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VALACICLOVIR COMBIX 500 mg FILM-COATED TABLETS

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About the medicine

How to use VALACICLOVIR COMBIX 500 mg FILM-COATED TABLETS

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

PACKAGE LEAFLET: INFORMATION FOR THE USER

Valaciclovir Combix 500 mg film-coated tablets EFG

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.

Contents of the pack and other information

  1. What is Valaciclovir Combix and what is it used for
  2. What you need to know before you take Valaciclovir Combix
  3. How to take Valaciclovir Combix
  4. Possible side effects
  5. Storage of Valaciclovir Combix
  6. Contents of the pack and further information

1. What is Valaciclovir Combix and what is it used for

Valaciclovir Combix belongs to a group of medicines called antivirals. It works by stopping or slowing the growth of viruses called herpes simplex (HSV), varicella zoster (VZV), and cytomegalovirus (CMV).

Valaciclovir Combix can be used for:

  • Treating shingles (in adults).
  • Treating HSV skin infections and genital herpes (in adults and adolescents over 12 years). It is also used to prevent these infections from coming back.
  • Treating cold sores (in adults and adolescents over 12 years).
  • Preventing CMV infection after organ transplants (in adults and adolescents over 12 years).
  • Treating and preventing HSV eye infections.
Doctor consultation

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2. What you need to know before you take Valaciclovir Combix

Do not take Valaciclovir Combix

  • If you are allergic to valaciclovir or aciclovir or any of the other ingredients of this medicine (listed in section 6).
  • Do not take Valaciclovir Combix if the above applies to you. If you are not sure, talk to your doctor or pharmacist before taking Valaciclovir Combix.
  • If you have kidney disease or are elderly, your doctor may use a lower dose. You should also drink plenty of fluid during treatment to stay hydrated.
  • If you have ever developed a skin rash with fever, swollen lymph nodes, increased liver enzymes, and/or eosinophilia (drug reaction with eosinophilia and systemic symptoms) after taking valaciclovir.

Warnings and precautions

Talk to your doctor or pharmacist before taking Valaciclovir Combix if:

  • You have kidney problems
  • You have liver problems
  • You are over 65 years old
  • Your immune system is weakened
  • Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) has been reported with the use of valaciclovir. DRESS is characterized by symptoms similar to the flu and a rash on the face, followed by a more widespread rash with elevated body temperature, elevated liver enzymes, and an increase in a type of white blood cell (eosinophilia) and swollen lymph nodes.

If you develop a severe rash associated with fever and swollen lymph nodes, stop taking valaciclovir and consult your doctor immediately.

If you are not sure if any of the above applies to you, talk to your doctor or pharmacist before taking Valaciclovir Combix.

Preventing the spread of genital herpes to others

If you are taking Valaciclovir Combix to treat or prevent genital herpes, or have had genital herpes in the past, you should practice safe sex, including the use of condoms. This is important to prevent spreading the infection to others. You should not have sexual intercourse if you have genital ulcers or blisters.

Using other medicines

Tell your doctor or pharmacist if you are using, or have recently used, other medicines, including those obtained without a prescription or herbal remedies.

Tell your doctor or pharmacist if you are taking any medicine that affects the kidneys. These include aminoglycosides, platinum compounds, iodinated contrast media, methotrexate, pentamidine, foscarnet, cyclosporine, tacrolimus, cimetidine, and probenecid.

Always tell your doctor or pharmacist about other medicines you are taking if you are taking valaciclovir for the treatment of shingles or after an organ transplant.

Pregnancy and breastfeeding

Valaciclovir is not normally recommended for use during pregnancy. If you are pregnant, think you may be pregnant, or are planning to become pregnant, do not take Valaciclovir Combix without consulting your doctor.

Your doctor will weigh the benefits to you against the risks to the baby if you take valaciclovir while pregnant or breastfeeding.

Driving and using machines

Valaciclovir may cause side effects that affect your ability to drive.

→ Do not drive or operate machinery unless you are sure it does not affect you.

3. How to take Valaciclovir Combix

Follow the instructions for taking this medicine exactly as your doctor or pharmacist has told you. If you are unsure, ask your doctor or pharmacist again.

The dose you should take will depend on why your doctor has prescribed Valaciclovir Combix for you. Your doctor will tell you the right dose.

Treatment of shingles

  • The usual dose is 1,000 mg (two 500 mg tablets) three times a day.
  • You should take Valaciclovir Combix for seven days.

Treatment of cold sores

  • The usual dose is 2,000 mg (four 500 mg tablets) twice a day.
  • The second dose should be taken 12 hours after the first dose (not before 6 hours).
  • You should take Valaciclovir Combix only for one day (two doses).

Treatment of HSV skin infections and genital herpes

  • The usual dose is 500 mg (one 500 mg tablet) twice a day.
  • For the first infection, you should take Valaciclovir Combix for five days or up to ten days if your doctor tells you to. For recurrent infections, the treatment duration is usually 3-5 days.

Prevention of recurrent HSV infections once you have had them

  • The usual dose is one 500 mg tablet once a day.
  • Some people with frequent recurrences may benefit from taking 250 mg twice a day.
  • You should take Valaciclovir Combix until your doctor tells you to stop.

To prevent CMV infection

  • The usual dose is 2,000 mg (four 500 mg tablets) four times a day.
  • You should space the doses 6 hours apart.
  • You will usually start taking Valaciclovir Combix as soon as possible after surgery.
  • You should take Valaciclovir Combix for about 90 days after surgery, or until your doctor tells you to stop.

Your doctor may adjust the dose of Valaciclovir Combix if:

  • You are over 65 years old
  • Your immune system is weakened
  • You have kidney problems.

→ Talk to your doctor before taking Valaciclovir Combix if any of the above applies to you.

Taking this medicine

  • Take this medicine by mouth.
  • Swallow the tablets whole with a glass of water.
  • Take Valaciclovir Combix at the same time each day.
  • Take Valaciclovir Combix as instructed by your doctor or pharmacist.

People over 65 years old or with kidney problems

It is very important that while taking Valaciclovir Combix, you drink water regularlythroughout the day. This will help reduce the side effects that can affect the kidneys or nervous system. Your doctor will monitor you for signs of this. Nervous system side effects can include feeling confused or agitated, or feeling abnormally sleepy or drowsy.

If you take more Valaciclovir Combix than you should

Valaciclovir is not normally harmful, unless you take too much for several days. If you take too many tablets, you may feel sick, vomit, or feel confused, agitated, or abnormally drowsy. Talk to your doctor or pharmacist if you take too much valaciclovir. Take the pack with you. You can also call the Toxicology Information Service on 91 562 04 20, quoting the medicine and the amount taken.

If you forget to take Valaciclovir Combix

  • If you forget to take Valaciclovir Combix, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose.
  • Do not take a double dose to make up for a missed dose.
Medicine questions

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4. Possible side effects

Like all medicines, Valaciclovir Combix can cause side effects in some people. The following side effects may occur with this medicine:

Symptoms to look out for

  • Severe allergic reactions (anaphylaxis). These are rare in people taking valaciclovir. Rapid development of symptoms including:
  • skin rash with redness, itching
  • swelling of the lips, face, neck, and throat, causing difficulty breathing (angioedema)
  • drop in blood pressure leading to collapse.

→ If you have an allergic reaction, stop taking Valaciclovir Combix and go to the doctor immediately.

Very common(may affect more than 1 in 10 people):

  • headache

Common(may affect up to 1 in 10 people):

  • nausea
  • dizziness
  • vomiting
  • diarrhea
  • skin reaction after sun exposure (photosensitivity)
  • rash

Uncommon(may affect up to 1 in 100 people):

  • feeling confused
  • seeing or hearing things that are not there (hallucinations)
  • feeling very sleepy
  • tremors
  • feeling agitated

These nervous system side effects usually occur in patients with kidney problems, elderly patients, or transplant patients taking high doses of 8 grams or more of valaciclovir per day. They usually improve when valaciclovir is stopped or the dose is reduced.

Other uncommon side effects:

  • difficulty breathing (dyspnea)
  • stomach pain
  • rash, sometimes with itching, hives (urticaria)
  • back pain (renal pain)
  • blood in urine

Uncommon side effects may appear in your blood tests:

  • reduction in the number of white blood cells (leukopenia)
  • reduction in the number of platelets, which are cells that help blood clot (thrombocytopenia)
  • increase in substances produced by the liver.

Rare(may affect up to 1 in 1,000 people):

  • unsteadiness and lack of coordination (ataxia)
  • slow and slurred speech (dysarthria)
  • seizures (convulsions)
  • altered brain function (encephalopathy)
  • loss of consciousness (coma)
  • confused or disordered thoughts

These nervous system side effects usually occur in people with kidney problems, elderly patients, or transplant patients taking high doses of 8 grams or more of valaciclovir per day. They usually improve when valaciclovir is stopped or the dose is reduced.

Other rare side effects:

  • kidney problems that cause little or no urine production

If you experience side effects, talk to your doctor or pharmacist, even if they are not listed in this leaflet.

Frequency not known(frequency cannot be estimated from available data):

  • Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), characterized by widespread rash, fever, elevated liver enzymes, blood disorders (eosinophilia), and swollen lymph nodes. See also section 2.
  • Kidney inflammation (tubulointerstitial nephritis).

Reporting side effects

If you experience any side effects, talk to your doctor or pharmacist, even if they are not listed in this leaflet. You can also report side effects directly to the Spanish Medicines and Healthcare Products Agency (AEMPS) via the website: https://www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Valaciclovir Combix

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date stated on the pack after EXP. The expiry date is the last day of the month stated.

Do not store above 30°C.

Medicines should not be disposed of via wastewater or household waste. Return any unused medicine to a pharmacy for disposal. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. Contents of the pack and further information

Composition of Valaciclovir Combix

  • The active ingredient is valaciclovir. Each tablet contains 500 mg of valaciclovir (as valaciclovir hydrochloride).

The other ingredients are: microcrystalline cellulose (E460i), crospovidone, povidone, magnesium stearate, coating agent (titanium dioxide -E171-, macrogol, talc -E553b-, and polyvinyl alcohol).

Appearance and packaging of the product

Valaciclovir tablets are presented in PVDC/PVC-Aluminum blisters.

Valaciclovir Combix 500 mg film-coated tablets are available in pack sizes of 10 and 42 film-coated tablets.

Valaciclovir Combix tablets are white, capsule-shaped, biconvex, film-coated tablets with "500" marked on one side and scored on the other.

The score line is only for breaking and making swallowing easier, but not to divide into equal doses.

Marketing authorization holder

Laboratorios Combix, S.L.U.

C/Badajoz, 2. Edificio 2

28223 Pozuelo de Alarcón (Madrid)

Spain

Manufacturer

Zydus France

ZAC Les Hautes Patures

Parc d’activités des Peupliers

25 Rue des Peupliers

92000 Nanterre

France

or

Misom Labs Ltd.

Malta Life Sciences Park

LS2.01.06

Industrial Estate

San Gwann, SGN 3000

Malta

Date of last revision of this leaflet December 2022

Detailed and up-to-date information on this medicine is available on the website of the Spanish Agency for Medicines and Healthcare Products (AEMPS) www.aemps.gob.es.

Online doctors for VALACICLOVIR COMBIX 500 mg FILM-COATED TABLETS

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Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
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  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

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He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques.

For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance.

Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults.

In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions.

Patients commonly seek his care for:

  • seasonal and perennial allergies
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Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.
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Lina Travkina

Family medicine 13 years exp.

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
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Additional care areas:

  • Preventive consultations and check-up planning.
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Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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Alina Tsurkan

Family medicine 13 years exp.

Dr. Alina Tsurkan is a licensed family medicine physician based in Portugal, offering online consultations for adults and children. She provides professional primary care, with a focus on prevention, accurate diagnosis, and long-term management of acute and chronic conditions.

Dr. Tsurkan supports patients with a wide range of health issues, including:

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She also provides:

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Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

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Doctor

Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Frequently Asked Questions

Is a prescription required for VALACICLOVIR COMBIX 500 mg FILM-COATED TABLETS?
VALACICLOVIR COMBIX 500 mg FILM-COATED TABLETS requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in VALACICLOVIR COMBIX 500 mg FILM-COATED TABLETS?
The active ingredient in VALACICLOVIR COMBIX 500 mg FILM-COATED TABLETS is valaciclovir. This information helps identify medicines with the same composition but different brand names.
How much does VALACICLOVIR COMBIX 500 mg FILM-COATED TABLETS cost in pharmacies?
The average pharmacy price for VALACICLOVIR COMBIX 500 mg FILM-COATED TABLETS is around 11.55 EUR. Prices may vary depending on the manufacturer and dosage form.
Who manufactures VALACICLOVIR COMBIX 500 mg FILM-COATED TABLETS?
VALACICLOVIR COMBIX 500 mg FILM-COATED TABLETS is manufactured by Laboratorios Combix S.L.U.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of VALACICLOVIR COMBIX 500 mg FILM-COATED TABLETS online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether VALACICLOVIR COMBIX 500 mg FILM-COATED TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to VALACICLOVIR COMBIX 500 mg FILM-COATED TABLETS?
Other medicines with the same active substance (valaciclovir) include VALACICLOVIR ALMUS 1000 mg FILM-COATED TABLETS, VALACICLOVIR ALMUS 500 mg FILM-COATED TABLETS, VALACICLOVIR ARISTO 500 mg FILM-COATED TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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