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AMIGNUL 12.5 mg Film-coated tablets

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About the medicine

How to use AMIGNUL 12.5 mg FILM-COATED TABLETS

Contents of the leaflet

  1. Introduction
  2. What is Amignul and what is it used for
  3. What you need to know before taking Amignul
  4. How to take Amignul
  5. Possible side effects
  6. Storage of Amignul
  7. Package contents and additional information

Introduction

Leaflet: Information for the user

Amignul 12.5 mg Film-coated tablets

Almotriptan

Read the entire leaflet carefully before starting to take the medicine, as it contains important information for you.

  • Keep this leaflet, as you may need to read it again.
  • If you have any doubts, consult your doctor, pharmacist, or nurse.
  • This medicine has been prescribed to you and should not be given to others, even if they have the same symptoms as you, as it may harm them.
  • If you experience side effects, consult your doctor, pharmacist, or nurse, even if they are not mentioned in this leaflet. See section 4.

Contents of the leaflet

  1. What is Amignul and what is it used for
  2. What you need to know before taking Amignul
  3. How to take Amignul
  4. Possible side effects
  5. Storage of Amignul
  6. Package contents and additional information

1. What is Amignul and what is it used for

Amignul is an antimigraine drug that belongs to a class of compounds known as selective serotonin receptor agonists. It is believed that Amignul reduces the inflammatory response associated with migraines by binding to serotonin receptors in cerebral blood vessels (cranial), causing vasoconstriction.

Amignul is used to relieve headache pain associated with migraine attacks with or without aura.

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2. What you need to know before taking Amignul

Do not take Amignul

  • if you are allergic to almotriptan or any of the other components of this medicine (listed in section 6)
  • if you have or have ever had any disease that limits blood flow to the heart, such as:
    • myocardial infarction
    • chest pain or discomfort that occurs normally after physical activity or stress
    • painless cardiac problems
    • chest pain that occurs at rest
    • severe hypertension (very high blood pressure)
    • uncontrolled, mild, or moderate hypertension
  • if you have had a stroke or a reduction in cerebral blood flow
    • if you have had an obstruction of the large arteries in the arms or legs (peripheral vascular disease)
  • if you are taking other medicines to combat migraines, including ergotamine, dihydroergotamine, and methysergide or another selective serotonin agonist (e.g., sumatriptan)
  • if you have severe liver disease.

Warnings and precautions

Consult your doctor, pharmacist, or nurse before starting to take Amignul:

  • if your type of migraine has not been diagnosed
  • if you are allergic (hypersensitive) to antibacterial medicines used to treat urinary tract infections (sulfonamides)
  • if the symptoms of your headache are different from those of your usual migraine attacks, for example, you hear noise in your ears or feel dizzy, have brief paralysis of a part of your body or paralysis of the muscles that control your eye movements, or any other new symptoms
  • if you are at risk of having heart disease, including high blood pressure and uncontrolled cholesterol, obesity, diabetes, are a smoker, have a family history of heart disease, are a postmenopausal woman, or are a man over 40 years old
  • if you have mild or moderate liver disease
  • if you have severe kidney disease
  • if you are over 65 years old, as you are more likely to experience increased blood pressure
  • if you are taking antidepressants (SSRIs or SNRIs). See also below, Taking Amignul with other medicines.

It has been suggested that excessive use of antimigraine medicines may lead to chronic headache.

Children and adolescents

Children under 18 years old should not take Amignul.

Over 65 years old

If you are over 65 years old, you should consult your doctor before taking this medicine.

Taking Amignul with other medicines

Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other type of medicine.

Please inform your doctor:

  • if you are taking any medicine for the treatment of depression, such as monoamine oxidase inhibitors (e.g., moclobemide), selective serotonin reuptake inhibitors (e.g., fluoxetine), or serotonin and norepinephrine reuptake inhibitors (e.g., venlafaxine), as these medicines may cause serotonin syndrome, a potentially very serious reaction to treatment. The symptoms of serotonin syndrome include: confusion, agitation, fever, sweating, uncoordinated movements of the limbs or eyes, uncontrolled muscle movements, or diarrhea.
  • if you are taking St. John's Wort (Hypericum perforatum) preparations, as they may increase the likelihood of side effects.

Almotriptan should not be taken at the same time as other medicines that contain ergotamine, which are also used to treat migraines. However, both medicines can be taken one after the other, provided that a minimum amount of time has passed between doses:

  • after taking almotriptan, it is recommended to wait at least 6 hours before taking ergotamine
  • after taking ergotamine, it is recommended to wait at least 24 hours before taking almotriptan.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medicine.

There is very limited information on the use of almotriptan during pregnancy. Amignul should only be used during pregnancy if prescribed by your doctor and after carefully considering the balance of benefits and risks.

Caution should be exercised when using this medicine during breastfeeding. You should avoid breastfeeding for 24 hours after treatment.

Driving and using machines

Amignul may cause drowsiness. If you experience it, you should not drive or operate machinery.

This medicine contains less than 23 mg of sodium (1mmol) per tablet; it is essentially "sodium-free".

3. How to take Amignul

Amignul should only be used to treat a migraine attack that has already started and not to prevent migraine attacks or headaches.

Follow the administration instructions of this medicine exactly as indicated by your doctor. If in doubt, consult your doctor or pharmacist again.

Adults (18-65 years)

The recommended dose is one Amignul tablet (12.5 mg of almotriptan) that should be taken as soon as possible after the start of a migraine attack. If the attack does not subside, do not take more than one tablet.

If you experience a second attack within the next 24 hours, you can take a second 12.5 mg tablet, but always provided that at least 2 hours have passed between the first and second tablets.

The maximum daily dose is two 12.5 mg tablets in 24 hours.

The tablets can be taken with liquid (e.g., water) and can be taken with or without food.

Amignul should be taken as soon as possible after the start of a migraine attack, although it is also effective if taken later.

Severe kidney disease

If you have severe kidney disease, do not take more than one 12.5 mg tablet in 24 hours.

If you take more Amignul than you should

If you accidentally take too many Amignul tablets, or if someone else or a child takes this medicine, consult your doctor or pharmacist immediately.

In case of overdose or accidental ingestion, consult the Toxicology Information Service. Telephone 915 620 420.

If you forget to take Amignul

Try to take Amignul as prescribed. Do not take a double dose to make up for forgotten doses.

If you have any other doubts about the use of this medicine, consult your doctor, pharmacist, or nurse.

Medicine questions

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4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everyone gets them.

Common(may affect up to 1 in 10 people)

  • dizziness
  • drowsiness
  • nausea
  • vomiting
  • fatigue

Uncommon(may affect up to 1 in 100 people)

  • tingling, itching, or numbness of the skin (paresthesia)
  • headache
  • ringing, noise, or clicking (tinnitus)
  • strong heartbeats (palpitations)
  • throat tightness
  • diarrhea
  • indigestion (dyspepsia)
  • dry mouth
  • muscle pain (myalgia)
  • bone pain
  • chest pain
  • feeling of weakness (asthenia)

Very rare(may affect up to 1 in 10,000 people)

  • coronary vasospasm
  • heart attack (myocardial infarction)
  • increased heart rate (tachycardia)

Frequency not known(cannot be estimated from available data)

  • allergic reactions (hypersensitivity reactions), including swelling of the mouth, neck, or hands (angioedema)
  • severe allergic reactions (anaphylactic reactions)
  • seizures
  • visual disturbances, blurred vision (visual disorders may also occur during a migraine attack itself)
  • intestinal vasospasm that can cause lack of blood flow and damage your intestine. You may experience abdominal pain and bloody diarrhea.

During treatment with Amignul, inform your doctor immediately:

  • if you have chest pain, tightness in the chest or throat, or any other symptoms that may suggest a heart attack. Please inform your doctor immediately and do not take any more Amignul tablets.

Reporting side effects

If you experience any side effects, consult your doctor or pharmacist, even if they are not listed in this leaflet. You can also report them directly through the Spanish Pharmacovigilance System for Human Use Medicines: https://www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Amignul

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiration date stated on the packaging, after "EXP". The expiration date is the last day of the month indicated.

This medicine does not require special storage conditions.

Medicines should not be disposed of via wastewater or household waste. Place the packaging and any unused medicine in the SIGRE collection point at your pharmacy. If in doubt, ask your pharmacist how to dispose of the packaging and any unused medicine. This will help protect the environment.

6. Package contents and additional information

Composition of Amignul

The active ingredient is almotriptan 12.5 mg (as almotriptan D,L-malate acid).

The other ingredients are:

Core of the tablet: mannitol (E-421), microcrystalline cellulose, povidone, sodium carboxymethyl starch, and sodium stearyl fumarate.

Coating material: hypromellose, titanium dioxide (E-171), macrogol 400, and carnauba wax.

Appearance of the product and package contents

Amignul is available in film-coated tablets, white, circular, and biconvex, for oral use, with a letter A engraved on one side.

Amignul is available in packs containing 2, 3, 4, 6, 7, 9, 12, 14, or 18 tablets. In Spain, packs of 4 and 6 tablets are marketed.

Marketing authorization holder and manufacturer

Marketing authorization holder

Almirall, S.A. General Mitre, 151 08022 - Barcelona (Spain).

Manufacturer

Industrias Farmacéuticas Almirall, S.A. Ctra. de Martorell, 41-61 08740 Sant Andreu de la Barca - Barcelona (Spain).

This medicine is authorized in the Member States of the European Economic Area under the following names:

Italy

Almotrex 12.5 mg film-coated tablets

Spain

Amignul 12.5 mg film-coated tablets

Date of the last revision of this leaflet: January 2021

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/

Online doctors for AMIGNUL 12.5 mg FILM-COATED TABLETS

Discuss questions about AMIGNUL 12.5 mg FILM-COATED TABLETS, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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5.0(38)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a General Practitioner with specialized training in chronic pain. He provides online consultations for adult patients in Spain and other European countries.

Dr. Popov understands that seeking help with weight-related concerns or pain that has persisted for months can be difficult. Many patients come to him after trying different approaches without feeling truly heard. During the consultation, the doctor creates a comfortable and supportive, non-judgmental environment where the patient’s medical history can be discussed in detail, questions can be answered, and the next steps can be decided together.

Weight Management and Metabolic Health

Dr. Popov can help assess overweight, obesity, and related conditions such as hypertension, diabetes, or metabolic disorders. During the consultation, the patient’s medical history, test results, current medications, and previous treatments will be reviewed.

If you would like to learn about possible medication options or have already started treatment, the doctor can assess your situation, review the effectiveness and tolerability of the therapy, and clearly explain its benefits, potential risks, and alternatives.

Not every patient requires the same treatment. A consultation does not guarantee a prescription — it provides an objective medical assessment and a plan tailored to your individual situation.

Pain and General Medicine

You can also consult Dr. Popov regarding:

* chronic pain, migraines, neuralgia, and fibromyalgia;

* back, neck, lower back, or joint pain;

* hypertension, diabetes, and follow-up of chronic conditions;

* review of test results, medical reports, and current treatment;

* preventive medicine and a second medical opinion.

How the Consultation Works

The video consultation lasts up to 30 minutes. The doctor will listen carefully, review the information you provide, and explain the next steps in clear and understandable language.

If additional tests, an in-person consultation, or urgent medical care are required, the doctor will inform you directly.

Dr. Popov’s goal is to make sure the patient feels heard and leaves the consultation with a clear understanding of their condition and the next steps they can take.

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Yevgen Yakovenko

General medicine12 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
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  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Lina Travkina

General medicine13 years of experience

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.

  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.

  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.

  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.

  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.

  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.

  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.

  • Medical advice and follow-up consultations.

  • Test interpretation and diagnostic guidance.

  • Structured support for undiagnosed complaints.

  • Second opinion on diagnoses and treatment plans.

  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.

  • Post-operative recovery support and pain management.

  • Preconception counselling and postpartum support.

  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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€75
Doctor
5.0(20)

Nuno Tavares Lopes

General medicine18 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies

  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management

  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses

  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment

  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance

  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis

  • Pain management: acute and chronic pain, post-surgical care

  • Public health: prevention, health screenings, long-term monitoring

  • Sick leave (Baixa médica) connected to Segurança Social in Portugal

  • IMT medical certificates for driving licence exchange

Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

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€70

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Frequently Asked Questions

AMIGNUL 12.5 mg FILM-COATED TABLETS requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

The active ingredient in AMIGNUL 12.5 mg FILM-COATED TABLETS is almotriptan. This information helps identify medicines with the same composition but different brand names.

The average pharmacy price for AMIGNUL 12.5 mg FILM-COATED TABLETS is around 29.3 EUR. Prices may vary depending on the manufacturer and dosage form.

AMIGNUL 12.5 mg FILM-COATED TABLETS is manufactured by Almirall S.A.. Pharmacy brands and packaging may differ depending on the distributor.

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether AMIGNUL 12.5 mg FILM-COATED TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy AMIGNUL 12.5 mg FILM-COATED TABLETS in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

Other medicines with the same active substance (almotriptan) include ALMOGRAN 12.5 mg FILM-COATED TABLETS, ALMOTRIPTAN CINFA 12.5 mg FILM-COATED TABLETS, ALMOTRIPTAN COMBIX 12.5 mg FILM-COATED TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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