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FRIDEX 1 mg/ml EYE DROPS IN SOLUTION IN SINGLE-DOSE CONTAINERS

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About the medicine

How to use FRIDEX 1 mg/ml EYE DROPS IN SOLUTION IN SINGLE-DOSE CONTAINERS

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

Fridex 1 mg/ml eye drops, solution in single-dose container

Dexamethasone phosphate

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What is Fridex and what is it used for
  2. What you need to know before you use Fridex
  3. How to use Fridex
  4. Possible side effects
  5. Storage of Fridex
  6. Contents of the pack and further information

1. What is Fridex and what is it used for

This medicine contains the active substance dexamethasone, which is a corticosteroid indicated to stop inflammatory symptoms (pain, heat, swelling, and redness).

This medicine is indicated for the treatment of eye inflammation.

If you have an eye infection (red eye, tears, and discharge), you will be given another medicine to take at the same time as Fridex (see Section 2).

Doctor consultation

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Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you use Fridex

Do not useFridex

  • if you are allergic to dexamethasone phosphate sodium or any of the other ingredients of this medicine (listed in section 6);
  • if you have an eye infection that may be caused by bacteria (acute purulent infection), fungi, or viruses (herpes virus, vaccinia virus, chickenpox virus) or caused by amoebas (a parasite);
  • if you have damage to the surface of the eye (small holes, ulcers, or lesions that have not healed properly);
  • if you have high pressure in the eye that is known to be caused by glucocorticoids (a family of corticosteroid medicines).

Warnings and precautions

Consult your doctor or pharmacist before starting to use this medicine.

Do not inject, do not swallow.

Avoid contact between the tip of the dispenser and the eye or eyelids.

Strict control of the eye is required during the use of Fridex, and in particular:

  • for children and the elderly. More frequent monitoring is recommended.
  • if you have an eye infection. Use this medicine only if you are being treated with an anti-infectious medicine at the same time.
  • if you have a corneal ulcer (an open sore on the surface of the eye with sometimes extreme pain, tears, squinting, and vision loss). Do not use this medicine unless inflammation is the main cause of delayed healing.
  • if you have high pressure in the eye. If you have already had high pressure in the eye after using an ocular steroid medicine, you are at risk of having it again if you use this medicine.
  • if you have glaucoma, a disease that can cause damage to the optic nerve and can cause vision loss.
  • children: do not use during long-term treatment without a break.
  • if you have severe allergic conjunctivitis (redness, swelling, itching, and tears in the eyes) that another medicine has not been able to treat. Use this medicine only for a short period of time.
  • if you have diabetes. Inform your ophthalmologist or optician about your illness before using this medicine.
  • if you have a red eye that has not been diagnosed. Do not use this medicine before talking to your doctor.
  • diabetic: if you are diabetic, inform your ophthalmologist or optician.
  • if you have a red eye that has not been diagnosed, do not use this medicine.
  • for children and the elderly. More frequent monitoring is recommended.

Avoid wearing contact lenses during the use of this medicine.

Consult your doctor if you notice swelling and weight gain around the trunk and face, as these are usually the first signs of a condition called Cushing's syndrome. A decrease in adrenal gland function may develop after stopping long-term or intensive treatment with this medicine. Consult your doctor before stopping treatment on your own. These risks are especially important in children and patients treated with a medicine called ritonavir or cobicistat.

Contact your doctor if you experience blurred vision or other visual disturbances.

Children

Do not use this medicine in children during long-term treatment without a break.

Using Fridex with other medicines

Tell your doctor or pharmacist if you are using, have recently used, or might use any other medicines.

If you are using other eye drops, wait 15 minutes before instilling the other medicine.

The combined use of eye drops containing steroids and eye drops containing beta-blockers (to treat high pressure in the eye) may cause calcium phosphate to settle on the surface of the eye.

Tell your doctor if you are using ritonavir or cobicistat, as these medicines may increase the amount of dexamethasone in the blood.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.

There is not enough information on the use of this medicine during pregnancy to assess the possible risks. For this reason, the use of this medicine during pregnancy is not recommended.

It is not known whether this medicine passes into breast milk. However, the dose of this medicine is low, so this medicine can be used during breastfeeding.

Driving and using machines

You may have blurred vision for a short time after using this eye drop. Wait until your vision is normal before driving or using machines.

Fridex contains phosphates

This medicine contains 0.4461 mg of phosphates in 0.3 ml, which is equivalent to 1.487 mg/ml.

If you have severe damage to the clear layer on the front of the eye (the cornea), phosphates may rarely cause cloudy patches on the cornea due to calcium accumulation during treatment.

3. How to use Fridex

Follow exactly the instructions for administration of this medicine given by your doctor or pharmacist. If you are unsure, consult your doctor or pharmacist again.

Dose

The recommended dose is 1 drop, 4 to 6 times a day in the eye to be treated.

If your condition is more severe, you may be told to start with 1 drop every hour and then change to 1 drop every 4 hours, after the medicine has started to work. It is important to reduce the dose slowly to avoid the condition getting worse again.

Use in elderly patients

No dose adjustment of the medicine is required.

Use in children

Do not use this medicine in children during long-term treatment without a break.

Method of administration

This medicine must be instilled into the eye. Do not inject or swallow the medicine.

Sequence of four steps showing application of drops in the eye from a white bottle with dispenser tip

  1. Open the aluminum pouch containing 5 single-dose containers.
  2. Wash your hands well before using these drops.
  3. Separate a single-dose container from the strip and open the top of the single-dose container (Figure 1).
  4. Tilt your head back and gently pull down the lower eyelid with your finger (Figure 2). Put one drop in the eye to be treated. Avoid contact between the tip of the container and the eye or eyelids (Figure 3).
  5. Immediately after putting the drop in the eye, gently press the inner corner of the eye closest to the nose with your finger for a few minutes (Figure 4). This helps prevent the eye drop from spreading to the rest of your body.
  6. Discard the single-dose container after use. Do not save it for later use.

Duration of treatment

You will usually need to use your drops for several days. Do not use this medicine for more than 14 days.

If you use more Fridex than you should

If you have put too much medicine in the eye and it hurts, rinse it with sterile water. Tell your doctor or pharmacist immediately.

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or call the Toxicology Information Service, phone: 91 562 04 20, indicating the medicine and the amount ingested.

If you forget to use Fridex

Do not use a double dose to make up for forgotten doses.

If you stop using Fridex

Do not stop using this medicine suddenly. Tell your doctor if you are thinking of stopping treatment.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Very common(may affect more than 1 in 10 people)

  • high pressure in the eye after 2 weeks of using the drops.

Common(may affect up to 1 in 10 people)

  • discomfort, irritation, burning, stinging, itching, and blurred vision after use. These are usually mild and do not last long.

Uncommon(may affect up to 1 in 100 people)

  • signs of an allergic reaction
  • healing that takes longer than expected
  • cloudy lens (cataract)
  • eye infections
  • high pressure in the eye (glaucoma)
  • if used frequently, it is possible that the kidneys do not produce enough hormones (suppression of adrenal function). This could be shown by low blood sugar levels, dehydration, weight loss, and feeling confused about where you are.

Rare(may affect up to 1 in 10,000 people)

  • inflamed surface of the eye that produces red eyes, tears, and irritation (conjunctivitis)
  • dilated pupil (mydriasis)
  • swelling of the face (facial edema)
  • drooping eyelids (ptosis)
  • inflammation of the eye that causes pain and redness (uveitis)
  • calcium deposits on the surface of the eye (corneal calcification)
  • inflamed surface of the eye that provides blurred vision, dry eyes, sensitivity to light, burning, tears, and a gritty feeling in the eye (crystalline keratopathy)
  • changes in the thickness of the surface of the eye
  • swelling of the surface of the eye (corneal edema)
  • ulcer on the surface of the eye that causes pain, tears, squinting, and vision loss
  • small holes in the surface of the eye (corneal perforation)

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly to the Spanish Medicines Surveillance System for Human Use: www.notificaRAM.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Fridex

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the carton. The expiry date is the last day of the month stated.

After opening the single-dose container: discard any remaining solution in the single-dose container after instillation.

Keep the single-dose containers in the pouch to protect them from light and use within 60 days.

Keep the single-dose container in the outer packaging to protect it from light.

Store below 25°C.

Medicines should not be disposed of via wastewater or household waste. Dispose of the containers and medicines you no longer need in the SIGRE collection point at the pharmacy or in any other system for collecting medicinal waste. If you are unsure, ask your pharmacist how to dispose of the containers and medicines you no longer need. This will help protect the environment.

6. Contents of the pack and further information

Composition of Fridex

  • The active substance is dexamethasone phosphate sodium. Each ml of solution contains 1 mg of dexamethasone phosphate (as dexamethasone phosphate sodium), equivalent to 40 micrograms of dexamethasone phosphate (with a theoretical drop volume of approximately 40 microliters).
  • The other ingredients are: disodium edetate, disodium phosphate dodecahydrate, sodium chloride, hydrochloric acid (for pH adjustment), sodium hydroxide (for pH adjustment), and water for injectable preparations.

Appearance of the product and contents of the pack

Fridex is a clear, colorless solution supplied in single-dose containers.

Each single-dose container contains 0.3 ml of solution.

A carton contains 20 or 30 single-dose containers packaged in pouches.

Marketing authorization holder and manufacturer

Marketing authorization holder

NTC S.r.l.

Via Luigi Razza, 3

20124 Milan (Italy)

Manufacturer

Farmigea SpA

Via Giovan Battista Oliva, 6/8

56121 Pisa (PI)

Italy

You can request more information about this medicine by contacting the local representative of the marketing authorization holder:

NTC Ophthalmics Iberica S.L.

Calle Pinar, 5,

28006 Madrid, Spain

This medicine is authorized in the Member States of the European Economic Area under the following names:

Portugal: Dexametasona NTC

United Kingdom: Dexamethasone phosphate 1 mg/mL (as sodium phosphate) Eye drops, Solution in a single-dose container

Spain: Fridex 1 mg/ml eye drops, solution in single-dose container

Date of last revision of this leaflet:July 2019

Detailed and up-to-date information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/

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Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques. For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance. Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults. In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions. Patients commonly seek his care for: 

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Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

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Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

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Dr. Lokchiri’s professional training includes:

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He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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Pain: how he can help

  • Chronic pain (more than 3 months
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General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
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What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

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Joao Silva

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Dr. João Silva is a physician with training and experience in the field of General and Family Medicine, dedicated to providing healthcare focused on the well-being and quality of life of his patients. Throughout his professional career, he has developed broad clinical competencies, striving to maintain a medical practice based on scientific evidence and continuous knowledge updates.

Between 2013 and 2019, he completed the Integrated Master's Degree in Medicine at the Abel Salazar Institute of Biomedical Sciences in Porto, where he acquired a solid academic and clinical education.

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General medicine 15 years exp.

Dr. Bulat Garipov is a radiologist with more than 15 years of experience, specializing in magnetic resonance imaging (MRI). Throughout his professional career, he has worked in leading diagnostic imaging centers, both in on-site practice and teleradiology, which has allowed him to develop a broad and versatile approach to radiology.

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Frequently Asked Questions

Is a prescription required for FRIDEX 1 mg/ml EYE DROPS IN SOLUTION IN SINGLE-DOSE CONTAINERS?
FRIDEX 1 mg/ml EYE DROPS IN SOLUTION IN SINGLE-DOSE CONTAINERS requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in FRIDEX 1 mg/ml EYE DROPS IN SOLUTION IN SINGLE-DOSE CONTAINERS?
The active ingredient in FRIDEX 1 mg/ml EYE DROPS IN SOLUTION IN SINGLE-DOSE CONTAINERS is dexamethasone. This information helps identify medicines with the same composition but different brand names.
Who manufactures FRIDEX 1 mg/ml EYE DROPS IN SOLUTION IN SINGLE-DOSE CONTAINERS?
FRIDEX 1 mg/ml EYE DROPS IN SOLUTION IN SINGLE-DOSE CONTAINERS is manufactured by Ntc S.R.L.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of FRIDEX 1 mg/ml EYE DROPS IN SOLUTION IN SINGLE-DOSE CONTAINERS online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether FRIDEX 1 mg/ml EYE DROPS IN SOLUTION IN SINGLE-DOSE CONTAINERS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to FRIDEX 1 mg/ml EYE DROPS IN SOLUTION IN SINGLE-DOSE CONTAINERS?
Other medicines with the same active substance (dexamethasone) include AMEXXINE 1 mg/ml EYE DROPS SOLUTION, COLIRCUSI DEXAMETHASONE 1 mg/ml eye drops solution, DEXAFREE 1 mg/ml EYE DROPS IN SOLUTION IN SINGLE-DOSE CONTAINERS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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