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FOLI-DOCE 400/2 micrograms tablets

This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use FOLI-DOCE 400/2 micrograms tablets

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User
Foli-doce400/2 micrograms tablets

folic acid/cyanocobalamin (vitamin B12)

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What is Foli-doce and what is it used for
  2. What you need to know before you take Foli-doce
  3. How to take Foli-doce
  4. Possible side effects
  5. Storage of Foli-doce
  6. Contents of the pack and other information

1. What is Foli-doce and what is it used for

Foli-doce provides the daily recommended supplement of folic acid and vitamin B12 in certain physiological situations such as pregnancy, for the prevention of neural tube defects (NTDs).

It is used for the prevention of deficiency states of folic acid and vitamin B12, in women of childbearing age who have planned a pregnancy, one month before conception and three months after, as prophylaxis of neural tube defects.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you take Foli-doce

Do not take Foli-doce

  • If you are allergic to folic acid, vitamin B12 or any of the other ingredients of this medicine (listed in section 6).

Warnings and precautions

Consult your doctor or pharmacist before you start taking Foli-doce.

Other medicines and Foli-doce

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.

Certain medicines may interfere with Foli-doce; in these cases, it may be necessary to change the dose, interrupt treatment with one of them, or wait at least 3 hours between administration of both.

It is important that you inform your doctor if you are taking or have recently taken any of the following medicines:

  • Anti-ulcer medicines such as cimetidine, omeprazole, and ranitidine, and antacids with magnesium and/or aluminum salts (medicines for gastric acidity). It is recommended to take Foli-doce 2 or 3 hours before this type of medication.
  • Chloramphenicol (antibiotic).
  • Phenytoin, phenobarbital, primidone (medicines for seizures)
  • Folic acid antagonists (methotrexate, a medicine used in rheumatoid arthritis and in the treatment of some cancers).
  • Fluorouracil (a medicine for cancer).
  • Cholestyramine or colestipol (a medicine to reduce cholesterol levels in the blood).
  • Other possible interactions: antiepileptics (valproic acid, carbamazepine), estrogens (oral contraceptives), prolonged use of corticosteroids, trimethoprim/sulfamethoxazole combination (treatment for certain infections), antimalarials, antituberculars, and alcohol abuse.
  • Sulfasalazine (used for the treatment of inflammatory bowel diseases, such as ulcerative colitis).

Pregnancy and breast-feeding

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Foli-doce is indicated in the prevention of folic acid and vitamin B12 deficiencies before and during pregnancy. However, consult your doctor or pharmacist before taking this medicine.

Both vitamin B12 and folic acid cross the placenta, although without adverse effects on the fetus. When eliminated, they reach breast milk, although no related problems have been described.

Driving and using machines

No effects on the ability to drive and use machines have been observed.

Foli-doce contains lactose and sodium

This medicine contains lactose. If your doctor has told you that you have an intolerance to some sugars, consult them before taking this medicine.

This medicine contains less than 23 mg of sodium (1 mmol) per tablet; it is essentially "sodium-free".

3. How to take Foli-doce

Take this medicine exactly as your doctor or pharmacist has told you. If you are not sure, ask your doctor or pharmacist again.

The normal dose is 1 tablet orally, administered once a day before meals.

If you take more Foli-doce than you should

Very high doses of folic acid and vitamin B12, higher than those of Foli-doce, are well tolerated, so there is no fear of intoxication even with massive accidental ingestion. However, in case of overdose or accidental ingestion, consult your doctor or pharmacist or call the Toxicology Information Service, telephone 915620420, indicating the medicine and the amount ingested.

If you forget to take Foli-doce

Do not take a double dose to make up for forgotten doses.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Exceptionally, hypersensitivity reactions to any of the components, and with unknown frequency, severe allergic reaction (anaphylactic reaction).

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist, even if it is possible side effects not listed in this leaflet. You can also report side effects directly through the Spanish Pharmacovigilance System for Human Use Medicines: https://www.notificaram.es By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Foli-doce

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the carton after "EXP". The expiry date refers to the last day of the month shown.

Store in a cool and dry place.

Medicines should not be disposed of via wastewater or household waste. Return any unused medicine to your pharmacist. Ask your pharmacist how to dispose of medicines no longer required. This will help to protect the environment.

6. Contents of the pack and other information

Composition of Foli-doce

  • The active substances are: folic acid and cyanocobalamin (vitamin B12). Each tablet contains 400 micrograms of folic acid (as folic acid hydrate) and 2 micrograms of vitamin B12.
  • The other ingredients (excipients) are: sodium carboxymethyl starch (type A) (potato), microcrystalline cellulose, magnesium stearate, and lactose monohydrate.

Appearance and packaging

The tablets are round and yellow in color.

Container with 28 tablets.

Marketing authorisation holder

ITF Abacus Farma, S.A.

C/ San Rafael, 3

28108 Alcobendas, Madrid

Spain

Tel. 916572323

Manufacturer

ITALFARMACO SpA

Viale Fulvio Testi 330

20126 Milan

Italy

You can request more information about this medicine from the local representative of the marketing authorisation holder:

Italfarmaco, S.A.

C/ San Rafael, 3

28108 Alcobendas, Madrid

Spain

Date of last revision of this leaflet:April 2018

Detailed information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/.

Online doctors for FOLI-DOCE 400/2 micrograms tablets

Discuss questions about FOLI-DOCE 400/2 micrograms tablets, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Chikeluo Okeke

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Dr Chikeluo Okeke is an internal medicine doctor with extensive international clinical experience. Originally from Nigeria, he has worked across multiple European healthcare systems and currently practises in Sweden. This professional path has given him a strong understanding of different medical approaches and the ability to work effectively with patients from diverse cultural and linguistic backgrounds.

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Online consultations with Dr Chikeluo Okeke offer reliable internal medicine care without geographic limitations, focused on medical relevance, clarity, and patient comfort.

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Experience and qualifications:

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Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Daniel Cichi

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Dr Daniel Cichi is a family medicine doctor with over 20 years of clinical experience. He provides online consultations for adults, supporting patients with acute symptoms, chronic conditions, and everyday health concerns that require timely medical guidance. His background includes work in emergency care, ambulance services, and family medicine, which allows him to assess symptoms quickly, identify warning signs, and help patients choose the safest next steps – whether that means home care, treatment adjustment, or in-person evaluation. Patients commonly consult Dr Daniel Cichi for: 

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Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

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Dr Antonio Cayatte is a physician in General and Acute Medicine with over 30 years of experience across clinical care, medical research, and education. He offers online consultations for adults with a wide range of symptoms, both acute and chronic. His clinical background includes: 

  • assessment of sudden or unclear symptoms
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Dr Cayatte earned his degree from the University of Lisbon and taught internal medicine at Boston University School of Medicine. He holds active medical registrations in both Portugal and the UK and is a Fellow of the American Heart Association. Consultations are available in English and Portuguese. Patients value his clarity, professionalism, and balanced approach to evidence-based care.

Dr. Antonio Cayatte provides comprehensive care for a broad spectrum of common health concerns, including:

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Sviatoslav Chekhun

Oncology 13 years exp.

Dr. Sviatoslav Chekhun is a medical oncologist with international clinical and research experience, specializing in modern medical oncology and a personalized approach to cancer treatment.

Currently (since 2025), he works as a Medical Oncologist at Institut Català d’Oncologia (Girona, Spain). Previously, he completed his residency in Medical Oncology and was involved in clinical research at Hospital Universitari Germans Trias i Pujol.

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Earlier in his career, he worked as a medical oncologist at the Kyiv City Clinical Oncological Center and contributed to regulatory evaluation of medicinal products at the State Expert Center of the Ministry of Health of Ukraine.

When to consult Dr. Chekhun:

  •  for diagnosis or clarification of a cancer diagnosis
  •  to obtain a second opinion on an existing treatment plan 
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Consultation format

Dr. Chekhun provides online consultations, where you can receive:

  •  expert second opinion 
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Important:
Prescription and monitoring of medications must be carried out by your treating physician in an in-person (offline) setting. An online consultation does not replace a face-to-face visit but helps you make more informed decisions about your treatment.

Dr. Sviatoslav Chekhun combines clinical practice, research, and international experience, enabling him to provide patients with modern, evidence-based approaches in oncology.

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Alexander Nazarchuk

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Dr. Alexander Nazarchuk is a physician specialising in allergology and internal medicine. He provides online consultations for adults, following the principles of evidence-based medicine — no outdated treatments or unnecessary tests, with clear explanations and a personalised approach. He helps patients with a wide range of allergic and therapeutic conditions, from common day-to-day complaints to complex cases involving allergies, gastrointestinal issues, cardiovascular concerns, respiratory symptoms, and more.

You can consult Dr. Nazarchuk for:

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  • Abdominal pain, bloating, changes in bowel habits, nausea, heartburn.
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  • Hyperlipidaemia and elevated cholesterol.
  • Cough, nasal congestion, fever, sore throat.
  • Anaemia, including iron deficiency and related conditions.
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During consultations, Dr. Nazarchuk takes a thorough, structured approach — analysing symptoms, identifying potential causes, and helping patients make informed decisions. Whether treatment, further investigation, or monitoring is needed, he explains each step clearly so you understand your health and how best to manage it.

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Frequently Asked Questions

Is a prescription required for FOLI-DOCE 400/2 micrograms tablets?

FOLI-DOCE 400/2 micrograms tablets requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

What is the active substance in FOLI-DOCE 400/2 micrograms tablets?

The active ingredient in FOLI-DOCE 400/2 micrograms tablets is cyanocobalamin, combinations. This information helps identify medicines with the same composition but different brand names.

How much does FOLI-DOCE 400/2 micrograms tablets cost in pharmacies?

The average pharmacy price for FOLI-DOCE 400/2 micrograms tablets is around 3.98 EUR. Prices may vary depending on the manufacturer and dosage form.

Who manufactures FOLI-DOCE 400/2 micrograms tablets?

FOLI-DOCE 400/2 micrograms tablets is manufactured by Itf Abacus Farma S.A.. Pharmacy brands and packaging may differ depending on the distributor.

Which doctors can assess the use of FOLI-DOCE 400/2 micrograms tablets online?

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether FOLI-DOCE 400/2 micrograms tablets is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

How to buy FOLI-DOCE 400/2 micrograms tablets in Spain?

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy FOLI-DOCE 400/2 micrograms tablets in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

What are the alternatives to FOLI-DOCE 400/2 micrograms tablets?

Other medicines with the same active substance (cyanocobalamin, combinations) include BECAREN 1000 micrograms TABLETS, HYDROXOCOBALAMIN BASE 1 mg/ml INJECTABLE SOLUTION, MEGAMILBEDOCE 5,000 micrograms/mL Injectable Solution. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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