Bg pattern

LOPERAMIDE OPKO 2 mg HARD CAPSULES

Prescription review online

Prescription review online

A doctor will review your case and decide whether a prescription is medically appropriate.

Talk to a doctor about this medicine

Talk to a doctor about this medicine

Discuss your symptoms and possible next steps in a quick online consultation.

This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use LOPERAMIDE OPKO 2 mg HARD CAPSULES

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

Show original

Introduction

Package Leaflet: Information for the Patient

Loperamide OPKO 2 mg Hard Capsules

Loperamide Hydrochloride

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

*Follow exactly the administration instructions of the medicine contained in this leaflet or as indicated by your doctor, pharmacist, or nurse.

  • Keep this leaflet, you may need to read it again.
  • If you need advice or more information, consult your pharmacist.
  • If you experience side effects, consult your pharmacist, even if it is a side effect not listed in this leaflet. See section 4.
  • You should consult a doctor if it worsens or does not improve after 2 days.

Contents of the Package Leaflet

  1. What is Loperamide OPKO 2 mg Capsules and what is it used for
  2. What you need to know before taking Loperamide OPKO 2 mg Capsules
  3. How to take Loperamide OPKO 2 mg Capsules
  4. Possible side effects
  5. Storage of Loperamide OPKO 2 mg Capsules
  6. Contents of the pack and further information

1. What is Loperamide OPKO 2 mg Capsules and what is it used for

Loperamide is an antidiarrheal that reduces defecations and secretions, resulting in a decrease in liquid stools.

Loperamide is indicated for the symptomatic treatment of acute diarrhea in adults and children over 12 years of age.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before taking Loperamide OPKO 2 mg Capsules

Do not take Loperamide OPKO 2 mg Capsules:

  • Children under 12 years of age
  • If you are allergic to loperamide or any of the other components of this medicine (listed in section 6)
  • If you have a high fever (over 38 °C) and blood in the stool (acute dysentery)
  • If you suffer from ulcerative colitis (inflammation of the intestine)
  • If you suffer from intense diarrhea after taking antibiotics
  • If you suffer from diarrhea caused by an infection caused by a microorganism such as Salmonella, Shigella, or Campylobacter.

Treatment should be stopped quickly and a doctor consulted if constipation, abdominal distension (flatulence), or ileus (absence of defecations) occurs.

Warnings and precautions

Consult your doctor or pharmacist before starting to take Loperamide OPKO 2 mg Hard Capsules

  • If you have intense diarrhea, your body loses more fluids, sugars, and salts than usual. You will need to drink more than usual to replenish fluids. Ask your pharmacist about preparations to replenish sugars and salts
  • If you have AIDS and your stomach swells, stop taking this medicine immediately and consult your doctor
  • If you have any liver disease, consult your doctor before taking this medicine, as it could produce toxicity in the central nervous system.
  • If you have had diarrhea for more than 48 hours, stop taking this medicine and consult your doctor.

Treatment with this medicine is only symptomatic, so the diarrhea should be treated from its cause.

Do not take this medicine for a use other than indicated (see section 1) and never take more than the recommended amount (see section 3). Serious cardiac problems (whose symptoms include rapid or irregular heartbeats) have been reported in patients who have taken an excessive amount of loperamide, the active ingredient of Loperamide OPKO 2 mg Hard Capsules.

Patients with diarrhea should drink plenty of fluids to avoid dehydration, which is manifested by dry mouth, excessive thirst, decreased urine output, wrinkled skin, dizziness, and drowsiness. This is especially important in children and the elderly.

Children and adolescents

Do not use in children and adolescents under 12 years of age.

Other medicines and Loperamide OPKO 2 mg Hard Capsules

Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.

It is especially important if you are taking medicines that contain

  • Ritonavir, saquinavir (used to treat HIV)
  • Quinidine (used to treat abnormal heart rhythms)
  • Desmopressin oral (used to treat central diabetes insipidus and nocturnal urinary incontinence in children)
  • Itraconazole or ketoconazole (used to treat fungal infections)
  • Gemfibrozil (used to lower cholesterol)

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Pregnant women, especially in the first trimester, should not take this medicine unless prescribed by a doctor.

Do not take Loperamide OPKO 2 mg Hard Capsules if you are breastfeeding. Small amounts of the medicine may pass into breast milk.

Driving and using machines

You can drive and use tools and machines, unless you feel tired, dizzy, or drowsy. Do not drive or use machines in these situations.

Loperamide OPKO 2 mg Hard Capsules contains lactose

If your doctor has told you that you have an intolerance to some sugars, consult them before taking this medicine.

3. How to take Loperamide OPKO 2 mg Capsules

Follow exactly the administration instructions of the medicine contained in this leaflet or as indicated by your doctor or pharmacist. In case of doubt, ask your doctor or pharmacist.

The recommended dose is

Adults

  • 2 capsules (4 mg) as an initial dose, followed by 1 capsule (2 mg) after each diarrheal stool.
  • The maximum dose for adults is 8 capsules (16 mg) per day

A one-hour break should be made after the initial dose.

Children over 12 years of age

  • 1 capsule (2 mg) as an initial dose, followed by 1 capsule (2 mg) after each diarrheal stool

The maximum dose in children between 12 and 18 years of age is 4 capsules (8 mg).

A one-hour break should be made after the initial dose.

Treatment should not exceed 48 hours.

Loperamide OPKO 2 mg Hard Capsules should not be used in children under 12 years of age.

Take the capsules with a glass of water.

Patient with liver disease should consult their doctor.

Elderly population

No dose adjustment is necessary in elderly patients.

Kidney problems

No dose adjustment is necessary in patients with renal insufficiency.

Liver problems

If you have liver insufficiency, consult your doctor or pharmacist before taking this medicine.

If you take more Loperamide OPKO 2 mg Capsules than you should

Symptoms

In case of overdose (including relative overdose caused by liver dysfunction), central nervous system depression (stupor, altered coordination, drowsiness, miosis, muscle hypertonia, and respiratory depression), urinary retention, and ileus may occur. Children may be more sensitive to the effects on the central nervous system.

Cardiac events, such as prolonged QT interval and QRS complex, torsades de pointes, other serious ventricular arrhythmias, cardiac arrest, and syncope have been observed in patients who ingested an overdose of loperamide (see section 4.4). Fatal cases have also been reported. Overdose may unmask a pre-existing Brugada syndrome.

Treatment

In cases of overdose, ECG monitoring of the QT interval prolongation should be initiated.

If symptoms of central nervous system overdose occur, naloxone may be administered as an antidote. Since the duration of action of loperamide is longer than that of naloxone (1 to 3 hours), repeated treatment with naloxone may be indicated. Therefore, the patient should be closely monitored for at least 48 hours to detect possible central nervous system depressions.

In case of overdose or accidental ingestion, consult your doctor or pharmacist, or call the Toxicology Information Service, Phone 91 562 04 20 (indicating the medicine and the amount ingested).

If you forget to take Loperamide OPKO 2 mg Capsules

You should only take this medicine when you need it, following the instructions above about the doses.

If you forget to take a dose, take it after the next loose stool.

Do not take a double dose to make up for forgotten doses.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Seek medical attention immediately if you experience any of the following serious side effects:

Serious adverse reactions

Rare:

  • Immune system: hypersensitivity, anaphylactic reaction (including anaphylactic shock), anaphylactoid reaction.
  • Nervous system: loss of consciousness, stupor, altered consciousness, hypertonia, altered coordination.
  • Eyes: miosis
  • Gastrointestinal tract: acute pancreatitis
  • Skin and subcutaneous tissue: bullous eruptions (including Stevens-Johnson syndrome, toxic epidermal necrolysis, and erythema multiforme), angioedema, urticaria, pruritus
  • Kidney and urinary tract: urinary retention

Frequent:

  • Nervous system: headache, dizziness
  • Gastrointestinal tract: constipation, nausea, flatulence

Uncommon:

  • Nervous system: drowsiness
  • Gastrointestinal tract: abdominal pain, abdominal discomfort, dry mouth, upper abdominal pain, vomiting, dyspepsia (including paralytic ileus), megacolon (including toxic megacolon), abdominal distension
  • Skin and subcutaneous tissue: rash

Rare:

  • Symptoms and reactions at the administration site: fatigue

In children and adolescents, the following side effects may also occur:

The side effects observed in children and adolescents in clinical studies were generally similar to those observed in adults and children over 12 years of age.

Reporting of side effects

If you experience any side effect, talk to your doctor or pharmacist, even if it is a possible side effect not listed in this leaflet.

You can also report side effects directly through the Spanish Pharmacovigilance System for Human Use Medicines: www.notificaRAM.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Loperamide OPKO 2 mg Capsules

Keep this medicine out of the sight and reach of children.

This medicine does not require any special storage conditions.

Do not use this medicine after the expiry date which is stated on the outer packaging after (EXP). The expiry date is the last day of the month indicated.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help protect the environment.

6. Contents of the pack and further information

Composition of Loperamide OPKO 2 mg Capsules

  • The active substance is loperamide hydrochloride. Each capsule contains 2 mg of loperamide hydrochloride.
  • The other ingredients are lactose monohydrate

The capsule is made of:

Titanium dioxide (E171)

Black iron oxide (E172)

Red iron oxide (E172)

Yellow iron oxide (E172)

Brilliant blue FCF (E133)

Gelatin.

Appearance of the product and pack contents

The loperamide hydrochloride capsule is a hard gelatin capsule of size «4» 14.0 mm to 14.8 mm filled with white to off-white powder with a grey and green cap. Blister packs of aluminum and PVC with 20 hard capsules.

Marketing authorization holder and manufacturer

Marketing authorization holder:

OPKO Health Spain, S.L.U.

Pl. 13-15, 08908

L’Hospitalet de Llobregat (Barcelona)

Spain

Manufacturer:

Meiji Pharma Spain, S.A.

Avda. de Madrid, 94,

Alcalá de Henares,

28802 Madrid,

Spain

Date of last revision of this leaflet: January 2023.

Detailed information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es

Online doctors for LOPERAMIDE OPKO 2 mg HARD CAPSULES

Discuss questions about LOPERAMIDE OPKO 2 mg HARD CAPSULES, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

0.0 (0)
Doctor

Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
Camera Book a video appointment
€58
5.0 (5)
Doctor

Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques. For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance. Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults. In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions. Patients commonly seek his care for: 

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns

Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.

Camera Book a video appointment
€80
5.0 (1055)
Doctor

Andrei Popov

General medicine 7 years exp.

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

Camera Book a video appointment
€80
5.0 (183)
Doctor

Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

Camera Book a video appointment
€50

Frequently Asked Questions

Is a prescription required for LOPERAMIDE OPKO 2 mg HARD CAPSULES?
LOPERAMIDE OPKO 2 mg HARD CAPSULES does not require a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in LOPERAMIDE OPKO 2 mg HARD CAPSULES?
The active ingredient in LOPERAMIDE OPKO 2 mg HARD CAPSULES is loperamide. This information helps identify medicines with the same composition but different brand names.
Who manufactures LOPERAMIDE OPKO 2 mg HARD CAPSULES?
LOPERAMIDE OPKO 2 mg HARD CAPSULES is manufactured by Opko Health Spain S.L.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of LOPERAMIDE OPKO 2 mg HARD CAPSULES online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether LOPERAMIDE OPKO 2 mg HARD CAPSULES is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to LOPERAMIDE OPKO 2 mg HARD CAPSULES?
Other medicines with the same active substance (loperamide) include ABECLIN 2 mg TABLETS, DIARFIN 2 mg HARD CAPSULES, DIARFIN FLAS 2 mg ORAL LYOPHILIZED. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
bg-pattern-dark

Stay informed about Oladoctor

News about new services, product updates and useful information for patients.

Follow us on social media