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BERINERT 3000 IU POWDER AND SOLVENT FOR SUBCUTANEOUS INJECTION

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About the medicine

How to use BERINERT 3000 IU POWDER AND SOLVENT FOR SUBCUTANEOUS INJECTION

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Contents of the leaflet

  1. Introduction
  2. What is Berinert and what is it used for
  3. What you need to know before you use Berinert
  4. How to use Berinert
  5. Possible side effects
  6. Storage of Berinert
  7. Container Contents and Additional Information

Introduction

Package Leaflet: Information for the User

Berinert 3000 UI

Powder and solvent for solution for subcutaneous injection

Human C1 esterase inhibitor

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack and other information:

  1. What is Berinert and what is it used for
  2. What you need to know before you use Berinert
  3. How to use Berinert
  4. Possible side effects
  5. Storage of Berinert
  6. Contents of the pack and other information

1. What is Berinert and what is it used for

What is Berinert?

Berinert is presented as a powder and solvent. The prepared solution should be administered by subcutaneous injection.

Berinert is prepared from human plasma (the liquid part of the blood). The active substance is human C1 esterase inhibitor protein, obtained from plasma.

What is Berinert used for?

Berinert is used for the prevention of recurrent attacks of hereditary angioedema (HAE) in adolescent and adult patients. Hereditary angioedema is a congenital vascular disease. It is not an allergic disease. HAE is caused by insufficient, absent, or defective synthesis of C1 esterase inhibitor, which is an important protein. The disease is characterized by the following symptoms:

  • sudden swelling of hands and feet,
  • sudden swelling of the face with a feeling of tightness,
  • swelling of the eyelids, lips, possible swelling of the larynx (voice organ) with breathing difficulties,
  • swelling of the tongue,
  • colic-like pain in the abdominal region.

Generally, all parts of the body can be affected.

Doctor consultation

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2. What you need to know before you use Berinert

The following sections contain information that your doctor should consider before administering Berinert to you.

Do not use Berinert:

  • If you have experienced life-threatening immediate hypersensitivity reactions, including anaphylaxis, to C1 esterase inhibitor or to any of the other components of this medicine (listed in section 6).

Tell your doctor or pharmacist if you are allergic to any medicine or any food.

Warnings and precautions

Consult your doctor or pharmacist before starting to use Berinert,

    Berinert administration should be discontinued immediately (e.g., by interrupting the injection).
  • If you have a history of blood coagulation problems. Blood clots have occurred in patients treated with Berinert intravenously. The use of Berinert at very high doses in diseases other than HAE could increase the risk of blood clots. However, in the case of subcutaneous Berinert, there is no established relationship with blood clots at the recommended dose. Consult your doctor if you have a history of heart or blood vessel disease, infarction, blood clots, or thick blood, a permanent catheter/device in one of your veins, or have been immobilized for some time. These situations may increase the risk of developing a blood clot after using Berinert. Also, inform your doctor about the medications you are using, as some medications, such as contraceptives or certain androgens, may increase the risk of developing a blood clot.

Your doctor will carefully weigh the benefits of treatment with Berinert against the risk of these complications.

Viral safety

When administering medicines derived from human blood or plasma, certain measures must be taken to prevent infections from being passed on to patients. Such measures include:

  • careful selection of blood and plasma donors to exclude those who are at risk of being carriers of infectious diseases, and
  • testing for specific virus and infection markers in individual donations and in plasma pools.

Manufacturers of these products also include stages in the processing of blood or plasma to eliminate/inactivate viruses. Despite this, when administering medicines derived from human blood or plasma, the possibility of transmitting infectious agents cannot be entirely excluded. This also applies to emerging or unknown viruses or other types of infections.

The measures taken are considered effective for enveloped viruses such as human immunodeficiency virus (HIV, the AIDS virus), hepatitis B virus, hepatitis C virus (liver inflammation), and for non-enveloped viruses such as hepatitis A virus (liver inflammation) and parvovirus B19.

It is possible that your doctor may recommend vaccination against hepatitis A and B if you are treated periodically/repeatedly with human plasma-derived medicines.

It is strongly recommended that each time Berinert is administered, the administration date, batch number, and injected volume be recorded.

Using Berinert with other medicines

  • Tell your doctor or pharmacist if you are using, have recently used, or might use any other medicines, including those without a prescription.
  • Berinert should not be mixed with other medicines and diluents in the same syringe.

Pregnancy and breastfeeding

  • If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medicine.

Driving and using machines

Berinert does not affect your ability to drive or use machines.

Berinert contains sodium

This medicine contains 29 mg of sodium (main component of cooking/table salt) in each vial. This is equivalent to 1.5% of the maximum recommended daily sodium intake for an adult.

3. How to use Berinert

Berinert is indicated for self-administration by subcutaneous injection. You or your caregiver should be trained, as necessary, on how to administer Berinert.

Dosage

The recommended dose of Berinert is 60 IU/kg body weight.

Pediatric population

The recommended dose is the same as for adults.

If you use more Berinert than you should

No cases of overdose have been reported.

Reconstitution and administration

If your doctor decides that you can treat yourself at home, they will give you detailed instructions. You will be given a diary where you will record each injection administered at home, which you will bring with you every time you visit the doctor. You or your caregiver will be regularly reviewed on how to administer the injections to ensure that they are done correctly over time.

General instructions

  • The powder must be dissolved and withdrawn from the vial under aseptic conditions. Use the syringe provided with the product.
  • The prepared solution should be clear and transparent to slightly opalescent. After filtering or transferring the solution (see below), it should be visually checked for particles or discoloration before administration.
  • Do not use the solution if it is visibly cloudy or contains particles or residues.
  • Any unused medicine or residual material should be disposed of in accordance with local regulations and following your doctor's instructions.

Reconstitution

Before opening any vial, allow the Berinert powder and solvent to reach room temperature. To do this, you can leave the vials at room temperature for about an hour or hold them in your closed hands for a few minutes. DO NOT expose the vials to direct heat. The vials should not be heated to a temperature above body temperature (37 °C).

Carefully remove the protective caps from the solvent vial and the powder vial. Clean the exposed rubber stoppers of both vials with an alcohol swab and let them dry. You can now transfer the solvent to the powder vial using the included administration system (Mix2Vial). Please follow the instructions below:

Pharmaceutical vial stopper with cylindrical shape and crossed grooves on the top 1

  1. Open the Mix2Vial blister by tearing off the seal. Do not remove the Mix2Vial from the blister.

Vial with stopper and plunger showing downward pressure direction with black arrow 2

  1. Place the solvent vial on a clean and flat surface and hold it firmly. Hold the Mix2Vial along with the blister and push the blue terminal downwards, engaging it with the solvent vial stopper.

Transparent cylinder with plunger and arrow indicating upward direction on a circular base connected to another cylinder with rings 3

  1. Carefully remove the blister from the Mix2Vial by holding the edge and pulling it vertically upwards. Make sure you only remove the blister and not the Mix2Vial.

Schematic view of a medicine vial with separate components such as the stopper and the cylindrical base 4

  1. Place the lyophilized powder vial on a flat and firm surface. Invert the solvent vial with the attached Mix2Vial and push the transparent adapter terminal downwards, engaging it with the powder vial stopper. The solvent will automatically transfer to the lyophilized powder vial.

Medical device with three concentric cylinders connected and a circular connector at the bottom 5

  1. With one hand, hold the vial with the attached Mix2Vial and, with the other hand, hold the solvent vial. Carefully unscrew the system in a counterclockwise direction, separating it into two pieces.

Discard the solvent vial with the attached blue Mix2Vial adapter.

Medicine vial with cap and safety ring showing curved arrows indicating rotational movement 6

  1. Subject the reconstituted solution vial with the attached transparent adapter to gentle rotational movements until the substance is completely dissolved. Do not shake.

Injection device with transparent cylinder and black plunger indicated by an arrow pointing downwards 7

  1. Fill an empty and sterile syringe with air. Use the syringe provided with the product. Holding the solution vial in a vertical position, connect the syringe to the Luer Lock adapter of the attached Mix2Vial by screwing it clockwise. Inject the air into the solution vial.

Transfer and administration

8

  1. Holding the syringe plunger down, invert the system and slowly draw the solution into the syringe by pulling the syringe plunger back.

9

  1. Once the solution has been transferred to the syringe, firmly hold the syringe body (keeping the plunger down) and disconnect the transparent Mix2Vial adapter from the syringe by unscrewing it counterclockwise.

Administration

Self-administration (subcutaneous administration)

Your doctor will teach you how to administer Berinert safely. Once you know how to self-administer the medicine, follow the instructions provided below.

Table 2. Instructions for self-administration of Berinert

Step 1: Attach the accessories

Take the Berinert syringe, the following disposable accessories, and other items (needles or other containers, treatment diary or logbook):

  • Hypodermic needle or subcutaneous infusion set
  • Sterile needle (use a silicone-free needle)
  • Alcohol swabs
  • Gloves (if recommended by your healthcare professional)

Step 2: Clean the surface

  • Thoroughly clean a table or flat surface using alcohol swabs.

Step 3: Wash your hands

  • Wash and dry your hands thoroughly.
  • If you have been recommended to wear gloves during infusion preparation, put on the gloves.

Step 4: Prepare the injection site

  • Unless your doctor has told you to use another area, select a site on your abdomen (belly) for the injection (Figure 1).
  • Use a different site from your last injection; you should change the injection sites.
  • New injection sites should be at least 5 inches (5 centimeters) away from the site of the previous injection.
  • Never inject into an area where the skin appears itchy, swollen, painful, wounded, or red.
  • Avoid injecting into areas with scars or stretch marks.
  • Clean the skin at the injection site with an alcohol swab and let the skin dry (Figure 2).

Female human torso with breast contour and marks indicating possible injection sites on abdomen and ribs

Figure 1

Needle inserted into the skin at a 45-degree angle and a curved arrow indicating the direction of injection

Figure 2

Step 5: Injection into the abdominal area

As indicated by your healthcare professional:

  • Attach a hypodermic needle or subcutaneous infusion set to the syringe according to your healthcare professional's instructions. Prepare the needle or tubing as necessary and as you have been taught.

Injection with a hypodermic needle:

  • Insert the needle into the skin fold (Figure 3).

Injection with a subcutaneous infusion set:

  • Insert the needle into the skin fold (Figure 4).

Hand holding syringe with needle inserted into skin showing subcutaneous injection angle

Figure 3

Hands holding a device with cable and connector, possibly an electrode or sensor, on the skin

Figure 4

Step 6: Clean up

  • After injecting the complete dose of Berinert, remove the needle.
  • Dispose of any unused solution and administration equipment according to local requirements.

Step 7: Record the treatment

  • Each time you use Berinert, record the batch number on the Berinert vial label in your treatment diary or logbook with the date and time of infusion .
Medicine questions

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Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Immediately contact your doctor

Side effects with Berinert are rare.

The following side effects have been observed very frequently (may affect more than 1 in 10 people):

  • Reactions at the injection site (bruising, feeling of cold, suppuration, erythema, hematoma, hemorrhage, hardening, edema, pain, pruritus, rash, scarring, swelling, urticaria, heat).
  • Nasopharyngitis (stuffy nose, sneezing, runny eyes).

The following side effects have been observed frequently (may affect up to 1 in 10 people):

  • Hypersensitivity or allergic reactions (such as hypersensitivity, pruritus, rash, and urticaria)
  • Dizziness

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly through the Spanish Pharmacovigilance System for Human Use Medicines: www.notificaRAM.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Berinert

  • Keep this medicine out of the sight and reach of children.
  • Do not use this medicine after the expiry date which is stated on the label and carton after EXP.
  • Do not store above 30 °C.
  • Do not freeze.
  • Store the vial in the outer packaging to protect it from light.
  • Berinert does not contain preservatives, so the prepared solution should be used immediately.
  • If the prepared solution is not administered immediately, it should be used within 8 hours and only stored in the vial.

6. Container Contents and Additional Information

Berinert Composition

The active ingredient is:

Human C1 esterase inhibitor (3,000 IU/vial; after reconstitution with 5.6 ml of water for injectable preparations 500 IU/ml).

"Thisinformation is intended only for healthcare professionals".

The other components are:

Glycine, sodium chloride, sodium citrate.

Solvent:water for injectable preparations.

Product Appearance and Container Contents

Berinert is presented as a white powder and is supplied with water for injectable preparations as a solvent.

The prepared solution should be transparent and clear to slightly opalescent.

Presentation

A container contains:

1 vial with powder

1 vial with 5.6 ml of water for injectable preparations

1 transfer device with 20/20 filter

Administration equipment (inner box):

1 disposable 10 ml syringe

1 hypodermic needle

1 subcutaneous injection device (butterfly)

2 alcohol swabs

1 dressing

Multiple packaging of 5 x 3,000 IU, including a box with 5 administration equipment.

Multiple packaging of 20 x 3,000 IU, including 4 boxes with 5 administration equipment.

Only some pack sizes may be marketed.

Marketing Authorization Holder and Manufacturer

CSL Behring GmbH

Emil-von-Behring-Strasse 76

35041 Marburg

Germany

For further information about this medicinal product, please contact the local representative of the marketing authorization holder:

CSL Behring S.A.

c/ Tarragona 157, 18th floor

08014 Barcelona

Spain

This medicinal product is authorized in the Member States of the European Economic Areaand in the United Kingdom (Northern Ireland)under the following names:

Berinert 3000 I.E. Powder and solvent for solution for injection Austria

Berinert 3000 IE, powder and solvent for solution for injection Belgium, Netherlands

Berinert 3000 Cyprus, Germany, Greece, Poland, Portugal

???????? 3000, ???? ? ???????????

?? ??????????? ???????

C1- ????????? ?????????, ??????? Bulgaria

Berinert 3000 IU Czech Republic, Slovakia

Berinert 3000 IU powder and solvent for solution for injection _______________________________ Croatia

Berinert Denmark, Italy

Berinert SC Estonia

Berinert 3000 IU, powder and solvent for solution for injection Finland

Berinert 3000 UI, powder and solvent for injectable solution France, Luxembourg

Berinert 3000 NE powder and solvent for injectable solution Hungary

Berinert 3000 a.e. powder and solvent, solution for injection Iceland

Human C1-esterase inhibitor CSL Behring 3000 TV powder and solvent for injectable solution Lithuania

Berinert 3000 IU powder and liquid for injectable solution, solution Norway

Berinert 3000 3000 UI, powder and solvent for injectable solution Romania

Berinert 3000 i.e. powder and vehicle for solution for injection Slovenia

Berinert 3000 UI powder and solvent for subcutaneous injectable solution Spain

Berinert 3000 IE, powder and liquid for injectable solution, solution Sweden

Berinert 3000 IU Powder and solvent for solution for injection _____________________ United Kingdom, Malta, Ireland

Date of last revision of this leaflet:October 2021

Detailed and updated information on this medicinal product is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es

Thisinformation is intended only for healthcare professionals

QUALITATIVE AND QUANTITATIVE COMPOSITION

The potency of human C1 esterase inhibitor is expressed in International Units (IU), which is related to the current WHO standard for C1 esterase inhibitor products.

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Frequently Asked Questions

Is a prescription required for BERINERT 3000 IU POWDER AND SOLVENT FOR SUBCUTANEOUS INJECTION?
BERINERT 3000 IU POWDER AND SOLVENT FOR SUBCUTANEOUS INJECTION requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in BERINERT 3000 IU POWDER AND SOLVENT FOR SUBCUTANEOUS INJECTION?
The active ingredient in BERINERT 3000 IU POWDER AND SOLVENT FOR SUBCUTANEOUS INJECTION is c1-inhibitor, plasma derived. This information helps identify medicines with the same composition but different brand names.
Who manufactures BERINERT 3000 IU POWDER AND SOLVENT FOR SUBCUTANEOUS INJECTION?
BERINERT 3000 IU POWDER AND SOLVENT FOR SUBCUTANEOUS INJECTION is manufactured by Csl Behring Gmbh. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of BERINERT 3000 IU POWDER AND SOLVENT FOR SUBCUTANEOUS INJECTION online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether BERINERT 3000 IU POWDER AND SOLVENT FOR SUBCUTANEOUS INJECTION is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to BERINERT 3000 IU POWDER AND SOLVENT FOR SUBCUTANEOUS INJECTION?
Other medicines with the same active substance (c1-inhibitor, plasma derived) include BERINERT 1500 IU POWDER AND SOLVENT FOR INJECTABLE SOLUTION, BERINERT 2000 IU POWDER AND SOLVENT FOR SUBCUTANEOUS INJECTION SOLUTION, BERINERT 500 IU POWDER AND SOLVENT FOR INJECTION AND INFUSION SOLUTION. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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