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URSOBILANE 500 mg CAPSULES

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About the medicine

How to use URSOBILANE 500 mg CAPSULES

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Patient Information Leaflet

Ursobilane 500 mg capsules

Ursodeoxycholic acid

Read this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.
  • If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What Ursobilane 500 mg capsules are and what they are used for
  2. What you need to know before you take Ursobilane 500 mg capsules
  3. How to take Ursobilane 500 mg capsules
  4. Possible side effects
  5. Storing Ursobilane 500 mg capsules
  6. Contents of the pack and further information
Doctor consultation

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1. What Ursobilane 500 mg capsules are and what they are used for

The active substance in Ursobilane 500 mg capsules is ursodeoxycholic acid, which belongs to a group of medicines called bile stone dissolvers.

It is used to dissolve cholesterol gallstones, provided they are radiotransparent and the gallbladder is functioning (which should have been verified by a test called oral cholecystography). Ursobilane is also used to treat a rare disease of the bile ducts and liver called primary biliary cirrhosis.

2. What you need to know before you take Ursobilane 500 mg capsules

Do not take Ursobilane 500 mg capsules

  • If you are allergic to ursodeoxycholic acid or any of the other ingredients of this medicine (listed in section 6).
  • If you have a stomach or duodenal ulcer.
  • If you have a non-functioning gallbladder.
  • If you have calcified cholesterol stones, radio-opaque stones, or radiotransparent bile pigment stones.
  • If you have liver or intestinal disorders that may interfere with the circulation of bile salts.
  • If you are breastfeeding.

Warnings and precautions

Consult your doctor before taking Ursobilane 500 mg capsules:

  • If you are taking medicines that may cause a buildup of cholesterol in the bile, such as estrogens and hormonal contraceptives.
    • If you are being treated with medicines that may be toxic to the liver.

During treatment with Ursobilane 500 mg capsules, your doctor will perform tests to monitor your liver function.

Children and adolescents

The safety and efficacy of Ursobilane in children have not been established, so its use is not recommended in this population.

Other medicines and Ursobilane 500 mg capsules

Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.

Ursobilane 500 mg capsules may interact with other medicines such as:

  • Antacids containing aluminum.
  • Cholestyramine or colestipol, or other medicines for treating high cholesterol.
  • Antibiotics: neomycin.
  • Hormonal contraceptives, such as estrogens or progestogens.

Taking Ursobilane 500 mg capsules with food, drinks, and alcohol

It is preferable to take the medicine with meals.

Pregnancy, breastfeeding, and fertility

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.

Do not take this medicine while breastfeeding.

Driving and using machines

Ursobilane 500 mg capsules have no effect on the ability to drive or use machines.

Ursobilane 500 mg capsules contain the yellow-orange S dye (E-110)

This medicine may cause allergic reactions because it contains the yellow-orange S dye (E-110).

It may cause asthma, especially in patients allergic to acetylsalicylic acid.

Medicine questions

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3. How to take Ursobilane 500 mg capsules

Follow exactly the administration instructions of this medicine given by your doctor or pharmacist. If you are in doubt, consult your doctor or pharmacist again.

Ursobilane 500 mg capsules are only administered to adults.

The capsules should be swallowed whole, without chewing, with a little liquid. If you have difficulty swallowing, you can disperse the powder contained in the capsules in a liquid.

Take Ursobilane 500 mg capsules preferably with meals.

The recommended dose for the treatment of gallstones is 1 capsule per day (8-10 mg/kg/day).

It is essential that you visit your doctor regularly to check the progression of your disease. While taking this medicine, you will need to have laboratory tests every few months to check that the gallstones are dissolving and that your liver is functioning correctly.

The recommended dose for the treatment of primary biliary cirrhosis is 2 capsules per day (13-15 mg/kg/day), divided into several doses.

Your doctor will advise you to follow a moderate calorie and cholesterol diet during treatment with Ursobilane 500 mg capsules.

If you take more Ursobilane 500 mg capsules than you should

The most common symptom of an overdose of Ursobilane 500 mg capsules is the appearance of diarrhea.

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately, or call the Toxicology Information Service, phone 91 562 04 20, indicating the medicine and the amount ingested.

If you forget to take Ursobilane 500 mg capsules

Do not take a double dose to make up for forgotten doses.

If you stop taking Ursobilane 500 mg capsules

Do not stop treatment without consulting your doctor, as the expected effect will not be achieved.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

These side effects may occur with certain frequencies, which are defined below:

Very common: may affect more than 1 in 10 people.

Common: may affect up to 1 in 10 people.

Uncommon: may affect up to 1 in 100 people.

Rare: may affect up to 1 in 1,000 people.

Very rare: may affect up to 1 in 10,000 people.

Frequency not known: frequency cannot be estimated from the available data.

Gastrointestinal disorders

Rare:nausea and vomiting, difficulty digesting, alterations in taste, biliary pain, abdominal pain, feeling of gas, and constipation.

Very rare:diarrhea.

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly through the Spanish Pharmacovigilance System for Human Use Medicines: https://www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storing Ursobilane 500 mg capsules

Keep this medicine out of the sight and reach of children.

No special storage conditions are required.

Do not use this medicine after the expiry date which is stated on the carton after EXP. The expiry date is the last day of the month shown.

Medicines should not be disposed of via wastewater or household waste. Place the empty packaging and any unused medicine in the pharmacy's SIGRE collection point. If you have any doubts, ask your pharmacist how to dispose of the packaging and any unused medicine. This will help protect the environment.

6. Contents of the pack and further information

Composition of Ursobilane 500 mg capsules

The active substance is ursodeoxycholic acid. Each capsule contains 500 mg of ursodeoxycholic acid.

The other excipients are magnesium stearate, powdered cellulose, colloidal silica, and sodium carboxymethyl starch (type A) (from potato).

The components of the capsule are: gelatin, titanium dioxide (E-171), quinoline yellow (E-104), yellow-orange S (E-110), and indigo carmine (E-132).

Appearance and packaging

Green and orange capsules.

Aluminum-PVC/PVDC blister packs containing 60 capsules.

Marketing authorization holder and manufacturer

Marketing authorization holder

Laboratorio Estedi, S.L.

Montseny, 41

08012 Barcelona - Spain

Manufacturer

Laboratorio Estedi, S.L.

Leopoldo Alas, 7

08012 Barcelona - Spain

You can request more information about this medicine from the local representative of the marketing authorization holder:

Laboratorio Aldo-Unión, S.L.

C/Baronesa de Maldá, 73

08950 Esplugues de Llobregat

(Barcelona) Spain

Date of last revision of this leaflet:January 2012

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) (http://www.aemps.gob.es/)

Online doctors for URSOBILANE 500 mg CAPSULES

Discuss questions about URSOBILANE 500 mg CAPSULES, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

5.0 (808)
Doctor

Alina Tsurkan

Family medicine 13 years exp.

Dr. Alina Tsurkan is a licensed family medicine physician based in Portugal, offering online consultations for adults and children. She provides professional primary care, with a focus on prevention, accurate diagnosis, and long-term management of acute and chronic conditions.

Dr. Tsurkan supports patients with a wide range of health issues, including:

  • Respiratory infections: cold, flu, bronchitis, pneumonia, and lingering coughs.
  • ENT conditions: sinusitis, tonsillitis, otitis (ear infections), sore throat, allergic rhinitis.
  • Eye conditions: allergic or infectious conjunctivitis, red eyes, irritation.
  • Digestive issues: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), constipation, bloating, nausea.
  • Urinary and reproductive health: urinary tract infections (UTIs), cystitis, prevention of recurrent infections.
  • Chronic diseases: hypertension, elevated cholesterol, weight management.
  • Neurological complaints: headaches, migraines, sleep disturbances, fatigue, general weakness.
  • Children’s health: fever, infections, digestive issues, follow-ups, vaccination guidance.

She also provides:

  • IMT medical certificates for driving licence exchange in Portugal.
  • Personalised preventive care and wellness consultations.
  • Interpretation of test results and medical reports.
  • Follow-up care and medication review.
  • Support in managing multiple coexisting conditions.
  • Remote prescription management and medical documentation.

Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

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€55
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Doctor

Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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Doctor

Daniel Cichi

Family medicine 24 years exp.

Dr Daniel Cichi is a family medicine doctor with over 20 years of clinical experience. He provides online consultations for adults, supporting patients with acute symptoms, chronic conditions, and everyday health concerns that require timely medical guidance. His background includes work in emergency care, ambulance services, and family medicine, which allows him to assess symptoms quickly, identify warning signs, and help patients choose the safest next steps – whether that means home care, treatment adjustment, or in-person evaluation. Patients commonly consult Dr Daniel Cichi for: 

  • acute symptoms: fever, infections, flu-like illness, cough, sore throat, shortness of breath;
  • chest discomfort, palpitations, dizziness, fatigue, and blood pressure concerns;
  • digestive problems: abdominal pain, nausea, diarrhoea, constipation, reflux;
  • sexually transmitted infections, erectile dysfunction;
  • muscle, joint, and back pain, minor injuries, post-traumatic symptoms;
  • chronic conditions: hypertension, diabetes, high cholesterol, thyroid disorders, weight loss, hair loss;
  • review and interpretation of lab tests, imaging reports, and medical documents;
  • medication review and treatment adjustment;
  • medical advice while travelling or living abroad;
  • second opinions and guidance on whether in-person care is needed.

Dr Cichi’s consultations are structured and practical. He focuses on clear explanations, risk assessment, and actionable recommendations, helping patients understand their symptoms and make informed decisions about their health.

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€55
5.0 (32)
Doctor

Dmytro Horobets

Family medicine 7 years exp.

Dr. Dmytro Horobets is a licensed family medicine physician in Poland, specialising in endocrinology, diabetology, obesity management, gastroenterology, pediatrics, general surgery, and pain medicine. He offers online consultations for adults and children, providing personalised medical support for a wide range of acute and chronic health concerns.

Areas of expertise:

  • Endocrinology: diabetes type 1 and type 2, prediabetes, thyroid disorders, metabolic syndrome, hormonal imbalance.
  • Obesity medicine: structured weight management plans, nutritional counselling, obesity-related health risks.
  • Gastroenterology: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), liver and biliary conditions.
  • Pediatric care: infections, respiratory symptoms, digestive issues, growth and development monitoring.
  • General surgery support: pre- and post-surgical consultations, wound care, rehabilitation.
  • Pain management: chronic and acute pain, back pain, joint pain, post-traumatic pain syndromes.
  • Cardiovascular health: hypertension, cholesterol control, risk assessment for heart disease.
  • Preventive medicine: regular check-ups, health screenings, long-term management of chronic conditions.

Dr. Horobets combines evidence-based medicine with a patient-centred approach. He carefully evaluates each patient’s medical history and symptoms, offering clear explanations and structured treatment plans adapted to individual needs.

Whether you need help managing diabetes, tackling weight-related health issues, interpreting lab results, or receiving general family medicine support, Dr. Horobets provides professional online care tailored to your specific health goals.

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€60

Frequently Asked Questions

Is a prescription required for URSOBILANE 500 mg CAPSULES?
URSOBILANE 500 mg CAPSULES requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in URSOBILANE 500 mg CAPSULES?
The active ingredient in URSOBILANE 500 mg CAPSULES is ursodeoxycholic acid. This information helps identify medicines with the same composition but different brand names.
How much does URSOBILANE 500 mg CAPSULES cost in pharmacies?
The average pharmacy price for URSOBILANE 500 mg CAPSULES is around 24.74 EUR. Prices may vary depending on the manufacturer and dosage form.
Who manufactures URSOBILANE 500 mg CAPSULES?
URSOBILANE 500 mg CAPSULES is manufactured by Laboratorio Estedi S.L.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of URSOBILANE 500 mg CAPSULES online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether URSOBILANE 500 mg CAPSULES is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to URSOBILANE 500 mg CAPSULES?
Other medicines with the same active substance (ursodeoxycholic acid) include URSODESOXYCHOLIC ACID GRINDEKS 250 mg HARD CAPSULES, ADISOCOL 150 mg TABLETS, ADISOCOL 250 mg HARD CAPSULES. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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