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MASTICAL 500 mg CHEWABLE TABLETS

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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use MASTICAL 500 mg CHEWABLE TABLETS

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

Mastical 500 mg Chewable Tablets

Calcium

Read the entire package leaflet carefully before starting to take this medication, as it contains important information for you.

  • Follow the administration instructions for this medication exactly as indicated in this package leaflet or as directed by your doctor or pharmacist. Keep this package leaflet, as you may need to read it again.
  • If you need advice or more information, consult your pharmacist.
  • If you experience side effects, consult your doctor or pharmacist, even if they are side effects not listed in this package leaflet. See section 4.

Contents of the Package Leaflet

  1. What is Mastical and what is it used for
  2. What you need to know before taking Mastical
  3. How to take Mastical
  4. Possible side effects
  5. Storage of Mastical
  6. Package Contents and Additional Information

1. What is Mastical and what is it used for

Mastical is a chewable tablet that contains calcium, an essential substance for bone formation.

Mastical is used to prevent and treat calcium deficiency and as a supplement in the treatment of osteoporosis. Mastical is also used under medical prescription as a phosphate binder in patients with high phosphate levels in the blood.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before taking Mastical

Do not take Mastical:

-if you are allergic to calcium or any of the other components of this medication (listed in section 6).

  • -if you have high levels of calcium in the blood or urine.
  • -if you have kidney stones.

Warnings and Precautions

Consult your doctor or pharmacist before starting to take Mastical:

  • -if you are taking diuretics (used to treat high blood pressure or edema) or cardiac glycosides (used to treat heart conditions).
  • -if you have excessive calcium levels in the blood or signs of kidney failure or have had kidney stones in the past.
  • -if you are taking high doses of calcium and also using products containing vitamin D.
  • -if you are taking high doses of calcium and also using antacids.

Using Mastical with Other Medications

Tell your doctor or pharmacist if you are taking, have recently taken, or may take any other medication.

Calcium carbonate may interfere with the absorption of tetracyclines if taken at the same time. For this reason, tetracyclines should be taken at least 2 hours before or 4-6 hours after taking Mastical.

Medications containing bisphosphonates should be taken at least 1 hour before taking Mastical.

Calcium may reduce the effects of levothyroxine. For this reason, levothyroxine should be taken at least 4 hours before or 4 hours after Mastical.

The effects of some antibiotics (quinolones) may be reduced if taken at the same time as calcium. For this reason, quinolones should be taken 2 hours before or 6 hours after taking Mastical.

Calcium salts may reduce the absorption of iron, zinc, and strontium ranelate. Consequently, iron, zinc, or strontium ranelate preparations should be taken at least 2 hours before or after Mastical.

Other medications that may interact with Mastical include thiazide diuretics and cardiac glycosides.

If you are using any of the mentioned medications, your doctor will provide you with more instructions.

Taking Mastical with Food and Drinks

Mastical can be taken with or without food and drinks.

Pregnancy, Breastfeeding, and Fertility

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medication.

During pregnancy, the daily intake of calcium should not exceed 2500 mg (including food and supplements). Mastical can be used during pregnancy in case of calcium deficiency.

Mastical can be used during breastfeeding. Calcium passes into breast milk.

Driving and Using Machines

Mastical has no known influence on the ability to drive and use machines.

Mastical Contains Isomalt

Mastical contains isomalt (E953). If your doctor has told you that you have an intolerance to certain sugars, consult with them before taking this medication.

3. How to Take Mastical

Follow the administration instructions for this medication exactly as indicated by your doctor or pharmacist. In case of doubt, consult your doctor or pharmacist again.

Dosage:

The recommended dose in adults is 500-1500 mg of calcium per day.

Use in Children

The recommended dose in children is 500-1000 mg of calcium per day.

The tablets can be chewed or sucked.

If You Take More Mastical Than You Should:

If you have taken more Mastical than you should, consult your doctor or pharmacist immediately.

If You Forget to Take Mastical:

Do not take a double dose to make up for forgotten doses.

If you have any other questions about the use of this medication, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible Side Effects

Like all medications, this medication can cause side effects, although not everyone will experience them.

Dyspepsia has occurred with an unknown frequency (cannot be estimated from available data).

Uncommon Side Effects (may affect up to 1 in 100 people)

High levels of calcium in the blood or urine.

Rare Side Effects (may affect up to 1 in 1,000 people)

Constipation, gas, nausea, abdominal pain, diarrhea.

Very Rare Side Effects (may affect up to 1 in 10,000 people)

Itching and urticaria. The milk-alkali syndrome usually occurs only when high amounts of calcium have been ingested; symptoms include frequent urge to urinate, headache, loss of appetite, nausea or vomiting, unusual fatigue and weakness, high levels of calcium in the blood, and kidney damage.

Reporting Side Effects

If you experience any side effects, consult your doctor or pharmacist, even if they are possible side effects not listed in this package leaflet. You can also report them directly through the Spanish Medicines Monitoring System: www.notificaRAM.es. By reporting side effects, you can help provide more information on the safety of this medication.

5. Storage of Mastical

Keep out of sight and reach of children.

Do not use this medication after the expiration date stated on the packaging. The expiration date is the last day of the month indicated.

Plastic bottle: Do not store above 30°C. Keep the container tightly closed to protect from moisture.

Shelf life after opening: 6 months.

Blister: Do not store above 25°C. Store in the original packaging to protect from moisture.

Medications should not be disposed of through wastewater or household waste. Dispose of packaging and unused medications at the pharmacy's SIGRE point. If in doubt, ask your pharmacist how to dispose of packaging and unused medications. This will help protect the environment.

6. Package Contents and Additional Information

Mastical 500 mg Composition

The active ingredient is 1250 mg of calcium carbonate (equivalent to 500 mg of calcium).

The other ingredients are:

Xylitol (E967), povidone, isomalt (E953), flavor enhancer (orange), magnesium stearate, sucralose (E955), mono- and diglycerides of fatty acids.

Product Appearance and Package Contents

Mastical is a round, white tablet.

Package sizes:

Plastic bottle: 20, 30, 50, 60, 90, 100, 120, and 180 tablets of 500mg.

30, 60, 90, 100 tablets of 1000mg.

Blister: 50 x 1 tablet (single dose).

Not all package sizes may be marketed.

Marketing Authorization Holder and Manufacturer

Marketing Authorization Holder:

CHEPLAPHARM Arzneimittel GmbH.

Ziegelhof 24.

17489 Greifswald.

Germany.

Manufacturers:

Asker Contract Manufacturing AS.

Drammensveien 852.

NO-1383 Asker, Norway.

or

Tjoapack Netherlands B.V.

Nieuwe Donk 9.

4879 AC Etten-Leur, Netherlands.

Local Representative:

Laboratorios Rubió, S.A.

Industria, 29 - Pol. Ind. Comte de Sert.

08755 Castellbisbal (Barcelona).

Spain.

This medication is authorized in the Member States of the European Economic Area under the following names:

500 mg:

Belgium: Calci - Chew.

Finland: Calcichew appelsiini 500 mg purutabletti.

Greece: Calcioral.

Luxembourg: Calcichew.

Netherlands: Caci - Chew 500 mg.

Spain: Mastical.

Sweden: Calcitugg 500 mg.

This package leaflet was approved in February 2023.

Online doctors for MASTICAL 500 mg CHEWABLE TABLETS

Discuss questions about MASTICAL 500 mg CHEWABLE TABLETS, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Joao Silva

General medicine 6 years exp.

Dr. João Silva is a physician with training and experience in the field of General and Family Medicine, dedicated to providing healthcare focused on the well-being and quality of life of his patients. Throughout his professional career, he has developed broad clinical competencies, striving to maintain a medical practice based on scientific evidence and continuous knowledge updates.

Between 2013 and 2019, he completed the Integrated Master's Degree in Medicine at the Abel Salazar Institute of Biomedical Sciences in Porto, where he acquired a solid academic and clinical education.

Subsequently, between January 2021 and December 2021, he completed the General Internship at the Entre Douro e Vouga Hospital Center in Santa Maria da Feira, where he had the opportunity to work in different hospital settings and deepen his competencies in several areas of medicine.

From January 2022 until March 2026, he works as a Resident Physician in General and Family Medicine at USF Salvador Machado in Oliveira de Azeméis, developing clinical activities in primary healthcare, follow-up of chronic patients, and health promotion in the community.

Complementing his medical training, Dr. João Silva also completed a Postgraduate Degree in Continuing and Palliative Care at CESPU, strengthening his preparation in the comprehensive approach to patient care, especially in situations requiring prolonged care and multidisciplinary support.

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Doctor

Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Doctor

Daniel Cichi

Family medicine 24 years exp.

Dr Daniel Cichi is a family medicine doctor with over 20 years of clinical experience. He provides online consultations for adults, supporting patients with acute symptoms, chronic conditions, and everyday health concerns that require timely medical guidance. His background includes work in emergency care, ambulance services, and family medicine, which allows him to assess symptoms quickly, identify warning signs, and help patients choose the safest next steps – whether that means home care, treatment adjustment, or in-person evaluation. Patients commonly consult Dr Daniel Cichi for: 

  • acute symptoms: fever, infections, flu-like illness, cough, sore throat, shortness of breath;
  • chest discomfort, palpitations, dizziness, fatigue, and blood pressure concerns;
  • digestive problems: abdominal pain, nausea, diarrhoea, constipation, reflux;
  • sexually transmitted infections, erectile dysfunction;
  • muscle, joint, and back pain, minor injuries, post-traumatic symptoms;
  • chronic conditions: hypertension, diabetes, high cholesterol, thyroid disorders, weight loss, hair loss;
  • review and interpretation of lab tests, imaging reports, and medical documents;
  • medication review and treatment adjustment;
  • medical advice while travelling or living abroad;
  • second opinions and guidance on whether in-person care is needed.

Dr Cichi’s consultations are structured and practical. He focuses on clear explanations, risk assessment, and actionable recommendations, helping patients understand their symptoms and make informed decisions about their health.

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Doctor

Lina Travkina

Family medicine 13 years exp.

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
  • Post-operative recovery support and pain management.
  • Preconception counselling and postpartum support.
  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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Doctor

Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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€58

Frequently Asked Questions

Is a prescription required for MASTICAL 500 mg CHEWABLE TABLETS?
MASTICAL 500 mg CHEWABLE TABLETS does not require a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in MASTICAL 500 mg CHEWABLE TABLETS?
The active ingredient in MASTICAL 500 mg CHEWABLE TABLETS is calcium carbonate. This information helps identify medicines with the same composition but different brand names.
How much does MASTICAL 500 mg CHEWABLE TABLETS cost in pharmacies?
The average pharmacy price for MASTICAL 500 mg CHEWABLE TABLETS is around 2.75 EUR. Prices may vary depending on the manufacturer and dosage form.
Who manufactures MASTICAL 500 mg CHEWABLE TABLETS?
MASTICAL 500 mg CHEWABLE TABLETS is manufactured by Cheplapharm Arzneimittel Gmbh. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of MASTICAL 500 mg CHEWABLE TABLETS online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether MASTICAL 500 mg CHEWABLE TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to MASTICAL 500 mg CHEWABLE TABLETS?
Other medicines with the same active substance (calcium carbonate) include CAOSINA 1000 mg ORAL SUSPENSION POWDER, CARBOCAL 600 MG TABLETS, NATECAL 600 mg CHEWABLE TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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