TAVULUS 18 micrograms powder for inhalation (hard capsule)

This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.

How to use TAVULUS 18 micrograms powder for inhalation (hard capsule)

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Contents of the leaflet

Introduction
What is Tavulus 18 micrograms and what is it used for
What you need to know before you start using Tavulus 18 micrograms
How to use Tavulus 18 micrograms
Possible side effects
Storage of Tavulus 18 micrograms
Container Contents and Additional Information

Introduction

Package Leaflet: Information for the Patient

Tavulus 18 micrograms powder for inhalation (hard capsule)

Tiotropium

Read this package leaflet carefully before you start using this medicine, because it contains important information for you.

Keep this package leaflet, you may need to read it again.
If you have any further questions, ask your doctor or pharmacist.
This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.
If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this package leaflet. See section 4.

Contents of the package leaflet:

What is Tavulus 18 micrograms and what is it used for
What you need to know before you start using Tavulus 18 micrograms
How to use Tavulus 18 micrograms
Possible side effects
Storage of Tavulus 18 micrograms
Contents of the pack and further information

1. What is Tavulus 18 micrograms and what is it used for

This medicine contains the active substance tiotropium. This medicine helps people with chronic obstructive pulmonary disease (COPD) to breathe more easily. Chronic obstructive pulmonary disease (COPD) is a long-term lung disease that makes it difficult to breathe and causes coughing. The term COPD is associated with chronic bronchitis and emphysema. Since COPD is a chronic disease, you must use this medicine every day and not just when you have breathing problems or other symptoms of COPD.

This medicine is a long-acting bronchodilator that helps to open up the airways and makes it easier to take and expel air from the lungs. Regular use of this medicine may also help you when you have difficulty breathing continuously due to your disease, and it will help you minimize the effects of the disease on your daily life. It also helps you to be active for longer. Daily use of this medicine will also help you prevent sudden and short-term symptoms of worsening of your COPD, which can last for several days. The effect of this medicine lasts for 24 hours, so you only need to use it once a day. For the correct dosing of this medicine, see section 3. How to use Tavulus 18 micrograms and the instructions for use at the end of this package leaflet.

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you start using Tavulus 18 micrograms

Do not use Tavulus 18 micrograms

If you are allergic (hypersensitive) to tiotropium or any of the other ingredients of this medicine (listed in section 6).
If you are allergic (hypersensitive) to atropine or its derivatives, such as ipratropium or oxitropium.

Warnings and precautions

Talk to your doctor or pharmacist before you start using this medicine:

Tell your doctor if you have narrow-angle glaucoma, prostate problems, or difficulty urinating.
If you have kidney problems, please talk to your doctor.
This medicine is intended for the maintenance treatment of your chronic obstructive pulmonary disease, it must not be used to treat a sudden episode of shortness of breath or wheezing.
After administration of this medicine, immediate allergic reactions such as rash, swelling, itching, wheezing, or shortness of breath may occur. If this happens, please talk to your doctor immediately.
Inhaled medicines like this medicine may cause chest tightness, coughing, wheezing, or shortness of breath immediately after inhalation. If this happens, please talk to your doctor immediately.
Be careful not to get the powder into your eyes, as this may cause blurred vision, pain, and/or eye redness. You should rinse your eyes immediatelywith warm water. Talk to your doctor immediatelyfor more information.
If you notice that your breathing gets worse, talk to your doctor as soon as possible.

Children and adolescents

This medicine is not recommended for children and adolescents under 18 years of age.

Other medicines and Tavulus 18 micrograms

Tell your doctor or pharmacist if you are using, have recently used, or might use any other medicines.

Tell your doctor or pharmacist if you are using or have used similar medicines for your lung disease, such as ipratropium or oxitropium.

No specific adverse reactions have been reported when this medicine has been used together with other medicines commonly used for the treatment of COPD, such as rescue inhalers, e.g., salbutamol, methylxanthines, such as theophylline, and/or oral and inhaled steroids, such as prednisolone.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine. You should not use this medicine unless your doctor has specifically recommended it.

Driving and using machines

Dizziness, blurred vision, or headache may affect your ability to drive or use machines.

Tavulus 18 micrograms contains lactose monohydrate

If administered according to the recommended dose, one capsule once a day, each dose provides up to 5.5 mg of lactose monohydrate. If your doctor has told you that you have an intolerance to some sugars, talk to them before taking this medicine.

3. How to use Tavulus 18 micrograms

Follow the instructions for administration of this medicine exactly as told by your doctor or pharmacist. If you are not sure, talk to your doctor or pharmacist again.

The recommended dose is the inhalation of the contents of one capsule (18 micrograms of tiotropium) once a day. Do not use more than the recommended dose.

This medicine is not recommended for children and adolescents under 18 years of age.

Try to use the capsule at the same time each day. This is important because this medicine is effective for 24 hours.

The capsules are for inhalation only and not for oral ingestion. Do not swallow the capsules.

The dry powder inhaler (MRX003-T10), into which you must insert the capsule of this medicine, pierces the capsule and allows you to inhale the powder.

Make sure you have a dry powder inhaler and that you are able to use it correctly. The instructions for use of the dry powder inhaler are at the end of this package leaflet.

Make sure you do not blow into the dry powder inhaler.

If you have any problems using the dry powder inhaler, ask your doctor, nurse, or pharmacist to show you how it works.

You should clean your dry powder inhaler once a month. The instructions for cleaning the dry powder inhaler are at the end of this package leaflet.

When using this medicine, be careful and do not let the powder get into your eyes. If powder gets into your eyes, it could cause blurred vision, pain, and/or eye redness. You should rinse your eyes immediatelywith warm water. Talk to your doctor immediatelyfor more information.

If you notice that your breathing gets worse, talk to your doctor as soon as possible.

If you use more Tavulus 18 micrograms than you should

If you inhale more than 1 capsule of this medicine in a day, talk to your doctor immediately. You may have a higher risk of experiencing a side effect such as dry mouth, constipation, difficulty urinating, increased heart rate, or blurred vision.

In case of overdose or accidental ingestion, contact the Toxicological Information Service. Phone: 91 562 04 20, talk to your doctor or pharmacist.

If you forget to use Tavulus 18 micrograms

If you have forgotten a dose, take a dose as soon as you remember, but do nottake two doses at the same time or on the same day. Then take your next dose as usual. Do not take a double dose to make up for forgotten doses.

If you stop using Tavulus 18 micrograms

Before you stop using this medicine, talk to your doctor or pharmacist. If you stop using this medicine, the signs and symptoms of your COPD may get worse.

If you have any other questions about the use of this medicine, ask your doctor or pharmacist.

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. The side effects described below have been experienced by people taking this medicine.

After administration of this medicine, individual or severe allergic reactions (anaphylactic reaction) may occur, including allergic reactions that cause swelling of the face or throat (angioedema) or other hypersensitivity reactions (such as a sudden drop in blood pressure or dizziness). Additionally, as with all inhaled medicines, some patients may experience unexpected chest tightness, coughing, wheezing, or shortness of breath immediately after inhalation (bronchospasm). If you experience any of these side effects, talk to your doctor immediately.

Common (may affect up to 1 in 10 people):

Dry mouth: this is usually mild

Uncommon (may affect up to 1 in 100 people):

Dizziness
Headache
Alterations in taste
Blurred vision
Irregular heart rhythm (atrial fibrillation)
Inflammation of the throat (pharyngitis)
Hoarseness (dysphonia)
Cough
Heartburn (gastroesophageal reflux disease)
Constipation
Fungal infection in the mouth or throat (oropharyngeal candidiasis)
Rash
Difficulty urinating (urinary retention)
Painful urination (dysuria)

Rare (may affect up to 1 in 1,000 people):

Difficulty sleeping (insomnia)
Visual halos or colored images associated with eye redness (glaucoma)
Increased eye pressure
Irregular heart rhythm (supraventricular tachycardia)
Increased heart rate (tachycardia)
Awareness of heartbeats (palpitations)
Chest tightness associated with coughing, wheezing, or shortness of breath immediately after inhalation (bronchospasm)
Nosebleed (epistaxis)
Inflammation of the larynx (laryngitis)
Inflammation of the paranasal sinuses (sinusitis)
Intestinal blockage or absence of bowel movement (intestinal obstruction including paralytic ileus)
Inflammation of the gums (gingivitis)
Inflammation of the tongue (glossitis)
Difficulty swallowing (dysphagia)
Inflammation of the mouth (stomatitis)
Feeling of dizziness (nausea)
Allergic reactions (hypersensitivity), including immediate reactions
Severe allergic reaction that causes swelling of the face and throat (angioedema)
Skin rash (urticaria)
Itching (pruritus)
Urinary tract infection

Not known (cannot be estimated from the available data):

Loss of body water (dehydration)
Tooth decay
Severe allergic reaction (anaphylactic reaction)
Skin infections or ulcers
Dry skin
Swelling of the joints

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this package leaflet. You can also report side effects directly to the Spanish Medicines Monitoring System: http://www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Tavulus 18 micrograms

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the pack and on the blister. The expiry date is the last day of the month stated.

Always use the capsule directly, within 30 minutes after opening the blister. Each dry powder inhaler should be replaced after 6 months, which corresponds to the administration of a maximum of 180 capsules.

Do not store above 30°C.

Keep the medicine in the original package to protect it from moisture.

Medicines should not be disposed of via wastewater or household waste. Return any unused capsules and packaging to a pharmacy for proper disposal. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. Container Contents and Additional Information

Composition of Tavulus 18 micrograms

The active ingredient is tiotropium. Each capsule contains 18 micrograms of active ingredient tiotropium (as bromide). During inhalation, 10 micrograms of tiotropium are released from the dry powder inhaler mouthpiece.
The other component is lactose monohydrate (which may contain small amounts of milk proteins).

Appearance of the Product and Container Contents

The Tavulus 18 microgram capsules, which release 10 micrograms of powder for inhalation per dose, are hard, colorless, and transparent capsules that contain a white powder and are marked with “T10” printed on the capsules.

This medication is presented in blisters. The containers contain the blisters and the dry powder inhaler. The dry powder inhaler has a white body with a red button.

Container formats:

Cardboard box containing 30 capsules (3 blisters) with a dry powder inhaler
Cardboard box containing 60 capsules (6 blisters) with a dry powder inhaler
Cardboard box containing 90 capsules (9 blisters) with a dry powder inhaler
Cardboard box containing 30 capsules (3 blisters)
Cardboard box containing 60 capsules (6 blisters)
Cardboard box containing 90 capsules (9 blisters)

Only some pack sizes may be marketed.

Marketing Authorization Holder and Manufacturer

Marketing Authorization Holder

Zentiva k.s.

U Kabelovny 130

Dolní Mecholupy

102 37 Prague 10

Czech Republic

Manufacturer:

Helm Pharmaceuticals GmbHNordkanalstrasse 28

20097 Hamburg

Germany

You can request more information about this medication by contacting the local representative of the marketing authorization holder: Zentiva Spain S.L.U.

Avenida de Europa, 19, Edificio 3, Planta 1.

28224 Pozuelo de Alarcón, Madrid

Spain

This medication is authorized in the EEA member states under the following names:

Spain	Tavulus 18 micrograms inhalation powder (hard capsule)
France	Tiogiva 18 micrograms powder for inhalation in capsule
Netherlands	Tavulus 18 microgram, inhalation powder in hard capsules

Date of the last revision of this leaflet:March 2024

Detailed information about this medication is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/.

Instructions for using the dry powder inhaler (MRX003R-T10)

Dear patient,

The dry powder inhaler (MRX003-T10) allows you to inhale the medication contained in the Tavulus capsule that your doctor has prescribed for your respiratory problems.

To ensure the correct administration of the medication, you must be trained by your doctor or any other healthcare professional on how to use the inhaler.

The dry powder inhaler is specially designed for Tavulus capsules, so it should not be used for any other medication.

Your medication comes with its Tavulus capsules in blisters.

Use, when applicable, the new dry powder inhaler provided with your medication. Each dry powder inhaler should be replaced after 6 months, which corresponds to a maximum administration of 180 capsules. Do not usethe device if you observe any deterioration or if the capsule remains in the device.

Figure A	The parts of your dry powder inhaler are (see Figure A): Protective cap (cover) Mouthpiece Mouthpiece edge Base Central chamber Piercing button Air inlet grills
Taking your daily dose of medication requires 4 main steps Step 1.Opening your dry powder inhaler:
Figure B	To open the protective cap of the dry powder inhaler: Open the protective cap (cover) by lifting the front edge Pull the protective cap (cover) upwards, away from the base, to expose the mouthpiece (see Figure B)
Figure C	Open the mouthpiece by pulling the mouthpiece edge upwards and away from the base to see the central chamber (see Figure C)
Step 2.Insert a capsule into the dry powder inhaler
Figure D	Remove a capsule from the blister (only immediately before use, see the blister handling section) and place the capsule in the central chamber of the dry powder inhaler. It does not matter which side of the capsule is facing up or down (see Figure D)
Figure E	Close the mouthpiece firmly against the base until you hear a click. Leave the protective cap (cover) open (see Figure E)
Step 3.Pierce the capsule
Figure F	Hold the dry powder inhaler with the mouthpiece pointing upwards (see Figure F) Press the piercing button completely and only once until it stops, and then release it. This is how the capsule is pierced and allows the medication to be released when you inhale. Do notpress the piercing button more than once. Keepyour inhaler in a vertical position. Do notshake your dry powder inhaler.
Step 4.Taking your daily dose (2 inhalations from the same capsule)
Figure G	Exhale completely in 1 breath, emptying your lungs of air (see Figure G). Important: Do notbreathe into your dry powder inhaler.
Figure H	In your next breath, inhale your medication: Keep your head in a vertical position while looking forward(see Figure H) Lift the dry powder inhaler to your mouth in a horizontal position. Do not block the air inlet grills. Close your lips tightly around the mouthpiece. Breathe slowly and deeply until your lungs are full, and you hear or feel the capsule vibrating (rattling) (see Figure H). Hold your breath for a few seconds and, at the same time, remove the dry powder inhaler from your mouth. Breathe normally again. Continue breathing normally. Repeat step 4 once to empty the capsule completely. Important: Do notpress the piercing button again. Remember: To receive the complete dose of medication every day, you must inhale 2 times from the same capsule. Make sure to exhale completely each time before inhaling with your dry powder inhaler. Do not exhale into your dry powder inhaler.
Care and Maintenance of Your Dry Powder Inhaler:
Figure I	After taking your daily dose, open the mouthpiece and remove the capsule, disposing of it in the trash Remove any capsule pieces or accumulated powder by turning the dry powder inhaler and placing it downwards, and gently but firmly tapping it (see Figure I). Then, close the mouthpiece and protective cap (cover) to store it. Keep the dry powder inhaler at room temperature (not above 30°C).
Cleaning Your Dry Powder Inhaler:
Figure J	Clean your dry powder inhaler monthly. It takes 24 hours for the dry powder inhaler to air dry after cleaning. Do notuse cleaners or detergents. Do notput your dry powder inhaler in the dishwasher to clean it Cleaning Steps Open the protective cap (cover) and mouthpiece. Open the base by pressing the piercing button upwards. Check the central chamber for any remaining capsule pieces or accumulated powder. If you see any, remove them. Rinse your dry powder inhaler with warm water, pressing the button several times to ensure the central chamber and piercing needle are under water. Check that all capsule pieces and accumulated powder have been removed. Dry your dry powder inhaler well by pouring out excess water over a piece of paper. Then, air dry it, leaving the protective cap (cover), mouthpiece, and base open and extending the pieces to dry completely. Do not usea hair dryer to dry your dry powder inhaler. Do not useyour dry powder inhaler if it is wet. If necessary, you can clean the outside of the mouthpiece with a damp cloth.
Handling the Blisters
Figure K	Each day, separate only 1 of the blister cavities by tearing along the perforated line (see Figure K)
Figure L	Removing the capsule from the blister: Do not cut the blister sheet or use sharp objects to remove the capsule from the blister. Fold one of the blister corners according to the arrow and separate the aluminum sheets. Peel off the printed sheet until you see the complete capsule (only immediately before use) (see Figure L). If you have opened more than 1 blister cavity, the capsule from that cavity should not be used and should be discarded.
Figure M	Each capsule contains only a small amount of powder (see Figure M). This is a complete dose Do not open the capsule, as it may not be usable.

Country of registration

Spain
Average pharmacy price

39.25 EUR
Active substance

tiotropium bromide
Prescription required

Yes
Manufacturer

Zentiva K.S.
This information is for reference only and does not constitute medical advice. Always consult a doctor before taking any medication. Oladoctor is not responsible for medical decisions based on this content.
Alternatives to TAVULUS 18 micrograms powder for inhalation (hard capsule)

BRALTUS 10 micrograms/dose released powder for inhalation (hard capsule)

Dosage form: PULMONARY INHALATION, 10 MICROGRAMS

Active substance: tiotropium bromide

Manufacturer: Teva Pharma S.L.U.

Prescription required

GREGAL 10 MICROGRAMS/RELEASED DOSE INHALATION POWDER (HARD CAPSULE)

Dosage form: PULMONARY INHALATION, 10 micrograms

Active substance: tiotropium bromide

Manufacturer: Teva Pharma S.L.U.

Prescription required

SPIRIVA 18 micrograms powder for inhalation

Dosage form: PULMONARY INHALATION, 18 micrograms

Active substance: tiotropium bromide

Manufacturer: Boehringer Ingelheim International Gmbh

Prescription required

Online doctors for TAVULUS 18 micrograms powder for inhalation (hard capsule)

Discuss questions about TAVULUS 18 micrograms powder for inhalation (hard capsule), including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Марія Мартеллі

Anaesthesiology 12 years exp.

Dr Maria Martelli is a medical doctor specialising in anaesthesiology and pain medicine. She provides online consultations for adults, focusing on the assessment and management of acute, chronic, and complex pain conditions, as well as supportive care in serious illness.

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She is especially attentive to patients living with long-term pain or serious illness, providing clear explanations, compassionate guidance, and medically sound recommendations adapted to each individual situation.

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Alexander Nazarchuk

Allergology 7 years exp.

Dr. Alexander Nazarchuk is a physician specialising in allergology and internal medicine. He provides online consultations for adults, following the principles of evidence-based medicine — no outdated treatments or unnecessary tests, with clear explanations and a personalised approach. He helps patients with a wide range of allergic and therapeutic conditions, from common day-to-day complaints to complex cases involving allergies, gastrointestinal issues, cardiovascular concerns, respiratory symptoms, and more.

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Allergology 8 years exp.

Dr Marta Reguero Capilla is an allergist and immunologist who works with both adults and children. She specialises in the diagnosis, treatment, and ongoing management of allergic and immune-related conditions through online consultations.

In her practice, Dr Reguero Capilla helps patients understand the causes of their symptoms, review test results, and choose appropriate treatment or monitoring strategies. Her consultations are suitable both for first-time assessments and for follow-up care over time.

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unexplained or recurrent allergic reactions;
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Dr Reguero Capilla works in a structured and attentive manner, explaining medical decisions clearly and helping patients make informed choices about their own health or their child’s care.

When clinically appropriate, she may provide recommendations for further tests or referrals that patients can use within Spanish medical networks, including Sanitas and DKV, in accordance with the terms and conditions of those services.

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Frequently Asked Questions

Is a prescription required for TAVULUS 18 micrograms powder for inhalation (hard capsule)?

TAVULUS 18 micrograms powder for inhalation (hard capsule) requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

What is the active substance in TAVULUS 18 micrograms powder for inhalation (hard capsule)?

The active ingredient in TAVULUS 18 micrograms powder for inhalation (hard capsule) is tiotropium bromide. This information helps identify medicines with the same composition but different brand names.

How much does TAVULUS 18 micrograms powder for inhalation (hard capsule) cost in pharmacies?

The average pharmacy price for TAVULUS 18 micrograms powder for inhalation (hard capsule) is around 39.25 EUR. Prices may vary depending on the manufacturer and dosage form.

Who manufactures TAVULUS 18 micrograms powder for inhalation (hard capsule)?

TAVULUS 18 micrograms powder for inhalation (hard capsule) is manufactured by Zentiva K.S.. Pharmacy brands and packaging may differ depending on the distributor.

Which doctors can assess the use of TAVULUS 18 micrograms powder for inhalation (hard capsule) online?

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether TAVULUS 18 micrograms powder for inhalation (hard capsule) is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

What are the alternatives to TAVULUS 18 micrograms powder for inhalation (hard capsule)?

Other medicines with the same active substance (tiotropium bromide) include BRALTUS 10 micrograms/dose released powder for inhalation (hard capsule), GREGAL 10 MICROGRAMS/RELEASED DOSE INHALATION POWDER (HARD CAPSULE), SPIRIVA 18 micrograms powder for inhalation. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

TAVULUS 18 micrograms powder for inhalation (hard capsule)

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