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ZEPATIER 50mg/100mg FILM-COATED TABLETS

ZEPATIER 50mg/100mg FILM-COATED TABLETS

Ask a doctor about a prescription for ZEPATIER 50mg/100mg FILM-COATED TABLETS

5.0(39)
Doctor

Yevgen Yakovenko

General surgery11 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use ZEPATIER 50mg/100mg FILM-COATED TABLETS

Introduction

Package Leaflet: Information for the User

ZEPATIER 50mg/100mg film-coated tablets

elbasvir/grazoprevir

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What ZEPATIER is and what it is used for
  2. What you need to know before you take ZEPATIER
  3. How to take ZEPATIER
  4. Possible side effects
  5. Storage of ZEPATIER
  6. Contents of the pack and other information

1. What ZEPATIER is and what it is used for

What ZEPATIER is

ZEPATIER is an antiviral medicine that contains the active substances elbasvir and grazoprevir.

What ZEPATIER is used for

ZEPATIER is used to treat chronic hepatitis C infection in adults and children aged 12 years and older who weigh at least 30 kilograms.

How ZEPATIER works

Hepatitis C is a virus that infects the liver. The active substances in the medicine work together to block two different proteins that the hepatitis C virus needs to grow and reproduce. This allows the infection to be eliminated from the body.

ZEPATIER is sometimes taken with another medicine, ribavirin.

It is very important that you also read the package leaflets of the other medicines that you will take with ZEPATIER. If you have any questions about your medicines, ask your doctor or pharmacist.

2. What you need to know before you take ZEPATIER

Do not take ZEPATIER

  • if you are allergic to elbasvir, grazoprevir or any of the other ingredients of this medicine (listed in section 6)
  • if you have moderate or severe liver problems
  • if you are taking any of the following medicines:
    • rifampicin, usually given for tuberculosis
    • HIV protease inhibitors such as atazanavir, darunavir, lopinavir, saquinavir or tipranavir
    • efavirenz or etravirine for HIV
    • elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate or elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide for HIV
    • ciclosporin to prevent organ rejection or to treat severe inflammatory diseases of the eyes, kidneys, joints or skin
    • bosentan for pulmonary arterial hypertension
    • carbamazepine or phenytoin, mainly used for epilepsy and seizures
    • modafinil to help people who cannot stay awake
    • St. John's Wort (Hypericum perforatum, a herbal medicine) for depression or other problems

If you are taking ZEPATIER with ribavirin, make sure you also read the "Do not take" section of the ribavirin package leaflet. If you are not sure about any information that appears in the package leaflet, contact your doctor or pharmacist.

Warnings and precautions

Tell your doctor or pharmacist before you start taking ZEPATIER if you:

  • have had a hepatitis B infection in the past, as your doctor may want to monitor you more closely
  • have ever taken any medicine for hepatitis C
  • have liver problems other than hepatitis C
  • have had a liver transplant
  • have diabetes. After starting ZEPATIER, you may need close monitoring of your blood glucose levels and/or adjustment of your anti-diabetic medication. After starting treatment with medicines like ZEPATIER, some diabetic patients have experienced low blood sugar levels (hypoglycaemia).
  • have any other illness.

Blood tests

Your doctor will perform blood tests before, during and after your treatment with ZEPATIER. This is to:

  • decide if you should take ZEPATIER and for how long
  • decide which other medicines you should take with ZEPATIER and for how long
  • detect side effects
  • check if your treatment has worked and you are free of hepatitis C
  • check how your liver is working - immediately tell your doctor if you have any of the following signs of liver problems: loss of appetite; feeling sick; feeling tired or weak; yellowing of your skin or eyes; changes in the colour of your stools. If you develop any of these symptoms, your doctor may want to perform a blood test to check your liver function.

Children

ZEPATIER must not be used in children under 12 years of age.

Other medicines and ZEPATIER

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. This includes herbal medicines and medicines obtained without a prescription. Keep a list of your medicines and show it to your doctor and pharmacist when you take a new medicine.

There are some medicines that you must not takewith ZEPATIER. See the list in "Do not take ZEPATIER if you are taking any of the following medicines."

Tell your doctor or pharmacist if you are taking any of the following medicines:

  • oral ketoconazole for fungal infections
  • tacrolimus to prevent organ rejection
  • dabigatran to prevent blood clots
  • rosuvastatin, atorvastatin, fluvastatin, simvastatin or lovastatin to lower blood cholesterol
  • sunitinib to treat certain types of cancer
  • warfarin and other similar medicines called vitamin K antagonists, used to thin the blood. Your doctor may increase the number of blood tests to check how your blood clots.

Your liver function may improve with hepatitis C treatment, and therefore may affect other medicines controlled by the liver. Your doctor may need to closely monitor these other medicines that you are taking and make adjustments during treatment with ZEPATIER.

Your doctor may need to change your medicines or change the dose of your medicines.

If any of the above applies to you (or you are not sure), consult your doctor or pharmacist before taking ZEPATIER.

Pregnancy and contraception

The effects of ZEPATIER in pregnancy are not known. If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.

ZEPATIER with ribavirin

  • You must not become pregnant if you are taking ZEPATIER with ribavirin. Ribavirin can be very harmful to the unborn baby. This means that you and your partner must take special precautions during sex if there is any chance that you or your partner may become pregnant.
  • You or your partner must use an effective method of contraception during treatment with ZEPATIER and ribavirin and for some time after finishing treatment. Ask your doctor about the different types of contraception that are suitable for you.
  • If you or your partner become pregnant while taking ZEPATIER with ribavirin or in the months following treatment, immediately tell your doctor.
  • It is very important that you carefully read the information about pregnancy and contraception in the package leaflet of ribavirin. It is important that both men and women read this information.

Breast-feeding

Ask your doctor for advice before taking ZEPATIER if you are breast-feeding. It is not known if the active substances in ZEPATIER pass into breast milk.

If you are taking ZEPATIER with ribavirin, make sure you also read the sections on Pregnancy and Breast-feeding in the package leaflet of this other medicine.

Driving and using machines

Do not drive or use machines if you feel tired after taking your medicine.

ZEPATIERcontainslactose

ZEPATIER contains lactose monohydrate. If your doctor has told you that you have an intolerance to some sugars, contact your doctor before taking this medicine.

ZEPATIER contains sodium

This medicine contains 69.85 mg of sodium (a major component of cooking/table salt) in each tablet. This is equivalent to 3.5% of the maximum recommended daily intake of sodium for an adult.

3. How to take ZEPATIER

Always take this medicine exactly as your doctor or pharmacist has told you. If you are not sure, check with your doctor or pharmacist. Ask your doctor or pharmacist before you take ZEPATIER if you have previously taken any medicine for hepatitis C or if you have any other illness.

How much to take

The recommended dose is one tablet once a daywith or without food.Your doctor will tell you how many weeks you should take ZEPATIER.

Swallow the tablet whole with or without food. Do not chew, crush or break the tablet. Tell your doctor or pharmacist if you have problems swallowing tablets.

If you take more ZEPATIERthan you should

If you take more ZEPATIER than you should, immediately tell your doctor. Take the medicine package with you to show the doctor what you have taken.

If you forget to take ZEPATIER

It is important that you do not miss any dose of this medicine. If you miss a dose, check how long it is since you should have taken ZEPATIER:

  • If it has been less than 16 hours since you should have taken your usual dose, take the missed dose as soon as possible. Then take the next dose at the usual time.
  • If it has been more than 16 hours since you should have taken your usual dose, do not take the missed dose. Wait and take the next dose at the usual time.
  • Do not take a double dose (two doses together) to make up for missed doses.

Do not stop taking ZEPATIER

Do not stop taking this medicine unless your doctor tells you to. It is very important that you complete the full treatment course. This will allow the medicine to treat your hepatitis C infection in the best way possible.

If you have any other questions about the use of this medicine, ask your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. The following side effects may happen with this medicine:

Tell your doctor or pharmacist if you notice any of the following side effects.

Very common:may affect more than 1 in 10 people

  • feeling very tired (fatigue)
  • headache

Common:may affect up to 1 in 10 people

  • nausea
  • feeling weak or lacking energy (asthenia)
  • itching
  • diarrhoea
  • difficulty sleeping (insomnia)
  • joint pain or painful, swollen joints
  • constipation
  • feeling dizzy
  • loss of appetite
  • feeling irritable
  • muscle pain
  • stomach pain
  • uncommon hair loss or thinning
  • feeling anxious (anxiety)
  • depression
  • dry mouth
  • vomiting

Uncommon:may affect up to 1 in 100 people

  • abnormalities in laboratory tests to check liver function

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of ZEPATIER

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the carton and blister after EXP. The expiry date refers to the last day of the month.

This medicine does not require any special storage conditions.

Store in the original package to protect from moisture.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help protect the environment.

6. Package Contents and Additional Information

ZEPATIER Composition

  • The active ingredients are:elbasvir and grazoprevir. Each film-coated tablet contains 50 mg of elbasvir and 100 mg of grazoprevir.
  • The other components are:

Core of the tablet:

Sodium lauryl sulfate, vitamin E polyethylene glycol succinate, copovidone, hypromellose, microcrystalline cellulose, mannitol (E421), lactose monohydrate, sodium croscarmellose, sodium chloride, anhydrous colloidal silica, magnesium stearate

Film coating:

Lactose monohydrate, hypromellose, titanium dioxide, triacetin, yellow iron oxide (E-172), red iron oxide (E-172), black iron oxide (E-172), carnauba wax

Appearance of the Product and Package Contents

The film-coated tablets are beige, oval, engraved with "770" on one side and smooth on the other. The tablet measures 21 mm in length and 10 mm in width.

The tablets are packaged in a box containing two cardboard cards, each with two aluminum blisters of 7 tablets. Each box contains a total of 28 tablets.

Marketing Authorization Holder

Merck Sharp & Dohme B.V.

Waarderweg 39

2031 BN Haarlem

Netherlands

Manufacturer

Organon Heist bv

Industriepark 30

2220 Heist-op-den-Berg

Belgium

You can request more information about this medication by contacting the local representative of the marketing authorization holder:

BE/LU

MSD Belgium

Tel/Tel: +32(0)27766211

[email protected]

LT

UAB Merck Sharp & Dohme

Tel. +370 5 2780 247

[email protected]

Text in a foreign language with contact information of a Bulgarian pharmaceutical company including phone and email

HU

MSD Pharma Hungary Kft.

Tel.: +36 1 888 5300

[email protected]

CZ

Merck Sharp & Dohme s.r.o.

Tel: +420 233 010 111

[email protected]

MT

Merck Sharp & Dohme Cyprus Limited

Tel: 8007 4433 (+356 99917558)

[email protected]

DK

MSD Danmark ApS

Tlf.: +45 4482 4000

[email protected]

NL

Merck Sharp & Dohme B.V.

Tel: 0800 9999000 (+31 23 5153153)

[email protected]

DE

MSD Sharp & Dohme GmbH

Tel.: +49 (0) 89 20 300 4500

[email protected]

NO

MSD (Norge) AS

Tlf: +47 32 20 73 00

[email protected]

EE

Merck Sharp & Dohme OÜ

Tel: +372 614 4200

[email protected]

AT

Merck Sharp & Dohme Ges.m.b.H.

Tel: +43 (0) 1 26 044

[email protected]

EL

MSD Α.Φ.Ε.Ε.

Τηλ: +30 210 98 97 300

[email protected]

PL

MSD Polska Sp. z o.o.

Tel.: +48 22 549 51 00

[email protected]

ES

Merck Sharp & Dohme de España, S.A.

Tel: +34 91 321 06 00

[email protected]

PT

Merck Sharp & Dohme, Lda

Tel: +351 21 4465700

[email protected]

FR

MSD France

Tél: +33 (0) 1 80 46 40 40

RO

Merck Sharp & Dohme Romania S.R.L.

Tel: +40 21 529 29 00

[email protected]

HR

Merck Sharp & Dohme d.o.o.

Tel: + 385 1 6611 333

[email protected]

SI

Merck Sharp & Dohme, inovativna zdravila d.o.o.

Tel: +386 1 520 4201

[email protected]

IE

Merck Sharp & Dohme Ireland (Human Health) Limited

Tel: +353 (0)1 2998700

[email protected]

SK

Merck Sharp & Dohme, s. r. o.

Tel: +421 2 58282010

[email protected]

IS

Vistor ehf.

Sími: + 354 535 7000

FI

MSD Finland Oy

Puh/Tel: +358 (0)9 804 650

[email protected]

IT

MSD Italia S.r.l.

Tel: 800 23 99 89 (+39 06 361911)

[email protected]

SE

Merck Sharp & Dohme (Sweden) AB

Tel: +46 77 5700488

[email protected]

CY

Merck Sharp & Dohme Cyprus Limited

Τηλ.: 800 00 673 (+357 22866700)

[email protected]

LV

SIA Merck Sharp & Dohme Latvija

Tel.: + 371 67025300

[email protected]

Date of the Last Revision of this Leaflet{MM/YYYY}.

Detailed information on this medication is available on the European Medicines Agency website: https://www.ema.europa.eu.

Online doctors for ZEPATIER 50mg/100mg FILM-COATED TABLETS

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for ZEPATIER 50mg/100mg FILM-COATED TABLETS – subject to medical assessment and local rules.

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Dr. Jonathan Marshall Ben Ami is a licensed family medicine doctor in Spain. He provides comprehensive care for adults and children, combining general medicine with emergency care expertise to address both acute and chronic health concerns.

Dr. Ben Ami offers expert diagnosis, treatment, and follow-up for:

  • Respiratory infections (cold, flu, bronchitis, pneumonia).
  • ENT conditions such as sinusitis, ear infections, and tonsillitis.
  • Digestive issues including gastritis, acid reflux, and irritable bowel syndrome (IBS).
  • Urinary tract infections and other common infections.
  • Management of chronic diseases: high blood pressure, diabetes, thyroid disorders.
  • Acute conditions requiring urgent medical attention.
  • Headaches, migraines, and minor injuries.
  • Wound care, health check-ups, and ongoing prescriptions.

With a patient-focused and evidence-based approach, Dr. Ben Ami supports individuals at all stages of life — offering clear medical guidance, timely interventions, and continuity of care.

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Yevgen Yakovenko

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Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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She integrates medical analysis, psychological insight, and real-life behaviour change tools to offer treatment plans tailored to each patient’s biochemistry, mental state, and lifestyle.

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  • Recovery from stress, burnout, and hormonal imbalances
  • Emotional support and psychosomatic symptom care
Her approach is never one-size-fits-all – each consultation begins with a deep dive into your unique health history, test results, and emotional landscape. Consultations are available in Ukrainian, Polish, and Russian.
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With a patient-centred approach, Dr. Raevskii helps individuals manage both chronic illnesses and complex oncological cases. His consultations are guided by current medical standards and adapted to each patient’s needs.

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  • Pain management: acute and chronic pain, post-surgical care
  • Public health: prevention, health screenings, long-term monitoring
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Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.

Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

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Dr Kovalenko combines evidence-based practice with a respectful, patient-centred approach. She takes time to explain, listens attentively, and helps each person make confident, informed decisions about their health.

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  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
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Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
  • Respiratory infections – cough, colds, bronchitis.
  • Lab test analysis, therapy adjustments, medication management.
  • Adult vaccinations – planning, contraindications assessment.
  • Cancer prevention – screening strategies and risk assessment.
  • Holistic approach – symptom relief, complication prevention, and quality of life improvement.
Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
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Doctor

Maryna Kuznetsova

Cardiology16 years of experience

Dr Marina Kuznetsova is an internal medicine doctor and cardiologist with a PhD in medicine. She provides online consultations for adults with chronic and acute conditions, with a strong focus on cardiovascular health. Her approach is based on current clinical guidelines and evidence-based treatment strategies.

Areas of expertise:

  • dyslipidaemia and lipid metabolism disorders
  • prevention and management of atherosclerosis
  • blood pressure monitoring and antihypertensive therapy
  • arrhythmias: diagnosis, follow-up, and treatment adjustment
  • cardiovascular care and recovery support after Covid-19
Dr Kuznetsova helps patients manage cardiovascular risk factors, optimise long-term treatment, and gain clarity in complex health situations – all through accessible and structured online care.
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€50
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Doctor

Antonio Cayatte

General medicine43 years of experience

Dr Antonio Cayatte is a physician in General and Acute Medicine with over 30 years of experience across clinical care, medical research, and education. He offers online consultations for adults with a wide range of symptoms, both acute and chronic.

His clinical background includes:

  • assessment of sudden or unclear symptoms
  • ongoing care for chronic conditions
  • follow-up after hospital discharge
  • interpretation of test results
  • medical support while abroad
Dr Cayatte earned his degree from the University of Lisbon and taught internal medicine at Boston University School of Medicine. He holds active medical registrations in both Portugal and the UK and is a Fellow of the American Heart Association.

Consultations are available in English and Portuguese. Patients value his clarity, professionalism, and balanced approach to evidence-based care.

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€60
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