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LEGALON 150 mg CAPSULES

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About the medicine

How to use LEGALON 150 mg CAPSULES

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the Patient

Legalon 150 mg Capsules

(Silymarin)

Read the entire package leaflet carefully before starting to take this medication, as it contains important information for you.

  • Keep this package leaflet, as you may need to read it again.
  • If you have any questions, consult your doctor or pharmacist.
  • This medication has been prescribed to you only, and you should not give it to others, even if they have the same symptoms as you, as it may harm them.
  • If you experience side effects, consult your doctor or pharmacist, even if they are not listed in this package leaflet. See section 4.

Contents of the Package Leaflet:

  1. What is Legalon 150 mg Capsules and what is it used for
  2. What you need to know before taking Legalon 150 mg Capsules
  3. How to take Legalon 150 mg Capsules
  4. Possible side effects
  5. Storage of Legalon 150 mg Capsules
  6. Package Contents and Additional Information

1. What is Legalon 150 mg Capsules and what is it used for

Legalon 150 mg Capsules belongs to a group of medications called "Hepatic Therapy, Lipotropics" with therapeutic activity on liver lesions, and its active ingredient is silymarin.

Legalon 150 mg Capsules is indicated for the treatment of liver lesions such as those caused by chronic alcohol consumption and hepatotoxic medications, hepatic steatosis (fatty liver), alcoholic hepatitis, and hepatic cirrhosis.

Doctor consultation

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2. What you need to know before taking Legalon 150 mg Capsules

Do not take Legalon 150 mg Capsules

If you are allergic to the active ingredient, silymarin, or to any of the other components of this medication (listed in section 6).

Warnings and Precautions

Treatment with dry extract of milk thistle fruit does not replace abstinence from the causes of liver damage (e.g., alcohol).

In case of jaundice (yellowish discoloration of the skin, yellowish discoloration of the whites of the eyes), consult your doctor.

The use of this medication for long periods of time should be monitored by your doctor.

Consult your doctor or pharmacist before starting to take Legalon 150 mg Capsules.

Other Medications and Legalon 150 mg Capsules:

Tell your doctor or pharmacist that you are using, have recently used, or may need to use any other medication.

Taking Legalon 150 mg Capsules with Food and Drinks:

No interaction has been described between the use of this medication and the consumption of food and drinks.

Pregnancy, Breastfeeding, and Fertility

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medication.

Pregnancy:

Since there are no studies in pregnant women, this medication will only be used during pregnancy when, in the strict medical opinion, the benefits justify the potential risks.

Breastfeeding:

It is unknown whether silymarin passes into breast milk, so it will only be used during breastfeeding when, in the strict medical opinion, the benefits justify the potential risks.

Driving and Using Machines

The influence of Legalon 150 mg Capsules on the ability to drive and use machines is nil.

Legalon 150 mg Capsules contains Sodium

This medication contains less than 23 mg of sodium (1 mmol) per capsule, which is essentially "sodium-free".

3. How to take Legalon 150 mg Capsules

Follow the administration instructions for this medication exactly as indicated by your doctor or pharmacist. If you have any doubts, consult your doctor or pharmacist again.

Adults

The recommended oral dose is 1 capsule (150 mg) three times a day, after the main meals.

The treatment period is established at 4 to 6 weeks, and as a maintenance dose, 1 capsule 2 times a day, unless otherwise medically indicated.

Use in Children and Adolescents

No data are available for this age group.

Use in the Elderly

No specific problems have been described in this age group.

Method of Administration

Swallow the capsules with a little liquid after the main meals.

If you take more Legalon 150 mg Capsules than you should:

In case of overdose or accidental ingestion, consult the Toxicology Information Service. Phone 91 562 04 20.

If you forget to take Legalon 150 mg Capsules

Do not take a double dose to make up for the forgotten doses.

If you interrupt treatment with Legalon 150 mg Capsules

Consult your doctor.

If you have any other questions about the use of this medication, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible Side Effects

Like all medications, Legalon 150 mg may cause side effects, although not everyone will experience them.

The adverse reactions of Legalon 150 mg are infrequent.

Uncommon (affecting 1 to 10 out of 1000 patients)

Gastrointestinal disorders: stomach pain and diarrhea.

Very rare (affecting less than 1 patient in 10,000)

Immune system disorders: allergic reactions.

Respiratory, thoracic, and mediastinal disorders: dyspnea.

Skin and subcutaneous tissue disorders: skin rash.

If you experience side effects, consult your doctor or pharmacist, even if they are not listed in this package leaflet.

Reporting Side Effects

If you experience any type of side effect, consult your doctor or pharmacist, even if it is a possible side effect not listed in this package leaflet. You can also report them directly through the Spanish Medication Pharmacovigilance System, https://www.notificaRAM.es. By reporting side effects, you can contribute to providing more information on the safety of this medication.

5. Storage of Legalon 150 mg Capsules

Keep this medication out of sight and reach of children. Store in the outer packaging.

Do not use Legalon 150 mg Capsules after the expiration date stated on the packaging after CAD or EXP. The expiration date is the last day of the month indicated.

Medications should not be disposed of through wastewater or household waste. Deposit the packaging and medications you no longer need at the SIGRE point in the pharmacy. If you have any doubts, ask your pharmacist how to dispose of the packaging and medications you no longer need. This will help protect the environment.

6. Package Contents and Additional Information

Composition of Legalon 150 mg Capsules:

The active ingredient is silymarin. Each capsule contains 196 mg of silymarin extract equivalent to 150 mg of silybinin.

The other components are: Mannitol (E-421), Polysorbate 80, Polyvinylpyrrolidone, Colloidal Anhydrous Silica, Magnesium Stearate, and Sodium Carboxymethylcellulose Type A.

The capsule is composed of: Red and Yellow Iron Oxides (E-172), Erythrosine (E-127), and Titanium Dioxide (E-171).

Appearance of the Product and Package Contents

Legalon 150 mg Capsules are presented in blisters containing 30 hard red capsules.

Marketing Authorization Holder:

Cooper Consumer Health B.V.

Verrijn Stuartweg 60,

1112 AX Diemen,

Netherlands

Manufacturer:

Alcalá Farma, S.L.

Avenida de Madrid 82

28802 Alcalá de Henares – Spain

You can request more information about this medication by contacting the local representative of the marketing authorization holder:

Vemedia Pharma Hispania, S.A.

C/ Aragón, 182, 5th floor

08011 - Barcelona

Spain

Date of Last Revision of this Package Leaflet: February 2025

Detailed and updated information about this medication is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) https://www.aemps.es/

Online doctors for LEGALON 150 mg CAPSULES

Discuss questions about LEGALON 150 mg CAPSULES, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Doctor

Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques. For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance. Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults. In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions. Patients commonly seek his care for: 

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns

Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.

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Lina Travkina

Family medicine 13 years exp.

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
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  • Preconception counselling and postpartum support.
  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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Doctor

Alina Tsurkan

Family medicine 13 years exp.

Dr. Alina Tsurkan is a licensed family medicine physician based in Portugal, offering online consultations for adults and children. She provides professional primary care, with a focus on prevention, accurate diagnosis, and long-term management of acute and chronic conditions.

Dr. Tsurkan supports patients with a wide range of health issues, including:

  • Respiratory infections: cold, flu, bronchitis, pneumonia, and lingering coughs.
  • ENT conditions: sinusitis, tonsillitis, otitis (ear infections), sore throat, allergic rhinitis.
  • Eye conditions: allergic or infectious conjunctivitis, red eyes, irritation.
  • Digestive issues: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), constipation, bloating, nausea.
  • Urinary and reproductive health: urinary tract infections (UTIs), cystitis, prevention of recurrent infections.
  • Chronic diseases: hypertension, elevated cholesterol, weight management.
  • Neurological complaints: headaches, migraines, sleep disturbances, fatigue, general weakness.
  • Children’s health: fever, infections, digestive issues, follow-ups, vaccination guidance.

She also provides:

  • IMT medical certificates for driving licence exchange in Portugal.
  • Personalised preventive care and wellness consultations.
  • Interpretation of test results and medical reports.
  • Follow-up care and medication review.
  • Support in managing multiple coexisting conditions.
  • Remote prescription management and medical documentation.

Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

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Doctor

Anna Biriukova

General medicine 6 years exp.

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

  • High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
  • Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
  • Leg swelling, chronic fatigue, reduced exercise tolerance.
  • EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
  • Post-COVID-19 cardiac monitoring and care.
Endocrinology – Diabetes, thyroid, metabolism:
  • Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
  • Individual treatment plans including oral medications and insulin therapy.
  • GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
  • Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
  • Metabolic syndrome – obesity, lipid disorders, insulin resistance.
Gastroenterology – Digestive health:
  • Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
  • Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
  • Respiratory infections – cough, colds, bronchitis.
  • Lab test analysis, therapy adjustments, medication management.
  • Adult vaccinations – planning, contraindications assessment.
  • Cancer prevention – screening strategies and risk assessment.
  • Holistic approach – symptom relief, complication prevention, and quality of life improvement.
Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
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Frequently Asked Questions

Is a prescription required for LEGALON 150 mg CAPSULES?
LEGALON 150 mg CAPSULES requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in LEGALON 150 mg CAPSULES?
The active ingredient in LEGALON 150 mg CAPSULES is silymarin. This information helps identify medicines with the same composition but different brand names.
Who manufactures LEGALON 150 mg CAPSULES?
LEGALON 150 mg CAPSULES is manufactured by Cooper Consumer Health B.V.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of LEGALON 150 mg CAPSULES online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether LEGALON 150 mg CAPSULES is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to LEGALON 150 mg CAPSULES?
Other medicines with the same active substance (silymarin) include SILARINE 80 mg HARD CAPSULES, CHENODEOXYCHOLIC ACID LEADIANT 250 mg HARD CAPSULES, URSODESOXYCHOLIC ACID GRINDEKS 250 mg HARD CAPSULES. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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