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ICATIBANTO FRESENIUS 30 mg Injectable Solution in Pre-filled Syringe

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About the medicine

How to use ICATIBANTO FRESENIUS 30 mg Injectable Solution in Pre-filled Syringe

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Contents of the leaflet

  1. Introduction
  2. What is Icatibant Fresenius and what is it used for
  3. What you need to know before you use Icatibant Fresenius
  4. How to use Icatibant Fresenius
  5. ¿
  6. Possible side effects
  7. Storage of Icatibant Fresenius
  8. Package Contents and Additional Information

Introduction

Package Leaflet: Information for the User

Icatibant Fresenius 30 mg solution for injection in pre-filled syringe EFG

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.
    • If you experience side effects, consult your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the package leaflet

  1. What is Icatibant Fresenius and what is it used for
  2. What you need to know before you use Icatibant Fresenius
  3. How to use Icatibant Fresenius
  4. Possible side effects

5 Storage of Icatibant Fresenius

  1. Contents of the pack and other information

1. What is Icatibant Fresenius and what is it used for

This medicine contains the active substance icatibant.

Icatibant is used to treat the symptoms of hereditary angioedema (HAE) in adults, adolescents, and children over 2 years of age.

In HAE, the levels of a substance present in the blood called bradykinin increase, producing symptoms such as swelling, pain, nausea, and diarrhea.

Icatibant blocks the activity of bradykinin and thus slows down the progression of the symptoms of an HAE attack.

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2. What you need to know before you use Icatibant Fresenius

Do not use Icatibant Fresenius

  • if you are allergic to icatibant or any of the other ingredients of this medicine (listed in section 6).

Warnings and precautions

Consult your doctor before starting treatment with Icatibant Fresenius:

  • if you have angina pectoris (reduced blood flow to the heart)
  • if you have recently had a stroke

The side effects related to Icatibant are similar to the symptoms of your own disease. Consult your doctor immediately if you notice that the symptoms of the attack worsen after Icatibant is administered.

In addition:

  • You or your caregiver must learn the technique of subcutaneous injection (under the skin) before self-administering or having Icatibant administered by your caregiver.
  • Immediately after self-administering Icatibant or having it administered by your caregiver while experiencing a laryngeal attack (upper airway obstruction), you should seek medical attention at a medical institution.
  • If your symptoms do not resolve after a self-administered injection of Icatibant or an injection administered by your caregiver, you should consult your doctor about the administration of additional injections of Icatibant. In adult patients, up to 2 additional injections can be administered within 24 hours.

Children and adolescents

Icatibant is not recommended for use in children under 2 years of age or weighing less than 12 kg, as it has not been studied in these patients.

Other medicines and Icatibant Fresenius

Tell your doctor if you are taking, have recently taken, or might take any other medicines.

No interactions of Icatibant with other medicines are known. If you are taking any medicine that is an angiotensin-converting enzyme inhibitor (ACEI) (e.g., captopril, enalapril, ramipril, quinapril, lisinopril) to lower blood pressure or for any other reason, inform your doctor before using Icatibant.

Medicine questions

Started taking the medicine and have questions?

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Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.

If you are breastfeeding, you should not breastfeed your child during the 12 hours following the last administration of Icatibant.

C

Do not drive or use machines if you feel tired or dizzy as a result of the HAE attack or after using Icatibant Fresenius.

I

This medicine contains less than 23 milligrams (1 mmol) of sodium per dose, so it is essentially "sodium-free".

3. How to use Icatibant Fresenius

Follow the instructions for administration of this medicine exactly as indicated by your doctor.

In case of doubt, consult your doctor again.

If you have never been administered Icatibant before, the first dose should always be injected by medical or nursing staff. The doctor will discharge you when it is considered safe for you to go home. After analyzing it with your doctor or nurse and learning the technique for subcutaneous injections (under the skin), you or your caregiver can administer Icatibant if you have an HAE attack. It is essential to inject Icatibant subcutaneously (under the skin) as soon as you notice an angioedema attack. The healthcare staff will teach you and your caregiver how to safely inject Icatibant, following the instructions in the package leaflet.

When and how often should you use Icatibant Fresenius?

Your doctor has determined the exact dose of Icatibant and will tell you how often it should be used.

  • The recommended dose of Icatibant is one injection (3 ml, 30 mg) administered subcutaneously (under the skin) as soon as you notice the angioedema attack (e.g., with increased skin swelling, especially on the face and neck, or increased abdominal pain).
  • If you do not notice an improvement in symptoms after six hours, you should seek medical advice on the administration of additional injections of Icatibant. In adults, up to 2 additional injections can be administered within 24 hours.
  • You should not receive more than 3 injections in a 24-hour period, and if you need more than 8 injections in a month, you should seek medical advice.

Children and adolescents from 2 to 17 years

  • The recommended dose of Icatibant is an injection of 1 ml up to a maximum of 3 ml, depending on body weight, administered subcutaneously (under the skin) as soon as symptoms of an angioedema attack appear (e.g., increased skin swelling, especially on the face and neck, or increased abdominal pain).
  • Consult the section on instructions for use to see the dose you should inject.
  • If you are unsure about the dose to inject, consult your doctor, pharmacist, or nurse.

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Icatibant Fresenius is administered by subcutaneous injection (under the skin). Each syringe should only be used once.

Icatibant Fresenius is injected with a short needle into the fatty tissue under the skin of the abdomen (belly). If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

The following step-by-step instructions are intended for

  • self-administration (adults)
  • administration by a caregiver or healthcare professional for adults, adolescents, or children over 2 years of age (weighing at least 12 kg).

The instructions include the following main steps:

  1. General information

2a) Preparation of the syringe for children and adolescents (2-17 years) weighing 65 kg or less

2b) Preparation of the syringe and needle for injection (all patients)

  1. Preparation of the injection site
  2. Injection of the solution
  3. Disposal of injection materials

Step-by-step instructions for injection

  1. General information
  • Clean the work surface (area) before starting the process.
  • Wash your hands with water and soap.
  • Open the tray by removing the seal.
  • Remove the pre-filled syringe from the tray.
  • Unscrew and remove the cap from the end of the pre-filled syringe.
  • Leave the pre-filled syringe with the cap unscrewed.

2a) Preparation of the syringe for children and adolescents (2-17 years) weighing 65 kg or less:

Important information for healthcare professionals and caregivers:

When the dose is less than 30 mg (3 ml), the following equipment is needed to extract the appropriate dose (see information below):

  1. Pre-filled syringe of Icatibant Fresenius (with icatibant solution)
  2. Connector (adapter)
  3. Syringe with plunger and needle showing labeled parts a, b, and c with side and front view Graduated syringe 3 ml

The required injection volume in ml should be prepared in an empty 3 ml graduated syringe (see table below).Table 1: Dosage guidelines for children and adolescents

Body weight

Injection volume

12 kg to 25 kg

1.0 ml

26 kg to 40 kg

1.5 ml

41 kg to 50 kg

2.0 ml

51 kg to 65 kg

2.5 ml

Patient weighing more than 65 kgwill use the entire contents of the pre-filled syringe (3 ml).

Yellow triangle with black border and black exclamation mark in the center indicating warning

If you are unsure about the volume of solution to extract, consult your doctor, pharmacist, or nurse

  1. Remove the caps from each end of the connector.

Warning triangle with black border and central black exclamation mark on white background

Avoid touching the ends of the connector and the tips of the syringes to prevent contamination

  1. Screw the connector onto the pre-filled syringe.
  2. Attach the graduated syringe to the other end of the connector, making sure both connections fit securely.

Disassembled syringe showing cylinder, plunger with rubber rings, and needle with transparent protector

Transfer the icatibant solution to the graduated syringe

  1. Transparent syringe with black plunger showing measurement marks and two needles with protectors on both ends, arrows indicating directionTo initiate the transfer of the icatibant solution, push the plunger of the pre-filled syringe (on the left end of the image below).
  2. If the icatibant solution does not start to transfer to the graduated syringe, gently pull the plunger of the graduated syringe until the icatibant solution starts to flow into the graduated syringe (see image below).
  3. Continue pushing the plunger of the pre-filled syringe until the required injection volume (dose) is transferred to the graduated syringe. Consult Table 1 for dosage information.

Pre-filled transparent syringe with black plunger and two white needle protectors, arrow indicating injection direction

If there is air in the graduated syringe:

  • Turn the connected syringes so that the pre-filled syringe is on top (see image below).

Pre-filled transparent syringe with retracted plunger and visible graduated scale, arrow indicating injection direction

  • Push the plunger of the graduated syringe to transfer the air back to the pre-filled syringe (this step may need to be repeated several times).
  • Extract the required volume of icatibant solution.
  1. Remove the pre-filled syringe and connector from the graduated syringe.
  2. Discard the pre-filled syringe and connector in the sharps container or other puncture-resistant container.

2b) Preparation of the syringe and needle for injection:

All patients (adults, adolescents, and children)

Hands holding and applying a grayish rectangular medicinal patch on the skin

  • Remove the safety needle from the blister.
  • Remove the seal from the needle (the needle should remain inside the cap).

Gloved hand holding an auto-injector with the needle inserted into the abdominal skin fold

  • Hold the syringe firmly. Carefully connect the needle to the pre-filled syringe with the colorless solution. Push the syringe firmly while turning it clockwise until it is securely attached to the needle.

Hand holding syringe with needle, showing pressure on the plunger with the thumb for injection, and arrow indicating direction

  • Pull the safety cap back towards the syringe and away from the needle.

Hands holding an injection device with a connected needle and a pressed button

  • Pull the syringe to remove the needle from the cap. Do not pull the plunger.

Hand holding syringe with needle, showing subcutaneous injection technique with skin pinch

  • The syringe is now ready to administer the injection.
  1. Preparation of the injection site

Hand holding a syringe applying a subcutaneous injection in the abdomen with a lifted skin fold

  • Choose the injection site. The injection site should be a fold of the abdomen, approximately 5-10 cm (2-4 inches) below the navel, to one side or the other. The area should be at least 5 cm (2 inches) away from any scar. Do not choose an area with bruises, inflammation, or pain.
  • Clean the injection site by rubbing it with an alcohol swab and let it dry.
  1. Injection of the solution

Hand holding syringe with needle inserted into the skin with metal protector and arrow indicating direction of insertion

  • Hold the syringe between two fingers, with your thumb on the end of the plunger.
  • Check that there is no air in the syringe by pressing the plunger until the first drop appears at the tip of the needle.

Hand holding syringe with needle inserting into the arm skin with an upward angle indicated by an arrow

  • Hold the syringe with the needle pointing towards the skin at an angle of 45 to 90 degrees.
  • Hold the syringe in one hand and with the other hand gently take a fold of skin between your thumb and fingers at the previously cleaned site.
  • Hold the skin fold, bring the syringe close, and quickly insert the needle into the skin fold.
  • Slowly press the plunger with a firm pulse until all the fluid has been injected into the skin and no liquid remains in the syringe.
  • Press slowly so that the process takes approximately 30 seconds.
  • Release the skin fold and gently remove the needle.
  1. Disposal of injection materials

Hand holding an auto-injector with two positions shown, one with the button pressed and the other without pressing

Hand disposing of a needle in a biological waste container with visible hazard symbol

  • Push the safety cover over the needle forward until you hear and feel it click into place.
  • Discard the syringe, needle, and its cap in the sharps container or other puncture-resistant container for disposal of sharp objects.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. Almost all patients who receive Icatibant notice a reaction at the injection site (such as skin irritation, inflammation, pain, itching, redness of the skin, and burning). These effects are usually mild and improve without the need for any additional treatment.

Very common (may affect more than 1 in 10 people):

Additional reactions at the injection site (feeling of pressure, bruising, decreased sensitivity and/or numbness, increased skin rash with itching and heat).

Common (may affect up to 1 in 10 people):

Nausea

Headache

Dizziness

Fever

Itching

Rash

Redness of the skin

Abnormal liver function tests

Frequency not known (cannot be estimated from the available data):

Hives (urticaria)

Tell your doctor immediately if you notice that the symptoms of the attack worsen after receiving Icatibant.

If you experience side effects, consult your doctor or pharmacist, even if they are not listed in this leaflet.

Reporting of side effects

If you experience any side effects, consult your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report them directly through the Spanish Pharmacovigilance System for Human Use Medicines: www.notificaRAM.es

By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Icatibant Fresenius

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the carton and the pre-filled syringe after “EXP”. The expiry date refers to the last day of the month stated.

Do not store above 30°C. Do not freeze.

Use immediately after opening and only in undamaged containers. For single use only.

Do not use this medicine if you notice that the syringe or needle is damaged or if you notice visible signs of deterioration, such as the solution being turbid, containing floating particles, or a change in the color of the solution.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of the containers and any unused medicines. This will help protect the environment.

6. Package Contents and Additional Information

Composition of Icatibant Fresenius

The active substance is icatibant. Each pre-filled syringe contains 30 milligrams of icatibant (as acetate). Each milliliter of solution contains 10 mg of icatibant. The other ingredients are sodium chloride, glacial acetic acid, sodium hydroxide, and water for injectable preparations.

Appearance and Package Contents of the Product

Icatibant Fresenius is presented as a clear and colorless injectable solution in a pre-filled syringe.

3 ml of solution in a 3 ml pre-filled syringe (Type I glass) with a plunger stopper (bromobutyl rubber coated with fluorocarbon polymer). The package includes a 25 G, 16 mm safety hypodermic needle.

Single unit package of one pre-filled syringe with one needle or multiple package of three pre-filled syringes with three safety needles.

Only certain package sizes may be marketed.

Marketing Authorization Holder

Fresenius Kabi España, S.A.U.

Torre Mapfre-Vila Olímpica

C/Marina 16-18

08005 Barcelona

Spain

Manufacturer

Fresenius Kabi Austria GmbH

Hafnerstraße 36

8055 Graz

Austria

This medicine is authorized in the Member States of the European Economic Areaand in the United Kingdom (Northern Ireland)under the following names:

Member State Name

Medicine Name

Austria

Icatibant Fresenius 30 mg Injektionslösung in einer Fertigspritze

Belgium

Icatibant Fresenius 30 mg oplossing voor injectie in een voorgevulde spuit, solution injectable en seringue pré-remplie, Injektionslösung in einer Fertigspritze

Croatia

Ikatibant Fresenius 30 mg otopina za injekciju u napunjenoj štrcaljki

Czech Republic

Icatibant Fresenius

Denmark

Icatibant Fresenius

Estonia

Icatibant Fresenius

Finland

Icatibant Fresenius 30 mg injektioneste, liuos, esitäytetty ruisku

France

ICATIBANT FRESENIUS 30 mg, solution injectable en seringue préremplie

Germany

Icatibant Fresenius 30 mg Injektionslösung in einer Fertigspritze

Hungary

Icatibant Fresenius 30 mg oldatos injekció eloretöltött fecskendoben

Ireland

Icatibant 30 mg solution for injection in pre-filled syringe

Italy

Icatibant Fresenius

Latvia

Icatibant Fresenius 30 mg šķidums injekcijām pilnšļirce

Lithuania

Icatibant Fresenius 30 mg injekcinis tirpalas užpildytame švirkšte

Netherlands

Icatibant Fresenius 30 mg, oplossing voor injectie in een voorgevulde spuit

Norway

Icatibant Fresenius

Poland

Icatibant Fresenius

Portugal

Icatibant Fresenius

Slovakia

Icatibant Fresenius 30 mg

Spain

Icatibanto Fresenius 30 mg solución inyectable en jeringa precargada EFG

Sweden

Icatibant Fresenius 30 mg injektionsvätska, lösning i förfylld spruta

United Kingdom (Northern Ireland)

Icatibant 30 mg solution for injection in pre-filled syringe

Date of the last revision of this leaflet: April2022

Detailed information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS), http://www.aemps.gob.es/

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Frequently Asked Questions

Is a prescription required for ICATIBANTO FRESENIUS 30 mg Injectable Solution in Pre-filled Syringe?
ICATIBANTO FRESENIUS 30 mg Injectable Solution in Pre-filled Syringe requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in ICATIBANTO FRESENIUS 30 mg Injectable Solution in Pre-filled Syringe?
The active ingredient in ICATIBANTO FRESENIUS 30 mg Injectable Solution in Pre-filled Syringe is icatibant. This information helps identify medicines with the same composition but different brand names.
Who manufactures ICATIBANTO FRESENIUS 30 mg Injectable Solution in Pre-filled Syringe?
ICATIBANTO FRESENIUS 30 mg Injectable Solution in Pre-filled Syringe is manufactured by Fresenius Kabi España, S.A.U.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of ICATIBANTO FRESENIUS 30 mg Injectable Solution in Pre-filled Syringe online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether ICATIBANTO FRESENIUS 30 mg Injectable Solution in Pre-filled Syringe is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to ICATIBANTO FRESENIUS 30 mg Injectable Solution in Pre-filled Syringe?
Other medicines with the same active substance (icatibant) include FIRAZYR 30 mg SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE, ICATIBANT ACCORD 30 mg Injectable Solution in Pre-filled Syringe, ICATIBANTO AGUETTANT 30 mg Injectable Solution in Pre-filled Syringe EFG. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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