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NIFE-PAR 5 mg/mL ORAL SOLUTION

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About the medicine

How to use NIFE-PAR 5 mg/mL ORAL SOLUTION

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

PACKAGE LEAFLET: INFORMATION FOR THE USER

nife-par 5 mg / ml oral solution

Nifedipine

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again. If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What nife-par 5 mg / ml oral solution is and what it is used for
  2. What you need to know before you take nife-par 5 mg / ml oral solution
  3. How to take nife-par 5 mg / ml oral solution
  4. Possible side effects
  5. Storage of nife-par 5 mg / ml oral solution
  6. Contents of the pack and further information

1. What nife-par 5 mg / ml oral solution is and what it is used for

The active substance, nifedipine, has a pronounced relaxing effect on the smooth muscle tissue of the uterine walls.

nife-par is indicated to delay imminent preterm labor in pregnant women who present:

  • Regular uterine contractions of at least 30 seconds in duration and a frequency of 4 or more contractions every 30 minutes.
  • Cervical dilation of 1 to 3 cm (0 to 3 cm in primiparous women) and cervical effacement of more than 50%.
  • Gestational age of 24 to 33 complete weeks.
  • Normal fetal heart rate.

This medication is for hospital use only.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you take nife-par 5 mg / ml oral solution

Do not take nife-par:

  • If you are allergic to nifedipine or any of the other components of this medication (listed in section 6).
  • If you are being treated with rifampicin.
  • If you are in the first 24 weeks of pregnancy, or in case of:
    • Premature rupture of membranes after 30 weeks of gestation
    • Fetal growth restriction and abnormal fetal heart rate
    • Antepartum hemorrhage requiring immediate delivery
    • Fetal death
    • Suspected intrauterine infection
  • Placental abruption
  • Any other condition in the mother or fetus for which continuation of pregnancy is hazardous
  • If you are in cardiovascular shock (the heart is so damaged that it is unable to supply enough blood to the body's organs), unstable angina, or if you have recently suffered a acute myocardial infarction.
  • If you have severe hypotension, overt heart failure, and severe aortic valve obstruction (a part of the heart).

Warnings and precautions

Be careful with nife-par

  • If you have liver disease.
  • If you have diabetes.
  • In case of pre-eclampsia.
  • It is recommended to monitor maternal blood pressure and uterine function during administration.

Taking nife-par with other medications

Tell your doctor or pharmacist if you are using, have recently used, or may need to use any other medication. Certain medications may interact with nife-par; in these cases, your doctor will need to adjust the dose or interrupt treatment with one of the medications. This is especially important when taking:

  • Antibiotics, such as rifampicin, erythromycin, quinupristin, or dalfopristin
  • Antiepileptics, such as phenytoin, phenobarbital, or carbamazepine; valproic acid
  • Antidepressants, such as fluoxetine or nefazodone
  • Antifungals (against fungi), such as ketoconazole, itraconazole, or fluconazole
  • Antiretroviral medications, such as indinavir, ritonavir, saquinavir, amprenavir, nelfinavir,

delavirdine

  • Medications to reduce high blood pressure, such as diltiazem
  • Immunosuppressive medications, such as tacrolimus
  • Cimetidine (medication to treat stomach ulcers)
  • Cisapride (medication for heartburn)

Taking nife-par with food and drinks

Do not drink grapefruit juice during treatment with nifedipine.

Pregnancy and breastfeeding

Consult your doctor or pharmacist before using any medication.

nife-par is contraindicated during the first 24 weeks of pregnancy.

Nifedipine is excreted in breast milk. As a precaution, breastfeeding should be initiated 36 hours after the last administration.

Driving and using machines

Not applicable.

nife-par contains ethanol and yellow-orange colorant

This medication contains 0.88 g of ethanol in each 2.0 ml dose. The amount in 2 ml of this medication is equivalent to 17 ml of beer or 7 ml of wine.

The alcohol in this medication may affect children. The effects that may appear are changes in behavior and drowsiness. It may also affect their ability to concentrate and perform physical activities.

The amount of alcohol in this medication may affect your ability to drive and use machines because it can alter your judgment and reaction time.

If you have epilepsy or liver problems, consult your doctor or pharmacist before taking this medication.

The amount of alcohol in this medication may alter the effect of other medications. Consult your doctor or pharmacist if you are taking other medications.

If you are pregnant or breastfeeding, consult your doctor or pharmacist before taking this medication.

If you have an alcohol addiction, consult your doctor or pharmacist before taking this medication.

This medication may cause allergic reactions because it contains yellow-orange colorant (E-110). It can cause asthma, especially in patients allergic to acetylsalicylic acid.

3. How to take nife-par 5 mg / ml oral solution

Follow exactly the administration instructions of this medication indicated by your doctor. If in doubt, consult your doctor or pharmacist again.

The route of administration is oral. Your doctor will determine the appropriate dose for your particular case.

The recommended dose is:

Initial dose (first hour):

  • 2.0 ml (10.0 mg of nifedipine).
  • If contractions do not subside, administer a new dose of 1.5 ml (7.5 mg of nifedipine) at 15 minutes. This new dose of 1.5 ml (7.5 mg of nifedipine) can be repeated every 15 minutes until contractions subside. The maximum dose during the first hour is 8 ml (40 mg)

Once contractions have subsided and 6 hours have passed since the last dose administered, the following regimen will be continued:

Maintenance dose (next 6-48 hours):

-3 ml (15 mg of nifedipine), every 6-8 hours, as needed.

The maximum daily dose is 32 ml/day (160 mg of nifedipine).

The duration of treatment will be 48 hours, and may be extended depending on the evolution of the risk of preterm labor, but in principle should not exceed 72 hours (3 days).

Instructions for correct administration of the solution

Open the vial and insert the syringe, included in the packaging, by pressing on the perforated cap hole. Invert the vial and withdraw the necessary dose.

If you take more nife-par than you should

If you have taken more nife-par than you should, consult your doctor immediately or call the Toxicology Information Service, Phone: 91 562 04 20, indicating the medication and the amount taken.

If you forget to take nife-par

Do not take a double dose to make up for forgotten doses.

If you stop treatment with nife-par

If you have any other questions about the use of this medication, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medications, this medication can cause side effects, although not everyone gets them.

Frequent: (at least 1 in 100 patients)

  • Headache, dizziness.
  • Edema (swelling) and vasodilation (dilation of blood vessels).
  • Constipation, nausea.
  • Feeling of discomfort.

Uncommon: (at least 1 in 1,000 patients)

  • Allergic reaction: allergic edema of skin and mucous membranes (swelling), laryngeal edema.
  • Anxiety reactions, sleep disturbances, agitation, nervousness.
  • Dizziness, migraine, and tremor.
  • Visual disturbances.
  • Tachycardia (rapid heart rate), palpitations, angina pectoris.
  • Hypotension, postural hypotension, fainting.
  • Epistaxis (nasal bleeding), nasal congestion, dyspnea (difficulty breathing), chest pain.

- Abdominal and gastrointestinal pain, dyspepsia (difficult digestion), flatulence (gas), dry mouth, diarrhea.

  • Alteration of liver function test results.
  • Rash, sweating.
  • Muscle cramps, joint swelling.
  • Increased urination.
  • Unspecific pain (pain of unknown cause), chills, asthenia (weakness).

Rare: (at least 1 in 10,000 patients)

  • Feeling of tingling in the limbs, increased sensitivity to touch.
  • Gingival hyperplasia (increase in gum thickness).
  • Abdominal distension (swelling), loss of appetite, vomiting.
  • Muscle pain.

Very rare: (less than 1 in 10,000 patients)

  • Hypotension that can cause cardiac problems.
  • Agranulocytosis, purpura (alteration of certain blood parameters).
  • Hyperglycemia (alteration of glucose test in blood)
  • Exfoliative dermatitis (skin peeling), photosensitivity dermatitis (exaggerated skin response to sunlight), urticaria.

Acute pulmonary edema has been reported (frequency unknown)

A meta-analysis of clinical trials conducted with nifedipine as a tocolytic showed that the incidence of adverse reactions was significantly higher with daily doses exceeding 60 mg.

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist, even if it is possible side effects not listed in this leaflet. You can also report them directly through the Spanish Pharmacovigilance System for Human Use Medications: https://www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medication.

5. Storage of nife-par 5 mg / ml oral solution

Keep this medication out of sight and reach of children.

Keep the vial in the box to protect it from light.

This medication does not require any special storage temperature.

Do not use this medication after the expiration date stated on the packaging after "EXP". The expiration date is the last day of the month indicated.

Medications should not be disposed of via wastewater or household waste. The unused solution should be disposed of in accordance with local requirements. This will help protect the environment.

6. Contents of the pack and further information

Composition of nife-par

  • The active substance is nifedipine. Each ml of solution contains 5 mg of nifedipine.
  • The other components are: ethanol 96º, glycerol, sodium cyclamate, sodium saccharin, 37% hydrochloric acid (for pH adjustment), yellow-orange colorant (E-110), lemon flavor, and purified water.

Appearance of the product and pack contents

Topaz glass vial with screw cap and stopper plus oral syringe.

Each vial contains 30 ml of oral solution.

Marketing authorization holder and manufacturer

LABORATORIO REIG JOFRE, S.A.

Gran Capitán, 10

08970 Sant Joan Despí (Barcelona)

Date of last revision of this leaflet:October 2019

Detailed and updated information on this medication is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.es/

Online doctors for NIFE-PAR 5 mg/mL ORAL SOLUTION

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Joao Silva

General medicine 6 years exp.

Dr. João Silva is a physician with training and experience in the field of General and Family Medicine, dedicated to providing healthcare focused on the well-being and quality of life of his patients. Throughout his professional career, he has developed broad clinical competencies, striving to maintain a medical practice based on scientific evidence and continuous knowledge updates.

Between 2013 and 2019, he completed the Integrated Master's Degree in Medicine at the Abel Salazar Institute of Biomedical Sciences in Porto, where he acquired a solid academic and clinical education.

Subsequently, between January 2021 and December 2021, he completed the General Internship at the Entre Douro e Vouga Hospital Center in Santa Maria da Feira, where he had the opportunity to work in different hospital settings and deepen his competencies in several areas of medicine.

From January 2022 until March 2026, he works as a Resident Physician in General and Family Medicine at USF Salvador Machado in Oliveira de Azeméis, developing clinical activities in primary healthcare, follow-up of chronic patients, and health promotion in the community.

Complementing his medical training, Dr. João Silva also completed a Postgraduate Degree in Continuing and Palliative Care at CESPU, strengthening his preparation in the comprehensive approach to patient care, especially in situations requiring prolonged care and multidisciplinary support.

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Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

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  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
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  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
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Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
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  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Daniel Cichi

Family medicine 24 years exp.

Dr Daniel Cichi is a family medicine doctor with over 20 years of clinical experience. He provides online consultations for adults, supporting patients with acute symptoms, chronic conditions, and everyday health concerns that require timely medical guidance. His background includes work in emergency care, ambulance services, and family medicine, which allows him to assess symptoms quickly, identify warning signs, and help patients choose the safest next steps – whether that means home care, treatment adjustment, or in-person evaluation. Patients commonly consult Dr Daniel Cichi for: 

  • acute symptoms: fever, infections, flu-like illness, cough, sore throat, shortness of breath;
  • chest discomfort, palpitations, dizziness, fatigue, and blood pressure concerns;
  • digestive problems: abdominal pain, nausea, diarrhoea, constipation, reflux;
  • sexually transmitted infections, erectile dysfunction;
  • muscle, joint, and back pain, minor injuries, post-traumatic symptoms;
  • chronic conditions: hypertension, diabetes, high cholesterol, thyroid disorders, weight loss, hair loss;
  • review and interpretation of lab tests, imaging reports, and medical documents;
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  • second opinions and guidance on whether in-person care is needed.

Dr Cichi’s consultations are structured and practical. He focuses on clear explanations, risk assessment, and actionable recommendations, helping patients understand their symptoms and make informed decisions about their health.

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Andreea Mateescu

Paediatrics 8 years exp.

Dr Andreea Mateescu is a board-certified paediatrician with 7 years of clinical experience. She graduated from Carol Davila University of Medicine and Pharmacy in Bucharest, Romania, and completed her paediatric residency at INSMC Alessandrescu-Rusescu. She also holds additional training in general ultrasound diagnostics.

Dr Mateescu focuses on providing high-quality, evidence-based medical care for children, with a strong emphasis on prevention, healthy development, and long-term wellbeing. She believes that clear, empathetic communication with both children and parents is essential for building trust and ensuring effective care.

Online consultations with Dr Mateescu are suitable for:

  • preventive check-ups and monitoring of growth and development;
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  • assessment of psychomotor, emotional, and physical development;
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  • nutritional guidance for infants and children, including formula selection when medically indicated;
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Dr Mateescu works with patience, empathy, and professionalism, ensuring that each child receives attentive, individualised care. Her goal is to support healthy, balanced development while helping parents feel confident and well-informed at every stage of their child’s care.
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Lina Travkina

Family medicine 13 years exp.

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
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Additional care areas:

  • Preventive consultations and check-up planning.
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  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
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  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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Lisa Drigo

Paediatrics 34 years exp.

Dr Lisa Drigo is an experienced paediatrician based in Italy with over 30 years of clinical practice. She graduated from Università Cattolica del Sacro Cuore in Rome and has spent decades working within the Italian healthcare system, supporting children and families with both acute care and long-term prevention.

She is well familiar with Italian paediatric standards, including local vaccination schedules, preventive check-ups, growth monitoring, and everyday medical issues faced by families living in Italy. This makes her consultations especially valuable for parents who want guidance that aligns with local medical practice.

Her primary focus is paediatrics, with additional support in family medicine when a child’s health needs to be assessed in a broader family or preventive context.

Patients most often consult her for:

  • Acute infections in children (fever, cough, sore throat, runny nose).
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  • Digestive symptoms such as abdominal pain, nausea, diarrhoea or constipation.
  • Monitoring of growth, weight, and developmental milestones.
  • Vaccination advice according to Italian schedules.
  • Allergic reactions, skin rashes, food sensitivities.
  • General health concerns and everyday questions from parents.
  • Preventive care, nutrition advice, and healthy lifestyle guidance.

Dr Drigo communicates in a clear, calm, and reassuring way, helping parents understand what is happening and what steps to take next. Online consultations allow families to receive reliable paediatric guidance aligned with Italian medical practice, without unnecessary stress or waiting.

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Pedro Alvarez Guerrero

Psychiatry 8 years exp.

Dr. Alvarez Guerrero graduated in Medicine from the San Pablo CEU University in Madrid. He subsequently completed his specialization in Psychiatry in the Department of Psychiatry at Hospital Sant Joan de Deu in Manresa (Barcelona), where over the course of four years he acquired solid training in the bio-psycho-social model, developing his expertise across the different areas of mental health.

During his residency, he undertook training placements at Hospital Clínic de Barcelona, where he trained for several months in the psychiatric consultation-liaison unit. He also completed another placement at Hospital de Cruces in Bilbao, in the first-episode psychosis unit.

Throughout his professional career, Dr. Alvarez Guerrero has sought to complement his medical training with psychotherapeutic tools that allow him to address mental health disorders from a comprehensive perspective. For this reason, he specialized in Brief Strategic Psychotherapy through the Spanish Society of Psychosomatic Medicine and Psychotherapy, an approach focused on targeted and effective interventions.

With the aim of deepening his knowledge and promoting the rational use of treatments, he also completed a Master’s Degree in Psychopharmacology at the University of Valencia, which has enabled him to rigorously integrate the most up-to-date scientific evidence into the clinical management of psychopharmacological treatments.

He has also shown a particular interest in the field of legal psychiatry, completing an Official Master’s Degree in Legal, Forensic and Criminological Psychopathology at the Universitat Internacional de Catalunya. This training has allowed him to acquire the necessary competencies for the preparation of psychiatric expert reports in judicial and medico-legal contexts, thereby broadening the scope of his professional activity.

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Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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Frequently Asked Questions

Is a prescription required for NIFE-PAR 5 mg/mL ORAL SOLUTION?
NIFE-PAR 5 mg/mL ORAL SOLUTION requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
Who manufactures NIFE-PAR 5 mg/mL ORAL SOLUTION?
NIFE-PAR 5 mg/mL ORAL SOLUTION is manufactured by Laboratorio Reig Jofre, S.A.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of NIFE-PAR 5 mg/mL ORAL SOLUTION online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether NIFE-PAR 5 mg/mL ORAL SOLUTION is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to NIFE-PAR 5 mg/mL ORAL SOLUTION?
Other medicines with the same active substance () include AGNUCASTON 20 mg FILM-COATED TABLETS, ATOSIBAN ALTAN 37.5 mg/5 ml CONCENTRATE FOR INFUSION SOLUTION, ATOSIBAN ALTAN 6.75 mg/0.9 mL Injectable Solution. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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