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SULFADIAZINE REIG JOFRE 500 mg TABLETS

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About the medicine

How to use SULFADIAZINE REIG JOFRE 500 mg TABLETS

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

Sulfadiazine Reig Jofre 500 mg Tablets

Sulfadiazine

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.,as it contains important information for you.

  • Keep this leaflet, as you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the Package Leaflet

  1. What is Sulfadiazine Reig Jofre and what is it used for
  2. What you need to know before you take Sulfadiazine Reig Jofre
  3. How to take Sulfadiazine Reig Jofre
  4. Possible side effects
  5. Storage of Sulfadiazine Reig Jofre
  6. Contents of the pack and further information

1. What is Sulfadiazine Reig Jofre and what is it used for

Sulfadiazine belongs to a group of medicines called sulfonamides, which act by preventing the growth and multiplication of bacteria and other organisms that cause infections.

It is used for the treatment of infections, such as pneumonia, urinary tract infections, meningitis, etc., caused by organisms sensitive to sulfadiazine.

You should consult a doctor if it worsens or does not improve.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you take Sulfadiazine Reig Jofre

Do not takeSulfadiazine Reig Jofre

  • If you are allergic to sulfadiazine or any of the other ingredients of this medicine (listed in section 6).
  • If you are allergic to other sulfonamides (antibiotics).
  • If you are allergic to sulfonylureas (medicines used to reduce blood sugar levels), such as chlorpropamide, glibenclamide, or glipizide.
  • If you are allergic to thiazides (medicines used to increase urine production), such as hydrochlorothiazide.
  • If you are allergic to carbonic anhydrase inhibitors, such as acetazolamide or dichlorphenamide, used for glaucoma (increased pressure inside the eye), epilepsy, or to increase urine production.
  • If you have severe kidney or liver function impairment.
  • If you have glucose-6-phosphate dehydrogenase deficiency (an enzyme found in red blood cells), as you are at risk of suffering from anemia due to premature destruction of red blood cells.
  • If you have porphyria (a hereditary disease of metabolism).
  • If you are in your third trimester of pregnancy.
  • It should not be administered to children under 2 months of age.

Warnings and precautions

Consult your doctor or pharmacist before taking Sulfadiazine Reig Jofre:

  • If you have kidney or liver function impairment, as the medicine may accumulate in your body. In these cases, your doctor may decide to reduce the dose.
  • If you have a history of allergy or asthma.
  • Sulfadiazine should be administered with caution in elderly patients.
  • There have been reports of skin reactions that can be life-threatening (Stevens-Johnson syndrome and toxic epidermal necrolysis) with the use of sulfadiazine. Initially, they appear as red, circular spots, often with a central blister.
  • Other additional signs that may appear are sores in the mouth, throat, nose, genitals, and conjunctivitis (swollen and red eyes).
  • These life-threatening skin reactions often occur with flu-like symptoms. The rash can progress to the formation of generalized blisters or peeling of the skin.
  • The period of highest risk of severe skin reactions is during the first few weeks of treatment.
  • If you have developed Stevens-Johnson syndrome or toxic epidermal necrolysis with the use of Sulfadiazine Reig Jofre, you should not use Sulfadiazine Reig Jofre again at any time.
  • If you develop a rash or these skin symptoms, stop using Sulfadiazine Reig Jofre, go to a doctor immediately, and inform them that you are using this medicine.

If any skin disorder (pallor, rash, dermatitis) appears, interrupt treatment with sulfadiazine and consult your doctor, as it may be indicative of very serious side effects.

If treatment is prolonged, your doctor may perform regular blood tests.

As it may cause the presence of crystals in the urine and the formation of kidney stones, adequate fluid intake should be maintained during treatment to avoid these problems.

This medicine may increase skin sensitivity to sunlight, so prolonged sun exposure should be avoided during treatment.

Other medicines and Sulfadiazine Reig Jofre

Tell your doctor or pharmacist if you are taking or have recently taken or might take any other medicines.

Certain medicines (including herbal or natural products) may influence the action of others; in these cases, it may be necessary to change the dose or interrupt treatment with one of the medicines.

It is important to inform your doctor if you are taking any of the following medicines:

  • Local anesthetics (medicines that produce temporary loss of sensitivity in the area where they are applied), such as benzocaine, procaine, or tetracaine.
  • Oral anticoagulants (used to "thin" the blood and prevent the formation of clots).
  • Methotrexate (used in the treatment of cancer and rheumatic diseases).
  • Phenytoin (used for epilepsy).
  • Sulfonylureas (medicines used to reduce blood sugar levels), such as chlorpropamide, glibenclamide, or glipizide.
  • Cyclosporin (used to prevent transplant rejection).

During treatment with sulfadiazine, the use of substances that produce toxic effects on the liver, bone marrow, and kidneys should be avoided.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

You should not take this medicine during the third trimester of pregnancy. In the first and second trimesters, it should only be used when, in the opinion of your doctor, the benefits outweigh the possible risks.

Sulfadiazine passes into breast milk. Do not take this medicine if you are breastfeeding a child under 2 months of age. In other cases, your doctor should assess the convenience of its administration during breastfeeding.

Driving and using machines

Although it is rare for drowsiness, dizziness, or confusion to occur when taking this medicine, if you notice any of these effects, you should not drive or operate hazardous machinery.

3. How to take Sulfadiazine Reig Jofre

Follow exactly the administration instructions of this medicine indicated by your doctor. If in doubt, consult your doctor or pharmacist again.

The recommended dose is:

Adults:

In severe cases, 4 tablets are recommended in the first dose, followed by 2 tablets every 4 hours. The average dose is 6 to 10 tablets per day for 5 to 10 days.

Children:

1 tablet per 5 kg of body weight is recommended, divided every 4 hours.

This medicine is administered orally.

In the case of small children or people with difficulty swallowing, it is recommended to take the tablets crushed and dissolved in water or another drink.

If you take more Sulfadiazine Reig Jofrethan you should

If you have taken more Sulfadiazine Reig Jofre than you should, consult your doctor, pharmacist, or call the Toxicology Information Service, phone 91 562 04 20, indicating the medicine and the amount taken.

Overdose with sulfadiazine is very rare. If it occurs, loss of appetite, colic, nausea, vomiting, dizziness, headache, drowsiness, loss of consciousness, fever, and the presence of blood and/or crystals in the urine may appear. Jaundice (yellowing of the skin and mucous membranes) and changes in blood cell count may also occur.

The recommended treatment is stomach lavage and administration of large amounts of fluids and sodium bicarbonate (12 g daily), aiming to maintain urine production of at least 2 liters per day.

If you forget to takeSulfadiazine Reig Jofre

Do not take a double dose to make up for forgotten doses.

If you stop takingSulfadiazine Reig Jofre

If you have any further questions on the use of this product, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, Sulfadiazine Reig Jofre can cause side effects, although not everybody gets them.

If you notice any of the following symptoms, stop treatment and consult your doctor quickly: fever, severe headache, inflammation of the mouth mucosa, conjunctivitis, rhinitis, skin rash, purpura (red spots on the skin), pallor, yellowing of the skin and mucous membranes, or weakness.

The most characteristic side effects are:

Frequent (at least 1 in 100 patients):

Nausea and vomiting.

Uncommon (at least 1 in 1,000 patients):

Depression, hallucinations, confusion, psychosis, drowsiness, agitation, insomnia, headache, dizziness, movement coordination disorders, balance disorders, ringing in the ears.

Rare (at least 1 in 10,000 patients):

Fever, serum sickness (allergic reaction), skin rash, itching, erythema (inflammatory redness of the skin), exfoliative dermatitis (generalized peeling of the skin), reactions to sunlight, yellowing of the skin and mucous membranes, liver necrosis (death of liver tissue), kidney stones, decreased urine production, presence of crystals, proteins, and/or blood in the urine, increased urea values in the blood, peripheral neuropathy (damage to the nerves that connect the brain and spinal cord to muscles, skin, and other tissues and organs, which can manifest with tingling, numbness, burning, or pain, among other symptoms), decreased red blood cell count (hemolytic anemia, aplastic anemia), decreased white blood cell count (leukopenia, agranulocytosis), decreased platelet count (thrombocytopenia), increased eosinophils (a type of white blood cell), increased methemoglobin in the blood (methemoglobinemia), characterized by the appearance of a bluish discoloration of the skin, and decreased prothrombin in the blood (hypoprothrombinemia), which favors the appearance of bleeding.

Very rare (less than 1 in 10,000 patients):

There have been reports of skin reactions that can be life-threatening (Stevens-Johnson syndrome, toxic epidermal necrolysis) (see section 2).

If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.

Reporting of side effects

If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly through the Spanish Pharmacovigilance System for Human Use Medicines: www.notificaRAM.es

By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Sulfadiazine Reig Jofre

No special storage conditions are required.

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the packaging after "EXP". The expiry date is the last day of the month shown.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help protect the environment.

6. Contents of the pack and further information

Composition ofSulfadiazine Reig Jofre

  • The active substance is sulfadiazine. Each tablet contains 500 mg of sulfadiazine.
  • The other ingredients (excipients) are sodium starch glycolate, cellulose, talc, methylcellulose, mannitol (E-421), and magnesium stearate.

Appearance of the product and pack contents

Box of 20 and 500 tablets.

Marketing authorization holder and manufacturer:

LABORATORIO REIG JOFRE, S.A.

Gran Capitán, 10, 08970 Sant Joan Despí (Barcelona)

Date of last revision of this leaflet: 05/2025

Online doctors for SULFADIAZINE REIG JOFRE 500 mg TABLETS

Discuss questions about SULFADIAZINE REIG JOFRE 500 mg TABLETS, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Doctor

Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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Doctor

Lina Travkina

Family medicine 13 years exp.

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
  • Post-operative recovery support and pain management.
  • Preconception counselling and postpartum support.
  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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€70
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Doctor

Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques. For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance. Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults. In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions. Patients commonly seek his care for: 

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns

Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.

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€80
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Doctor

Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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€50
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Doctor

Anna Biriukova

General medicine 6 years exp.

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

  • High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
  • Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
  • Leg swelling, chronic fatigue, reduced exercise tolerance.
  • EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
  • Post-COVID-19 cardiac monitoring and care.
Endocrinology – Diabetes, thyroid, metabolism:
  • Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
  • Individual treatment plans including oral medications and insulin therapy.
  • GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
  • Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
  • Metabolic syndrome – obesity, lipid disorders, insulin resistance.
Gastroenterology – Digestive health:
  • Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
  • Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
  • Respiratory infections – cough, colds, bronchitis.
  • Lab test analysis, therapy adjustments, medication management.
  • Adult vaccinations – planning, contraindications assessment.
  • Cancer prevention – screening strategies and risk assessment.
  • Holistic approach – symptom relief, complication prevention, and quality of life improvement.
Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
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€60

Frequently Asked Questions

Is a prescription required for SULFADIAZINE REIG JOFRE 500 mg TABLETS?
SULFADIAZINE REIG JOFRE 500 mg TABLETS requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in SULFADIAZINE REIG JOFRE 500 mg TABLETS?
The active ingredient in SULFADIAZINE REIG JOFRE 500 mg TABLETS is sulfadiazine. This information helps identify medicines with the same composition but different brand names.
How much does SULFADIAZINE REIG JOFRE 500 mg TABLETS cost in pharmacies?
The average pharmacy price for SULFADIAZINE REIG JOFRE 500 mg TABLETS is around 10.58 EUR. Prices may vary depending on the manufacturer and dosage form.
Who manufactures SULFADIAZINE REIG JOFRE 500 mg TABLETS?
SULFADIAZINE REIG JOFRE 500 mg TABLETS is manufactured by Laboratorio Reig Jofre, S.A.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of SULFADIAZINE REIG JOFRE 500 mg TABLETS online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether SULFADIAZINE REIG JOFRE 500 mg TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to SULFADIAZINE REIG JOFRE 500 mg TABLETS?
Other medicines with the same active substance (sulfadiazine) include SEPTRIN 80 mg/400 mg TABLETS, SEPTRIN FORTE 160 mg/800 mg TABLETS, SEPTRIN PEDIATRIC 20 mg/100 mg TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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