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ARIXTRA 7.5 mg/0.6 mL Injectable Solution, Prefilled Syringe

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About the medicine

How to use ARIXTRA 7.5 mg/0.6 mL Injectable Solution, Prefilled Syringe

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

Arixtra 5 mg/0.4 ml Solution for Injection

Arixtra 7.5 mg/0.6 ml Solution for Injection

Arixtra 10 mg/0.8 ml Solution for Injection

fondaparinux sodium

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

  • Keep this leaflet.You may need to read it again.
  • If you have any further questions,ask your doctor or pharmacist.
  • This medicine has been prescribed for you only.Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects,talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack and other information

  1. What is Arixtra and what is it used for
  1. What you need to know before you use Arixtra
  1. How to use Arixtra
  1. Possible side effects
  1. Storing Arixtra
  1. Contents of the pack and further information

1. What is Arixtra and what is it used for

Arixtra is a medicine used to treat or help prevent the formation of blood clots in blood vessels (an antithrombotic agent).Arixtra contains a synthetic substance called fondaparinux sodium.This stops the effect of coagulation factor Xa in the blood and thus prevents the formation of unwanted blood clots (thrombi) in blood vessels.

Arixtra is used to treat adults who have blood clots in the blood vessels of their legs (deep vein thrombosis)and/or lungs (pulmonary embolism).

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you use Arixtra

Do not use Arixtra:

  • if you are allergicto fondaparinux sodium or any of the other ingredients of this medicine (listed in section 6).
  • if you are bleeding heavily
  • if you have a bacterial infection of the heart
    • if you have severe kidney disease.
  • Tell your doctorif you think any of these conditions apply to you. If so, you must notuse Arixtra.

Warnings and precautions:

Consult your doctor or pharmacist before starting to use Arixtra:

  • if you have had problems in the past while being treated with heparin or similar medicines to heparin that cause a decrease in the blood platelet count (heparin-induced thrombocytopenia)
  • if you are at risk of uncontrolled bleeding(haemorrhage),such as:
    • stomach ulcer
  • bleeding disorders
  • recent bleeding in the brain(intracranial haemorrhage)
  • recent brain, spinal or eye surgery;
  • if you have severe liver disease
  • if you have kidney disease
  • if you are 75 years of age or older.
  • Tell your doctorif any of these conditions apply to you.

Children and adolescents

Arixtra has not been tested in children and adolescents under 17 years of age.

Using Arixtra with other medicines

Tell your doctor or pharmacist if you are using, have recently used or might use any other medicines, including those obtained without a prescription.

Using other medicines may affect how Arixtra works or may be affected by Arixtra.

Pregnancy and breast-feeding

Arixtra should not be given to pregnant women unless clearly necessary. Breast-feeding is not recommended during treatment with Arixtra. If you are pregnant, or think you might be pregnant, or are planning to become pregnant, consult your doctor or pharmacist before using this medicine.

Arixtra contains sodium

This medicine contains less than 23 mg of sodium per dose; it is essentially “sodium-free”.

The Arixtra syringe contains latex

The needle protector of the syringe contains latex, which may cause allergic reactions in people sensitive to latex.

  • Tell your doctorif you are allergic to latex before being treated with Arixtra.

3. How to use Arixtra

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

Follow the instructions for administration of this medicine exactly as told by your doctor or pharmacist. If you are unsure, consult your doctor or pharmacist.

Your weight

Normal dose

Less than 50 kg

5 mg once daily

Between 50 and 100 kg

7.5 mg once daily

More than 100 kg

10 mg once daily. This dose may be reduced to

7.5 mg once daily if you have moderate kidney disease.

It should be injected at approximately the same time each day.

How to administer Arixtra

  • Arixtra is given by injection under the skin (subcutaneously) into a skin fold in the lower abdominal area.The syringes are pre-filled with the exact dose that you need. There are different syringes for the 5 mg, 7.5 mg and 10 mg doses.
  • Do notinject Arixtra into a muscle (intramuscularly).

How long to use Arixtra

You should use Arixtra for the period of time that your doctor has told you, as Arixtra prevents a serious condition.

If you inject more Arixtra than you should

Contact your doctor or pharmacist immediately because there is an increased risk of bleeding.

If you forget to use Arixtra

  • Administer the dose as soon as you remember.Do not inject a double dose to make up for forgotten doses.
  • If you are unsure,contact your doctor or pharmacist.

If you stop using Arixtra

If you stop treatment before your doctor has told you to, the blood clot may not have been treated properly and you may be at risk of developing a new blood clot in a vein in your leg or lung. Before stopping treatment, contactyour doctor or pharmacist.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Symptoms to look out for

Severe allergic reactions(anaphylaxis): are very rare (up to 1 in 10,000) in patients using Arixtra. The symptoms include:

  • swelling, sometimes of the face or mouth (angioedema) that causes difficulty swallowing or breathing
  • collapse.
  • Contact a doctor immediatelyif you experience these symptoms. Stop using Arixtra.

Common side effects

These may affect more than 1 in 100 patientstreated with Arixtra.

  • bleeding(e.g. from the area where the operation was performed, from a stomach ulcer, nose, gums, blood in urine, coughing up blood, eye bleeding, bleeding into joints, internal bleeding in the uterus)
  • localised collection of blood(in any body organ or tissue)
  • anaemia(reduction in the number of red blood cells)
  • bruising

    Uncommon side effects

    These may affect up to 1 in 100 patientstreated with Arixtra.

    • swelling (oedema)
    • headache
    • pain
    • chest pain
    • difficulty breathing
    • skin rash or itching
    • wound exudation
    • fever
    • feeling or being sick (nausea or vomiting)

    reduction or increase in the number of platelets (blood cells needed for clotting)

    • increase in some chemicals (enzymes) produced by the liver

    Rare side effects

    These may affect up to 1 in 1,000 patientstreated with Arixtra.

    • allergic reaction
    • internal bleeding in the brain, liver or abdomen
      • anxiety or confusion
    • fainting or dizziness, low blood pressure
      • drowsiness or tiredness
      • flushing
      • cough
    • pain and inflammation at the injection site
      • wound infection

    )

    • increase in blood of non-protein nitrogen
    • leg pain or stomach pain
    • indigestion
    • diarrhoea or constipation
    • increase in bilirubin (a substance produced by the liver) in the blood
      • reduction of potassium in blood
      • pain around the top of the stomach or heartburn

    If you experience side effects, talk to your doctor or pharmacist, even if you think they are not related to this medicine.

    Reporting of side effects

    If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.

    5. Storing Arixtra

    • Keep this medicine out of the sight and reach of children.
    • Store below 25°C.Do not freeze
    • Arixtra does not need to be stored in the refrigerator.

    Do not use this medicine:

    • after the expiry datestated on the label and carton
    • if you notice the presence of particles or a change in colour of the solution
    • if the syringe is damaged
    • if the syringe has been opened and is not to be used immediately.

    Disposal of syringes

    Medicines or syringes should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines or syringes no longer required. This will help protect the environment.

    6. Container Contents and Additional Information

    Arixtra Composition

    The active ingredient:

    • 5 mg of fondaparinux sodium in 0.4 ml of injectable solution
    • 7.5 mg of fondaparinux sodium in 0.6 ml of injectable solution
    • 10 mg of fondaparinux sodium in 0.8 ml of injectable solution

    The other components are sodium chloride, water for injectable preparations, and hydrochloric acid and/or sodium hydroxide to adjust the pH (see section 2).

    Arixtra does not contain any animal products.

    Product Appearance and Container Contents

    Arixtra is a clear and colorless or slightly yellowish injectable solution. It is presented in a pre-filled syringe for single use, equipped with a safety system that helps prevent accidental needle sticks after use.

    It is presented in packs of 2, 7, 10, and 20 pre-filled syringes. Not all pack sizes may be marketed.

    Marketing Authorization Holder and Manufacturer

    Marketing Authorization Holder:

    Viatris Healthcare Limited, Damastown Industrial Park, Mulhuddart, Dublin 15, DUBLIN, Ireland

    Manufacturer:

    Aspen Notre Dame de Bondeville, 1 rue de l'Abbaye, F-76960 Notre Dame de Bondeville, France.

    Date of Last Revision of this Leaflet:

    Other Sources of Information

    Detailed information on this medicinal product is available on the European Medicines Agency website http://www.ema.europa.eu

    You can request more information about this medicinal product by contacting the local representative of the marketing authorization holder.

    België/Belgique/Belgien

    Viatris

    Tél/Tel: + 32 (0)2 658 61 00

    ????????

    ??????????

    ???.: +359 2 44 55400

    Ceská republika

    Viatris CZ s.r.o.

    Tel: + 420 222 004 400

    Lietuva

    Viatris UAB

    Tel: +370 5 205 1288

    Luxembourg/Luxemburg

    Viatris

    Tél/Tel: + 32 (0)2 658 61 00

    (Belgique/Belgien)

    Magyarország

    Viatris Healthcare Kft.Tel.: + 36 1 465 2100

    Danmark

    Viatris ApS

    Tlf: +45 28 11 69 32

    Malta

    V.J. Salomone Pharma Ltd

    Tel: + 356 21 22 01 74

    Deutschland

    Viatris Healthcare GmbH

    Tel: +49 800 0700 800

    Nederland

    Mylan Healthcare BV

    Tel: +31 (0)20 426 3300

    Eesti

    Viatris OÜTel: + 372 6363 052

    Norge

    Viatris AS

    Tlf: + 47 66 75 33 00

    Ελλ?δα

    Viatris Hellas Ltd

    Τηλ: +30 2100 100 002

    Österreich

    Mylan Österreich GmbH

    Tel: +43 1 86390

    España

    Viatris Pharmaceuticals, S.L.

    Tel: +34 900 102712

    Polska

    Mylan Healthcare Sp. z o.o.

    Tel.: + 48 22 546 64 00

    France

    Viatris Santé

    l: + 33 (0)4 37 25 75 00

    Portugal

    Viatris Healthcare, Lda.

    Tel: + 351 21 412 72 00

    Hrvatska

    Viatris Hrvatska d.o.o.

    Tel: +385 1 23 50 599

    România

    BGP Products SRL

    Tel: +40 372 579 000

    Ireland

    Mylan Ireland Limited

    Tel: +353 1 8711600

    Slovenija

    Viatris d.o.o.

    Tel: + 386 1 23 63 180

    Ísland

    Icepharma hf

    Sími: +354 540 8000

    Slovenská republika

    Viatris Slovakia s.r.o.

    Tel: +421 2 32 199 100

    Italia

    Viatris Italia S.r.l.

    Tel: + 39 02 612 46921

    Suomi/Finland

    Viatris Oy

    Puh/Tel: +358 20 720 9555

    Κ?προς

    Varnavas Hadjipanayis Ltd

    Τηλ: +357 2220 7700

    Sverige

    Viatris AB

    Tel: + 46 (0)8 630 19 00

    Latvija

    Viatris SIA

    Tel: +371 676 055 80

    United Kingdom (Northern Ireland)

    Mylan IRE Healthcare Limited

    +353 18711600

    Drawing 3. Syringe with a manualneedle protection system with the safety cap covering the needle AFTER USE

    Types of Safety Syringes:

    There are two types of safety syringes for Arixtra, designed to protect against accidental needle sticks after use. One type of syringe has an automaticneedle protection system and the other has a manualsystem.

    Syringe Components:

    • Needle protector

    ? Plunger

    ? Grip area (with fingers)

    • Needle safety cap

    Drawing 1.Syringe with an automaticneedle protection system

    Pre-filled syringe with medication showing retracted plunger and numbers indicating parts of the syringe

    Syringe with a manualneedle protection system

    Drawing 2. Syringe with a manualneedle protection system

    Syringe with plunger showing fill levels and hand holding the syringe with needle pointing upwards

    DESCRIPTION OF ARIXTRA USEInstructions for Use

    These instructions apply to both types of syringes (with automatic and manual needle protection systems).

    When there is a different instruction between syringes, it will be clearly specified.

    • Wash your handscarefully with water and soap and dry them with a towel.

    • Remove the syringe from the packaging and check that:

    • the expiration date has not passed
    • the solution is clear and colorless and does not contain particles
    • the syringe has not been opened or damaged
    • Sit or lie down in a comfortable position.Select a point in the lower abdomen (belly), at least 5 cm below the navel (drawing A).

    For each injection, alternate the left and right sidesof the lower abdomen. This will help reduce discomfort at the injection site.

    If injection in the lower abdomen is not possible, ask your doctor.

    Person sitting with flexed arm showing shaded injection area on the deltoid and lateral body scheme

    Drawing A

    1. Clean the injection area with a swab or cotton ball soaked in alcohol.

    1. Remove the needle protector: first by twisting (drawing

    B1) and then pulling outwards from the syringe body (drawing B2).

    Discard the needle protector.

    Important Note

    1. Do not touch the needleand prevent it from coming into contact with any surface before injection.
    1. It is normal to find a small air bubble in the syringe. Do not try to remove this air bubblebefore administering the injectionas you may lose part of the medication.
    1. Gently pinch the skinthat you previously cleaned to form a fold. Hold the fold between your thumb and index finger throughout the injection (drawing C).
    1. Hold the syringe firmlyby the grip area. Insert the needle into the skin fold at a right angle (drawing D).

    Drawing B1

    Hand holding syringe with needle inserted into foot, showing injection angle and skin pinch

    Drawing BHands holding and pinching the skin of the arm preparing for a subcutaneous injection

    Drawing C

    Hand holding syringe with needle inserted into the skin, arrow indicating direction of injection and cotton ball pressing the site

    Drawing D

    • Inject the entire contents of the syringeby pressing the plunger down to the maximum (drawing E).

    Hand holding an auto-injector with the needle pointing downwards being inserted into the thigh skin

    Drawing E

    Syringe with Automatic System

    Hand holding syringe with needle inserted into the skin showing the angle and formation of a small lump

    1. Release the plungerand the needle will automatically move from the skin to a safety cap where it will be permanently locked (drawing F).

    Drawing F

    Syringe with Manual System

    1. After injection, hold the syringe by the needle safety cap with the fingers of one hand, grasp the grip area with the fingers of the other hand, and pull back. This action releases the cap. Slide the cap along the syringe body until it is locked in a position that covers the needle, as shown in drawing 3.

    Do not dispose of the used needlein the trash can.Dispose of it according to the instructions given by your doctor or pharmacist.

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    Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

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    Frequently Asked Questions

    Is a prescription required for ARIXTRA 7.5 mg/0.6 mL Injectable Solution, Prefilled Syringe?
    ARIXTRA 7.5 mg/0.6 mL Injectable Solution, Prefilled Syringe requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
    What is the active substance in ARIXTRA 7.5 mg/0.6 mL Injectable Solution, Prefilled Syringe?
    The active ingredient in ARIXTRA 7.5 mg/0.6 mL Injectable Solution, Prefilled Syringe is fondaparinux. This information helps identify medicines with the same composition but different brand names.
    How much does ARIXTRA 7.5 mg/0.6 mL Injectable Solution, Prefilled Syringe cost in pharmacies?
    The average pharmacy price for ARIXTRA 7.5 mg/0.6 mL Injectable Solution, Prefilled Syringe is around 223.42 EUR. Prices may vary depending on the manufacturer and dosage form.
    Who manufactures ARIXTRA 7.5 mg/0.6 mL Injectable Solution, Prefilled Syringe?
    ARIXTRA 7.5 mg/0.6 mL Injectable Solution, Prefilled Syringe is manufactured by Viatris Healthcare Limited. Pharmacy brands and packaging may differ depending on the distributor.
    Which doctors can assess the use of ARIXTRA 7.5 mg/0.6 mL Injectable Solution, Prefilled Syringe online?
    Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether ARIXTRA 7.5 mg/0.6 mL Injectable Solution, Prefilled Syringe is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
    What are the alternatives to ARIXTRA 7.5 mg/0.6 mL Injectable Solution, Prefilled Syringe?
    Other medicines with the same active substance (fondaparinux) include ARIXTRA 1.5 mg/0.3 mL Injectable Solution, Prefilled Syringe, ARIXTRA 2.5 mg/0.5 mL Injectable Solution, Prefilled Syringe, ARIXTRA 5 mg/0.4 mL Injectable Solution, Prefilled Syringe. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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