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HUMATIN 250 mg Hard Capsules

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Doctor
5.0(11)

Anna Biriukova

Gastroenterology6 years of experience

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

  • High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
  • Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
  • Leg swelling, chronic fatigue, reduced exercise tolerance.
  • EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
  • Post-COVID-19 cardiac monitoring and care.
Endocrinology – Diabetes, thyroid, metabolism:
  • Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
  • Individual treatment plans including oral medications and insulin therapy.
  • GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
  • Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
  • Metabolic syndrome – obesity, lipid disorders, insulin resistance.
Gastroenterology – Digestive health:
  • Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
  • Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
  • Respiratory infections – cough, colds, bronchitis.
  • Lab test analysis, therapy adjustments, medication management.
  • Adult vaccinations – planning, contraindications assessment.
  • Cancer prevention – screening strategies and risk assessment.
  • Holistic approach – symptom relief, complication prevention, and quality of life improvement.
Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
Book a video appointment
€66
This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use HUMATIN 250 mg HARD CAPSULES

Contents of the leaflet

  1. Introduction
  2. What Humatin 250 mg hard capsules are and what they are used for
  3. What you need to know before taking Humatin 250 mg hard capsules
  4. How to take Humatin 250 mg hard capsules
  5. Possible side effects
  6. Storage of Humatin 250 mg hard capsules
  7. Contents of the pack and further information

Introduction

Leaflet:information for the patient

Humatin 250 mg hard capsules

paromomycin

Read this leaflet carefully before starting to take this medicine,as it contains important information for you.

  • Keep this leaflet, as you may need to read it again.
    1. If you have any questions, ask your doctor, pharmacist, or nurse.
  • This medicine has been prescribed for you only, and you should not give it to others, even if they have the same symptoms as you, as it may harm them.
    • If you experience side effects, consult your doctor, pharmacist, or nurse, even if they are not listed in this leaflet. See section 4.

Contents of the leaflet

  1. What Humatin 250 mg hard capsules are and what they are used for
  2. What you need to know before taking Humatin 250 mg hard capsules
  3. How to take Humatin 250 mg hard capsules
  4. Possible side effects

5 Storage of Humatin 250 mg hard capsules

  1. Contents of the pack and further information

1. What Humatin 250 mg hard capsules are and what they are used for

Humatin 250 mg hard capsules contain paromomycin, which belongs to a group of antibiotics called aminoglycoside antibiotics. It is used to treat intestinal infections and hepatic coma.

Antibiotics are used to treat bacterial infections and are not effective against viral infections such as the flu or common cold.

It is essential to follow the instructions regarding dosage, administration interval, and treatment duration indicated by your doctor.

Do not store or reuse this medicine. If you have any leftover antibiotic after completing treatment, return it to the pharmacy for proper disposal. Do not throw medicines down the drain or in the trash.

Humatin 250 mg hard capsules (paromomycin) are indicated in children and adults for the treatment of:

  • Acute and chronic non-invasive intestinal amebiasis.

In addition, it is indicated in adults for:

  • Adjunctive treatment of hepatic coma by reducing ammonia-forming bacteria in the gastrointestinal tract.
Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before taking Humatin 250 mg hard capsules

Do not take Humatin250 mghard capsules

  • if you are allergic to the active substance or any of the other ingredients of this medicine (listed in section 6).
  • if you have been previously treated with paromomycin and have developed hypersensitivity reactions
  • if you have had an allergic reaction to any other aminoglycoside antibiotic, as you may also be allergic to paromomycin
  • if you have pre-existing ear damage (dizziness, vertigo, ringing in the ears, or hearing loss)
  • if you have pathological muscle weakness (myasthenia gravis)
  • if you have constipation or intestinal obstruction
  • during pregnancy and breastfeeding

Due to the possible risk of damage to renal and auditory function, the active ingredient paromomycin contained in Humatin 250 mg capsules should not be administered without passing through the gastrointestinal tract (parenterally).

Warnings and precautions

Consult your doctor, pharmacist, or nurse before starting to take Humatin 250 mg hard capsules if:

  • you have renal insufficiency
  • you are undergoing long-term treatment (e.g., treatment of hepatic coma by reducing ammonia-forming bacteria in the gastrointestinal tract)
  • you have gastrointestinal ulcers or bleeding in the intestines

In the above-mentioned patient groups, auditory function should be regularly monitored.

If signs of ototoxicity (dizziness, vertigo, ringing in the ears, or hearing loss) or nephrotoxicity appear, it may be necessary to reduce the dose or even consider discontinuing treatment.

Prolonged and/or repeated use of Humatin 250 mg capsules may cause a new or secondary infection by bacteria or fungi insensitive to paromomycin (resistant). Be aware of the signs of a possible subsequent infection with these pathogens (fungal infection of the mucous membranes with redness and white coatings on the mucous membranes).

These infections should be treated accordingly.

If you experience intense, persistent, sometimes bloody mucous diarrhea and abdominal pain similar to cramps during or after treatment with Humatin 250 mg capsules, you should inform your doctor because this is due to a severe inflammation of the mucous membranes of the intestine (pseudomembranous enterocolitis) usually caused by Clostridioides difficileand should be treated immediately. This intestinal disease caused by antibiotic treatment can be life-threatening.

Other medicines and Humatin250 mghard capsules

Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.

When taking paromomycin, only a very small amount is absorbed into the bloodstream through the gastrointestinal tract, so interactions with other medicines in the body are unlikely. In theory, the same interactions that occur with systemically administered aminoglycosides may occur.

With the simultaneous use of certain muscle relaxants (non-depolarizing muscle relaxants), the blockade of stimulus transmission between nerve and muscle may be deepened and prolonged.

Due to the increased risk of side effects, special monitoring is required for patients who are being treated simultaneously or subsequently with other medicines that may be harmful to renal or auditory function, such as amphotericin B, colistin, cyclosporine, cisplatin, vancomycin, or certain diuretic drugs such as ethacrynic acid and furosemide.

Pregnancy, breastfeedingand fertility

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medicine.

Humatin 250 mg hard capsules should not be used during pregnancy and breastfeeding.

Driving and using machines

No data are available on the influence of paromomycin on the ability to drive and use machines.

3. How to take Humatin 250 mg hard capsules

Follow exactly the administration instructions of this medicine indicated by your doctor or pharmacist. If in doubt, consult your doctor or pharmacist again.

Your doctor will determine the most suitable dose and treatment duration for you, according to your condition and response to treatment. It is administered orally. As a general rule, the recommended dose of the medicine and the frequency of administration are as follows:

Non-invasive intestinal amebiasis:

Adults, adolescents, and children who can swallow capsules: the recommended total daily dose is 25-35 mg/kg/day, divided into 3 doses, administered with meals, for 5 days.

Hepatic coma:

Adults: 4 g/day, divided into 2-4 doses, for 5-6 days.

Paromomycin sulfate capsules should only be used in adults, adolescents, and children who can swallow capsules.

The capsule should be taken whole.

Special patient groups

Patient with hepatic insufficiency

Generally, no dose adjustment is necessary in patients with hepatic insufficiency.

Patient with renal insufficiency

Paromomycin that is absorbed into the bloodstream is mainly eliminated through the kidneys. Therefore, paromomycin should be used with caution in patients with renal insufficiency.

If you take more Humatin250 mghard capsules than you should

Since the active ingredient of Humatin 250 mg capsules, paromomycin, is barely absorbed into the bloodstream when the mucous membrane of the gastrointestinal tract is intact, it is unlikely that symptoms of overdose will occur with a small overdose of Humatin 250 mg capsules (see, however, regarding the possibility of ototoxicity in section 2).

If you suspect an overdose, inform your doctor so that they can decide how to proceed.

If you forget to take Humatin 250 mg hard capsules

Do not take a double dose to make up for forgotten doses.

In this case, continue taking the medicine at the next scheduled time according to the usual dosing schedule.

If you do not notice your error until the next day, do not take a double dose to make up for forgotten doses, and continue taking the same amount of Humatin 250 mg capsules as prescribed. It may be necessary to extend the treatment by one day. In this case, consult your doctor. You should also consult your doctor if you forget to take a dose or take too little.

If you stop taking Humatin 250 mg hard capsules

Treatment with Humatin 250 mg hard capsules should never be stopped on your own initiative, and you should not interrupt it without medical advice. You should also not change the prescribed dose on your own. It is imperative that you strictly adhere to the dose prescribed by your doctor. The success of treatment with Humatin 250 mg hard capsules depends on completing the entire treatment.

If you have any further questions about the use of this medicine, ask your doctor, pharmacist, or nurse.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

If you think any of the side effects you are experiencing is serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

Common (may affect up to 1 in 10 people):

  • soft stools,
  • diarrhea

Rare (may affect up to 1 in 1,000 people):

  • anorexia,
  • nausea,
  • vomiting,
  • gastric cramps,
  • abdominal or stomach pain,
  • digestive disorders with fatty stools (malabsorption syndrome)
  • allergic reactions such as hives

Very rare (may affect up to 1 in 10,000 people):

  • pancreatitis (inflammation of the pancreas),
  • headache,
  • dizziness,
  • increase in the number of certain white blood cells in the blood (eosinophilia)
  • blood in the urine (hematuria)

Reporting of side effects

If you experience any side effects, consult your doctor, pharmacist, or nurse, even if they are not listed in this leaflet. You can also report them directly through the Spanish Medicines Agency's website: www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Humatin 250 mg hard capsules

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date stated on the packaging after EXP. The expiry date is the last day of the month indicated.

Store at room temperature.

Medicines should not be disposed of via wastewater or household waste. Return the packaging and any unused medicine to the pharmacy. If in doubt, ask your pharmacist how to dispose of the packaging and any unused medicine. This will help protect the environment.

6. Contents of the pack and further information

Composition of Humatin250 mghard capsules

  • The active substance is paromomycin. Each hard capsule contains 250 mg of paromomycin.
  • The other ingredients (excipients) are:

Capsule content: magnesium stearate, anhydrous colloidal silica

Capsule composition: gelatin, titanium dioxide (CI = 77891) (E-171), yellow iron oxide (CI = 77492) (E 172), red iron oxide (CI = 77491) (E 172), black iron oxide (CI = 77499) (E 172), 1-butanol, Shellac gum, Shellac lacquer, isopropyl alcohol, ammonia, propylene glycol, antifoam C.

Appearance of the product and contents of the pack

Humatin 250 mg hard capsules are presented in the form of hard capsules with a yellow body and a black cap. The pack contains 8 capsules.

Marketing authorization holder and manufacturer

Marketing authorization holder:

Pfizer, S.L.

Avda. de Europa, 20 B.

Parque Empresarial La Moraleja.

28108 Alcobendas. Madrid

Spain.

Manufacturer:

Delpharm L'aigle.

Zone Industrielle Nº 1, Route de Crulai - L'Aigle – 61300

France

Date of the last revision of this leaflet: February 2022

Detailed information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/)

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Online doctors for HUMATIN 250 mg HARD CAPSULES

Discuss questions about HUMATIN 250 mg HARD CAPSULES, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

Doctor
5.0(11)

Anna Biriukova

Gastroenterology6 years of experience

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

  • High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
  • Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
  • Leg swelling, chronic fatigue, reduced exercise tolerance.
  • EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
  • Post-COVID-19 cardiac monitoring and care.
Endocrinology – Diabetes, thyroid, metabolism:
  • Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
  • Individual treatment plans including oral medications and insulin therapy.
  • GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
  • Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
  • Metabolic syndrome – obesity, lipid disorders, insulin resistance.
Gastroenterology – Digestive health:
  • Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
  • Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
  • Respiratory infections – cough, colds, bronchitis.
  • Lab test analysis, therapy adjustments, medication management.
  • Adult vaccinations – planning, contraindications assessment.
  • Cancer prevention – screening strategies and risk assessment.
  • Holistic approach – symptom relief, complication prevention, and quality of life improvement.
Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
Book a video appointment
€66
Doctor
5.0(38)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a General Practitioner with specialized training in chronic pain. He provides online consultations for adult patients in Spain and other European countries.

Dr. Popov understands that seeking help with weight-related concerns or pain that has persisted for months can be difficult. Many patients come to him after trying different approaches without feeling truly heard. During the consultation, the doctor creates a comfortable and supportive, non-judgmental environment where the patient’s medical history can be discussed in detail, questions can be answered, and the next steps can be decided together.

Weight Management and Metabolic Health

Dr. Popov can help assess overweight, obesity, and related conditions such as hypertension, diabetes, or metabolic disorders. During the consultation, the patient’s medical history, test results, current medications, and previous treatments will be reviewed.

If you would like to learn about possible medication options or have already started treatment, the doctor can assess your situation, review the effectiveness and tolerability of the therapy, and clearly explain its benefits, potential risks, and alternatives.

Not every patient requires the same treatment. A consultation does not guarantee a prescription — it provides an objective medical assessment and a plan tailored to your individual situation.

Pain and General Medicine

You can also consult Dr. Popov regarding:

* chronic pain, migraines, neuralgia, and fibromyalgia;

* back, neck, lower back, or joint pain;

* hypertension, diabetes, and follow-up of chronic conditions;

* review of test results, medical reports, and current treatment;

* preventive medicine and a second medical opinion.

How the Consultation Works

The video consultation lasts up to 30 minutes. The doctor will listen carefully, review the information you provide, and explain the next steps in clear and understandable language.

If additional tests, an in-person consultation, or urgent medical care are required, the doctor will inform you directly.

Dr. Popov’s goal is to make sure the patient feels heard and leaves the consultation with a clear understanding of their condition and the next steps they can take.

Book a video appointment
€86
Doctor
5.0(12)

Yevgen Yakovenko

General medicine12 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

Book a video appointment
€72
Doctor
5.0(3)

Lina Travkina

General medicine13 years of experience

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.

  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.

  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.

  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.

  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.

  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.

  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.

  • Medical advice and follow-up consultations.

  • Test interpretation and diagnostic guidance.

  • Structured support for undiagnosed complaints.

  • Second opinion on diagnoses and treatment plans.

  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.

  • Post-operative recovery support and pain management.

  • Preconception counselling and postpartum support.

  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

Book a video appointment
€75
Doctor
5.0(21)

Nuno Tavares Lopes

General medicine18 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies

  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management

  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses

  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment

  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance

  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis

  • Pain management: acute and chronic pain, post-surgical care

  • Public health: prevention, health screenings, long-term monitoring

  • Sick leave (Baixa médica) connected to Segurança Social in Portugal

  • IMT medical certificates for driving licence exchange

Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

Book a video appointment
€70

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Frequently Asked Questions

HUMATIN 250 mg HARD CAPSULES requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

The active ingredient in HUMATIN 250 mg HARD CAPSULES is paromomycin. This information helps identify medicines with the same composition but different brand names.

The average pharmacy price for HUMATIN 250 mg HARD CAPSULES is around 6.24 EUR. Prices may vary depending on the manufacturer and dosage form.

HUMATIN 250 mg HARD CAPSULES is manufactured by Pfizer S.L.. Pharmacy brands and packaging may differ depending on the distributor.

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether HUMATIN 250 mg HARD CAPSULES is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy HUMATIN 250 mg HARD CAPSULES in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

Other medicines with the same active substance (paromomycin) include DIFICLIR 200 mg FILM-COATED TABLETS, DIFICLIR 40 mg/ml ORAL SUSPENSION GRANULES, MYCOSTATIN 100,000 IU/ml ORAL SUSPENSION. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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