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Akis 75 mg injectable solution in jeringa precargada

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Abdullah Alhasan

General medicineCardiology11 years of experience

Dr. Abdullah Alhasan is a physician specialising in cardiology and general medicine, with international clinical experience and a commitment to evidence-based care. He offers online consultations for adults, focusing on both acute symptoms and long-term health management.

Main areas of consultation:

  • Chest pain, shortness of breath, heart palpitations, high blood pressure
  • Hypertension control and cardiovascular disease prevention
  • Interpretation of ECG, blood tests, and Holter monitor results
  • Management of heart failure and coronary artery disease
  • General medical issues: infections, fever, fatigue, gastrointestinal symptoms
  • Guidance on diagnostics, treatment plans, and medication adjustments
Dr. Alhasan’s approach is based on thorough assessment, clear communication, and personalised care – helping patients understand their health and make informed decisions about their treatment.
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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use AKIS 75 mg Injectable Solution in Pre-filled Syringe

Contents of the leaflet

  1. Introduction
  2. What is Akis and what is it used for
  3. What you need to know before you use Akis
  4. How to use Akis
  5. Possible side effects
  6. Storage of Akis
  7. Package Contents and Additional Information
  8. Composition of Akis

Introduction

Package Leaflet: Information for the User

Akis 25, 50 and 75 mg solution for injection in pre-filled syringe

Diclofenac sodium

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

  • Keep this leaflet. You may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.
  • In this leaflet, Akis 25, 50 and 75 mg solution for injection in pre-filled syringe will be referred to as Akis.

Contents of the pack

  1. What is Akis and what is it used for
  2. What you need to know before you use Akis
  3. How to use Akis
  4. Possible side effects
  5. Storage of Akis
  6. Contents of the pack and other information

1. What is Akis and what is it used for

This medicine contains the active substance diclofenac sodium. Akis belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). Other NSAIDs include aspirin and ibuprofen. These medicines reduce pain and inflammation.

Akis, administered by intramuscular or subcutaneous injection, is used to treat a number of painful conditions, including:

  • Painful attacks in the joints or back
  • Gout attacks
  • Pain caused by kidney stones
  • Pain caused by injuries, fractures or trauma
  • It is also used to prevent or treat pain after an operation

Administered by intravenous injection, this medicine is used in the hospital setting to prevent or treat pain after an operation.

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2. What you need to know before you use Akis

Do not use Akis

  • if you are allergic to diclofenac, aspirin, ibuprofen or other NSAIDs; if you are allergic to the active substance or any of the other ingredients of this medicine (listed in section 6 at the end of this leaflet)
  • if you have had bleeding in your stomach or intestines after taking NSAIDs
  • if you have had two or more episodes of stomach (gastric) or duodenal (peptic) ulcers or bleeding in the digestive tract. This may include blood in your vomit or when you empty your bowels, or black, tarry stools
  • if you have or have had severe liver failure
  • if you have or have had severe heart failure
  • if you have established cardiovascular disease and/or cerebrovascular disease, for example, if you have had a heart attack, stroke, mini-stroke (TIA) or blockages in the blood vessels of the heart or brain, or an operation to remove a blockage or perform a coronary bypass
  • if you have or have had problems with blood circulation (peripheral arterial disease)
  • if you have or have had severe kidney failure
  • if you have asthma, urticaria or acute rhinitis (allergy) caused by the use of NSAIDs or aspirin
  • if you have any blood clotting disorder or are currently taking anticoagulants (such as warfarin)
  • if you are more than 6 months pregnant (see also Pregnancy, breastfeeding and fertility)
  • if you are under 18 years of age

In addition, do not use this medicine by intravenous injection:

  • if you are using another NSAID or anticoagulant (including low-dose heparin)
  • if you have a history of bleeding tendency, in particular, cerebral hemorrhage
  • if you have undergone a high-risk operation for bleeding
  • if you have a history of asthma
  • if you have moderate or severe kidney impairment
  • if you are dehydrated
  • if you have had significant blood loss

Be careful with Akis

Make sure your doctor knows before taking diclofenac:

  • if you smoke
  • if you have diabetes
  • if you have angina, blood clots, high blood pressure, high cholesterol or high triglycerides.

Side effects can be minimized by using the lowest effective dose for the shortest possible time.

Consult your doctor before starting to take Akis

  • if you think you may be allergic to diclofenac, aspirin, ibuprofen or any other NSAID, or to any of the other ingredients of Akis (listed at the end of the leaflet). The signs of a hypersensitivity reaction are swelling of the face and mouth (angioedema), breathing difficulties, chest pain, runny nose, skin rash or any other allergic reaction.
  • if you have ever had a stomach ulcer, stomach pain or bleeding in the digestive tract. Your symptoms may include blood in your vomit or when you empty your bowels, or black, tarry stools
  • if you suffer from any intestinal disorder that includes ulcerative colitis or Crohn's disease
  • if you have or have had kidney or liver problems
  • if you have or have had any blood disorder or bleeding tendency
  • if you have or have had chronic obstructive pulmonary disease (COPD), nasal polyps or rhinitis or seasonal asthma
  • if you have lupus (systemic lupus erythematosus or SLE) or any similar problem
  • if you are planning to become pregnant, as this medicine interferes with your ability to become pregnant
  • if you have recently undergone or are about to undergo stomach or intestinal surgery before receiving/taking/using Akis, as Akis may sometimes worsen the healing of intestinal wounds after surgery.

Other special warnings

  • medicines like Akis may be associated with a small increased risk of heart attack ("myocardial infarction") or stroke. Any risk is more likely with high doses and with prolonged treatment. Do not exceed the recommended dose or duration of treatment
  • this is an anti-inflammatory medicine, so it may reduce the symptoms of infection, such as headache or fever. If you do not feel well and need to see a doctor, remember to tell them that you are taking Akis
  • elderly patients are more likely to experience side effects associated with this medicine, so inform your doctor about any unusual symptoms

Other medicines and Akis

Consult your doctor or pharmacist if you are taking or have recently taken any other medicines, including those obtained without a prescription (e.g., over-the-counter medicines or drugs). Some medicines may interfere with your treatment.

Tell your doctor if you are taking any of the following medicines:

  • any other NSAID or COX-2 inhibitor (e.g., aspirin or ibuprofen) (medicines for inflammation or pain)
  • medicines for diabetes
  • anticoagulants (blood-thinning tablets, such as warfarin or heparin)
  • antiplatelet medicines (to prevent blood from clotting)
  • diuretics (water tablets)
  • lithium (a medicine for certain types of depression)
  • phenytoin (a medicine for epilepsy)
  • cardiac glycosides (e.g., digoxin; medicines for heart problems)
  • methotrexate (a medicine for certain types of inflammation and cancer)
  • cyclosporin and tacrolimus (medicines for certain types of inflammation and after organ transplants)
  • quinolone antibiotics (medicines used to treat certain infections)
  • corticosteroids (medicines for inflammation and for treating problems with the immune system)
  • colestyramine (a medicine used to reduce cholesterol)
  • colestipol (a medicine used to treat liver problems and Crohn's disease)
  • sulfinpyrazone (a medicine used to treat gout)
  • voriconazole (a medicine used to treat fungal infections)
  • pemetrexed (a chemotherapy medicine used to treat certain types of cancer)
  • deferasirox (a medicine used in patients who receive long-term blood transfusions)
  • mifepristone (a medicine used during the termination of pregnancy)
  • medicines for heart problems or high blood pressure, such as beta blockers or ACE inhibitors
  • tacrolimus (a medicine that reduces the action of the immune system, used to prevent organ rejection in certain patients)
  • medicines used to treat anxiety and depression, known as selective serotonin reuptake inhibitors (SSRIs)
  • zidovudine (a medicine for HIV infection)

Pregnancy and breastfeeding

  • Do not take Akis if you are in the last 3 months of pregnancy, as it may harm your baby or cause problems during delivery. It may cause kidney or heart problems in your baby. It may affect your tendency and that of your baby to bleed and delay or prolong delivery more than expected. You should not take Akis during the first 6 months of pregnancy unless it is clearly necessary and as directed by your doctor. If you need treatment during this period or while trying to become pregnant, you should take the minimum dose for the shortest possible time. From the 20th week of pregnancy, Akis may cause kidney problems in your baby if taken for more than a few days, which may lead to low levels of the fluid that surrounds the baby (oligohydramnios) or narrowing of a blood vessel (ductus arteriosus) in the baby's heart. If you need treatment for more than a few days, your doctor may recommend additional checks.
  • You should tell your doctor if you are breastfeeding. If you are breastfeeding, your doctor will consider whether you should use this medicine

Driving and using machines

This medicine may make some people feel dizzy, tired, drowsy or have blurred vision. Do not drive or use tools or machines if you are affected in this way.

This medicine contains less than 1 mmol of sodium (23 mg) per dose unit; it is essentially "sodium-free".

3. How to use Akis

Your doctor will decide when and how to treat you with this medicine. You will be given an intramuscular injection (an injection into a muscle, usually in the buttocks) or a subcutaneous injection (an injection into the skin, usually in the buttocks or thigh) or an intravenous injection (an injection into a vein, usually in the arm).

This medicine should not be administered by intravenous infusion (i.v.).

Adults: the usual initial dose is 25 to 75 mg, depending on the severity of your pain. If you still have severe pain, your doctor may decide to give you a second injection after 6 hours. The maximum daily dose is 150 mg. You will only be given this medicine for one or two days.

Elderly patients: your doctor may give you a lower dose than the usual dose for adults.

Children and adolescents: not suitable for children (under 18 years).

A doctor, nurse or pharmacist will prepare the injection. The injection will usually be given to you by a nurse or doctor. Your doctor or nurse will not inject you twice in the same place.

If you use more Akis than you should

If you have been given too much medicine, you may experience the following symptoms: nausea and vomiting, stomach pain, stomach or intestinal bleeding, rarely diarrhea, dizziness, ringing in the ears (tinnitus), and occasionally, convulsions (seizures or fits). In severe cases, your kidneys or liver may be damaged (symptoms include difficulty swallowing water or drinking more water than usual, muscle cramps, fatigue, swelling of the hands, feet or face, feeling sick or vomiting, yellowing of the skin).

In case of overdose or accidental administration, consult your doctor or nurse immediately or go to the emergency department of the nearest hospital, bringing this leaflet with you, or call the Toxicology Information Service, telephone 91 562 04 20, indicating the medicine and the amount administered.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Tell your doctor immediately if you notice any of the following:

  • severe allergic reactions that may include: swelling of the face, throat or tongue, difficulty breathing, wheezing, runny nose, skin rash
  • stomach pain, indigestion, acidity, gas, feeling sick or vomiting
  • any sign of bleeding in the stomach or intestines, for example, blood when you empty your bowels, black, tarry stools or blood in your vomit
  • severe skin rash, itching, urticaria, bruising, red or painful areas, peeling or blistering of the skin. These conditions can also affect the mouth, lips, eyes, nose and genitals
  • yellowing of your skin or the whites of your eyes
  • persistent sore throat or fever
  • an unexpected change in the amount of urine you produce and/or its appearance
  • bruising more easily than usual or frequent sore throats or infections
  • chest pain, which may be a sign of a potentially serious allergic reaction called Kounis syndrome
  • reactions at the injection site, including pain, redness, swelling, formation of a hard lump, ulcers or bruising at the injection site. These symptoms can evolve into blackening and necrosis of the skin and underlying tissues around the injection site, leaving a scar when healed. This complication is also known as Nicolau syndrome.

Very common side effects(may affect up to 1 in 10 people)

  • Pain, redness or lumps at the injection site

Common side effects(may affect between 1 in 100 and 1 in 10 people)

  • Feeling unwell, feeling sick in the place of injection

Uncommon side effects(reported in 1 in 1,000 to 1 in 100 people)

  • Dizziness and headache
  • Diarrhea, vomiting and constipation
  • Inflammation of the stomach lining that causes pain, illness and loss of appetite
  • Liver problems
  • Skin rash, itching

Other side effects

The following list of side effects has been reported in patients treated with NSAIDs.

Effects on the heart, chest or blood

  • Medicines like Akis may be associated with a small increased risk of heart attack ("myocardial infarction") or stroke.
  • High blood pressure, heart attack, fast or irregular heartbeat, chest pain and swelling of the body, hands or feet.
  • Asthma, shortness of breath.
  • Blood disorders, such as anemia (reduced number of red blood cells). Symptoms include fatigue, headache, dizziness and paleness.

Effects on the stomach and digestive system

  • Peptic (stomach) and mouth ulcers, tongue infections, disorders of the lower intestine (including inflammation and worsening of Crohn's disease).
  • Inflammation of the pancreas or stomach lining (whose symptoms include severe stomach pain that can spread to the back or shoulders).

Effects on the nervous system

  • Numbness or tingling, paresthesia of the hands and feet or limbs, blurred or double vision, loss or alteration of hearing, tinnitus (ringing in the ears), and occasionally, convulsions (seizures or fits).
  • Hallucinations (seeing or hearing things that are not there), depression, disorientation, sleep problems, irritability, anxiety, memory problems and convulsions (seizures or fits).
  • Inflammation of the layers that cover the brain. Whose symptoms include stiffness in the neck, headache, nausea, vomiting, fever or disorientation and extreme sensitivity to bright light.

Effects on the liver and kidneys

  • Liver disorders. Symptoms may include illness, loss of appetite, general malaise, sometimes with jaundice.
  • Kidney disorders or kidney failure. Symptoms include blood in the urine, foamy urine, swelling of the feet and hands or body.

Effects on the skin and hair

  • Severe skin rash, such as Stevens-Johnson syndrome and other skin conditions that can worsen when exposed to sunlight.
  • Hair loss.

Effects on the immune system

  • Hypersensitivity reaction

Reporting of side effects

If you experience any side effects, talk to your doctor, pharmacist or nurse, even if it is possible side effects that are not listed in this leaflet. You can also report side effects directly through the Spanish Pharmacovigilance System for Human Use Medicines: https://www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Akis

  • Keep this medicine out of the sight and reach of children
  • Do not use this medicine after the expiry date which is stated on the carton and on the syringe after CAD.
  • Store below 25°C. Do not refrigerate or freeze. Keep in the original packaging to protect from light
  • Use immediately after opening. Discard any unused contents
  • Do not use this medicine if it is cloudy or if small particles can be seen

After injection of the correct dose, your doctor or nurse will discard any remaining solution, along with the syringe, needles, and packaging.

Medicines should not be disposed of via wastewater or household waste. Deposit the packaging and any unused medicines at the pharmacy's SIGRE Point. If in doubt, ask your pharmacist how to dispose of the packaging and medicines you no longer need. This will help protect the environment.

6. Package Contents and Additional Information

Composition of Akis

The active ingredient is: sodium diclofenac.

Each 1 ml syringe contains:

25 mg of sodium diclofenac or

50 mg of sodium diclofenac or

75 mg of sodium diclofenac

The other ingredients are: hydroxypropyl-beta-cyclodextrin, polysorbate 20, water for injectable preparations.

Appearance of the Product and Package Contents

This medicine is a clear to slightly amber injectable solution, contained in a glass pre-filled syringe. It is supplied in packaging with two sterile needles (one 27-gauge (gray) for subcutaneous injection and one 21-gauge (green) for intramuscular or intravenous injection).

Package sizes of 1, 3, and 5 pre-filled syringes.

This medicine is also supplied in glass ampoules in package sizes of 1, 3, or 5 ampoules.

Only some pack sizes may be marketed.

Marketing Authorization Holder and Manufacturer

IBSA Farmaceutici Italia Srl

Via Martiri di Cefalonia 2

26900 Lodi

Italy

Tel + 39(0) 371 617292

Email: [email protected]

For further information about this medicine, please contact the local representative of the marketing authorization holder:

Instituto Bioquimico Iberico IBSA S.L.

Avenida Diagonal 605,

Planta 8, Local 1,

08028 Barcelona (Spain)

Date of the Last Revision of this Leaflet:February 2023

Other Sources of Information

Detailed information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/

If you find this leaflet difficult to see or read, or would like it in a different format, please contact the marketing authorization holder.

Online doctors for AKIS 75 mg Injectable Solution in Pre-filled Syringe

Discuss questions about AKIS 75 mg Injectable Solution in Pre-filled Syringe, including use, safety considerations and whether a prescription is appropriate, subject to medical assessment and local regulations.

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Main areas of consultation:

  • Chest pain, shortness of breath, heart palpitations, high blood pressure
  • Hypertension control and cardiovascular disease prevention
  • Interpretation of ECG, blood tests, and Holter monitor results
  • Management of heart failure and coronary artery disease
  • General medical issues: infections, fever, fatigue, gastrointestinal symptoms
  • Guidance on diagnostics, treatment plans, and medication adjustments
Dr. Alhasan’s approach is based on thorough assessment, clear communication, and personalised care – helping patients understand their health and make informed decisions about their treatment.
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Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

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Licence no. 264505958

Dr. Cristina Andrada Brazo is a highly experienced Spanish physician with more than 15 years of clinical practice in emergency medicine, urgent care, and clinical neurophysiology. She provides professional online medical consultations for patients across Spain, helping both residents and international visitors receive timely medical advice, diagnosis, treatment recommendations, and electronic prescriptions when clinically appropriate.

As a licensed physician fully integrated with the Spanish electronic prescription system, Dr. Andrada can issue legally valid e-prescriptions following a medical assessment during an online consultation. Whether you need help with an acute illness, prescription renewal, neurological symptoms, or travel-related healthcare, she offers convenient, patient-centered medical care without the need to visit a clinic.

Dr. Andrada combines extensive emergency medicine experience with advanced expertise in neurology, epilepsy, sleep medicine, and headache disorders. Her international clinical background includes several years working in Switzerland, where she collaborated with multidisciplinary teams in emergency departments and neurology services. This experience strengthened her commitment to evidence-based medicine, compassionate communication, and high-quality patient care.

She graduated in Medicine from the University of Seville and completed her residency in Clinical Neurophysiology at Hospital Virgen de la Salud and the National Hospital for Paraplegics in Toledo. She currently works as a Clinical Neurophysiology Specialist at Hospital San Pedro in Logroño.

To further expand her expertise, Dr. Andrada completed several postgraduate qualifications, including Master's degrees in Sleep Physiology and Medicine, Medical Professionalism and Clinical Practice, Epilepsy, and Clinical Management.

Patients appreciate her thorough consultations, practical treatment recommendations, and empathetic approach. She speaks Spanish, French, and Portuguese, allowing her to communicate comfortably with patients from different backgrounds.

Conditions Dr. Cristina Andrada Treats Online

Dr. Andrada provides online consultations for a wide range of common medical conditions, including:

  • Fever, flu, COVID-19 symptoms, sore throat and respiratory infections
  • Sinusitis, bronchitis, cough and seasonal allergies
  • Urinary tract infections (UTIs)
  • Migraine and tension headaches
  • Dizziness and vertigo
  • Epilepsy and seizure follow-up
  • Sleep disorders, including insomnia and circadian rhythm disturbances
  • Heartburn, gastritis, diarrhea and constipation
  • Back pain, muscle injuries and joint pain
  • Minor skin infections and allergic reactions
  • Fatigue and general medical assessment
  • Prescription renewals for appropriate chronic treatments
  • Follow-up consultations after surgery or previous medical treatment
  • Travel medicine advice and preventive healthcare
  • Interpretation of laboratory results and medical reports

If your condition requires urgent in-person assessment or emergency care, Dr. Andrada will advise you on the most appropriate next steps.

Book an Online Consultation

Book a secure online consultation with Dr. Cristina Andrada Brazo through Oladoctor and receive professional medical advice from an experienced Spanish physician without leaving home. Online appointments are available for adults throughout Spain, with fast access to medical care and electronic prescriptions whenever clinically indicated.

Book a video appointment
€56
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Doctor
5.0(12)

Yevgen Yakovenko

General medicine12 years of experience
Licence no. 35/35/09707

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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€72
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Frequently Asked Questions

AKIS 75 mg Injectable Solution in Pre-filled Syringe requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

The active ingredient in AKIS 75 mg Injectable Solution in Pre-filled Syringe is diclofenac. This information helps identify medicines with the same composition but different brand names.

AKIS 75 mg Injectable Solution in Pre-filled Syringe is manufactured by Ibsa Farmaceutici Italia S.R.L.. Pharmacy brands and packaging may differ depending on the distributor.

Doctors such as Endocrinologists, Rheumatologists, Neurologists, General medicine doctors may assess whether AKIS 75 mg Injectable Solution in Pre-filled Syringe is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

The prescription is issued by a doctor after assessing your health. In Spain, AKIS 75 mg Injectable Solution in Pre-filled Syringe is then dispensed in pharmacies with that prescription. An online consultation does not guarantee that a prescription will be issued: the decision always rests with the doctor.

To request an assessment, you can use Oladoctor:

Other medicines with the same active substance (diclofenac) include AKIS 25 mg Injectable Solution in Pre-filled Syringe, AKIS 50 mg Injectable Solution in Pre-filled Syringe, DAGESIL 75 mg/3 mL Injectable Solution and Perfusion Solution. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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