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FRISPEC 6.5 mg/ml SYRUP

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About the medicine

How to use FRISPEC 6.5 mg/ml SYRUP

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

PACKAGE LEAFLET: Information for the user

frispec 6.5 mg/ml Syrup

Guaifenesin

Read this leaflet carefully before you start taking this medicine because it contains important information for you.

Follow the administration instructions of the medicine contained in this leaflet or as indicated by your doctor or pharmacist.

  • Keep this leaflet, as you may need to read it again.
  • If you need advice or more information, consult your pharmacist.
  • If you experience side effects, consult your doctor or pharmacist even if they are not listed in this leaflet.
  • You should consult a doctor if your condition worsens or does not improve after 7 days of treatment.

Contents of the package leaflet:

  1. What is frispec and what is it used for
  2. What you need to know before taking frispec
  3. How to take frispec
  4. Possible side effects
  5. Storage of frispec
  6. Package contents and additional information

1. What is frispec and what is it used for

Guaifenesin, the active ingredient of this medicine, belongs to the group of medicines called expectorants.

It is indicated to relieve productive cough by reducing phlegm (mucus) and facilitating its expulsion.

For adults and children over 2 years old.

You should consult a doctor if your condition worsens or does not improve after 7 days of treatment.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before taking frispec

Do not take frispec:

  • If you are allergic to guaifenesin or any of the other components of this medicine (listed in section 6)
    • Children under 2 years old cannot take this medicine.

Warnings and precautions:

Consult your doctor, pharmacist, or nurse before taking Frispec if:

  • You have had a cough for more than 7 days or if your cough is recurrent or accompanied by fever, rash, or persistent headache
  • You have a persistent cough that may be caused by asthma
  • You have a cough with a large amount of mucus (phlegm)
  • You have severe liver or kidney problems

Interference with laboratory tests

If you are going to have a urine test, it is essential that you inform your doctor or nurse that you are taking or have recently taken this medicine, as it may alter some results.

Children

Children under 2 years old cannot take this medicine because it is contraindicated.

Taking frispec with other medicines:

Inform your doctor or pharmacist if you are taking, have recently taken, or may need to take any other medicine.

It is not recommended to take this medicine with other cough medicines (antitussives or cough suppressants)

Taking frispec with food, drinks, and alcohol:

You can take this medicine with or without food.

Do not drink alcohol while being treated with this medicine.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medicine.

This medicine should not be used during pregnancy unless your doctor prescribes it.

Do not take this medicine if you are breastfeeding unless your doctor prescribes it.

Driving and using machines:

If you experience dizziness during treatment with this medicine, do not drive or use machines.

frispec contains sucrose, methyl parahydroxybenzoate, glycerol, sodium benzoate, and sodium

This medicine contains sucrose. If your doctor has told you that you have an intolerance to certain sugars, consult with them before taking this medicine.

Patients with diabetes mellitus should note that this medicine contains 9.75 g of sucrose per 15 ml.

It may cause allergic reactions (possibly delayed) because it contains methyl parahydroxybenzoate (E-218).

This medicine may cause headache, stomach upset, and diarrhea because it contains glycerol.

This medicine contains 0.1 g of benzoic acid salt per unit volume, equivalent to 0.1 g / weight volume.

This medicine contains less than 1 mmol of sodium (23 mg) per unit volume; that is, it is essentially "sodium-free".

3. How to take frispec

Follow the administration instructions of the medicine contained in this leaflet or as indicated by your doctor, pharmacist, or nurse. In case of doubt, consult your doctor, pharmacist, or nurse.

The recommended dose is:

Adults and adolescents over 12 years old: administer 30 ml (195 mg) every 4 hours if necessary.

Over 65 years old: the same as for adults.

Patient with kidney/liver disease: should consult a doctor.

Use in children

Children from 6 to 12 years old: administer 15 ml (97.5 mg) every 4 hours if necessary.

Children from 2 to 5 years old: administer under medical control 7.5 ml (48.75 mg) every 4 hours if necessary.

Children under 2 years old: it is contraindicated

Method of administration

This medicine is taken orally.

Shake the bottle before use. Measure the amount to be taken with the measuring spoon provided with the package.

The syrup can be taken alone or mixed with water. You should take a glass of water after taking each dose.

You should consult a doctor if your condition worsens or does not improve after 7 days of treatment

If you take more frispec than you should:

If you take more medicine than you should, you may experience stomach upset, nausea, diarrhea, and drowsiness.

Prolonged and high-dose use of this medicine may produce kidney stones.

In case of overdose or accidental ingestion, consult your doctor, go to a medical center, or call the Toxicology Information Service (phone: 91 562 04 20), indicating the medicine and the amount ingested.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, frispec can cause side effects, although not everyone gets them.

The following may occur: nausea, vomiting, diarrhea, stomach upset, headache, and dizziness.

If you experience any of the following side effects, stop taking this medicine and consult your doctor immediately:

  • Allergic reactions including skin rash (which can be severe, with blisters, abrasion, and peeling of the skin) and itching.

Reporting side effects:

If you experience any side effects, consult your doctor, pharmacist, or nurse, even if they are not listed in this leaflet. You can also report them directly through the Spanish Medicines and Healthcare Products Agency (AEMPS) website: http://www.aemps.gob.es/

5. Storage of frispec

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiration date stated on the package after CAD. The expiration date is the last day of the month indicated.

No special storage conditions are required.

Medicines should not be disposed of via wastewater or household waste. Deposit the packages and medicines you no longer need at the SIGRE point in your pharmacy. If in doubt, ask your pharmacist how to dispose of packages and medicines you no longer need. This will help protect the environment.

6. Package contents and additional information

Composition of frispec:

  • The active ingredient is guaifenesin. Each ml of syrup contains 6.5 mg of guaifenesin
  • The other ingredients (excipients) are methyl parahydroxybenzoate (E-218), anise essence, pine essence, sodium benzoate (E-211), sucrose, glycerol (E-422), sodium saccharin, and purified water.

Appearance of the product and package contents

Transparent oral solution with anise flavor. frispec is presented in a bottle containing 150 ml.

Marketing authorization holder

Farline Comercializadora de Productos Farmacéuticos, S.A.

C/ Santa Engracia, 31

28010 – Madrid (Spain)

Manufacturer

ALCALÁ FARMA, S.L.

Avenida de Madrid 82,

Alcala de Henares. 28802. Spain

Date of the last revision of this leaflet:September 2022

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Healthcare Products (AEMPS) http://www.aemps.gob.es/

Online doctors for FRISPEC 6.5 mg/ml SYRUP

Discuss questions about FRISPEC 6.5 mg/ml SYRUP, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Doctor

Tarek Agami

General medicine 11 years exp.

Dr. Tarek Agami is a general practitioner registered in both Portugal and Israel, with broad experience in family and preventive medicine. He offers online consultations for adults and children, providing personalised support for primary care needs, chronic disease management, and everyday health concerns.

Dr. Agami received clinical training and worked in leading medical institutions in Israel (Kaplan Medical Center, Barzilai Medical Center, Wolfson Medical Center) and Portugal (European Healthcare City, Viscura Internacional, Hospital Dr. José Maria Grande, Hospital Vila Franca de Xira). His approach combines international medical standards with individualised attention to each patient.

Main areas of consultation:

  • Diagnosis and treatment of acute and chronic conditions (high blood pressure, diabetes, respiratory infections, cardiovascular symptoms)
  • Evaluation of symptoms and guidance on further diagnostic testing
  • Preventive check-ups and regular health monitoring
  • Medical support during travel or after relocation
  • Treatment adjustments and lifestyle recommendations based on your personal history
Dr. Agami provides medical support for patients using GLP-1 medications (such as Ozempic or Mounjaro) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Portugal and Israel.

Dr. Agami is committed to evidence-based, patient-centred care, ensuring that each person receives trusted medical support tailored to their health goals.

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Doctor

Nuno Tavares Lopes

Family medicine 18 years exp.

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management
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  • Sick leave (Baixa médica) connected to Segurança Social in Portugal
  • IMT medical certificates for driving licence exchange
Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.

Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

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Anastasiia Shalko

Family medicine 13 years exp.

Dr. Anastasiia Shalko is a general practitioner with a background in both paediatrics and general medicine. She graduated from Bogomolets National Medical University in Kyiv and completed her paediatric internship at the P.L. Shupyk National Medical Academy of Postgraduate Education. After working as a paediatrician in Kyiv, she relocated to Spain, where she has been practising general medicine since 2015, providing care for both adults and children.

Her work focuses on urgent, short-term medical concerns – situations where patients need quick guidance, symptom assessment and clear next steps. She helps people understand whether their symptoms require in-person evaluation, home management or a change in treatment. Common reasons for booking an online consultation include:

  • acute respiratory symptoms (cough, sore throat, runny nose, fever)
  • viral illnesses such as colds and seasonal infections
  • gastrointestinal complaints (nausea, diarrhoea, abdominal pain, gastroenteritis)
  • sudden changes in how a child or adult feels
  • questions about existing treatment and whether adjustments are needed
  • renewal of prescriptions when clinically appropriate
Dr. Shalko works specifically with urgent and short-term problems, providing practical recommendations and helping patients determine the safest next step. She explains symptoms clearly, guides patients through decision-making and offers straightforward medical advice for everyday acute issues.

She does not provide long-term management of chronic conditions, ongoing follow-up or comprehensive care plans for complex long-term illnesses. Her consultations are designed for acute symptoms, sudden concerns and situations where timely medical input is important.

With clinical experience in both paediatrics and general medicine, Dr. Shalko confidently supports adults and children. Her communication style is clear, simple and reassuring, helping patients feel informed and supported throughout the consultation.

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Doctor

Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques.

For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance.

Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults.

In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions.

Patients commonly seek his care for:

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns
Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.
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Doctor

Daniel Cichi

Family medicine 24 years exp.

Dr Daniel Cichi is a family medicine doctor with over 20 years of clinical experience. He provides online consultations for adults, supporting patients with acute symptoms, chronic conditions, and everyday health concerns that require timely medical guidance.

His background includes work in emergency care, ambulance services, and family medicine, which allows him to assess symptoms quickly, identify warning signs, and help patients choose the safest next steps – whether that means home care, treatment adjustment, or in-person evaluation.

Patients commonly consult Dr Daniel Cichi for:

  • acute symptoms: fever, infections, flu-like illness, cough, sore throat, shortness of breath;
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  • digestive problems: abdominal pain, nausea, diarrhoea, constipation, reflux;
  • muscle, joint, and back pain, minor injuries, post-traumatic symptoms;
  • chronic conditions: hypertension, diabetes, high cholesterol, thyroid disorders;
  • review and interpretation of lab tests, imaging reports, and medical documents;
  • medication review and treatment adjustment;
  • medical advice while travelling or living abroad;
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Dr Cichi’s consultations are structured and practical. He focuses on clear explanations, risk assessment, and actionable recommendations, helping patients understand their symptoms and make informed decisions about their health.
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€55

Frequently Asked Questions

Is a prescription required for FRISPEC 6.5 mg/ml SYRUP?
FRISPEC 6.5 mg/ml SYRUP does not require a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in FRISPEC 6.5 mg/ml SYRUP?
The active ingredient in FRISPEC 6.5 mg/ml SYRUP is guaifenesin. This information helps identify medicines with the same composition but different brand names.
Who manufactures FRISPEC 6.5 mg/ml SYRUP?
FRISPEC 6.5 mg/ml SYRUP is manufactured by Farline Comercializadora De Productos Farmaceuticos S.A.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of FRISPEC 6.5 mg/ml SYRUP online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether FRISPEC 6.5 mg/ml SYRUP is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to FRISPEC 6.5 mg/ml SYRUP?
Other medicines with the same active substance (guaifenesin) include FORMULAEXPEC 13.33 mg/ml SYRUP HONEY FLAVORED, INISTON MUCOSIDAD 20mg/ml ORAL SOLUTION MINT FLAVOR, ABRILAR SYRUP. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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