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MONOPROST 50 micrograms/ml eye drops in solution

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About the medicine

How to use MONOPROST 50 micrograms/ml eye drops in solution

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Leaflet: information for the user

Monoprost 50 micrograms/ml eye drops solution

Latanoprost

Read the entire leaflet carefully before starting to use this medicine, as it contains important information for you.

  • Keep this leaflet, as you may need to read it again.
  • If you have any doubts, consult your doctor, pharmacist, or nurse.
  • This medicine has been prescribed to you only, and you should not give it to others, even if they have the same symptoms as you, as it may harm them.
  • If you experience side effects, consult your doctor, pharmacist, or nurse, even if they are side effects not listed in this leaflet. See section 4.

Contents of the leaflet:

  1. What is Monoprost and what is it used for
  2. What you need to know before starting to use Monoprost
  3. How to use Monoprost
  4. Possible side effects
    1. Storage of Monoprost
    2. Package contents and additional information

1. What is Monoprost and what is it used for

Monoprost belongs to a group of medicines known as prostaglandins. It reduces the pressure inside the eye by increasing the natural flow of fluid from the inside of the eye to the bloodstream.

Monoprost is used to treat diseases known as open-angle glaucoma and ocular hypertensionin adults. Both diseases are related to an increase in pressure inside the eye, which can affect vision.

Monoprost is a preservative-free eye drop solution.

Doctor consultation

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Discuss your symptoms and treatment with a doctor online.

2. What you need to know before starting to use Monoprost

Do not use Monoprost

  • If you are allergic (hypersensitive) to latanoprost or any of the other components of this medicine (listed in section 6).

Warnings and precautions

Consult your doctor, pharmacist, or nurse before starting to use Monoprost if you think any of the following situations apply to you:

  • If you have had or are going to have eye surgery (including cataract surgery).
  • If you have eye problems (such as eye pain, irritation, or inflammation, blurred vision).
  • If you have severe asthma or uncontrolled asthma.
  • If you use contact lenses. You can continue to use Monoprost, but you must follow the instructions included in section 3 for contact lens users.

If you have had or are having a viral eye infection caused by the herpes simplex virus (HSV) Children and adolescents

Do not give this medicine to children and adolescents under 18 years of age. Monoprost has not been investigated in this population.

Using Monoprost with other medicines

Monoprost may interact with other medicines. Inform your doctor or pharmacist about any other medicines you are using, have recently used, or may need to use.

Pregnancy, breastfeeding, and fertility

Do not use Monoprostif you are pregnant or breastfeeding.

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medicine.

Driving and using machines

When using Monoprost, blurred vision may occur for a short period. If this happens, do not driveor use tools or machines until your vision is clear again.

Important information about some of the components of Monoprost

Monoprost contains macrogolglycerol hydroxystearate (derived from castor oil), which may cause skin allergic reactions.

3. How to use Monoprost

Usual dose

  • Follow your doctor's instructions for using Monoprost exactly. If in doubt, consult your doctor or pharmacist again.
  • The usual dose for adults (including elderly patients) is one drop in the affected eye(s) once a day. It is preferable to administer it at night.
  • Do not use Monoprost more than once a day, as the effectiveness of the treatment may decrease if it is administered more frequently.
  • Follow the administration instructions for the medicine contained in this leaflet or as indicated by your doctor, until your doctor tells you to stop the treatment. If in doubt, ask your doctor, pharmacist, or nurse.
  • This medicine is a preservative-free eye drop solution. Do not let the tip of the bottle touch the eyes or the surrounding areas. It may become contaminated with bacteria that can cause eye infections, leading to serious damage to the eyes, including vision loss. To avoid possible contamination of the bottle, avoid letting the tip of the bottle come into contact with any surface.

Contact lens users

If you use contact lenses, you must remove them before using Monoprost. After applying Monoprost, wait 15 minutes before putting your contact lenses back in.

Instructions for use

It is essential to follow the following instructions when using this product:

Eye drop bottle with cap and arrows indicating direction of application next to a stylized eye and an arrow pointing

Before using this medicine for the first time:

  • Check that the protective safety cap is intact. To open the bottle, firmly unscrew the cap.
  • Wash your hands carefully and remove the cap from the bottle. With the bottle upside down, press down several times to activate the pumping mechanism until the first drop appears.This process is only necessary the first time you use it and is not necessary for subsequent administrations.

Medicine vial with adapter and needle connected ready for administration

  1. Before each use, wash your hands carefully and remove the cap from the bottle. Avoid any contact between the dropper tip and your fingers.

Hand holding an auto-injector with the needle exposed pointing downwards ready for injection

  1. Place your thumb on the tab at the top of the bottle and your index finger on the base of the bottle. Then, also place your middle finger on the second tab at the base of the bottle. Hold the bottle upside down.

Hand holding a syringe with the needle inserted into the skin of the hand showing direction of entry and exit

  1. To use, tilt your head slightly backwards and hold the dropper bottle vertically over your eye. With the index finger of your other hand, gently pull the lower eyelid down. The created space is called the lower conjunctival sac. Avoid contact between the dropper tip and your fingers or eyes.

To apply one drop to the lower conjunctival sac of the affected eye(s), briefly but firmly pressthe bottle. Thanks to the automatic dosing, exactly one drop is released with each pump.

If the drop does not fall, gently shake the bottle to extract the remaining drop from the end of the dropper. In this case, repeat step 3.

Hand holding an insulin applicator with a short needle visible preparing to inject into the skin

  1. Close your eyelids and press the inner corner of your eye closest to your nose with your finger for 1 minute. This helps prevent the eye drops from reaching the rest of your body.
  1. Immediately close the bottle cap after use.

If you use Monoprost with other eye drops

Wait at least 5 minutes between applying Monoprost and administering other eye drops.

If you use more Monoprost than you should

If you have applied more drops in the eye than you should, you may feel mild irritation in the eye, and your eyes may also become red and tear; this situation should disappear, but if you are concerned, contact your doctor.

In case of accidental ingestion of Monoprost, consult your doctor as soon as possible.

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or call the Toxicological Information Service, phone: 91 562 04 20, indicating the medicine and the amount ingested.

If you forget to use Monoprost

Continue with the administration of the next dose as usual. Do not apply an extra drop in the eye to make up for the missed dose. If you have doubts, consult your doctor or pharmacist.

If you stop using Monoprost

If you want to stop using Monoprost, you must consult your doctor.

If you have any other doubts about using this medicine, ask your doctor, pharmacist, or nurse.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everyone gets them.

The following adverse reactions are known with the use of Monoprost:

Very common: may affect more than 1 in 10 patients.

  • Gradual change in eye color due to the increase in the amount of brown pigment in the colored part of the eye known as the iris.
    • If you have mixed-color eyes (blue-brown, gray-brown, yellow-brown, or green-brown), you are more likely to notice this change than if your eyes are a single color (blue, gray, green, or brown).
    • The change in eye color may take years to develop, although it can usually be noticed after 8 months of treatment.
    • The change in eye color may be permanent and may be more noticeable if Monoprost is used only in one eye.
    • The change in eye color does not seem to be associated with the appearance of any problems.
    • The change in eye color does not progress once treatment with Monoprost has been stopped.
  • Redness of the eye.
  • Eye irritation (feeling of stinging, feeling of grit in the eye, itching, pain, and feeling of a foreign body in the eye).
  • Gradual change in the eyelashes of the treated eye and the fine hair around the treated eye, observed in most patients of Japanese origin. These changes include an increase in color (darkening), length, thickness, and number of eyelashes.

Common: may affect up to 1 in 10 patients

  • Irritation or erosion of the eye surface, eyelid inflammation (blepharitis), eye pain, and sensitivity to light (photophobia), conjunctivitis.

Uncommon: may affect up to 1 in 100 patients

  • Swelling of the eyelids, dry eye, inflammation or irritation of the eye surface (keratitis), blurred vision, inflammation of the colored part of the eye (uveitis), swelling of the retina (macular edema).
  • Skin rash.
  • Chest pain (angina), feeling the heartbeat (palpitations).
  • Asthma, difficulty breathing (dyspnea).
  • Chest pain.
  • Headache, dizziness.
  • Muscle pain, joint pain.
  • Nausea, vomiting.

Rare: may affect up to 1 in 1,000 patients

  • Inflammation of the iris (iritis), symptoms of swelling or injury/damage to the eye surface, swelling around the eye (periorbital edema), misdirected eyelashes or an additional row of eyelashes, accumulation of fluid in the colored part of the eye (iris cyst).
  • Skin reactions on the eyelids, darkening of the eyelid skin.
  • Worsening of asthma.
  • Severe itching of the skin.
  • Development of a viral eye infection caused by the herpes simplex virus (HSV).

Very rare: may affect up to 1 in 10,000 patients

  • Worsening of angina in patients who also have heart problems.
  • Sunken appearance of the eye (deepening of the eye groove).

Reporting side effects

If you experience any side effects, consult your doctor, pharmacist, or nurse, even if they are side effects not listed in this leaflet. You can also report them directly through the Spanish Medicines Monitoring System: https//: notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Monoprost

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiration date shown on the box and bottle. The expiration date is the last day of the month indicated.

Before the first opening of the bottle: Do not store above 25°C.

After the first opening of the bottle: Monoprost can be used for up to 1 month for the 2.5 ml bottle and up to 3 months for the 6 ml bottle, without special storage conditions.

Note the date of first opening on the box.

Medicines should not be disposed of through wastewater or household waste. Deposit the packaging and any unused medicines in the SIGRE collection point at the pharmacy. If in doubt, ask your pharmacist how to dispose of the packaging and any unused medicines. This will help protect the environment.

6. Package contents and additional information

Composition of Monoprost

The active ingredient is latanoprost.

1 ml of eye drops contains 50 micrograms of latanoprost.

The other components (excipients) are: macrogolglycerol hydroxystearate 40, sorbitol, carbomer 974P, macrogol 4000, disodium edetate, sodium hydroxide (for pH adjustment), water for injectable preparations.

Appearance of the product and package contents

Monoprost is a slightly yellowish, opalescent solution without preservatives.

Monoprost is available in the following package sizes:

  • 2.5 ml multidose bottle (at least 70 preservative-free drops) for 1 month of treatment, which includes a pump equipped with an Easygrip device with ergonomic supports.
  • 6 ml multidose bottle (at least 190 preservative-free drops) for 3 months of treatment, which includes a pump equipped with an Easygrip device with ergonomic supports.

Not all package sizes may be marketed.

Marketing authorization holder and manufacturer

Marketing authorization holder

LABORATOIRES THEA

12 RUE LOUIS BLERIOT

63017 CLERMONT-FERRAND CEDEX 2

FRANCE

Manufacturer

DELPHARM TOURS

RUE PAUL LANGEVIN

37170 CHAMBRAY LES TOURS

FRANCE

Or

LABORATOIRES THEA

12 RUE LOUIS BLERIOT

63017 CLERMONT-FERRAND CEDEX 2

FRANCE

Local representative

Laboratorios Thea, S.A.

C/ Enric Granados nº 86-88, 2ª planta

08008 – BARCELONA

This medicine is authorized in the Member States of the European Economic Area under the following names:

Germany, Belgium, Bulgaria, Cyprus, Denmark, Spain, Finland, France, Greece, Netherlands, Iceland, Italy, Luxembourg, Norway, Poland, Portugal, Sweden

Monoprost

Austria, Slovenia, Czech Republic, Slovakia, Romania

Monopost

Date of the last revision of this leaflet: February 2024

Detailed and updated information about this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/.

Online doctors for MONOPROST 50 micrograms/ml eye drops in solution

Discuss questions about MONOPROST 50 micrograms/ml eye drops in solution, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Doctor

Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques. For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance. Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults. In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions. Patients commonly seek his care for: 

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Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.

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Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

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Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
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He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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Andrei Popov

General medicine 7 years exp.

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

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Doctor

Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

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Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
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Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Doctor

Joao Silva

General medicine 6 years exp.

Dr. João Silva is a physician with training and experience in the field of General and Family Medicine, dedicated to providing healthcare focused on the well-being and quality of life of his patients. Throughout his professional career, he has developed broad clinical competencies, striving to maintain a medical practice based on scientific evidence and continuous knowledge updates.

Between 2013 and 2019, he completed the Integrated Master's Degree in Medicine at the Abel Salazar Institute of Biomedical Sciences in Porto, where he acquired a solid academic and clinical education.

Subsequently, between January 2021 and December 2021, he completed the General Internship at the Entre Douro e Vouga Hospital Center in Santa Maria da Feira, where he had the opportunity to work in different hospital settings and deepen his competencies in several areas of medicine.

From January 2022 until March 2026, he works as a Resident Physician in General and Family Medicine at USF Salvador Machado in Oliveira de Azeméis, developing clinical activities in primary healthcare, follow-up of chronic patients, and health promotion in the community.

Complementing his medical training, Dr. João Silva also completed a Postgraduate Degree in Continuing and Palliative Care at CESPU, strengthening his preparation in the comprehensive approach to patient care, especially in situations requiring prolonged care and multidisciplinary support.

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Bulat Garipov

General medicine 15 years exp.

Dr. Bulat Garipov is a radiologist with more than 15 years of experience, specializing in magnetic resonance imaging (MRI). Throughout his professional career, he has worked in leading diagnostic imaging centers, both in on-site practice and teleradiology, which has allowed him to develop a broad and versatile approach to radiology.

Over the years, he has gained solid experience in interpreting MRI studies in various areas, including:

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  •  Musculoskeletal system (MSK)
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  •  Abdomen and pelvis
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Additionally, Dr. Garipov is open to new collaboration opportunities in radiology and teleradiology projects. He offers his expertise in MRI, providing both first and second readings of studies, as well as advanced image interpretation, ensuring accurate and high-quality diagnostics.

You could consult Dr. Bulat Garipov in cases where accurate interpretation of MRI studies or a second expert opinion is required. His expertise is especially valuable in cases of suspected neurological conditions, back and joint pain, vascular disorders, as well as in the diagnosis of abdominal and pelvic diseases. The doctor also provides support in complex or unclear clinical situations, including the review of previously performed studies, which helps improve diagnostic accuracy and determine the optimal treatment strategy. A teleradiology format is available, allowing you to receive a professional opinion remotely.

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Frequently Asked Questions

Is a prescription required for MONOPROST 50 micrograms/ml eye drops in solution?
MONOPROST 50 micrograms/ml eye drops in solution requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in MONOPROST 50 micrograms/ml eye drops in solution?
The active ingredient in MONOPROST 50 micrograms/ml eye drops in solution is latanoprost. This information helps identify medicines with the same composition but different brand names.
Who manufactures MONOPROST 50 micrograms/ml eye drops in solution?
MONOPROST 50 micrograms/ml eye drops in solution is manufactured by Laboratoires Thea. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of MONOPROST 50 micrograms/ml eye drops in solution online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether MONOPROST 50 micrograms/ml eye drops in solution is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to MONOPROST 50 micrograms/ml eye drops in solution?
Other medicines with the same active substance (latanoprost) include CATIOLANZE 50 micrograms/ml EMULSION EYE DROPS, LATANEST 50 micrograms/ml eye drops solution, LATANOPROST AUROVITAS 50 micrograms/ml EYE DROPS SOLUTION. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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