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VENOTON

VENOTON

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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use VENOTON

INSTRUCTIONS for medical use of the medicinal product HEPAVAL®

Composition

active substance: glutathione; 1 vial contains sodium glutathione 643 mg, which is equivalent to 600 mg of glutathione; 1 ampoule of solvent contains 4 ml of water for injections.

Pharmaceutical form

Powder for solution for injection.

Main physical and chemical properties

White hygroscopic powder; clear colorless liquid, odorless.

Pharmacotherapeutic group

Antidotes. ATC code V03A B32.

Pharmacological properties

Pharmacodynamics

Glutathione is a tripeptide that is a natural component of cells of all tissues of the body. Its significant distribution is associated with a wide range of biological functions and has fundamental importance for numerous biochemical and metabolic processes.

The sulfhydryl groups of cysteine that are part of glutathione are powerful nucleophilic agents. In connection with this, they become the main target of electrophilic attack by chemicals or their active metabolites, which leads to the inactivation of potentially toxic exogenous substances. Thus, the drug has a protective effect on vital nucleophilic areas, the attack on which begins the process of cell damage.

In addition, glutathione (GSH), restored as a result of interaction with a large number of oxidized organic metabolites, forms less toxic conjugated compounds, which are further easily metabolized and excreted in the form of mercapturic acids.

Given these properties, glutathione is prescribed in cases of hepatotoxicity reactions, the mechanisms of development of which may be ethyl or medicinal hepatotoxicosis or pathogenetically caused hepatotoxicosis associated with violations of detoxification mechanisms.

Pharmacokinetics

After intravenous administration, glutathione is mainly distributed in erythrocytes, while in plasma it is quickly broken down by gamma-glutamyltranspeptidase and gamma-glutamyl-cyclotransferase. Thus, the plasma level of reduced glutathione (GSH), even after the use of high doses, is insignificant (peak concentration in plasma is approximately 1 nmol/ml 5 minutes after intravenous administration of 600 mg), while the level of cysteine metabolite is higher (peak concentration in plasma is approximately 17 nmol/ml). The concentration in the blood, determined in whole blood, reaches a value of approximately 100 nmol/ml 5-10 minutes after intravenous administration of 600 mg of glutathione. The concentration of the drug in the blood gradually decreases, almost reaching initial values approximately 60 minutes after administration.

Clinical characteristics

Indications

Prevention of neuropathy induced by chemotherapy with cisplatin or other similar substances.

Contraindications

Increased sensitivity to the active substance or to other components of the drug.

Interaction with other medicinal products and other types of interactions

Unknown.

Special warnings and precautions for use

Use during pregnancy or breastfeeding.

Although glutathione did not show any signs of embryotoxicity and fetotoxicity during experimental studies, its use is not recommended for pregnant women and women who are breastfeeding.

Ability to affect the reaction rate when driving vehicles or using other mechanisms.

Glutathione does not affect the ability to drive vehicles or use other mechanisms.

Dosage and administration

In the most severe degree of damage: 600-1200 mg (1-2 vials) per day by intramuscular or slow intravenous administration.

In moderate degree of damage: half of the above dose is used.

Preparation of the drug for administration

In the case of intramuscular administration, the drug must be completely dissolved directly in the vial using the solvent included in the package.

In the case of intravenous administration, the drug must be dissolved in the solvent from the package (water for injection) and administered either by direct slow injection or by infusion after adding the prepared solution to at least 20 ml of sterile infusion solution.

Pediatric population

The possibility of use in children has not been studied.

Overdose

No information is available regarding overdose.

Undesirable effects

In rare cases, the development of nausea, vomiting, headache, as well as skin rashes is possible. These reactions usually disappear after termination of therapy.

Shelf life

3 years.

Storage conditions

Store in the original packaging at a temperature not exceeding 25 °C.

The restored solution is stable for approximately 2 hours during storage at room temperature and for at least 8 hours during storage at a temperature from 0 ° to + 5 ° C.

Store in a place inaccessible to children.

Packaging

Powder for solution for injection 600 mg in vials No. 10 in a set with solvent (water for injection) 4 ml in ampoules No. 10 in a cardboard box.

Release category

By prescription.

Manufacturer

LABORATORIO ITALIANO BIOCHIMICO FARMACEUTICO LISAFARMA S.P.A.

Location of the manufacturer and its address.

VIA LICINIO, 11 – 22036 ERBA (province of Como), Italy.

Applicant

VALARTIN PHARMA LLC.

Location of the applicant.

Ukraine, 08135, Kyiv region, Kyiv-Svyatoshinsky district, village of Chaiky, Grushevskogo street, 60.

Alternatives to VENOTON in other countries

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Alternative to VENOTON in Spain

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Alternative to VENOTON in Poland

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Dosage form: Tablets, 20 mg
Marketing authorisation holder (MAH): Teva Pharmaceuticals CR, s.r.o.
Prescription not required
Dosage form: Tablets, 20 mg
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Online doctors for VENOTON

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for VENOTON – subject to medical assessment and local rules.

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Dr. Andrei Popov is a licensed pain management specialist and general practitioner based in Spain. He provides expert online care for adults dealing with both chronic and acute pain, as well as a wide range of everyday health concerns.

He specialises in diagnosing and treating pain conditions that affect quality of life, including:

  • Chronic pain lasting more than 3 months.
  • Migraines and recurring headaches.
  • Neck, back, lower back, and joint pain.
  • Post-traumatic pain following injury or surgery.
  • Nerve-related pain, fibromyalgia, and neuralgia.
In addition to pain management, Dr. Popov helps patients with:
  • Respiratory infections (colds, bronchitis, pneumonia).
  • High blood pressure and metabolic conditions such as diabetes.
  • Preventive care and routine health check-ups.

Online consultations last up to 30 minutes and include a detailed symptom review, personalised treatment planning, and medical follow-up when needed.

Dr. Popov’s approach is rooted in evidence-based medicine, combined with individualised care tailored to each patient’s history, lifestyle, and clinical needs.

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She helps with:

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Dr Minorskaya also specialises in the diagnosis and management of gastrointestinal conditions, including bloating, abdominal pain, chronic nausea, IBS, and SIBO. She supports patients with unexplained physical symptoms that may be linked to somatisation or stress, helping them find relief and improve quality of life.

She offers care for people undergoing GLP-1 therapy (Ozempic, Mounjaro, and others) for weight management. Her support follows Spanish clinical guidelines, from treatment planning and side effect counselling to regular follow-ups and coordination with private or public healthcare providers.

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Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Common concerns addressed during consultation:

  • Nasal congestion, runny nose, sinusitis, rhinitis, and hay fever.
  • Ear pain, otitis (middle ear infections), earwax buildup, hearing loss.
  • Sore throat, tonsillitis, pharyngitis, chronic throat irritation.
  • Hoarseness, loss of voice, laryngitis.
  • Allergic rhinitis, sneezing, nasal itching, seasonal allergies.
  • Snoring, mouth breathing, enlarged adenoids.
  • Frequent colds, lingering post-viral symptoms.
  • Foreign objects in the ear or nose.
  • ENT-related check-ups and chronic condition follow-up.

Dr. Fursenko helps patients manage symptoms early, avoid complications, and receive timely treatment. Online ENT consultations are a convenient way to access care for both urgent and recurring conditions — from anywhere.

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Dr. Laafif combines scientific expertise with human empathy, helping patients restore emotional balance, improve daily functioning, and regain confidence in their recovery journey.
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General medicine20 years of experience

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Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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Dr. Tsurkan supports patients with a wide range of health issues, including:

  • Respiratory infections: cold, flu, bronchitis, pneumonia, and lingering coughs.
  • ENT conditions: sinusitis, tonsillitis, otitis (ear infections), sore throat, allergic rhinitis.
  • Eye conditions: allergic or infectious conjunctivitis, red eyes, irritation.
  • Digestive issues: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), constipation, bloating, nausea.
  • Urinary and reproductive health: urinary tract infections (UTIs), cystitis, prevention of recurrent infections.
  • Chronic diseases: hypertension, elevated cholesterol, weight management.
  • Neurological complaints: headaches, migraines, sleep disturbances, fatigue, general weakness.
  • Children’s health: fever, infections, digestive issues, follow-ups, vaccination guidance.

She also provides:

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  • Remote prescription management and medical documentation.

Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

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  • Diagnosis and management of common conditions: hypertension, diabetes, respiratory and digestive disorders.
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  • Supportive care for oncology patients – pain control, symptom relief, and side effect management.
  • Preventive medicine and health screenings.
  • Development of tailored treatment plans based on clinical guidelines.

With a patient-centred approach, Dr. Raevskii helps individuals manage both chronic illnesses and complex oncological cases. His consultations are guided by current medical standards and adapted to each patient’s needs.

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Svetlana Kovalenko

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What patients commonly consult her for:

  • High blood pressure, type 2 diabetes, cholesterol management
  • Cold and flu symptoms: fever, cough, sore throat
  • Fatigue, sleep problems, headaches, general discomfort
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  • Preventive check-ups and advice on healthy lifestyle habits

Dr Kovalenko combines evidence-based practice with a respectful, patient-centred approach. She takes time to explain, listens attentively, and helps each person make confident, informed decisions about their health.

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Lina Travkina

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Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
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  • Preconception counselling and postpartum support.
  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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