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ZINFORO 600 MG POWDER FOR CONCENTRATE FOR PERFUSION SOLUTION

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About the medicine

How to use ZINFORO 600 MG POWDER FOR CONCENTRATE FOR PERFUSION SOLUTION

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet:information for the user

Zinforo600mg powder for concentrate for solution for infusion

ceftaroline fosamil

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or nurse.
  • If you get any side effects, talk to your doctor or nurse. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What is Zinforo and what is it used for
  2. What you need to know before you use Zinforo
  3. How to use Zinforo
  4. Possible side effects
  5. Storage of Zinforo
  6. Contents of the pack and other information

1. What is Zinforo and what is it used for

What is Zinforo

Zinforo is an antibiotic medicine that contains the active substance ceftaroline fosamil. It belongs to a group of medicines called “cephalosporin antibiotics”.

What is Zinforo used for

Zinforo is used to treat children (from birth) and adults with:

  • skin and soft tissue infections
  • a lung infection called “pneumonia”

How Zinforo works

Zinforo works by killing certain bacteria that can cause serious infections.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you use Zinforo

Do not use Zinforo

  • if you are allergic to ceftaroline fosamil or any of the other ingredients of this medicine (listed in section 6)
  • if you are allergic to cephalosporins (a class of antibiotics)
  • if you have had severe allergic reactions to other antibiotics such as penicillin or carbapenem.

Do not use Zinforo if any of the above applies to you. If you are not sure, talk to your doctor or nurse before using Zinforo.

Warnings and precautions

Talk to your doctor or nurse before starting Zinforo:

  • if you have kidney problems (your doctor may need to prescribe a lower dose)
  • if you have ever had seizures (epileptic fits or convulsions)
  • if you have ever had a non-severe allergic reaction to other antibiotics such as penicillin or carbapenem
  • if you have had severe diarrhea when taking antibiotics in the past.

You may get another infection caused by another bacterium during or after treatment with Zinforo.

You may develop signs and symptoms of severe skin reactions such as fever, joint pain, skin rash, scaly red rash, skin bumps containing pus, blisters, or peeling of the skin, circular red patches often with blisters in the center on the trunk, ulcers in the mouth, throat, nose, genitals, and eyes. If this happens, talk to your doctor or nurse immediately.

Lab tests

You may develop an abnormal response to a lab test (called Coombs test) that detects certain antibodies that can act against red blood cells. If your red blood cell count decreases, your doctor may check if these antibodies have caused this decrease in red blood cells.

If any of the above applies to you (or you are not sure), talk to your doctor or nurse before using Zinforo.

Other medicines and Zinforo

Tell your doctor or nurse if you are using, have recently used, or might use any other medicines.

Pregnancy and breastfeeding

If you are pregnant, talk to your doctor before using Zinforo. Do not use this medicine during pregnancy unless your doctor has told you to.

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.

Driving and using machines

Zinforo may cause side effects such as dizziness. This may affect your ability to drive or use machines.

3. How to use Zinforo

Zinforo will be given to you by a doctor or nurse.

How much to use

The recommended dose for adults is 600 mg every 12 hours. Your doctor may increase your dose to 600 mg every 8 hours for some infections. The recommended dose for children depends on the child's age and weight and is given every 8 or 12 hours. It is given through a drip into a vein over 5 to 60 minutes if you receive the standard dose or 120 minutes if you receive a higher dose.

A treatment cycle usually lasts from 5 to 14 days for skin infections and 5 to 7 days for pneumonia.

Patients with kidney problems

If you have kidney problems, your doctor may reduce your dose, as Zinforo is removed from your body through your kidneys.

If you use more Zinforo than you should

If you think you have been given too much Zinforo, tell your doctor or nurse immediately.

If you miss a dose of Zinforo

If you think you have missed a dose, tell your doctor or nurse immediately.

If you have any other questions about using this medicine, ask your doctor or nurse.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. The following side effects may happen with this medicine:

Tell your doctor immediately if you get any of these symptoms, as you may need urgent medical treatment:

  • Sudden swelling of your face, lips, tongue, or throat; a severe rash; and problems swallowing or breathing. These can be signs of a severe allergic reaction (anaphylaxis) and can be life-threatening;
  • Diarrhea that becomes severe or doesn't stop, or stools that contain blood or mucus during or after stopping treatment with Zinforo. In this situation, do not take medicines that stop or slow down bowel movements.

Very common (may affect more than 1 in 10 people)

  • Changes in a blood test called “Coombs test” commonly seen in patients taking this type of antibiotic. This test detects certain antibodies that can act against your red blood cells.

Common (may affect up to 1 in 10 people)

  • Fever
  • Headache
  • Feeling dizzy
  • Itching, skin rash
  • Diarrhea, stomach pain
  • Nausea or vomiting
  • Increased production of liver enzymes (detected in blood tests)
  • Pain and irritation of the veins
  • Redness, pain, or swelling at the injection site.

Uncommon (may affect up to 1 in 100 people)

  • Anemia
  • Raised itchy rash (urticaria)
  • An increase in creatinine levels in the blood. Creatinine indicates how well your kidneys are working
  • Bleeding or bruising more than usual. This may be due to a decrease in platelet count in the blood
  • Changes in tests that determine how your blood clots
  • A decrease in the total number of white blood cells, or a certain type of white blood cells in the blood (leucopenia and neutropenia).
  • Changes in your mental state, such as confusion, reduced level of consciousness, abnormal movements, or seizures (encephalopathy): these have occurred in people when the dose given is too high, especially in people with kidney problems.

Rare (may affect up to 1 in 1,000 people)

  • A significant decrease in the number of certain white blood cells in the blood (agranulocytosis). You may get a fever, symptoms similar to flu, sore throat, or other infections that could be serious.
  • An increase in the number of certain white blood cells in the blood (eosinophilia).

Frequency not known (cannot be estimated from the available data)

  • A type of lung disease where eosinophils (a type of white blood cell) appear in the lungs in larger numbers (eosinophilic pneumonia).

Sudden chest pain, which may be a sign of a potentially serious allergic reaction, called Kounis syndrome, which has been seen with other medicines of the same type. If this happens, talk to a doctor or nurse immediately.

Reporting of side effects

If you experience any side effects, talk to your doctor or nurse, even if it is possible side effects not listed in this leaflet. You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Zinforo

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the carton. The expiry date is the last day of the month stated.

Store below 30°C.

Keep in the original packaging to protect from light.

Medicines should not be disposed of via wastewater or household waste. The hospital will dispose of all waste materials safely. This will help protect the environment.

6. Contents of the pack and other information

What Zinforo contains

  • Each vial contains 600 mg of ceftaroline fosamil.
  • The other ingredient is arginine.

Appearance and packaging

Zinforo is a pale yellowish-white to yellow powder for concentrate for solution for infusion in a vial. It is available in packs containing 10 vials.

Marketing authorisation holder

Pfizer Ireland Pharmaceuticals Unlimited Company

Operations Support Group

Ringaskiddy, County Cork

Ireland

Manufacturer

ACS Dobfar S.p.A.

Via A. Fleming 2

37135 Verona

Italy

You can request more information about this medicine from the local representative of the marketing authorisation holder:

België/Belgique/Belgien

Luxembourg/Luxemburg

Pfizer NV/SA

Tél/Tel: +32 (0)2 554 62 11

Latvija

Pfizer Luxembourg SARL filiale Latvija

Tel: +371 670 35 775

България

Пфайзер България ЕООД

Тел.: +359 2 970 4333

Lietuva

Pfizer Luxembourg SARL filialas Lietuvoje

Tel. +3705 2514000

Ceská republika

Pfizer, spol. s r.o.

Tel: +420-283-004-111

Magyarország

PFIZER Kft.

Tel. + 36 1 488 37 00

Danmark

Pfizer ApS

Tlf.: +45 44 20 11 00

Malta

Vivian Corporation Ltd.

Tel: +35621 344610

Deutschland

PFIZER PHARMA GmbH

Tel: +49 (0)30 550055-51000

Nederland

Pfizer bv

Tel: +31 (0)800 63 34 636

Eesti

Pfizer Luxembourg SARL Eesti filiaal

Tel: +372 666 7500

Norge

Pfizer AS

Tlf: +47 67 52 61 00

Ελλάδα

Pfizer ΕΛΛΑΣ Α.Ε.

Τηλ.: +30 210 67 85 800

Österreich

Pfizer Corporation Austria Ges.m.b.H.

Tel: +43 (0)1 521 15-0

España

Pfizer, S.L.

Tel: +34 91 490 99 00

Polska

Pfizer Polska Sp. z o.o.

Tel.: +48 22 335 61 00

France

Pfizer

Tél: +33 (0)1 58 07 34 40

Portugal

Laboratórios Pfizer, Lda.

Tel: +351 21 423 5500

Hrvatska

Pfizer Croatia d.o.o.

Tel: + 385 1 3908 777

România

Pfizer România S.R.L.

Tel: +40 (0)21 207 28 00

Ireland

Pfizer Healthcare Ireland Unlimited Company

Tel: +1800 633 363 (toll free)

+44 (0)1304 616161

Slovenija

Pfizer Luxembourg SARL

Pfizer, podružnica za svetovanje s podrocja farmacevtske dejavnosti, Ljubljana

Tel: + 386 (0)1 52 11 400

Ísland

Icepharma hf.

Sími: +354 540 8000

Slovenská republika

Pfizer Luxembourg SARL, organizacná zložka

Tel: +421–2–3355 5500

Italia

Pfizer S.r.l.

Tel: +39 06 33 18 21

Suomi/Finland

Pfizer Oy

Puh./Tel: +358 (0)9 430 040

Κύπρος

Pfizer ΕΛΛΑΣ Α.Ε. (CYPRUS BRANCH)

Τηλ: +357 22 817690

Sverige

Pfizer AB

Tel: +46 (0)8 550 520 00

Date of last revision of this leaflet: 01/2025.

Other sources of information

Detailed information on this medicine is available on the European Medicines Agency web site: https://www.ema.europa.eu.

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This information is intended only for healthcare professionals:

Important: Consult the summary of product characteristics before prescribing.

Aseptic technique must be used to prepare the infusion solution. The contents of the Zinforo vial should be reconstituted with 20 ml of water for injections. The following are the instructions for reconstituting the Zinforo vial:

Dose concentration

(mg)

Volume of diluent to add

(ml)

Approximate concentration of ceftaroline

(mg/ml)

Amount to withdraw

600

20

30

Total volume

The reconstituted solution must be further diluted to produce the Zinforo infusion solution. A 250 ml, 100 ml, or 50 ml infusion bag can be used to prepare the infusion, based on the required patient volume. Suitable diluents for infusion include: sodium chloride 9 mg/ml (0.9%) solution for injection, dextrose 50 mg/ml (5%) solution for injection, sodium chloride 4.5 mg/ml and dextrose 25 mg/ml solution for injection (0.45% sodium chloride and 2.5% dextrose), or Ringer's lactate solution. The resulting solution should be administered over 5 to 60 minutes for the standard dose or 120 minutes for the high dose in infusion volumes of 50 ml, 100 ml, or 250 ml.

The infusion volumes for pediatric patients will vary according to the child's weight. The concentration of the infusion solution during preparation and administration should not exceed 12 mg/ml of ceftaroline fosamil.

The reconstitution time is less than 2 minutes. Mix slowly to reconstitute and check to ensure the contents have dissolved completely. Parenteral drugs should be inspected visually for particles before administration.

The color of the Zinforo infusion solutions ranges from clear, pale yellow to dark yellow depending on concentration and storage conditions. It is free from particles. When stored as recommended, the potency of the product is not affected.

Chemical and physical stability in use has been demonstrated for up to 12 hours at 2 - 8 °C and 6 hours at 25 °C.

From a microbiological point of view, the product should be used immediately unless the opening/reconstitution/dilution method precludes the risk of microbial contamination. If not used immediately, in-use storage times and conditions before use are the responsibility of the user.

The compatibility of Zinforo with other medicines has not been established. Zinforo should not be mixed or physically added to solutions containing other drugs.

Each vial is for single use only.

Disposal of unused medicine and all materials that have come into contact with it should be done in accordance with local regulations.

Online doctors for ZINFORO 600 MG POWDER FOR CONCENTRATE FOR PERFUSION SOLUTION

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Doctor

Даниэль Чики

Family medicine 24 years exp.

Dr Daniel Cichi is a family medicine doctor with over 20 years of clinical experience. He provides online consultations for adults, supporting patients with acute symptoms, chronic conditions, and everyday health concerns that require timely medical guidance. His background includes work in emergency care, ambulance services, and family medicine, which allows him to assess symptoms quickly, identify warning signs, and help patients choose the safest next steps – whether that means home care, treatment adjustment, or in-person evaluation. Patients commonly consult Dr Daniel Cichi for: 

  • acute symptoms: fever, infections, flu-like illness, cough, sore throat, shortness of breath;
  • chest discomfort, palpitations, dizziness, fatigue, and blood pressure concerns;
  • digestive problems: abdominal pain, nausea, diarrhoea, constipation, reflux;
  • sexually transmitted infections, erectile dysfunction;
  • muscle, joint, and back pain, minor injuries, post-traumatic symptoms;
  • chronic conditions: hypertension, diabetes, high cholesterol, thyroid disorders, weight loss, hair loss;
  • review and interpretation of lab tests, imaging reports, and medical documents;
  • medication review and treatment adjustment;
  • medical advice while travelling or living abroad;
  • second opinions and guidance on whether in-person care is needed.

Dr Cichi’s consultations are structured and practical. He focuses on clear explanations, risk assessment, and actionable recommendations, helping patients understand their symptoms and make informed decisions about their health.

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Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Doctor

Томаш Гжеловський

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques.

For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance.

Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults.

In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions.

Patients commonly seek his care for:

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns
Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.
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Doctor

Lina Travkina

Family medicine 13 years exp.

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
  • Post-operative recovery support and pain management.
  • Preconception counselling and postpartum support.
  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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Doctor

Alina Tsurkan

Family medicine 13 years exp.

Dr. Alina Tsurkan is a licensed family medicine physician based in Portugal, offering online consultations for adults and children. She provides professional primary care, with a focus on prevention, accurate diagnosis, and long-term management of acute and chronic conditions.

Dr. Tsurkan supports patients with a wide range of health issues, including:

  • Respiratory infections: cold, flu, bronchitis, pneumonia, and lingering coughs.
  • ENT conditions: sinusitis, tonsillitis, otitis (ear infections), sore throat, allergic rhinitis.
  • Eye conditions: allergic or infectious conjunctivitis, red eyes, irritation.
  • Digestive issues: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), constipation, bloating, nausea.
  • Urinary and reproductive health: urinary tract infections (UTIs), cystitis, prevention of recurrent infections.
  • Chronic diseases: hypertension, elevated cholesterol, weight management.
  • Neurological complaints: headaches, migraines, sleep disturbances, fatigue, general weakness.
  • Children’s health: fever, infections, digestive issues, follow-ups, vaccination guidance.

She also provides:

  • IMT medical certificates for driving licence exchange in Portugal.
  • Personalised preventive care and wellness consultations.
  • Interpretation of test results and medical reports.
  • Follow-up care and medication review.
  • Support in managing multiple coexisting conditions.
  • Remote prescription management and medical documentation.

Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

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Frequently Asked Questions

Is a prescription required for ZINFORO 600 MG POWDER FOR CONCENTRATE FOR PERFUSION SOLUTION?
ZINFORO 600 MG POWDER FOR CONCENTRATE FOR PERFUSION SOLUTION requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in ZINFORO 600 MG POWDER FOR CONCENTRATE FOR PERFUSION SOLUTION?
The active ingredient in ZINFORO 600 MG POWDER FOR CONCENTRATE FOR PERFUSION SOLUTION is ceftaroline fosamil. This information helps identify medicines with the same composition but different brand names.
Who manufactures ZINFORO 600 MG POWDER FOR CONCENTRATE FOR PERFUSION SOLUTION?
ZINFORO 600 MG POWDER FOR CONCENTRATE FOR PERFUSION SOLUTION is manufactured by Pfizer Ireland Pharmaceuticals Unlimited Company. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of ZINFORO 600 MG POWDER FOR CONCENTRATE FOR PERFUSION SOLUTION online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether ZINFORO 600 MG POWDER FOR CONCENTRATE FOR PERFUSION SOLUTION is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to ZINFORO 600 MG POWDER FOR CONCENTRATE FOR PERFUSION SOLUTION?
Other medicines with the same active substance (ceftaroline fosamil) include CEFTAROLINA FOSAMILO QILU 600 mg POWDER FOR CONCENTRATE FOR INFUSION SOLUTION, FETCROJA 1 g POWDER FOR CONCENTRATE FOR PERFUSION SOLUTION, ZERBAXA 1 g/0.5 g POWDER FOR CONCENTRATE FOR INFUSION SOLUTION. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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