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DUKORAL SUSPENSION AND EFFERVSCENT GRANULES FOR ORAL SUSPENSION

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About the medicine

How to use DUKORAL SUSPENSION AND EFFERVSCENT GRANULES FOR ORAL SUSPENSION

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

DUKORAL suspension and effervescent granule for oral suspension

Cholera vaccine (inactivated, oral)

Read all of this leaflet carefully before you start using this vaccine, because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor, pharmacist, or nurse.
  • This vaccine has been prescribed for you, do not pass it on to others.
  • If you experience any side effects, talk to your doctor, pharmacist, or nurse, even if they are not listed in this leaflet. See section 4.
  • Make sure to mix the vaccine with the buffer solution as described in this leaflet. See section 3.

Contents of thepackage leaflet

  1. What is Dukoral and what is it used for
  2. What you need to know before you start using Dukoral
  3. How to use Dukoral
  4. Possible side effects
  5. Storage of Dukoral
  6. Contents of the pack and further information

1. What is Dukoral and what is it used for

Dukoral is an oral cholera vaccine that stimulates the intestinal immune defenses. The vaccine protects adults and children from 2 years of age against cholera.

Dukoral makes the body produce its own protection against cholera. After receiving the vaccine, the body will create substances called antibodies that fight the toxin and cholera bacteria that cause diarrhea.

Doctor consultation

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2. What you need to know before you start using Dukoral

Do not use Dukoral

? if you are allergic to any of the components of the vaccine (listed in section 6) or to formaldehyde.

? if you have an acute gastric disorder or an infection accompanied by fever (vaccination should be postponed).

Warnings and precautions

Talk to your doctor before starting to take Dukoral

? if you are receiving treatment that affects your immune system

? if you have an immune system disease (including HIV infection).

The vaccine may provide a lower level of protection than that which occurs in people without immune system impairment.

The vaccine does not provide complete protection and it is important to follow dietary and hygiene recommendations to avoid contracting diseases that cause diarrhea.

Children

Do not administer this vaccine to children under 2 years of age as protection has not been studied in this group.

Use ofDukoral withother medicines

Tell your doctor if you are taking, have recently taken, or might take any other medicine.

Do not take any other medicine from one hour before to one hour after administration of the vaccine.

Use of Dukoral with food and drinks

Avoid ingestion of food and drinks from one hour before to one hour after administration of the vaccine.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor before taking the vaccine.

Driving and using machines

There is no reason to suspect that Dukoral affects the ability to drive and use machines.

Dukoralcontains sodium

Dukoral contains approximately 1.1 g of sodium per dose, which should be taken into account in patients with low-sodium diets.

3. How to use Dukoral

Follow the instructions for administration of the medicine contained in this leaflet or as indicated by your doctor. In case of doubt, consult your doctor again.

Adults and children from 6 years of age:The primary vaccination consists of two doses orally (by mouth) separated by a minimum interval of one week (up to six weeks).

  • Take the first dose no later than two weeks before starting your trip.
  • Take the second dose at least one week after the first dose and at least one week before your trip.

It takes approximately one week for protection to begin after the last dose.

To achieve continued protection, revaccination is recommended after two years. If it has been less than two years since your last dose of the vaccine, a single dose will renew your protection. If it has been more than two years since your last dose of the vaccine, primary vaccination should be repeated (2 doses).

Children from 2 to less than 6 years of age:The primary vaccination consists of three doses taken orally (by mouth) separated by a minimum interval of one week (up to six weeks). Only half of the buffer solution should be mixed with the vaccine.

  • Administer the first dose to the child no later than three weeks before starting your trip.
  • Administer the second dose to the child at least one week after the first dose.
  • Administer the third dose to the child at least one week after the second dose and at least one week before your trip.

It takes approximately one week for protection to begin after the last dose. To achieve continued protection, revaccination is recommended after six months. If it has been less than six months since the last dose of the vaccine, a single dose will renew protection. If it has been more than six months since the last vaccination, primary vaccination should be repeated (3 doses).

The suspension is a white suspension that is supplied in a glass vial for single dose. Each vial comes with a sachet containing a white, effervescent granule of sodium bicarbonate. The effervescent granule should be dissolved in a glass of cold water, and the resulting buffer solution should be mixed with the suspension. It is important to use the buffer solution, as it protects the vaccine against gastric acid.

Drink the entire mixture within 2 hours after mixing with the buffer solution.

Instructions for use:

Powder pouring into a glass with 150ml of water, stir, mix gently and drink within 2 hours according to the instructions

  1. To prepare the buffer solution, dissolve the effervescent granule in a glass of cold water (approx. 150 ml) by gently stirring.

Do not use any other liquid.

For children from 2 to less than 6 years:discard half of the buffer solution.

  1. Shake the Dukoral suspension vial (1 vial = 1 dose).
  1. Pour the contents of the Dukoral suspension vial into the glass of buffer solution (see 1). Mix by gently stirring.
  2. Drink the entire mixture within 2 hours. Avoid ingestion of food and drinks from one hour before to one hour after drinking the mixture.

If you take more Dukoral than you should

If you take the doses with a time interval of less than one week, contact your doctor, pharmacist, or nurse.

As each vial of Dukoral contains only one dose, it is unlikely that an overdose will occur.

If you have taken more than one dose at a time, contact your doctor, pharmacist, or nurse.

If you forget to take Dukoral

You can take the second dose of Dukoral up to 6 weeks after the first dose (children from 2 to less than 6 years of age have to take 3 doses). If more than 6 weeks have passed, contact your doctor, pharmacist, or nurse.

If you have any further questions on the use of this vaccine, ask your doctor, pharmacist, or nurse.

Medicine questions

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Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, Dukoral can cause side effects, although not everybody gets them.

Contact a doctor immediately if you experience the following serious side effects:

  • Severe diarrhea with loss of body water
  • Severe allergic reactions that cause swelling of the face or throat and difficulty breathing

Other side effects:

Uncommon side effects (may affect up to 1 in 100 people)

  • Diarrhea, stomach pain, abdominal cramps, abdominal rumbling, abdominal swelling, gas in the stomach, and general abdominal discomfort
  • Headache

Rare side effects (may affect up to 1 in 1,000 people)

  • Fever
  • General malaise, feeling of dizziness
  • Nausea, vomiting, loss or decreased appetite
  • Swelling, inflammation inside the nose, and cough

Very rare side effects (may affect up to 1 in 10,000 people)

  • Rash
  • Sore throat, decreased sense of taste
  • Fatigue/feeling of tiredness
  • Sweating, chills
  • Joint pain
  • Difficulty sleeping

Other side effects (frequency cannot be estimated from the available data)

  • Pseudo-flu symptoms, respiratory symptoms, chills, general pain, weakness
  • Hives, itching
  • Swelling of the lymph nodes
  • Numbness or tingling
  • High blood pressure

Reporting of side effects

If you experience any side effects, talk to your doctor, pharmacist, or nurse, even if they are not listed in this leaflet. You can also report them directly through the national reporting system included in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Dukoral

Keep this medicine out of the sight and reach of children.

Do not use Dukoral after the expiry date which is stated on the carton after EXP. The expiry date is the last day of the month stated.

Store in a refrigerator (between 2°C and 8°C). Do not freeze.

The product from the vial and sachet unopened, stored in the outer carton, remains stable at temperatures not above 25°C for a period of 14 days. At the end of this period, the product should be used or discarded.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. Contents of the pack and further information

Composition of Dukoral

  • The active substances are: 31.25x10^9 bacteria* of the following strains of V. choleraeO1: classical biotype Inaba (inactivated by heat), El Tor biotype Inaba (inactivated with formalin), classical biotype Ogawa (inactivated by heat), classical biotype Ogawa (inactivated with formalin). Recombinant cholera toxin B subunit (TCBr), 1 mg.

*bacterial content prior to inactivation

  • The other components of the suspension that contains the vaccine are sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium chloride, and water for injections.
  • The effervescent granule contains sodium bicarbonate, citric acid, sodium carbonate, sodium saccharin, sodium citrate, and raspberry flavor.

Appearance of the product and contents of the pack

Dukoral is presented as a suspension and effervescent granule for oral suspension. The suspension is a white suspension that is presented in a vial. The effervescent granule is white with a raspberry flavor and is supplied in a sachet.

Dukoral is presented in packs of 1, 2, and 20 doses. Not all pack sizes may be marketed.

Marketing authorisation holder and manufacturer

Valneva Sweden AB, 105 21 Stockholm, Sweden.

[email protected]

Date of last revision ofthis leaflet:MM/AAAA

Other sources of information

Detailed information on this medicine is available on the European Medicines Agency website: http://www.ema.europa.eu.

On the European Medicines Agency website, you can find this leaflet in all languages of the European Union/European Economic Area.

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Frequently Asked Questions

Is a prescription required for DUKORAL SUSPENSION AND EFFERVSCENT GRANULES FOR ORAL SUSPENSION?
DUKORAL SUSPENSION AND EFFERVSCENT GRANULES FOR ORAL SUSPENSION requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in DUKORAL SUSPENSION AND EFFERVSCENT GRANULES FOR ORAL SUSPENSION?
The active ingredient in DUKORAL SUSPENSION AND EFFERVSCENT GRANULES FOR ORAL SUSPENSION is cholera, inactivated, whole cell. This information helps identify medicines with the same composition but different brand names.
How much does DUKORAL SUSPENSION AND EFFERVSCENT GRANULES FOR ORAL SUSPENSION cost in pharmacies?
The average pharmacy price for DUKORAL SUSPENSION AND EFFERVSCENT GRANULES FOR ORAL SUSPENSION is around 49.39 EUR. Prices may vary depending on the manufacturer and dosage form.
Who manufactures DUKORAL SUSPENSION AND EFFERVSCENT GRANULES FOR ORAL SUSPENSION?
DUKORAL SUSPENSION AND EFFERVSCENT GRANULES FOR ORAL SUSPENSION is manufactured by Valneva Sweden Ab. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of DUKORAL SUSPENSION AND EFFERVSCENT GRANULES FOR ORAL SUSPENSION online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether DUKORAL SUSPENSION AND EFFERVSCENT GRANULES FOR ORAL SUSPENSION is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to DUKORAL SUSPENSION AND EFFERVSCENT GRANULES FOR ORAL SUSPENSION?
Other medicines with the same active substance (cholera, inactivated, whole cell) include VAXCHORA effervescent powder and powder for oral suspension, BEXSERO Injectable Suspension in Pre-filled Syringe, BEXSERO Injectable Suspension in Pre-filled Syringe. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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