octostim to avoid fluid accumulation in the following cases :

  • children or elderly patients
  • treatment with diuretic medications (those that increase urine production) (see section "Use of Other Medications").
  • Coronary heart disease, hypertension
  • diseases characterized by alterations in the proportion of water and electrolytes (calcium, magnesium...) in the blood
  • patients at risk of increased intracranial pressure (pressure inside the skull)
  • Patient with kidney problems.

Considering the possibility of excessive fluid retention, you should monitor for headache, nausea, weight gain, and blood pressure during treatment. Treatment should be discontinued in case of weight gain and signs of fluid retention/hyponatremia (decreased sodium in the blood).

Consult your doctor if you belong to any of the patient groups mentioned above.

Interaction of Octostim with Other Medications

Inform your doctor or pharmacist if you are using, have recently used, or may need to use any other medication.

This medication may interact with medications that can increase the antidiuretic effect (reduction of urine production) of desmopressin and, therefore, increase the risk of water retention and hyponatremia (decreased sodium in the blood): tricyclic antidepressants, chlorpromazine (medication for the treatment of psychiatric problems), carbamazepine (medication to prevent seizures), and chlorpropamide (medication for the treatment of diabetes mellitus) and non-steroidal anti-inflammatory drugs.

Pregnancy, Breastfeeding, and Fertility

If you are pregnant or breastfeeding, or think you may be pregnant or plan to become pregnant, consult your doctor or pharmacist before using this medication.

If you are pregnant, your doctor will assess the risk versus the benefit of treatment

Desmopressin, although in small amounts, passes into breast milk, so in the case of breastfeeding, it is recommended to replace breastfeeding.

Driving and Using Machines

The influence of Octostim on the ability to drive and use machines is nil or insignificant.

Warnings about excipients:

This medication may cause bronchospasm (sudden feeling of suffocation) because it contains benzalkonium chloride.

3. How to Use Octostim

Follow the administration instructions for this medication exactly as indicated by your doctor or pharmacist. If in doubt, consult your doctor or pharmacist again.

Octostim is administered intranasally.

Therapeutic control of bleeding or prevention of bleeding:

300 micrograms (1 spray in each nostril) are administered during bleeding (bleeding). The dose can be repeated every 12 hours for a maximum of 2-3 days. In the case of surgery, it is recommended to administer desmopressin intravenously.

It is essential that you read and follow the following instructions on how to use Octostim

Before using Octostim for the first time, you must prepare the pump by pressing it 4 times, or until a spray is obtained. If you have not used Octostim during the past week, it is necessary to prepare the pump again by pressing it once, or until a spray appears.

IMPORTANT! When using Octostim, the end of the tube must always be submerged in the liquid.

INSTRUCTIONS FOR USE:

Vial with liquid and numbers 1 to 5 showing steps of use with hands holding and connecting devices

  1. Remove the protective cap from the applicator.
  2. Hold the bottle with your thumb, index, and middle fingers as indicated in figure 2.
  3. Slightly tilt your head back while inserting the applicator directly into the nostril as indicated in figure 3. Start nebulization by covering the other nostril simultaneously. Inhale the product gently in each dose.
  4. Repeat the administration in the other nostril
  5. Replace the protective cap. Store the bottle always in a vertical position.

If you use more Octostim than you should

If you have used more Octostim than you should, consult your doctor, pharmacist, or call the Toxicology Information Service, phone 915 620 420, indicating the medication and the amount used.

If you use Octostim more than you should or accidentally, the symptoms would be those consequent to water retention and/or decreased sodium in the blood, such as headache, nausea, vomiting, weight gain, and in severe cases, convulsions.

Treatment should be discontinued, and fluid intake restricted, and symptomatic treatment if necessary.

If you forget to take Octostim

If you miss a dose, apply the next dose at the usual time. Do not take a double dose to make up for the missed doses.

If you interrupt treatment with Octostim

Your doctor will indicate the duration of your treatment with Octostim. Do not stop treatment before, as it may not have the expected effect.

If you have any other questions about the use of this medication, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible Side Effects

Like all medications, Octostim can cause side effects, although not everyone will experience them.

The following side effects are frequent, may affect up to 1 in 10 people:

  • headache
  • stomach pain
  • nausea
  • nasal congestion/rhinitis
  • nasal bleeding
  • transient tachycardia
  • facial flushing
  • eye redness

The following side effects are very rare, may affect up to 1 in 10,000 people:

  • sodium deficiency in the blood (hyponatremia)

Other side effects for which the frequency is not known:

  • weight gain, vomiting, muscle spasms, swelling, fatigue, confusion, dizziness, and in severe cases, convulsions and allergic reactions to benzalkonium chloride (preservative)
  • redness and itching.

.

If you consider that any of the side effects you are experiencing is serious or if you notice any side effect not mentioned in this package leaflet, inform your doctor or pharmacist.

Reporting of Side Effects:

If you experience any type of side effect, consult your doctor or pharmacist, even if it is a possible side effect not listed in this package leaflet. You can also report them directly through the Spanish Medication Surveillance System for Human Use: http://www.notificaram.es. By reporting side effects, you can contribute to providing more information on the safety of this medication.

5. Storage of Octostim

Keep this medication out of the sight and reach of children.

Do not use Octostim after the expiration date stated on the packaging. The expiration date is the last day of the month indicated.

The validity period after the first opening of the packaging is 6 months.

Do not store above 25°C.

Always store the bottle in a vertical position.

Medications should not be disposed of through wastewater or household waste. Deposit the packaging and medications you no longer need at the pharmacy's SIGRE point. If in doubt, ask your pharmacist how to dispose of the packaging and medications you no longer need. This will help protect the environment.

6. Package Contents and Additional Information

Composition of Octostim:

The active ingredient is desmopressin acetate. 1 milliliter of nasal spray solution contains 1.5 milligrams of desmopressin acetate, equivalent to 1.34 milligrams of desmopressin.

The other components are:

Benzalkonium chloride

Citric acid monohydrate,

Sodium chloride,

Disodium phosphate dihydrate,

Purified water.

Appearance of the Product and Package Contents

Octostim is presented in 10-milliliter brown glass bottles containing 2.5 milliliters of solution, which are equipped with pre-compressed aerosol pumps with an applicator and a protective cap, designed to release 150 micrograms each time the pump is pressed.

Marketing Authorization Holder and Manufacturer

Marketing Authorization Holder

FERRING S.A.U.

C/ Arquitecto Sánchez Arcas 3, 1º.

28040 Madrid

SPAIN

Manufacturer

FERRING GmbH

Wittland, 11

24109 Kiel

GERMANY

Date of the Last Revision of this Package Leaflet:July 2022

Detailed and updated information on this medication is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/

Online doctors for OCTOSTIM 1.5 mg/ml NASAL SPRAY SOLUTION

Discuss questions about OCTOSTIM 1.5 mg/ml NASAL SPRAY SOLUTION, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

5.0 (63)
Doctor

Nuno Tavares Lopes

Family medicine 18 years exp.

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management
  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses
  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment
  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance
  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis
  • Pain management: acute and chronic pain, post-surgical care
  • Public health: prevention, health screenings, long-term monitoring
  • Sick leave (Baixa médica) connected to Segurança Social in Portugal
  • IMT medical certificates for driving licence exchange
Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.

Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

Camera Book a video appointment
€59
5.0 (17)
Doctor

Anastasiia Shalko

Family medicine 13 years exp.

Dr. Anastasiia Shalko is a general practitioner with a background in both paediatrics and general medicine. She graduated from Bogomolets National Medical University in Kyiv and completed her paediatric internship at the P.L. Shupyk National Medical Academy of Postgraduate Education. After working as a paediatrician in Kyiv, she relocated to Spain, where she has been practising general medicine since 2015, providing care for both adults and children.

Her work focuses on urgent, short-term medical concerns – situations where patients need quick guidance, symptom assessment and clear next steps. She helps people understand whether their symptoms require in-person evaluation, home management or a change in treatment. Common reasons for booking an online consultation include:

  • acute respiratory symptoms (cough, sore throat, runny nose, fever)
  • viral illnesses such as colds and seasonal infections
  • gastrointestinal complaints (nausea, diarrhoea, abdominal pain, gastroenteritis)
  • sudden changes in how a child or adult feels
  • questions about existing treatment and whether adjustments are needed
  • renewal of prescriptions when clinically appropriate
Dr. Shalko works specifically with urgent and short-term problems, providing practical recommendations and helping patients determine the safest next step. She explains symptoms clearly, guides patients through decision-making and offers straightforward medical advice for everyday acute issues.

She does not provide long-term management of chronic conditions, ongoing follow-up or comprehensive care plans for complex long-term illnesses. Her consultations are designed for acute symptoms, sudden concerns and situations where timely medical input is important.

With clinical experience in both paediatrics and general medicine, Dr. Shalko confidently supports adults and children. Her communication style is clear, simple and reassuring, helping patients feel informed and supported throughout the consultation.

Camera Book a video appointment
€50
5.0 (3)
Doctor

Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques.

For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance.

Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults.

In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions.

Patients commonly seek his care for:

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns
Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.
Camera Book a video appointment
€80
0.0 (0)
Doctor

Andreea Mateescu

Paediatrics 8 years exp.

Dr Andreea Mateescu is a board-certified paediatrician with 7 years of clinical experience. She graduated from Carol Davila University of Medicine and Pharmacy in Bucharest, Romania, and completed her paediatric residency at INSMC Alessandrescu-Rusescu. She also holds additional training in general ultrasound diagnostics.

Dr Mateescu focuses on providing high-quality, evidence-based medical care for children, with a strong emphasis on prevention, healthy development, and long-term wellbeing. She believes that clear, empathetic communication with both children and parents is essential for building trust and ensuring effective care.

Online consultations with Dr Mateescu are suitable for:

  • preventive check-ups and monitoring of growth and development;
  • vaccination planning, including personalised and catch-up schedules;
  • assessment of psychomotor, emotional, and physical development;
  • diagnosis and management of acute and chronic paediatric conditions;
  • nutritional guidance for infants and children, including formula selection when medically indicated;
  • care for children with complex or rare conditions;
  • practical guidance and ongoing support for parents.
Dr Mateescu works with patience, empathy, and professionalism, ensuring that each child receives attentive, individualised care. Her goal is to support healthy, balanced development while helping parents feel confident and well-informed at every stage of their child’s care.
Camera Book a video appointment
€60
0.0 (0)
Doctor

Daniel Cichi

Family medicine 24 years exp.

Dr Daniel Cichi is a family medicine doctor with over 20 years of clinical experience. He provides online consultations for adults, supporting patients with acute symptoms, chronic conditions, and everyday health concerns that require timely medical guidance.

His background includes work in emergency care, ambulance services, and family medicine, which allows him to assess symptoms quickly, identify warning signs, and help patients choose the safest next steps – whether that means home care, treatment adjustment, or in-person evaluation.

Patients commonly consult Dr Daniel Cichi for:

  • acute symptoms: fever, infections, flu-like illness, cough, sore throat, shortness of breath;
  • chest discomfort, palpitations, dizziness, fatigue, and blood pressure concerns;
  • digestive problems: abdominal pain, nausea, diarrhoea, constipation, reflux;
  • muscle, joint, and back pain, minor injuries, post-traumatic symptoms;
  • chronic conditions: hypertension, diabetes, high cholesterol, thyroid disorders;
  • review and interpretation of lab tests, imaging reports, and medical documents;
  • medication review and treatment adjustment;
  • medical advice while travelling or living abroad;
  • second opinions and guidance on whether in-person care is needed.
Dr Cichi’s consultations are structured and practical. He focuses on clear explanations, risk assessment, and actionable recommendations, helping patients understand their symptoms and make informed decisions about their health.
Camera Book a video appointment
€55

Frequently Asked Questions

Is a prescription required for OCTOSTIM 1.5 mg/ml NASAL SPRAY SOLUTION?
OCTOSTIM 1.5 mg/ml NASAL SPRAY SOLUTION requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in OCTOSTIM 1.5 mg/ml NASAL SPRAY SOLUTION?
The active ingredient in OCTOSTIM 1.5 mg/ml NASAL SPRAY SOLUTION is desmopressin. This information helps identify medicines with the same composition but different brand names.
Who manufactures OCTOSTIM 1.5 mg/ml NASAL SPRAY SOLUTION?
OCTOSTIM 1.5 mg/ml NASAL SPRAY SOLUTION is manufactured by Ferring S.A.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of OCTOSTIM 1.5 mg/ml NASAL SPRAY SOLUTION online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether OCTOSTIM 1.5 mg/ml NASAL SPRAY SOLUTION is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to OCTOSTIM 1.5 mg/ml NASAL SPRAY SOLUTION?
Other medicines with the same active substance (desmopressin) include DESMIRIN 360 micrograms/ml ORAL SOLUTION, DESMOPRESSIN ARISTO 120 MICROGRAMS SUBLINGUAL TABLETS, DESMOPRESSIN ARISTO 240 MICROGRAMS SUBLINGUAL TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
bg-pattern-dark

Stay informed about Oladoctor

News about new services, product updates and useful information for patients.

Follow us on social media