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Elocta 1000 IU powder and solvent for injectable solution

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About the medicine

How to use Elocta 1000 IU powder and solvent for injectable solution

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

Show original

Contents of the leaflet

  1. Introduction
  2. What is ELOCTA and what is it used for
  3. What you need to know before you use ELOCTA
  4. How to use ELOCTA
  5. Possible side effects
  6. Storage of ELOCTA
  7. Container Contents and Additional Information

Introduction

Package Leaflet: Information for the User

ELOCTA 250 UI powder and solvent for solution for injection

ELOCTA 500 UI powder and solvent for solution for injection

ELOCTA 750 UI powder and solvent for solution for injection

ELOCTA 1000 UI powder and solvent for solution for injection

ELOCTA 1500 UI powder and solvent for solution for injection

ELOCTA 2000 UI powder and solvent for solution for injection

ELOCTA 3000 UI powder and solvent for solution for injection

ELOCTA 4000 UI powder and solvent for solution for injection

efmoroctocog alfa (recombinant coagulation factor VIII)

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor, pharmacist, or nurse.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What is ELOCTA and what is it used for
  2. What you need to know before you use ELOCTA
  3. How to use ELOCTA
  4. Possible side effects
  5. Storage of ELOCTA
  6. Contents of the pack and other information

1. What is ELOCTA and what is it used for

ELOCTA contains the active substance efmoroctocog alfa, a recombinant coagulation factor VIII, Fc fusion protein. Factor VIII is a protein that is naturally produced by the body and is necessary for blood to clot and stop bleeding. ELOCTA is a medicine used to treat and prevent bleeding in patients of all ages with hemophilia A (a bleeding disorder caused by a lack of factor VIII).

ELOCTA is prepared using recombinant technology without the addition of any human or animal component in the manufacturing process.

How ELOCTA works

In patients with hemophilia A, factor VIII is missing or does not work properly. ELOCTA is used to replace the missing or deficient factor VIII. ELOCTA increases factor VIII levels in the blood and temporarily corrects the tendency to bleed.

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2. What you need to know before you use ELOCTA

Do not use ELOCTA:

Warnings and precautions

Talk to your doctor, pharmacist, or nurse before you start using ELOCTA.

  • There is a small chance that you may have an allergic reaction (anaphylactic reaction) to ELOCTA. Signs of allergic reactions include itching all over the body, hives, feeling of tightness in the chest, difficulty breathing, and low blood pressure. If any of these symptoms occur, stop the injection immediately and contact your doctor.
  • The formation of inhibitors (antibodies) is a known complication that can occur during treatment with all factor VIII medicines. These inhibitors, especially in large quantities, can prevent the treatment from working properly, so you and your child will be carefully monitored for the development of such inhibitors. If your bleeding or your child's bleeding is not being controlled with ELOCTA, contact your doctor immediately.

Cardiovascular events

If you have heart disease or are at risk of heart disease, be careful when using factor VIII medicines and talk to your doctor.

Catheter-related complications

If you need a central venous access device (CVAD), consider the risk of CVAD-related complications, including local infections, bacteria in the blood, and thrombosis at the catheter insertion site.

Documentation

We strongly recommend that each time ELOCTA is administered, the product name and batch number are recorded.

Other medicines and ELOCTA

Tell your doctor or pharmacist if you are using, have recently used, or might use any other medicines.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.

Driving and using machines

No effects on the ability to drive or use machines have been observed.

ELOCTA contains sodium

This medicine contains less than 1 mmol of sodium (23 mg) per vial; this is essentially "sodium-free".

However, depending on your body weight and dose, you may receive more than one vial, which should be taken into account if you are on a low-sodium diet.

3. How to use ELOCTA

Treatment with ELOCTA will be started by a doctor who is experienced in the care of patients with hemophilia. Follow the instructions for administration of this medicine exactly as told by your doctor (see section Instructions for preparation and administration). If you are unsure, talk to your doctor, pharmacist, or nurse.

ELOCTA is given by injection into a vein. Your doctor will calculate your dose of ELOCTA (in International Units or "IU") based on your individual needs for factor VIII replacement treatment and whether it is used for prevention or treatment of bleeding. Talk to your doctor if you think you are not getting control of your bleeding with the dose you are receiving.

How often you need an injection will depend on how well ELOCTA is working for you. Your doctor will do the necessary laboratory tests to make sure you have adequate factor VIII levels in your blood.

Treatment of bleeding

The dose of ELOCTA is calculated based on your body weight and the desired factor VIII levels. The target factor VIII levels depend on the severity and location of the bleeding.

Prevention of bleeding

The usual dose of ELOCTA is 50 IU per kilogram of body weight, given every 3 to 5 days. Your doctor may adjust the dose within the range of 25 to 65 IU per kilogram of body weight. In some cases, especially in younger patients, shorter dosing intervals or higher doses may be needed.

Use in children and adolescents

ELOCTA can be used in children and adolescents of all ages. In children under 12 years of age, higher doses or more frequent injections may be needed.

If you use more ELOCTA than you should

Tell your doctor as soon as possible. Follow the instructions for administration of ELOCTA exactly as told by your doctor. If you are unsure, talk to your doctor, pharmacist, or nurse.

If you forget to use ELOCTA

Do not take a double dose to make up for forgotten doses. Take your dose as soon as you remember and then go back to your normal dosing schedule. If you are not sure what to do, talk to your doctor or pharmacist.

If you stop using ELOCTA

Do not stop using ELOCTA without talking to your doctor. If you stop using ELOCTA, you may no longer be protected against bleeding or a bleeding that is already present may not stop.

If you have any further questions on the use of this medicine, ask your doctor, pharmacist, or nurse.

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4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

If severe and sudden allergic reactions (anaphylactic reactions) occur, the injection should be stopped immediately. Contact your doctor immediately if you experience any of the following symptoms of allergic reactions: swelling of the face, rash, itching all over the body, hives, feeling of tightness in the chest, difficulty breathing, and low blood pressure.

In previously untreated children with factor VIII medicines (see section 2) inhibitors may occur very frequently (more than 1 in 10 patients); however, in patients who have received prior treatment with factor VIII (more than 150 days of treatment), the risk is infrequent (less than 1 in 100 patients). If this happens, the medicines may stop working properly and you may experience persistent bleeding. In this case, contact your doctor immediately.

The following side effects may occur with this medicine.

Uncommon side effects (may affect up to 1 in 100 people)

Headache, dizziness, taste disturbances, slow heart rate, high blood pressure, flushing, vascular pain after injection, cough, lower abdominal pain, skin rash, papular rash, device-related thrombosis, joint swelling, muscle pain, back pain, joint pain, general malaise, chest pain, feeling of cold, feeling of heat, and low blood pressure.

Reporting of side effects

If you experience any side effects, talk to your doctor, pharmacist, or nurse, even if it is possible side effects not listed in this leaflet. You can also report side effects directly through the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of ELOCTA

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the carton and on the label of the vial after "EXP". The expiry date refers to the last day of the month shown.

Do not use this medicine if it has been stored at room temperature for more than 6 months.

Store in a refrigerator (2°C - 8°C).

Do not freeze.

Store in the original package to protect from light.

Alternatively, ELOCTA can be stored at room temperature (up to 30°C) for a single period not exceeding 6 months. Record the date when ELOCTA is removed from the refrigerator and stored at room temperature on the carton. After storage at room temperature, the medicine should not be returned to the refrigerator.

Once ELOCTA has been prepared, it should be used immediately. If it is not possible to use the prepared ELOCTA solution immediately, it should be used within 6 hours. Do not refrigerate the prepared solution. Protect the prepared solution from direct sunlight.

The prepared solution should be clear to slightly opalescent and colorless. Do not use this medicine if you notice it is cloudy or contains visible particles.

Dispose of any unused solution properly. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. Container Contents and Additional Information

ELOCTA Composition

  • The active ingredient is efmoroctocog alfa (recombinant coagulation factor VIII, Fc fusion protein). Each vial of ELOCTA nominally contains 250, 500, 750, 1,000, 1,500, 2,000, 3,000, or 4,000 IU of efmoroctocog alfa.
  • The other components are sucrose, sodium chloride, L-histidine, calcium chloride dihydrate, polysorbate 20, sodium hydroxide, hydrochloric acid, and water for injections. See section 2 if you are on a low-sodium diet.

Product Appearance and Container Contents

ELOCTA is presented as a powder and solvent for solution for injection. The powder is a white to off-white powder or cake. The solvent supplied for the preparation of the solution for injection is a clear and colorless solution. After preparation, the solution for injection is clear to slightly opalescent and colorless.

Each ELOCTA container contains 1 vial of powder, 3 mL of solvent in a prefilled syringe, 1 plunger rod, 1 vial adapter, 1 infusion set, 2 alcohol swabs, 2 plaster strips, and 1 gauze.

Marketing Authorization Holder and Manufacturer

Swedish Orphan Biovitrum AB (publ)

SE-112 76 Stockholm,

Sweden

Date of Last Revision of this Leaflet: 01/2021

Detailed information on this medicinal product is available on the European Medicines Agency website: http://www.ema.europa.eu.

Turn the leaflet over to read the preparation and administration instructions.

Preparation and Administration Instructions

ELOCTA is administered by intravenous (IV) injection after dissolving the injectable powder with the solvent supplied in the prefilled syringe. The ELOCTA container contains:

Vial with powder, prefilled syringe, plunger rod, adapter, infusion set, alcohol swabs, plaster strips, and gauze

ELOCTA must not be mixed with other injectable solutions or infusion solutions.

Wash your hands before opening the container.

Preparation:

  1. Check the name and dose of the medication on the container to ensure it contains the correct medication. Check the expiration date on the ELOCTA carton. Do not use the medication if it is expired.
  1. If ELOCTA has been stored in the refrigerator, allow the ELOCTA vial (A) and the solvent syringe (B) to reach room temperature before use. Do not use external heat.
  1. Hand holding a glass vial with liquid and a gray cap, curved arrow indicating cap rotationPlace the vial on a clean and flat surface. Remove the plastic closure cap from the ELOCTA vial.
  1. Vial of medication with rubber stopper and hand applying a sterile gauze over the top of the vialClean the top of the vial with one of the alcohol swabs (F) provided in the container and let it air dry. Do not touch the top of the vial or allow it to come into contact with anything once cleaned.
  1. Remove the paper protector cap from the plastic vial adapter (D). Do not remove the adapter from its protective cap. Do not touch the inside of the vial adapter container.
  1. Hold the vial adapter in its protective cap and place it directly over the top of the vial. Press firmly downwards until the adapter is fully engaged with the top of the vial, with the adapter's spike penetrating the vial's stopper. Preparation of the injection with vial and syringe, showing not to tilt the vial and the needle in a cross
  1. Syringe with attached needle being prepared for injection over a vial with black protective capAttach the plunger rod (C) to the solvent syringe by inserting the tip of the plunger rod into the syringe's plunger opening. Turn the plunger rod clockwise until it is fully seated on the syringe's plunger.
  1. Auto-injector device with exposed needle and arrow indicating direction of insertion into the skin of the handRemove the tamper-evident plastic cap from the solvent syringe by folding it back along the perforation until it breaks off. Set the cap aside with the open end facing down on a flat surface. Do not touch the inside of the cap or the tip of the syringe.
  1. Remove the protective cap from the vial adapter by lifting it off and discard it. Hand holding an injection device over a vial with a black arrow indicating the direction of connection
  1. Hand holding an auto-injector with visible needle and spring mechanism ready to injectConnect the solvent syringe to the vial adapter by inserting the syringe tip into the adapter opening. Push firmly and turn the syringe clockwise until it is fully connected.
  1. Prefilled syringe with connected vial showing the plunger being pressed down with black arrows indicating the directionSlowly press the plunger rod downwards to inject all of the solvent into the ELOCTA vial.
  1. With the syringe still connected to the adapter and the plunger rod pressed downwards, gently swirl the vial in a circular motion until the powder is dissolved.

Do not shake. Auto-injector device with connected vial showing curved arrows indicating rotation for connection

  1. The final solution should be inspected visually before administration. The solution should be clear to slightly opalescent and colorless. Do not use the solution if it is cloudy or contains visible particles.
  1. Hand holding a prefilled syringe with transparent medication and a black plunger with arrow indicating downward directionEnsuring the syringe plunger rod is still fully pressed downwards, invert the vial. Slowly pull the plunger rod downwards to transfer all of the solution into the syringe through the vial adapter.
  1. Hand holding an auto-injector with a black arrow indicating the direction of injection into the cylindrical deviceDisconnect the syringe from the vial adapter by gently pulling the vial while turning it counterclockwise.

Note: If using more than one vial of ELOCTA per injection, each vial must be prepared separately according to the previous instructions (steps 1 to 13) and the solvent syringe must be removed, leaving the vial adapter in place. A single larger luer lock syringe may be used to withdraw the prepared contents from each of the vials.

  1. Discard the vial and adapter.

Note: If the solution is not to be used immediately, the syringe cap should be carefully replaced over the syringe tip. Do not touch the syringe tip or the inside of the cap.

After preparation, ELOCTA can be stored at room temperature for a maximum of 6 hours before administration. After this time, the prepared ELOCTA solution must be discarded. Protect it from direct sunlight.

Administration (Intravenous Injection):

ELOCTA should be administered using the infusion set (E) provided in the container.

  1. Open the infusion set container and remove the cap from the end of the tube. Connect the syringe with the prepared ELOCTA solution to the end of the tube of the infusion set by turning it clockwise.

Hand holding an infusion device with a transparent connector and a flexible black tube coiled

  1. If necessary, apply a tourniquet and prepare the injection site by cleaning the skin well with the other alcohol swab provided in the container.

Hand applying an adhesive patch to the skin of the arm in two sequential steps showing application

  1. Remove all air from the infusion set tube by slowly pressing the plunger rod downwards until the liquid has reached the needle of the infusion set. Do not push the solution through the needle. Remove the transparent plastic protective cap from the needle.
  1. Insert the infusion set needle into a vein as directed by your doctor or nurse, and remove the tourniquet. If preferred, you can use one of the plaster strips (G) provided in the container to hold the plastic wings of the needle in place at the injection site. The prepared product should be injected intravenously over several minutes. Your doctor may adjust the recommended injection rate to make it more comfortable for you.
  1. Once the injection is complete and the needle is removed, the needle protector should be folded back over the needle.

Hand holding a prefilled injection device with a black arrow indicating the direction of removal of the protective cap

  1. Discard the used needle, any unused solution, the syringe, and the empty vial in an appropriate medical waste container, as these materials may cause harm to others if not disposed of properly. Do not reuse the equipment.

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Frequently Asked Questions

Is a prescription required for Elocta 1000 IU powder and solvent for injectable solution?
Elocta 1000 IU powder and solvent for injectable solution requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in Elocta 1000 IU powder and solvent for injectable solution?
The active ingredient in Elocta 1000 IU powder and solvent for injectable solution is coagulation factor VIII. This information helps identify medicines with the same composition but different brand names.
Who manufactures Elocta 1000 IU powder and solvent for injectable solution?
Elocta 1000 IU powder and solvent for injectable solution is manufactured by Swedish Orphan Biovitrum Ab (Publ). Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of Elocta 1000 IU powder and solvent for injectable solution online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether Elocta 1000 IU powder and solvent for injectable solution is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to Elocta 1000 IU powder and solvent for injectable solution?
Other medicines with the same active substance (coagulation factor VIII) include ADVATE 1,000 IU POWDER AND SOLVENT FOR INJECTABLE SOLUTION, ADVATE 1500 IU POWDER AND SOLVENT FOR INJECTABLE SOLUTION, ADVATE 1000 IU POWDER AND SOLVENT FOR INJECTABLE SOLUTION. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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